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1. 发明申请

US20090023684A1 FLUID FOR PERITONEAL DIALYSIS 审中-公开
标题翻译：流体用于透析
公开(公告)号：US20090023684A1
公开(公告)日：2009-01-22
申请号：US11912279
申请日：2006-04-13
申请人： Hitomi Ohta , Toshiharu Hanaya , Shigeharu Fukuda , Yoshikatsu Miwa , Toshio Miyake
发明人： Hitomi Ohta , Toshiharu Hanaya , Shigeharu Fukuda , Yoshikatsu Miwa , Toshio Miyake
IPC分类号： A61K31/715
CPC分类号： A61K31/716 , A61K31/702 , A61K31/7048 , A61M1/287 , A61K2300/00
摘要： The present invention has an object to provide a fluid for peritoneal dialysis with satisfactory body fluid removability, high biocompatibility, and improved storage stability, and the object is attained by a fluid for peritoneal dialysis containing one or more saccharides selected from cyclonigerosylnigerose, cyclomaltosylmaltose, and L-ascorbic acid 2-glucoside.
摘要翻译：本发明的目的是提供一种用于腹膜透析的流体，其具有令人满意的体液清除性，高生物相容性和改善的储存稳定性，并且目的是通过含有一种或多种选自旋风黑素糖， L-抗坏血酸2-葡萄糖苷。

2. 发明申请

US20120035187A1 ANTI-NEURODEGENERATIVE DISEASE AGENT 审中-公开
标题翻译：抗神经病变药物
公开(公告)号：US20120035187A1
公开(公告)日：2012-02-09
申请号：US13146840
申请日：2010-01-25
申请人： Hitomi Ohta , Kenji Akita , Tsunetaka Ohta , Toshio Kawata , Shigeharu Fukuda
发明人： Hitomi Ohta , Kenji Akita , Tsunetaka Ohta , Toshio Kawata , Shigeharu Fukuda
IPC分类号： A61K31/496 , C07D417/14 , C07D263/57 , C07D213/38 , C07D417/06 , C07D413/06 , C07D403/06 , C07D403/14 , A61K31/4709 , A61K31/427 , A61K31/428 , A61K31/423 , A61K31/44 , A61K31/404 , A61P25/00 , A61P25/28 , A61P25/16 , A61P3/10 , A61P27/02 , A61P35/04 , A61P17/04 , A61P39/06 , A61P35/00 , C07D401/14
CPC分类号： C07D277/22 , C07D209/14 , C07D213/74 , C07D215/06 , C07D215/12 , C07D231/22 , C07D235/20 , C07D261/12 , C07D263/56 , C07D277/28 , C07D277/64 , C07D277/84 , C07D311/74 , C07D333/32 , C07D333/64 , C07D405/06 , C07D413/06 , C07D417/06
摘要： The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General formula 1: wherein in General formula 1, R1 through R3 independently represent a hydrogen atom or an appropriate substituent; Z1 represents a heterocyclic ring and Z2 represents the same or different heterocyclic or aromatic ring as in Z1, wherein the heterocyclic and aromatic rings optionally have a substituent; represents an integer of 0, 1 or 2; p represents an integer of 0 or 1, with the proviso that p is 1 when o is 0 or 2, and p is 0 when o is 1; R1 and R2 do not exist when o is 0, while, when p is 0, R3 does not exist and the binding between the carbon atom to which R2 binds and Z2 is a single bond; X1− represents an appropriate counter anion and q represents an integer of 1 or 2.
摘要翻译：本发明的目的是提供抗神经退行性疾病的新型药剂，通过提供含有下述通式1表示的化合物作为有效成分的抗神经变性疾病试剂来解决本发明的目的：其中在通式1中，R 1至R 3独立地表示氢原子或适当的取代基; Z1表示杂环，Z2表示与Z1中相同或不同的杂环或芳环，其中杂环和芳环任选具有取代基; 表示0,1或2的整数; p表示0或1的整数，条件是当o为0或2时p为1，当o为1时p为0; 当o为0时，R1和R2不存在，而当p为0时，R3不存在，R2结合的碳原子与Z2为单键的结合; X 1表示适当的抗衡阴离子，q表示1或2的整数。

3. 发明授权

US09215887B2 Method for inhibiting coloring of a syrupy sweetener comprising a non-reducing oligosaccharide having a beta-fructofranosidic linkage and a reducing saccharide, and use thereof 有权
标题翻译：用于抑制糖浆状甜味剂着色的方法，其包含具有β-呋喃糖苷键和还原糖的非还原性寡糖，及其用途
公开(公告)号：US09215887B2
公开(公告)日：2015-12-22
申请号：US12990729
申请日：2009-04-27
申请人： Kenshi Yoshida , Ikuo Sawatani , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Kenshi Yoshida , Ikuo Sawatani , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23L1/09 , A23L1/236 , A23C9/13 , A23C9/154 , A23C11/04 , A23K1/16 , A23L1/03 , A23L1/06 , A23L1/272 , A23L2/60 , C12P19/00 , C12P19/18 , A23L1/30
CPC分类号： A23L1/2363 , A23C9/1307 , A23C9/1544 , A23C11/04 , A23K20/10 , A23K20/163 , A23L2/60 , A23L5/00 , A23L5/41 , A23L7/00 , A23L21/00 , A23L21/10 , A23L27/33 , A23L29/035 , A23L29/30 , A23V2002/00 , C12P19/00 , C12P19/18 , C12Y204/01019 , C12Y302/01026 , A23V2250/61 , A23V2250/606 , A23V2250/5046
摘要： The objects of the present invention are to provide a method for inhibiting the coloration of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, without deteriorating the taste inherent to the syrupy sweetener; and to provide a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, which is stabilized by the method. The present invention attains the above objects by providing a method for inhibiting the coloring of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, which comprises a step of incorporating a lactate into the syrupy sweetener, and by providing a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, which is stabilized by the method.
摘要翻译：本发明的目的是提供一种抑制糖浆状甜味剂的着色的方法，其包含还原糖与具有呋喃呋喃糖苷键的非还原性寡糖，而不会降低糖浆状甜味剂固有的味道; 并提供一种糖浆状甜味剂，其包含还原糖以及通过该方法稳定的具有呋喃呋喃糖苷键的非还原性寡糖。本发明通过提供一种抑制糖浆状甜味剂着色的方法来实现上述目的，该方法包括还原糖以及具有呋喃呋喃糖苷键的非还原寡糖，其包括将乳酸盐掺入糖浆中的步骤并且通过提供糖浆状甜味剂，其包含还原糖以及通过该方法稳定的具有呋喃呋喃糖苷键的非还原性寡糖。

4. 发明授权

US08759030B2 Process for producing 2-O-alpha-D-glucopyranosyl-L-ascorbic acid 有权
标题翻译：制备2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的方法
公开(公告)号：US08759030B2
公开(公告)日：2014-06-24
申请号：US10523920
申请日：2003-07-07
申请人： Kazuhisa Mukai , Keiji Tsusaki , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuhisa Mukai , Keiji Tsusaki , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/44
CPC分类号： C12P19/60
摘要： The object of the present invention is to provide a method and a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid where 5-O-α-glucopyranosyl-L-ascorbic acid and 6-O-α-glucopyranosyl-L-ascorbic acid are not formed or formed in such a small amount that the formation of these can nor be detected. The present invention solves the above object by providing a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid comprising the steps of allowing α-isomaltosyl glucosaccharide-forming enzyme together with or without cyclomaltodextrin glucanotransferase (EC 2.4.1.19) to act on a solution comprising L-ascorbic acid and, an α-glucosyl saccharide to form 2-O-α-glucopyranosyl-L-ascorbic acid and collecting the formed 2-O-α-glucopyranosyl-L-ascorbic acid.
摘要翻译：本发明的目的是提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法和方法，其中5-O-α-吡喃葡萄糖基-L-抗坏血酸和6-O-α-吡喃葡萄糖基 - L-抗坏血酸不是以这样的少量形成或形成，也可以不形成。本发明通过提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法来解决上述目的，其包括以下步骤：将α-异麦芽糖基葡萄糖形成酶与或不与环糊精葡聚糖转移酶（EC 2.4.1.19）一起作用于包含L-抗坏血酸和α-葡萄糖基糖的溶液中以形成2-O-α-吡喃葡萄糖基-L-抗坏血酸并收集形成的2-O-α-吡喃葡萄糖基-L-抗坏血酸。

5. 发明授权

US08524889B2 Highly-branched starch, its production and uses 有权
标题翻译：高分支淀粉，其生产和用途
公开(公告)号：US08524889B2
公开(公告)日：2013-09-03
申请号：US13443296
申请日：2012-04-10
申请人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C07H1/06 , C08B31/00
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着抗退行性的具有6-α-麦芽糖基 - 和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种生产支化淀粉而不降低分子量的方法的材料淀粉及其用途。

6. 发明申请

US20120196331A1 HIGHLY-BRANCHED STARCH, ITS PRODUCTION AND USES 有权
标题翻译：高分配淀粉，其生产和用途
公开(公告)号：US20120196331A1
公开(公告)日：2012-08-02
申请号：US13443296
申请日：2012-04-10
申请人： Tomoyuki NISHIMOTO , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki NISHIMOTO , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/22
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着的耐退化性的具有6-α-麦芽糖基和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种不降低分子量的支链淀粉的制备方法的材料淀粉及其用途。

7. 发明申请

US20080003651A1 alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same 有权
标题翻译： α-异麦芽糖基葡萄糖形成酶，其工艺和用途
公开(公告)号：US20080003651A1
公开(公告)日：2008-01-03
申请号：US11797932
申请日：2007-05-09
申请人： Michio Kubota , Keiji Tsusaki , Takanobu Higashiyama , Shigeharu Fukuda , Toshio Miyake
发明人： Michio Kubota , Keiji Tsusaki , Takanobu Higashiyama , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/04
CPC分类号： A23G1/40 , A21D2/181 , A23C9/005 , A23C9/1307 , A23C9/1544 , A23C9/156 , A23G3/42 , A23G4/10 , A23G9/34 , A23L2/60 , A23L15/00 , A23L15/20 , A23L27/30 , A23L33/10 , A23L33/21 , A61K8/60 , A61K8/66 , A61K9/0014 , A61K47/26 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07H3/04 , C07H3/06 , C12N9/1051 , C12N9/2425 , C12N9/2428 , C12P19/04 , C12Y302/01001 , C12Y302/01002 , C12Y302/01003 , C12Y302/0102
摘要： The object of the present invention is to provide an α-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an α-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the α-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the α-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; α-isomaltosyl-transferring method using the enzyme; method for forming α-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(166)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(16} using both the α-isomaltosylglucosaccharide-forming enzyme and the α-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.
摘要翻译：本发明的目的是提供一种α-异麦芽糖基葡萄糖形成酶，其工艺，环四糖和包含可通过使用酶获得的糖的糖组合物; 并且通过建立形成葡糖聚合度至少为3并且在非还原末端具有α-1,6糖苷键作为连接的α糖异构体糖结合酶和α - 通过催化从葡萄糖聚合度至少为2并具有α-1,4糖苷键作为连接的糖的α-葡糖基转移而在非还原性末端的连接以外的1,4-葡糖苷键所述非还原端基本上不增加所述还原能力; 使用该酶的α-异麦芽糖基转移法; 形成α-异麦芽糖基糖的方法; 制备具有环{66）-alpha-D-吡喃葡萄糖基 - （163）-al-D-glucopyranosyl-（166）-al-D-glucopyranosyl-（163）-al-D-glucopyranosyl-（163）-al-D-glucopyranosyl- （16）同时使用α-异麦芽糖基糖产生酶和α-异麦芽糖基转移酶;以及可用其获得的糖的用途。

8. 发明申请

US20070154996A1 Method for transferring a glucosyl residue 审中-公开
标题翻译：转移葡糖基残基的方法
公开(公告)号：US20070154996A1
公开(公告)日：2007-07-05
申请号：US10587711
申请日：2005-01-27
申请人： Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/04
CPC分类号： C12P19/18 , C12P19/44
摘要： An object of the present invention is to provide novel methods for forming glucosyl-transferred polyalcohols, glucosyl-transferred glucuronic acid, and glucosyl-transferred derivatives of glucose whose C-6 hydroxyl group bound to a saccharide by using an enzymatic reaction. The present invention solves the above object by providing a method for transferring a glucosyl residue to polyalcohols, glucuronic acid and/or derivatives of glucose whose C-6 hydroxyl group bound to a saccharide, comprising a step of: allowing a trehalose phosphorylase to act on a saccharide containing glucose as a component sugar and one or more polyalcohols selected from the group consisting of inositol, ribitol, erythritol, and glycerol; glucuronic acid and/or a salt thereof; and/or one or more derivatives of glucose whose C-6 hydroxyl group bound to a saccharide selected from the group consisting of isomaltose, gentiobiose, melibiose, isomaltotriose, and isopanose.
摘要翻译：本发明的目的是提供通过酶促反应形成C-6羟基与糖结合的葡萄糖转移的多元醇，葡糖基转移的葡萄糖醛酸和葡萄糖转移的葡萄糖转移衍生物的新方法。本发明通过提供一种将葡糖基残基转移到多糖，葡糖醛酸和/或其C-6羟基与糖结合的葡萄糖的衍生物的方法，包括以下步骤：使海藻糖磷酸化酶作用于含有葡萄糖作为组分糖和一种或多种选自肌醇，核糖醇，赤藓糖醇和甘油的多元醇的糖; 葡萄糖醛酸和/或其盐; 和/或一种或多种C-6羟基结合于选自异麦芽糖，龙胆糖，蜜二糖，异麦芽三糖和异丙糖的糖的葡萄糖衍生物。

9. 发明授权

US07214667B2 Drugs against articular failure 有权
标题翻译：药物针对关节功能衰竭
公开(公告)号：US07214667B2
公开(公告)日：2007-05-08
申请号：US11136717
申请日：2005-05-25
申请人： Shigeharu Fukuda , Takeshi Ario , Toshio Miyake
发明人： Shigeharu Fukuda , Takeshi Ario , Toshio Miyake
IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H5/06
CPC分类号： A23G4/10 , A23L2/52 , A23L5/00 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/40 , A61K8/60 , A61K8/735 , A61K31/7008 , A61K31/7016 , A61K31/727 , A61K31/728 , A61K2800/59 , A61Q19/10 , A61K2300/00
摘要： The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans. The present invention solves the object by providing an agent for treating articular disorders, comprising an amino sugar and trehalose as effective ingredients.
摘要翻译：本发明的目的是提供一种对从关节疾病中恢复健康而言比通过氨基糖和糖胺聚糖获得的效果更高的效果的组合物。本发明通过提供用于治疗关节疾病的试剂来解决本发明的目的，其包括氨基糖和海藻糖作为有效成分。

10. 发明授权

US07192746B2 α-Isomaltosyltransferase, process for producing the same and use thereof 有权
标题翻译： α-异麦芽糖基转移酶，其制备方法和用途
公开(公告)号：US07192746B2
公开(公告)日：2007-03-20
申请号：US10296153
申请日：2001-05-22
申请人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
发明人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18 , C12N9/10 , C12N1/20
CPC分类号： A23G1/423 , A21D2/181 , A23C9/005 , A23C9/1307 , A23G1/40 , A23G1/56 , A23G3/346 , A23G4/10 , A23G2200/06 , A23L2/60 , A23L9/12 , A23L11/07 , A23L13/428 , A23L15/30 , A23L19/01 , A23L27/33 , A23L29/35 , A61K8/60 , A61K8/66 , A61Q11/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C07H3/06 , C12N9/1048 , C12P19/18
摘要： The object of the present invention is to provide an α-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→} from a saccharide having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end; microorganisms which produce the enzyme; process for producing the enzyme; cyclotetrasaccharide or saccharide compositions comprising the same; and uses thereof.
摘要翻译：本发明的目的是提供一种α-异麦芽糖基转移酶，其形成具有环{ - > 6）-al-D-glucopyranosyl-（1-> 3）-al-D-glucopyranosyl- （1-> 6）-α-D-吡喃葡萄糖基 - （1-> 3）-alpha-D-吡喃葡萄糖基 - （1->}，其葡萄糖聚合度至少为3，并具有α-1 ，6个糖苷键作为非还原末端的连接键和除非还原末端之间的连接以外的α-1,4糖苷键;产生该酶的微生物;产生该酶的方法;环四糖或糖组合物，其包含相同;及其用途。

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