专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100042075A1 MULTI-OPENING RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 有权
标题翻译：用于控制释放或储存内容物暴露的多开式储存装置
公开(公告)号：US20100042075A1
公开(公告)日：2010-02-18
申请号：US12581558
申请日：2009-10-19
申请人： John T. Santini, JR. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, JR.
发明人： John T. Santini, JR. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, JR.
IPC分类号： A61M37/00
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.
摘要翻译：提供了诸如医疗装置的装置，其包括具有至少一个具有两个或更多个开口的储存器的主体部分，所述两个或多个开口部分地由储存器盖支撑件限定; 设置在储存器内部的储存器内容物，例如药物制剂或传感器; 以及封闭两个或更多储存器开口的储存器盖。可能破裂的储存盖控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。

2. 发明申请

US20090024113A1 MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS 审中-公开
标题翻译：具有保护性内部墙壁的多储存医疗设备
公开(公告)号：US20090024113A1
公开(公告)日：2009-01-22
申请号：US12193523
申请日：2008-08-18
申请人： John M. Maloney , Zouhair Sbiaa , John T. Santini, JR. , Norman F. Sheppard, JR. , Scott A. Uhland
发明人： John M. Maloney , Zouhair Sbiaa , John T. Santini, JR. , Norman F. Sheppard, JR. , Scott A. Uhland
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： An implantable medical device is provided for controlled delivery or exposure of reservoir contents. The device may include a substrate; a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate; reservoir contents disposed in the reservoirs; a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo, wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo. For example, to enhance the resistance of the substrate to etching in vivo, the interior sidewalls of the reservoirs may include a protective coating (such as gold, platinum, carbon, silicon carbide, silicon dioxide, or platinum silicide), or the sidewalls may include a doped silicon.
摘要翻译：提供可植入医疗装置用于控制输送或暴露储存器内容物。该装置可以包括基板; 在所述基板中的多个分立储存器，其中所述储存器具有内壁和所述基板中的至少一个开口; 蓄水池内容物; 储存器盖封闭每个储存器的至少一个开口以密封每个储存器中的储存器内容物; 以及用于选择性地分解储存器盖以释放或暴露储存器内容物在体内的控制电路，其中储存器的内壁包括在体内保护基板的材料。例如，为了增强衬底在体内蚀刻的电阻，储存器的内侧壁可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅或硅化铂），或者侧壁可以包括掺杂硅。

3. 发明申请

US20100137696A1 MEDICAL DEVICE WITH RESERVOIR-BASED SENSORS 有权
标题翻译：具有基于储存器的传感器的医疗装置
公开(公告)号：US20100137696A1
公开(公告)日：2010-06-03
申请号：US12688508
申请日：2010-01-15
申请人： John T. Santini, JR. , Norman F. Sheppard, JR. , Chung Chang Young , Robert S. Langer
发明人： John T. Santini, JR. , Norman F. Sheppard, JR. , Chung Chang Young , Robert S. Langer
IPC分类号： A61B5/1473 , A61N1/08
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
摘要翻译：提供一种医疗装置，其可以包括具有开口并包含传感器的储存器; 储存器盖封闭开口以将传感器与储存器外部的环境部件隔离，储存器盖不可渗透到环境部件并且适于选择性地进行相变以使储存器盖分解，从而将传感器暴露于环境部件。使用的方法可以包括（i）选择性地分解储存器盖以暴露设置在植入患者体内的装置的储存器内部的传感器，所述分解包括引起储存器盖中的相变; 以及（ii）使用所述传感器来产生输出信号，其中所述输出信号被记录并存储在可写入计算机存储器芯片中，指向微处理器以进行即时分析和处理，或者发送到远离所述设备的远程位置。

4. 发明申请

US20090018413A1 IMPLANTABLE MEDICAL DEVICE FOR DIAGNOSTIC SENSING 有权
标题翻译：用于诊断感测的可植入医疗装置
公开(公告)号：US20090018413A1
公开(公告)日：2009-01-15
申请号：US12240728
申请日：2008-09-29
申请人： John T. Santini, JR. , Norman F. Sheppard, JR.
发明人： John T. Santini, JR. , Norman F. Sheppard, JR.
IPC分类号： C12M1/34 , A61B5/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening; a reacting component contained in each reservoir; and at least one non-degradable barrier layer covering each reservoir opening, the barrier layer being permeable to an analyte to be detected, wherein the reacting component remains inside the reservoirs and can react with the analyte to be detected, and wherein the device is adapted for implantation into the body of a patient.
摘要翻译：提供可植入的医疗装置，用于与外部检测器一起检测体内分析物。在一个实施例中，该装置基本上由基底组成; 多个分立储存器，位于基板中，每个储存器具有至少一个开口; 每个储存器中包含的反应组分; 以及覆盖每个储存器开口的至少一个不可降解的阻挡层，所述阻挡层对待检测的分析物是可渗透的，其中所述反应成分保留在所述储存器的内部并且可以与待检测的分析物反应，并且其中所述装置适应用于植入患者的身体。

5. 发明申请

US20110172587A1 METHOD AND SYSTEM FOR DRUG DELIVERY TO THE EYE 失效
标题翻译：药物递送到眼睛的方法和系统
公开(公告)号：US20110172587A1
公开(公告)日：2011-07-14
申请号：US13012426
申请日：2011-01-24
申请人： John T. Santini, JR. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, JR. , Stephen J. Herman
发明人： John T. Santini, JR. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, JR. , Stephen J. Herman
IPC分类号： A61F9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
摘要翻译：提供了将药物输送到眼睛的方法和系统。该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。

6. 发明申请

US20080302659A1 ELECTROCHEMICAL BIOSENSORS AND ARRAYS 有权
标题翻译：电化学传感器和阵列
公开(公告)号：US20080302659A1
公开(公告)日：2008-12-11
申请号：US12134966
申请日：2008-06-06
申请人： Norman F. Sheppard, JR. , John T. Santini, JR.
发明人： Norman F. Sheppard, JR. , John T. Santini, JR.
IPC分类号： G01N33/487 , A61M25/00
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/004 , G01N27/3272
摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
摘要翻译：以各种电流，电位和电导率的传感器装置配置提供电化学传感器装置。电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储存器内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

7. 发明申请

US20120241216A1 COMPRESSION AND COLD WELD SEALING METHODS AND DEVICES 有权
标题翻译：压缩和冷焊密封方法和装置
公开(公告)号：US20120241216A1
公开(公告)日：2012-09-27
申请号：US13488355
申请日：2012-06-04
申请人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, JR. , Douglas Snell , Catherine M.B. Santini
发明人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, JR. , Douglas Snell , Catherine M.B. Santini
IPC分类号： F16B11/00 , B23K20/00 , H01R4/02
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , H01L2924/16315 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：提供压缩冷焊方法，接头结构和密封的密封装置。该方法包括提供具有至少一个第一接头结构的第一基底，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接头结构的第二基底，所述第二接头结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合金属的接合面。在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。密封装置可以包含药物制剂，生物传感器或MEMS装置。

8. 发明申请

US20130211219A1 Implantable Biosensor Device and Methods of Use Thereof 审中-公开
标题翻译：植入式生物传感器装置及其使用方法
公开(公告)号：US20130211219A1
公开(公告)日：2013-08-15
申请号：US13818545
申请日：2011-08-12
申请人： Jonathan R. Coppeta , Robert Farra , Kenneth L. Hilts , Norman F. Sheppard, JR.
发明人： Jonathan R. Coppeta , Robert Farra , Kenneth L. Hilts , Norman F. Sheppard, JR.
IPC分类号： A61B5/145 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/046 , A61B2562/066
摘要： Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir, a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.
摘要翻译：提供了传感器装置和方法，用于检测流体中分析物的存在或浓度。设备有一个水库; 位于储存器内的工作电极，覆盖工作电极的至少一部分的催化剂; 储存器中的产氧辅助电极; 以及用于隔离储存器内的工作和辅助电极的储存器盖。该装置还包括用于选择性地破裂盖以允许来自储存器外部的分析物与催化剂接触的装置。所述方法可以包括体内葡萄糖监测，并且可以包括将装置植入患者体内; 分解储存器盖以允许葡萄糖进入储存器; 使用产生氧的辅助电极产生氧气; 并且在葡萄糖氧化酶的存在下使用工作电极氧化由氧与葡萄糖的反应产生的过氧化氢，从而检测患者的内源性葡萄糖。

9. 发明申请

US20090030404A1 CONTAINMENT DEVICE WITH MULTI-LAYER RESERVOIR CAP STRUCTURE 有权
标题翻译：具有多层储层结构的容纳装置
公开(公告)号：US20090030404A1
公开(公告)日：2009-01-29
申请号：US12243791
申请日：2008-10-01
申请人： Scott A. Uhland , Benjamin F. Polito , John M. Maloney , Norman F. Sheppard, JR. , Stephen J. Herman , Barry M. Yomtov
发明人： Scott A. Uhland , Benjamin F. Polito , John M. Maloney , Norman F. Sheppard, JR. , Stephen J. Herman , Barry M. Yomtov
IPC分类号： A61K9/22
CPC分类号： A61M25/0082 , A61B5/0215 , A61B5/042 , A61B5/1459 , A61B5/1473 , A61B5/4839 , A61M5/14276 , A61M25/0069 , A61M37/00 , A61M2005/1726 , A61M2205/0244 , A61M2205/123 , A61M2205/3653 , A61N1/32 , Y10T436/25
摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.
摘要翻译：提供了用于控制释放或暴露储存器内容物的装置和方法。该装置包括基板，基板中的多个储存器，设置在储存器中的储存器内容物，覆盖每个储存器的分立存储器盖，用于密封储存器中的储存器内容物;以及控制电路，用于选择性地分解储存器盖以释放或暴露水库内容物。储存器盖中的至少一个包括涂覆有一个或多个保护层的第一导电层。在一个实施例中，控制电路包括电输入引线和连接到并直接接触每个所述储存器盖的电输出引线和电源，用于以有效破裂每个储存器盖水箱盖。

10. 发明申请

US20110089957A1 MULTI-CHANNEL POTENTIOSTAT FOR BIOSENSOR ARRAYS 有权
标题翻译：生物传感器阵列的多通道电位
公开(公告)号：US20110089957A1
公开(公告)日：2011-04-21
申请号：US12905710
申请日：2010-10-15
申请人： Norman F. Sheppard, JR.
发明人： Norman F. Sheppard, JR.
IPC分类号： G01R27/08 , G01R1/30
CPC分类号： G01N27/3273
摘要： Arrays of biosensors are provided along with methods for operating the arrays of biosensors. The array of biosensors may include a first reference electrode that is connected to an input of a first control amplifier; a first working electrode and a second working electrode in proximity with the first reference electrode; and a counter electrode that is connected to at least an output of the first control amplifier, where the first control amplifier is operative with the counter electrode to maintain a first specified voltage between the first working electrode and the first reference electrode, and between the second working electrode and the first reference electrode. The array of biosensors optionally may further include a second reference electrode that is connected to an input of a second control amplifier, where the second control amplifier is operative with the counter electrode to maintain a second specified voltage between the first working electrode and the second reference electrode, and between the second working electrode and the second reference electrode.
摘要翻译：提供生物传感器的阵列以及用于操作生物传感器阵列的方法。生物传感器阵列可以包括连接到第一控制放大器的输入的第一参考电极; 第一工作电极和靠近第一参考电极的第二工作电极; 以及对电极，其连接到所述第一控制放大器的至少一个输出端，其中所述第一控制放大器与所述对电极一起操作以维持所述第一工作电极和所述第一参考电极之间的第一规定电压，工作电极和第一参考电极。生物传感器的阵列可选地还可以包括连接到第二控制放大器的输入的第二参考电极，其中第二控制放大器与对电极一起操作以在第一工作电极和第二参考电极之间保持第二规定电压电极，以及第二工作电极和第二参考电极之间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式