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    • 9. 发明授权
    • Skin preparations for external use
    • 外用皮肤准备
    • US06939859B1
    • 2005-09-06
    • US09937414
    • 2000-03-30
    • Hironobu MuraseToshiaki Fujii
    • Hironobu MuraseToshiaki Fujii
    • A01N43/04A01N43/16A61K31/35A61K31/70A61K31/7048A61P17/00A61P17/16A61P43/00C07H15/26C07H17/065
    • A61K8/602A61Q19/02A61Q19/08
    • An dermatological agent for external use is disclosed which contains a chromanol glycoside represented by the following general formula (1) (wherein R1, R2, R3, and R4 which may be the same or different, each represent a hydrogen atom or a lower alkyl group, R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group, X represents a monosaccharic residue or an oligosaccharic residue optionally having the hydrogen atom of the hydroxyl group in the saccharic residue substituted with a lower alkyl group or a lower acyl group, n represents an integer in the range of 0-6, and m represents an integer in the range of 1-6). This is a novel dermatological agent for external use which excels in stability and percutaneous absorbency, manifests an effective action safely at a small application rate, and effectively prevents and cures the dermopathy. It is very useful as an agent for preventing and curing the disorders caused by the ultraviolet light, an agent for preventing and allaying the sedimentation of pigment in the skin, an agent for beautifying the skin in white, an agent for preventing the senescence of the skin, an agent for activating cells, an agent for preventing and curing the dermopathy, and a cosmetic preparation.
    • 公开了一种外用皮肤病药,其含有以下通式(1)表示的色原糊精糖苷(其中R 1,R 2,R 3,R 3, 和/或相同或不同的R 4各自表示氢原子或低级烷基,R 5表示氢原子,低级烷基 基团或低级酰基,X表示任选具有由低级烷基或低级酰基取代的糖残基中的羟基的氢原子的单糖残基或寡糖残基,n表示在 0-6,m表示1-6的整数。 这是一种外用的新型皮肤病学药剂,其稳定性和经皮吸收性优异,以小的施用率安全地显示出有效的作用,有效地防止并治愈了皮肤病。 作为用于预防和治疗由紫外线引起的疾病的药剂,用于预防和消除皮肤中色素沉淀的药剂,美白白皮肤剂,防止紫外线衰老的药剂是非常有用的 皮肤,活化细胞的药剂,用于预防和治愈皮肤病的药剂和化妆品制剂。