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1. 发明授权

US07132650B1 High throughput multi-dimensional sample analysis 有权
标题翻译：高通量多维样本分析
公开(公告)号：US07132650B1
公开(公告)日：2006-11-07
申请号：US10951255
申请日：2004-09-25
申请人： Ronald C. Gamble , Stephen D. O'Connor , Bruce Wilcox , Matthew M. Gregori
发明人： Ronald C. Gamble , Stephen D. O'Connor , Bruce Wilcox , Matthew M. Gregori
IPC分类号： H01J49/42
CPC分类号： G01N30/7233 , G01N30/466 , G01N30/80 , G01N2030/8447 , H01J49/0018 , H01J49/0431 , H01J49/107 , Y10T137/86863 , Y10T137/86871 , Y10T436/115831
摘要： High throughput analytical systems and methods employing multiple liquid phase separation process regions coupled to a common mass spectrometer are provided. Disclosed systems and methods permits parallel separation and parallel storage of discrete eluate fractions, followed by sequential discharge and ionization of previously stored eluate portions to yield a composite ion stream containing the sequential series of eluate portions, followed by mass analysis of the ion stream. A common manifold may receive ions and utilize pressurized gas or ion gating to direct ions within the manifold toward the mass spectrometer inlet.
摘要翻译：提供了使用耦合到共同的质谱仪的多个液相分离工艺区域的高通量分析系统和方法。公开的系统和方法允许离散洗脱液级分的并行分离和平行存储，随后顺序地排出和离子化先前储存的洗脱液部分，以产生含有顺序一系列洗脱液部分的复合离子流，随后对离子流进行质量分析。常见的歧管可以接收离子并利用加压气体或离子门控来将歧管内的离子引向质谱仪入口。

2. 发明授权

US07261812B1 Multi-column separation devices and methods 有权
标题翻译：多柱分离装置和方法
公开(公告)号：US07261812B1
公开(公告)日：2007-08-28
申请号：US10638258
申请日：2003-08-07
申请人： Christoph D. Karp , Joseph F. Covington , Matthew M. Gregori , Steven E. Hobbs , Jeffrey A. Koehler , Stephen D. O'Connor , Paren P. Patel , Scott G. Beach
发明人： Christoph D. Karp , Joseph F. Covington , Matthew M. Gregori , Steven E. Hobbs , Jeffrey A. Koehler , Stephen D. O'Connor , Paren P. Patel , Scott G. Beach
IPC分类号： B01D15/08
CPC分类号： B01D15/1864 , B01D15/1885 , G01N30/603 , G01N30/6043 , G01N30/6091 , G01N30/6095
摘要： Chromatographic separation devices include multiple batch-processed columns joined by a body structure and adapted to perform parallel analyses. Both slurry-packed and monolithic column embodiments are provided. One or more liquid-permeable frits of various types may be used to retain stationary phase material within columns. A fluidic distribution network may be used to distribute stationary phase material and/or mobile phase solvents to multiple columns. Separation devices, including microfluidic embodiments, may be fabricated with various materials including polymers. Multi-column fabrication and separation methods are provided.
摘要翻译：色谱分离装置包括由身体结构连接并适于执行平行分析的多个批处理柱。提供浆料包装和整体柱实施例。可以使用一种或多种各种类型的透液性玻璃料将固定相材料保持在塔内。可以使用流体分配网络将固定相材料和/或流动相溶剂分配到多个塔。包括微流体实施例的分离装置可以用包括聚合物的各种材料制成。提供了多列制造和分离方法。

3. 发明申请

US20110178610A1 SYSTEMS AND METHODS FOR MANAGING UTILITY CONSUMPTION 审中-公开
标题翻译：用于管理实用消费的系统和方法
公开(公告)号：US20110178610A1
公开(公告)日：2011-07-21
申请号：US13120920
申请日：2009-10-15
申请人： Stephen D. O'Connor , Ronald C. Gamble , Richard A. Suchter
发明人： Stephen D. O'Connor , Ronald C. Gamble , Richard A. Suchter
IPC分类号： G05B13/04 , G06G7/48
CPC分类号： G06Q10/06
摘要： A system and method for monitoring and managing utility consumption includes use of (A) one or more sensors arranged to monitor an operating condition and/or utility consumption of at least one segment or appliance of a first facility; (B) a memory including at least one of (i) stored utility consumption information correlated or normalized to at least one designated parameter affecting utility consumption or (ii) hypothetical utility consumption; (C) a processor to compare the monitored information with the stored information, and (D) an output medium to store and/or display the comparison information. Stored consumption information may relate to the first facility or a second facility. Hypothetical utility consumption information may relate to a segment or appliance of the first facility operated according to optimized conditions, or an upgraded segment or appliance.
摘要翻译：一种用于监测和管理公用事业消耗的系统和方法包括使用（A）布置成监测第一设施的至少一个段或设备的运行状况和/或公用事业消耗的一个或多个传感器; （B）存储器，其包括以下至少一个：（i）存储的与至少一个影响公用事业消耗的指定参数相关或归一化的公用消费信息;（ii）假设的公用事业消费; （C）处理器，用于将所监视的信息与存储的信息进行比较，以及（D）存储和/或显示比较信息的输出介质。存储的消费信息可能与第一设施或第二设施有关。假设效用消耗信息可以涉及根据优化条件操作的第一设施的段或设备，或升级的段或设备。

4. 发明授权

US06987263B2 High throughput systems and methods for parallel sample analysis 有权
标题翻译：高通量系统和并行样本分析方法
公开(公告)号：US06987263B2
公开(公告)日：2006-01-17
申请号：US10736154
申请日：2003-12-13
申请人： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
发明人： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
IPC分类号： B01D54/44 , H01J49/00
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.
摘要翻译：提供了使用优选与流体相分离技术耦合的质谱分析多个样品的系统。多分析仪质谱仪包括多个入口，多个质量分析仪和多个换能器，用于并行进行多个样品的质量分析。模块化质量分析器可以包括真空外壳，底盘以及设置在底盘内的多个质量分析模块。模块优选地设置在空间紧凑的二维阵列中。共同的多级真空系统可以与设置在模块内和模块之间的挡板或隔板一起使用，以利用最少数量的泵来保持光谱仪内的差分真空条件。通常的控制输入可以提供给多分析仪光谱仪中的多个模块或其他组件。用于多分析仪光谱仪的流体相分离装置可以是利用色谱，电泳或其它分离方法的微流体装置。

5. 发明授权

US07393645B2 Compositions for the electronic detection of analytes utilizing monolayers 有权
标题翻译：使用单层电子检测分析物的组合物
公开(公告)号：US07393645B2
公开(公告)日：2008-07-01
申请号：US11208384
申请日：2005-08-19
申请人： Jon Faiz Kayyem , Stephen D. O'Connor
发明人： Jon Faiz Kayyem , Stephen D. O'Connor
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/54353 , C12Q1/6825 , G01N2610/00 , C12Q2565/519 , C12Q2563/113
摘要： The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.
摘要翻译：本发明涉及使用具有导电低聚物和绝缘体的混合物的自组装单层来检测目标分析物。

6. 发明授权

US06880576B2 Microfluidic devices for methods development 有权
标题翻译：用于方法开发的微流体装置
公开(公告)号：US06880576B2
公开(公告)日：2005-04-19
申请号：US10838877
申请日：2004-05-03
申请人： Christoph D. Karp , Stephen D. O'Connor , Eugene Dantsker
发明人： Christoph D. Karp , Stephen D. O'Connor , Eugene Dantsker
IPC分类号： B01F5/04 , B01F5/06 , B01F13/00 , B01F15/02 , B01L3/00 , F15C1/14
CPC分类号： B01F5/0471 , B01F5/064 , B01F13/0059 , B01F15/0205 , B01F15/0264 , B01J19/0093 , B01J2219/00783 , B01J2219/00889 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0681 , B01L2300/0864 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , B01L2400/06 , B01L2400/0688 , B81B2201/058 , B81C1/00119 , B81C2201/019 , B82Y30/00 , G01N30/6095 , Y10T137/2076 , Y10T137/2082 , Y10T137/2164 , Y10T137/2224
摘要： Microfluidic devices with multiple fluid process regions for subjecting similar samples to different process conditions in parallel are provided. One or more common fluid inputs may be provided to minimize the number of external fluid supply components. Solid materials such as chromatographic separation media or catalyst media is preferably provided in each fluid process region. Solid materials may be supplied to the devices in the form of slurry, with particles retained by porous elements or frits. Different fluid process regions may having different effective lengths, different solid material types or amounts, or may receive different ratios of common fluids supplied to the device. The flow resistances of dissimilar fluid process regions may be balanced passively with the addition of impedance elements in series with each fluid process region.
摘要翻译：提供了具有多个流体工艺区域的微流体装置，用于使相似的样品并行地处理不同的工艺条件。可以提供一个或多个常见的流体输入以最小化外部流体供应部件的数量。固体材料如色谱分离介质或催化剂介质优选在每个流体工艺区域中提供。固体材料可以以浆料的形式供应给设备，其中颗粒被多孔元件或玻璃料保留。不同的流体工艺区域可以具有不同的有效长度，不同的固体材料类型或量，或者可以接收提供给设备的不同比例的常用流体。不同流体工艺区域的流动阻力可以被动地平衡，同时与每个流体处理区域串联的阻抗元件的添加。

7. 发明授权

US06814938B2 Non-planar microfluidic devices and methods for their manufacture 失效
标题翻译：非平面微流体装置及其制造方法
公开(公告)号：US06814938B2
公开(公告)日：2004-11-09
申请号：US09864610
申请日：2001-05-23
申请人： Christoph D. Karp , Stephen D. O'Connor , Vincent K. Gustafson
发明人： Christoph D. Karp , Stephen D. O'Connor , Vincent K. Gustafson
IPC分类号： B01L302
CPC分类号： B01L3/0217 , B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , G01N2035/1062 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/2575
摘要： Non-planar microfluidic devices and methods for transferring fluids between vessels and microfluidic devices are provided. The devices may be contoured to physically contact non-planar vessels, such as pipes, tubes, vials, or syringes to establish fluid communication between a vessel and a microfluidic device. Devices according to the invention may be constructed from flexible, rigid, or combinations of flexible and rigid materials. In certain embodiments, microfluidic devices are composed of sandwiched stencils, and self-adhesive tapes may be used for one or more layers. A microfluidic device may be removably attached to a vessel with a non-permanent adhesive or adhesive layer. Continuously wrapped microfluidic devices fashioned from a single layer, in addition to rewindable microfluidic devices constructed from multiple layers, are provided. A multi-plunger syringe permits a microfluidic device or other reservoir coupled to the vessel to be filled on the draw stroke of the syringe plunger.

8. 发明授权

US06619311B2 Microfluidic regulating device 失效
公开(公告)号：US06619311B2
公开(公告)日：2003-09-16
申请号：US10127081
申请日：2002-04-19
申请人： Stephen D. O'Connor , Christoph D. Karp
发明人： Stephen D. O'Connor , Christoph D. Karp
IPC分类号： G05D701
CPC分类号： B01L3/5025 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0689 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0487 , B01L2400/0622 , B01L2400/0638 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0044 , F16K99/0046 , F16K99/0051 , F16K99/0055 , F16K99/0059 , F16K99/0061 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , Y10T137/2496 , Y10T137/2559 , Y10T137/2663 , Y10T137/87249
摘要： Microfluidic flow control devices are provided. In one embodiment, a regulating device includes overlapping channel segments separated by a deformable membrane in fluid communication with one another. Pressure differentials between the channel segments deform the membrane towards the channel with the lower pressure, thereby restricting flow. The restricted flow increases pressure in the low pressure channel, reversing the deformation of the membrane and regulating the pressure between the channels

9. 发明授权

US06290839B1 Systems for electrophoretic transport and detection of analytes 失效
标题翻译：电泳运输和检测分析物系统
公开(公告)号：US06290839B1
公开(公告)日：2001-09-18
申请号：US09134058
申请日：1998-08-14
申请人： Jon Faiz Kayyem , Gary Blackburn , Stephen D. O'Connor
发明人： Jon Faiz Kayyem , Gary Blackburn , Stephen D. O'Connor
IPC分类号： G01N2726
CPC分类号： B82Y15/00 , B82Y30/00 , C12Q1/6825 , C12Q2565/501 , C12Q2565/107
摘要： The invention relates to compositions and methods useful in the electrophoretic transport of target analytes to a detection electrode comprising a self-assembled monolayer (SAM). Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
摘要翻译：本发明涉及用于将目标分析物电泳转运到包括自组装单层（SAM）的检测电极的组合物和方法。检测通过直接或间接使用与目标分析物相关的电子转移部分（ETM）进行，以允许电子检测ETM。

10. 发明授权

US6096273A Electrodes linked via conductive oligomers to nucleic acids 失效
公开(公告)号：US6096273A
公开(公告)日：2000-08-01
申请号：US743798
申请日：1996-11-05
申请人： Jon F. Kayyem , Stephen D. O'Connor , Michael Gozin , Changjun Yu , Thomas J. Meade
发明人： Jon F. Kayyem , Stephen D. O'Connor , Michael Gozin , Changjun Yu , Thomas J. Meade
IPC分类号： C07H21/00 , C12Q1/68 , G01N15/06
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

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