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    • 6. 发明授权
    • 올리고머 프로브 어레이용 기판과 올리고머 프로브 어레이및 이들의 제조 방법
    • 用于低级探针阵列的基底,低分辨率探针阵列及其制造方法
    • KR100843147B1
    • 2008-07-03
    • KR1020070014534
    • 2007-02-12
    • 삼성전자주식회사
    • 김경선지성민하정환김원선
    • C12N15/09C12Q1/68C12N15/10
    • B01J19/0046B01J2219/00497B01J2219/00527B01J2219/00585B01J2219/00596B01J2219/00605B01J2219/00659B01J2219/00711B01J2219/00722B01J2219/00725B82Y30/00C40B40/06C40B40/10C40B50/18C40B80/00Y10T428/31504C12Q1/6837C12Q1/6876
    • A substrate for an oligomer probe array and an oligomer probe array are provided to improve integrity and reaction yield of the oligomer probe array, function as a linker or a spacer through an intermediate film included therein to provide a selective reaction region and show less tangling phenomenon and improved resolution of the intermediate film. A substrate for an oligomer probe array comprises: a substrate; and an intermediate film formed on the substrate and represented by a formula(1) and is prepared by providing the substrate and then forming the intermediate film on the substrate. An oligomer probe array comprises: an oligomer probe; a substrate including an active region where the oligomer probe is coupled and an in-active region where the oligomer probe is not coupled; and an intermediate film including a chemical structure represented by a formula(2) on the active region and including the chemical structure of the formula(1) on the inactive region and is prepared by providing the substrate, forming the intermediate film including the structure of the formula(1) on the substrate, exposing at least a portion of the intermediate film to light, and coupling the oligomer probe to at least a portion of the exposed intermediate film. In the formulae, R1 is C2-8 alkyl, aryl, cycloalkyl or cycloalkenyl; R2 is C2-8 alkyl, aryl, cycloalkyl or cycloalkenyl; Y is coupled to a linker, a spacer or the oligomer probe; X is coupled to the substrate directly or via a fixation layer; the fixation layer includes Si(OR)3, wherein R is C1-2 alkyl.
    • 提供了用于低聚物探针阵列和低聚物探针阵列的底物,以提高低聚物探针阵列的完整性和反应产率,通过包含在其中的中间膜作为连接体或间隔子,提供选择性反应区并显示较少的缠结现象 并提高中间膜的分辨率。 用于低聚物探针阵列的衬底包括:衬底; 以及形成在所述基板上并由式(1)表示的中间膜,并且通过提供所述基板然后在所述基板上形成所述中间膜来制备。 低聚物探针阵列包括:低聚物探针; 底物,其包含其中所述低聚物探针偶联的活性区和所述低聚物探针未偶联的活性区; 在活性区域具有由式(2)表示的化学结构的中间膜,在惰性区域上包含式(1)的化学结构,并且通过提供基材而制备,形成包含以下结构的中间膜: 在基板上的式(1),使至少一部分中间膜曝光,并将低聚物探针偶联到暴露的中间膜的至少一部分上。 在该式中,R 1是C 2-8烷基,芳基,环烷基或环烯基; R2是C2-8烷基,芳基,环烷基或环烯基; Y连接到接头,间隔物或低聚物探针; X直接地或通过固定层耦合到衬底; 固定层包括Si(OR)3,其中R是C 1-2烷基。
    • 7. 发明授权
    • 마이크로 어레이 및 이의 제조 방법
    • 微波炉及其制造方法
    • KR100791335B1
    • 2008-01-07
    • KR1020060066634
    • 2006-07-17
    • 삼성전자주식회사
    • 하정환지성민김경선김원선
    • C12Q1/68
    • C40B40/06C40B50/18C40B60/14C12Q1/6837C12Q1/6876
    • A microarray is provided to be directly coupled to an oligomer probe without a separate structure through a fixated branch exposed on the surface of a siloxane resin layer constituting a probe cell active or coupled to a linker providing selective activation characteristic and provide a spatial margin through free interaction between the fixated branch and a target sample. A microarray comprises a substrate; a siloxane resin layer which is represented by the formula(1) or (2), has a molecular weight of 1,000-10,000 and is on the substrate; an oligomer probe coupled to the siloxane resin layer. In the formulae, each R1 and R2 is C1-30 hydrocarbon, respectively; and each X1 and X2 is hydroxyl, aldehyde, carboxyl, amino, thiol, halo or sulfonate, respectively. In the microarray, at least portion of the hydrocarbon is a fixated branch which is exposed to the surface of the siloxane resin layer and the oligomer probe is coupled to the fixated branch.
    • 提供微阵列以直接耦合到低聚物探针,而不通过暴露在构成探针细胞的硅氧烷树脂层的表面上的固定支化物的单独结构,该探针细胞有活性或偶联至提供选择性活化特性的接头,并通过游离提供空间裕度 固定分支与目标样本之间的相互作用。 微阵列包括基底; 由式(1)或(2)表示的硅氧烷树脂层的分子量为1,000〜10000,在基材上; 耦合到硅氧烷树脂层的低聚物探针。 式中,R 1和R 2分别为C 1-3烃基; 并且各个X 1和X 2分别是羟基,醛,羧基,氨基,硫醇,卤素或磺酸酯。 在微阵列中,烃的至少一部分是固定分支,其暴露于硅氧烷树脂层的表面,并且低聚物探针与固定分支连接。