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1. 发明授权

US10016140B2 Automated non-magnetic medical monitor using shape memory actuators 有权
公开(公告)号：US10016140B2
公开(公告)日：2018-07-10
申请号：US14401708
申请日：2013-06-13
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Francis Patrick O'Neill , Ronald Paul Consiglio
IPC分类号： F16K99/00 , A61B5/0235 , F16K31/00 , F16K31/02 , A61B5/022 , A61B5/0225 , A61B5/151 , A61B17/00 , A61M39/24
CPC分类号： A61B5/0235 , A61B5/02233 , A61B5/0225 , A61B5/055 , A61B5/15119 , A61B2017/00867 , A61B2017/00911 , A61M2039/2486 , F16K31/002 , F16K31/025 , F16K99/0038 , F16K99/0044
摘要： When employing a valve in a medical device in or near a bore of a magnetic resonance (MR) scanner, MR-compatible materials are employed to minimize the susceptibility of the valve to the strong magnetic fields generated by the MR scanner. An MR-compatible actuator comprises a shame memory alloy (SMA) wire or member (12) that is actuated by application of a constant power signal. The constant power signal is supplied by a control circuit (50) that is generated using a power feedback signal derived from measured current and voltage feedback signals. Once the SMA member is actuated, the power signal can be reduced and pulse width modulated to maintain the SMA member in an active state, which in turn maintains the valve in a closed state until the power signal is terminated.

2. 发明申请

US20180119799A1 OPEN LOOP CONTROL SYSTEM FOR A MEMS MICROVALVE 审中-公开
公开(公告)号：US20180119799A1
公开(公告)日：2018-05-03
申请号：US15797847
申请日：2017-10-30
申请人： DunAn Microstaq, Inc.
发明人： E. Nelson Fuller , Parthiban Arunasalam , Wayne C. Long , Arvind P. Rao , Kevin Sinkar , Gengxun K. Gurley
IPC分类号： F16H61/00 , G05D7/06 , G05B15/02 , F16H61/10
CPC分类号： F16H61/0021 , F16H59/72 , F16H61/0009 , F16H61/10 , F16H2059/683 , F16K99/0011 , F16K99/0028 , F16K99/0044 , G05B15/02 , G05D7/0635 , G05D16/2013
摘要： A system for controlling fluid pressure to a transmission system through a MEMS microvalve includes a transmission controller configured to receive a target command pressure, a current system command pressure input signal, and a transmission system operating temperature. A power determination module determines a temperature-related power factor from the target command pressure, the current system command pressure input signal, the transmission system operating temperature received in the controller, and a look-up table within the controller. A power signal module adjusts the current system command pressure input signal by the temperature-related power factor and applies the adjusted current system command pressure input signal to the MEMS microvalve via the controller.

3. 发明授权

US09829451B2 Microfluidic reconfiguration device for multi-plexed sample analysis 有权
公开(公告)号：US09829451B2
公开(公告)日：2017-11-28
申请号：US14350034
申请日：2012-10-09
申请人： Simon Fraser University
发明人： Bonnie L. Gray , Lesley Shannon
IPC分类号： G01N27/02 , G01N21/01 , F16K99/00 , H01F1/44 , B01L3/00 , G01N27/447
CPC分类号： G01N27/02 , B01L3/502 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/027 , B01L2200/04 , B01L2200/10 , B01L2200/12 , B01L2300/0819 , B01L2300/0877 , B01L2300/123 , B01L2400/043 , B01L2400/0672 , F16K99/0032 , F16K99/0044 , F16K99/0046 , F16K2099/0084 , G01N21/01 , G01N27/44791 , H01F1/447
摘要： A reconfigurable microfluidics multiplexing device for biological and chemical sample analysis which comprises: a cartridge comprising one or more sample fluid tracks (both horizontal and vertical) in a single plane, an array comprising one or more electronically programmable valves capable of being configured to alter fluid steering in the fluid tracks; a means for the array to interface with the fluid tracks; a means to control fluid flow in the fluid tracks; and a user interface to direct control of valves via control logic within the device; wherein, by the interface, valve positions are controllable and alterable.

4. 发明授权

US09689408B2 Bistable actuator, actuator arrangement, method for actuation and use 有权
公开(公告)号：US09689408B2
公开(公告)日：2017-06-27
申请号：US14387091
申请日：2013-01-31
申请人： Karlsruher Institut für Technologie
发明人： Bastian Rapp , Christiane Neumann , Elisabeth Wilhelm , Achim Voigt
IPC分类号： F15B15/10 , F16K99/00 , F15B15/14 , G09B21/00 , F02F3/00 , F02B75/38
CPC分类号： F15B15/10 , F02B75/38 , F02F3/00 , F02F3/0015 , F15B15/1404 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0069 , G09B21/004 , Y10T137/0318
摘要： A method for bistably actuating an actuator includes applying positive pressure in an actuator fluid supply that is fluidly connected to an actuator chamber by means of an actuator fluid supply connection, wherein a working positive pressure is generated in the actuator chamber, whereby an actuator element fluidly connected to the actuator chamber is brought from a resting position to an actuation position, pressure-tight sealing of the actuator fluid supply connection, so that the working positive pressure in the actuator chamber is maintained and the actuator element remains in the actuation position.

5. 发明授权

US09546743B2 Sealable microvalve that can be repeatedly opened and sealed 有权
标题翻译：可密封的微型阀可以反复打开和密封
公开(公告)号：US09546743B2
公开(公告)日：2017-01-17
申请号：US14455302
申请日：2014-08-08
申请人： Northeastern University
发明人： Carol Livermore-Clifford , Chenye Yang
IPC分类号： F16K99/00
CPC分类号： F16K99/0009 , F16K99/0032 , F16K99/0044 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K2099/0069 , F16K2099/0074 , F16K2099/008
摘要： A substantially leak-free, sealable microvalve that can be repeatedly opened and sealed is presented. The resealable microvalve includes a block with a through via and a sealing plate. The gap between the block and the sealing plate is sealed by a sealing material. The sealing material can be melted when heat is applied and can be solidified when heat is absent. To close the resealable microvalve, heat is applied by flowing a current through a resistive heater and an actuator brings the block and the sealing plate into a contacting position. By removing the heat, the sealing material is solidified and creates a sealed state. To open the resealable microvalve, heat is applied to the sealing material. When the sealing material melts, the actuator moves the block and the sealing plate into a spaced apart position.
摘要翻译：提出了可重复打开和密封的基本无泄漏，可密封的微型阀。可重新密封的微型阀包括具有通孔和密封板的块体。块体与密封板之间的间隙由密封材料密封。当加热时密封材料可以熔化，并且当不存在热时可以固化。为了关闭可重新密封的微型阀，通过使电流流过电阻加热器来施加热量，并且致动器使块和密封板进入接触位置。通过去除热量，密封材料固化并产生密封状态。为了打开可重新密封的微型阀，将热量施加到密封材料上。当密封材料熔化时，致动器将块和密封板移动到间隔开的位置。

6. 发明授权

US09505608B2 Microvalve having a reduced size and improved electrical performance 有权
标题翻译：微型阀具有减小的尺寸和改善的电性能
公开(公告)号：US09505608B2
公开(公告)日：2016-11-29
申请号：US14713332
申请日：2015-05-15
申请人： DunAn Microstaq, Inc.
发明人： Parthiban Arunasalam , Chen Yang , E. Nelson Fuller , Joe A. Ojeda, Sr. , Gengxun Kara Gurley
IPC分类号： F16K11/065 , B81B7/00 , F16K99/00
CPC分类号： B81B7/0061 , B81B2201/054 , B81B2203/0307 , B81B2203/0315 , F16K99/0011 , F16K99/0028 , F16K99/0044 , F16K2099/008
摘要： A microvalve includes a displaceable member having an elongated arm portion, a plurality of actuator ribs connected through a central spine to the elongated arm portion, and a hinge portion. Each of the actuator ribs has a first portion and a second portion, the first portions each having an end connected to the central spine, the second portions each having an end connected to the central spine. A channel is formed in the plate. A plurality of elongated openings is formed in the plate and define the actuator ribs, each elongated opening having longitudinally extending side edges. One of the elongated openings separates each rib in the second portion of ribs from an adjacent rib or the plate. The channel and a longitudinally extending side edge of one of the elongated openings separate the second portion of the actuator ribs from the plate and define an electrical isolation region.
摘要翻译：微型阀包括具有细长臂部分的可移动构件，通过中心脊连接到细长臂部分的多个致动器肋和铰链部分。每个致动器肋具有第一部分和第二部分，第一部分各自具有连接到中心脊的端部，第二部分各自具有连接到中心脊部的端部。在板中形成通道。多个细长开口形成在板中并限定致动器肋，每个细长开口具有纵向延伸的侧边缘。一个细长的开口将肋的第二部分中的每个肋与相邻的肋或板分开。一个细长开口的通道和纵向延伸的侧边缘将致动器肋的第二部分与板分隔开并限定电隔离区。

7. 发明申请

US20160250640A1 INTEGRATED APPARATUS FOR PERFORMING NUCLEIC ACID EXTRACTION AND DIAGNOSTIC TESTING ON MULTIPLE BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于在多种生物样品上进行核酸提取和诊断测试的综合设备
公开(公告)号：US20160250640A1
公开(公告)日：2016-09-01
申请号：US14941087
申请日：2015-11-13
申请人： HANDYLAB, INC.
发明人： Jeff Williams , Kerry Wilson , Kalyan Handique
IPC分类号： B01L3/00 , B01L9/06 , B01L3/02 , B01L7/00
CPC分类号： B01L3/502761 , B01L3/0275 , B01L3/5027 , B01L3/52 , B01L7/52 , B01L9/06 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/06 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0832 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/026 , G01N2035/00881 , G01N2035/0425 , G01N2035/0436
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
摘要翻译：本文描述的技术通常涉及用于从多个样品，特别是来自生物样品中提取多核苷酸的系统，另外还涉及随后扩增和检测提取的多核苷酸的系统。该技术更特别涉及在微流体通道内的多个目的核苷酸样品上进行PCR并检测这些核苷酸的微流体系统。

8. 发明授权

US09259734B2 Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples 有权
公开(公告)号：US09259734B2
公开(公告)日：2016-02-16
申请号：US13417108
申请日：2012-03-09
申请人： Jeff Williams , Kalyan Handique , Kerry Wilson
发明人： Jeff Williams , Kalyan Handique , Kerry Wilson
IPC分类号： B01L7/00 , B01L3/00 , B01L9/00 , F16K99/00 , B01L9/06 , G01N35/02 , G01N35/04 , G01N35/00 , G01N35/10
CPC分类号： B01L7/52 , B01L3/5027 , B01L3/5085 , B01L9/06 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2200/147 , B01L2200/148 , B01L2200/16 , B01L2300/021 , B01L2300/045 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1861 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B01L2400/0611 , B01L2400/0677 , B01L2400/0683 , F16K99/0001 , F16K99/003 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0084 , G01N35/026 , G01N2035/00881 , G01N2035/0436 , G01N2035/103
摘要： The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

9. 发明授权

US09127782B2 Single use microfluidic valve 有权
标题翻译：单用微流控阀
公开(公告)号：US09127782B2
公开(公告)日：2015-09-08
申请号：US12766231
申请日：2010-04-23
申请人： Marjolaine Allain , Skandar Basrour , Jean Berthier , Patrick Pouteau
发明人： Marjolaine Allain , Skandar Basrour , Jean Berthier , Patrick Pouteau
IPC分类号： F16K99/00 , B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L2400/0677 , F16K99/00 , F16K99/003 , F16K99/0044 , F16K2099/0084 , F16K2099/0086 , Y10T137/0318 , Y10T137/1797
摘要： A microfluidic valve including a microchannel, a membrane arranged so as to seal off the microchannel and equipped with resistive units, characterized in that at least one face of the membrane includes at least one groove, and in that the resistive units are arranged in the groove and are capable, when an electric control current flows through them, of expanding sufficiently under the effect of the heat produced by the flow of the electric current to cause the rupture of at least one part of the membrane.
摘要翻译：一种微流体阀，包括微通道，膜被设置成密封微通道并配备有电阻单元，其特征在于，所述膜的至少一个表面包括至少一个凹槽，并且所述电阻单元布置在所述凹槽中并且当电控制电流流过它们时，能够在由电流流动产生的热量的作用下充分膨胀，从而导致膜的至少一部分的破裂。

10. 发明申请

US20150083228A1 BISTABLE ACTUATOR, ACTUATOR ARRANGEMENT, METHOD FOR ACTUATON AND USE 有权
标题翻译：双动执行器，执行器安装，执行和使用方法
公开(公告)号：US20150083228A1
公开(公告)日：2015-03-26
申请号：US14387091
申请日：2013-01-31
申请人： Karlsruher Institut für Technologie
发明人： Bastian Rapp , Christiane Neumann , Elisabeth Wilhelm , Achim Voigt
IPC分类号： F15B15/10
CPC分类号： F15B15/10 , F02B75/38 , F02F3/00 , F02F3/0015 , F15B15/1404 , F16K99/0032 , F16K99/0044 , F16K99/0061 , F16K2099/0069 , G09B21/004 , Y10T137/0318
摘要： A method for bistably actuating an actuator includes applying positive pressure in an actuator fluid supply that is fluidly connected to an actuator chamber by means of an actuator fluid supply connection, wherein a working positive pressure is generated in the actuator chamber, whereby an actuator element fluidly connected to the actuator chamber is brought from a resting position to an actuation position, pressure-tight sealing of the actuator fluid supply connection, so that the working positive pressure in the actuator chamber is maintained and the actuator element remains in the actuation position.
摘要翻译：用于双稳态地致动致动器的方法包括在通过致动器流体供应连接流体地连接到致动器室的致动器流体供应中施加正压力，其中在致动器室中产生工作正压，由此致动器元件流体地连接到致动器室的静止位置被施加到致动位置，致动器流体供应连接器的压力密封，使得致动器室中的工作正压力保持并且致动器元件保持在致动位置。

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