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    • 3. 发明公开
    • 올리고머 프로브 어레이 및 이의 제조 방법
    • 低分子探针阵列及其制备方法
    • KR1020080075738A
    • 2008-08-19
    • KR1020070015056
    • 2007-02-13
    • 삼성전자주식회사
    • 김원선하정환지성민김경선류만형
    • C12Q1/68B82Y15/00
    • C12Q1/6837B01J19/0046B01J2219/00432B01J2219/00434B01J2219/00466B01J2219/00497B01J2219/005B01J2219/00527B01J2219/00576B01J2219/00585B01J2219/00596B01J2219/00648B01J2219/00659B01J2219/00662B01J2219/00675B01J2219/00711B01J2219/00722B01J2219/00725B82Y30/00B82Y15/00C12Q2563/155
    • An oligomer probe array is provided to improve reaction yield by immobilizing nanoparticles to an immobilization layer, and increase detection intensity after hybridizing with a target material by using photo crystal structure formed by nanoparticles. An oligomer probe array(100) comprises: a substrate(110); an immobilization layer(120) on the substrate, containing a plurality of probe cell regions(A) where the nanoparticles are coupled, which are divided by probe cell separation regions(B); nanoparticles(140) coupled to the immobilization layer and forming photo crystal structure for amplifying wavelength of light emitted from fluorescent materials attached to a target material to be hybridized; and an oligomer probe(165) coupled to the nanoparticles, wherein the diameter of nanoparticles is 100-1,000 nm and the distance between nanoparticle centers is 100-1,000 nm; and the nanoparticle is polystyrene, polymethylmethacrylate, polymethylmethacrylate copolymer or silica, glass, magnet, Wang resin, Merrifield resin, metal, plastic, cellulose, sephadex or sepharose. Further, the plurality of probe cell regions have three-dimensional surfaces.
    • 提供了一种低聚物探针阵列,以通过将纳米颗粒固定在固定化层上来提高反应产率,并通过使用纳米颗粒形成的光致结晶结构,与目标物质杂交后提高检测强度。 低聚物探针阵列(100)包括:基底(110); 在所述基板上的固定层(120),其包含被所述探针单元分离区域(B)分割的多个所述纳米粒子耦合的探针单元区域(A)。 纳米颗粒(140),其耦合到固定层并形成光晶体结构,用于放大从附着于待杂交的靶材上的荧光材料发出的光的波长; 和耦合到纳米颗粒的低聚物探针(165),其中纳米颗粒的直径为100-1,000nm,并且纳米颗粒中心之间的距离为100-1000nm; 纳米颗粒是聚苯乙烯,聚甲基丙烯酸甲酯,聚甲基丙烯酸甲酯共​​聚物或二氧化硅,玻璃,磁铁,王氏树脂,Merrifield树脂,金属,塑料,纤维素,sephadex或sepharose。 此外,多个探针单元区域具有三维表面。