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1. 发明授权

US08403915B2 Multi-opening reservoir devices for controlled release or exposure of reservoir contents 有权
标题翻译：用于控制释放或暴露储存器内容物的多开式储存装置
公开(公告)号：US08403915B2
公开(公告)日：2013-03-26
申请号：US12581558
申请日：2009-10-19
申请人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
IPC分类号： A61K9/22 , A61M5/14
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.
摘要翻译：提供了诸如医疗装置的装置，其包括具有至少一个具有两个或更多个开口的储存器的主体部分，所述两个或多个开口部分地由储存器盖支撑件限定; 设置在储存器内部的储存器内容物，例如药物制剂或传感器; 以及封闭两个或更多储存器开口的储存器盖。可能破裂的储存盖控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。

2. 发明授权

US07604628B2 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 有权
标题翻译：用于控制释放或暴露储层内容物的多盖储存装置
公开(公告)号：US07604628B2
公开(公告)日：2009-10-20
申请号：US11217799
申请日：2005-09-01
申请人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.
摘要翻译：提供了一种储存器装置，其中单个储存器具有至少两个开口，其间具有支撑结构，并且通过覆盖开口的储存器盖封闭以控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。该装置包括基板; 设置在基板中的至少一个储存器，储存器具有两个或更多个开口; 水库内容位于水库; 两个或更多个分立的储存器盖，每个储存器盖密封地覆盖至少一个储存器开口; 以及用于选择性地使贮存器盖分解或渗透的控制装置。

3. 发明申请

US20100042075A1 MULTI-OPENING RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 有权
标题翻译：用于控制释放或储存内容物暴露的多开式储存装置
公开(公告)号：US20100042075A1
公开(公告)日：2010-02-18
申请号：US12581558
申请日：2009-10-19
申请人： John T. Santini, JR. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, JR.
发明人： John T. Santini, JR. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, JR.
IPC分类号： A61M37/00
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.
摘要翻译：提供了诸如医疗装置的装置，其包括具有至少一个具有两个或更多个开口的储存器的主体部分，所述两个或多个开口部分地由储存器盖支撑件限定; 设置在储存器内部的储存器内容物，例如药物制剂或传感器; 以及封闭两个或更多储存器开口的储存器盖。可能破裂的储存盖控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。

4. 发明申请

US20090024113A1 MULTI-RESERVOIR MEDICAL DEVICE HAVING PROTECTED INTERIOR WALLS 审中-公开
标题翻译：具有保护性内部墙壁的多储存医疗设备
公开(公告)号：US20090024113A1
公开(公告)日：2009-01-22
申请号：US12193523
申请日：2008-08-18
申请人： John M. Maloney , Zouhair Sbiaa , John T. Santini, JR. , Norman F. Sheppard, JR. , Scott A. Uhland
发明人： John M. Maloney , Zouhair Sbiaa , John T. Santini, JR. , Norman F. Sheppard, JR. , Scott A. Uhland
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： An implantable medical device is provided for controlled delivery or exposure of reservoir contents. The device may include a substrate; a plurality of discrete reservoirs in the substrate, wherein the reservoirs have interior walls and at least one opening in the substrate; reservoir contents disposed in the reservoirs; a reservoir cap closing the at least one opening of each of the reservoirs to seal the reservoir contents in each of the reservoirs; and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo, wherein the interior walls of the reservoirs comprise a material to protect the substrate in vivo. For example, to enhance the resistance of the substrate to etching in vivo, the interior sidewalls of the reservoirs may include a protective coating (such as gold, platinum, carbon, silicon carbide, silicon dioxide, or platinum silicide), or the sidewalls may include a doped silicon.
摘要翻译：提供可植入医疗装置用于控制输送或暴露储存器内容物。该装置可以包括基板; 在所述基板中的多个分立储存器，其中所述储存器具有内壁和所述基板中的至少一个开口; 蓄水池内容物; 储存器盖封闭每个储存器的至少一个开口以密封每个储存器中的储存器内容物; 以及用于选择性地分解储存器盖以释放或暴露储存器内容物在体内的控制电路，其中储存器的内壁包括在体内保护基板的材料。例如，为了增强衬底在体内蚀刻的电阻，储存器的内侧壁可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅或硅化铂），或者侧壁可以包括掺杂硅。

5. 发明授权

US07413846B2 Fabrication methods and structures for micro-reservoir devices 有权
标题翻译：微储层装置的制造方法和结构
公开(公告)号：US07413846B2
公开(公告)日：2008-08-19
申请号：US10988667
申请日：2004-11-15
申请人： John M. Maloney , Zouhair Sbiaa , John T. Santini, Jr. , Norman F. Sheppard, Jr. , Scott A. Uhland
发明人： John M. Maloney , Zouhair Sbiaa , John T. Santini, Jr. , Norman F. Sheppard, Jr. , Scott A. Uhland
IPC分类号： G03F7/20
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂），或者包含硅的侧壁可以掺杂硼或另一种杂质。

6. 发明授权

US06875208B2 Microchip devices with improved reservoir opening 失效
标题翻译：具有改进水箱开口的Microchip器件
公开(公告)号：US06875208B2
公开(公告)日：2005-04-05
申请号：US10159550
申请日：2002-05-31
申请人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Nolan T. Flynn , Scott A. Uhland , Zouhair Sbiaa , John M. Maloney
发明人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Nolan T. Flynn , Scott A. Uhland , Zouhair Sbiaa , John M. Maloney
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00 , A61M37/00
CPC分类号： A61K9/0097 , A61K9/0009 , Y10T137/8242
摘要： Microchip devices and methods of manufacture thereof are provided to increase the uniformity and reliability of active exposure and release of microchip reservoir contents. In one embodiment, the microchip device for the controlled release or exposure of molecules or secondary devices comprises: (1) a substrate having a plurality of reservoirs; (2) reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs; (3) reservoir caps positioned on the reservoirs over the reservoir contents; (4) electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and (5) a current distribution means, a stress induction means, or both, operably engaged with or integrated into the reservoir cap, to enhance reservoir cap disintegration.
摘要翻译： Microchip的器件及其制造方法被提供以增加微芯片储存器内容物的主动曝光和释放的均匀性和可靠性。在一个实施例中，用于分子或次要装置的受控释放或暴露的微芯片装置包括：（1）具有多个储存器的基板; （2）位于储层中的包含分子，次要装置或二者的储层内容物; （3）位于油藏内的油藏内的储层盖; （4）电活化装置，用于使贮存器盖分解以开始在所选择的储存器中暴露或释放储存器内容物; 和（5）电流分配装置，应力感应装置或两者，可操作地与储存器盖接合或集成到储存器盖中，以增强储存器盖分解。

7. 发明申请

US20060105275A1 Fabrication methods and structures for micro-reservoir devices 有权
标题翻译：微储层装置的制造方法和结构
公开(公告)号：US20060105275A1
公开(公告)日：2006-05-18
申请号：US10988667
申请日：2004-11-15
申请人： John Maloney , Zouhair Sbiaa , John Santini , Norman Sheppard , Scott Uhland
发明人： John Maloney , Zouhair Sbiaa , John Santini , Norman Sheppard , Scott Uhland
IPC分类号： G03F7/00
CPC分类号： B01L3/50853 , A61K9/0024 , A61K9/0097 , B01L2200/12 , B01L2300/0819 , B01L2400/0677
摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.
摘要翻译：提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂），或者包含硅的侧壁可以掺杂硼或另一种杂质。

8. 发明申请

US20080015494A1 MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
标题翻译：用于透析，生物传感或输送物质的多储层泵装置
公开(公告)号：US20080015494A1
公开(公告)日：2008-01-17
申请号：US11776351
申请日：2007-07-11
申请人： John Santini , Michael Cima , Jonathan Coppeta , James Prescott , Zouhair Sbiaa , Mark Staples
发明人： John Santini , Michael Cima , Jonathan Coppeta , James Prescott , Zouhair Sbiaa , Mark Staples
IPC分类号： A61M31/00
CPC分类号： A61M37/0015 , A61M5/1409 , A61M5/14248 , A61M5/1452 , A61M5/14526 , A61M2005/14204 , A61M2005/14268 , A61M2037/0023
摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.
摘要翻译：提供泵补丁装置用于药物递送。该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。

9. 发明申请

US20060057737A1 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 有权
公开(公告)号：US20060057737A1
公开(公告)日：2006-03-16
申请号：US11217799
申请日：2005-09-01
申请人： John Santini , Zouhair Sbiaa , Jonathan Coppeta
发明人： John Santini , Zouhair Sbiaa , Jonathan Coppeta
IPC分类号： G01N1/00 , A61K9/22
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

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