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1. 发明专利

JPH11276172A Abc transporter gene 失效
标题翻译： ABC运输基因
公开(公告)号：JPH11276172A
公开(公告)日：1999-10-12
申请号：JP8059798
申请日：1998-03-27
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： SHIBATANI TAKEJI , OMORI KENJI , AKATSUKA HIROYUKI , KAWAI ERI , IDEI AKIKO
IPC分类号： C12N15/09 , C12N1/21 , C12N9/20
摘要： PROBLEM TO BE SOLVED: To obtain a new ABC transporter gene encoding a polypeptide constituting an ATP-binding cassette transporter of Pseudomonas fluorescens and capable of efficiently producing useful proteins, e.g. lipase, by microbes.
SOLUTION: This new ABC transporter gene is such one as to encode a polypeptide constituting an ATP-binding cassette transporter of Pseudomonas fluorescens, consisting of e.g. a polypeptide having the amino acid sequence described in formula I to III, or a polypeptide having an amino acid sequence wherein one or several amino acid residue(s) is (are) added, deleted or substituted in the above amino acid sequence and to efficiently produce useful proteins, e.g. lipase through the function of secreting proteins extracellularly. This gene is obtained by separating a chromosomal DNA from the Pseudomonas fluorescens No.33 strain and conducting PCR using a primer consisting of a partial sequence of the ABC transporter gene.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：获得编码构成荧光假单胞菌的ATP结合盒转运蛋白的多肽的新的ABC转运蛋白基因，并能够有效地产生有用的蛋白质，例如，脂肪酶，微生物。解决方案：这种新的ABC转运蛋白基因是编码构成荧光假单胞菌（Pseudomonas fluorescens）的ATP结合盒转运蛋白的多肽的一种。具有式I至III中描述的氨基酸序列的多肽或具有氨基酸序列的多肽，其中在上述氨基酸序列中添加，缺失或取代一个或多个氨基酸残基并有效地产生有用的蛋白质，例如脂肪酶通过细胞外分泌蛋白质的功能。通过从荧光假单胞菌No.33菌株中分离染色体DNA并使用由ABC转运蛋白基因的部分序列组成的引物进行PCR获得该基因。

2. 发明专利

JPH09216875A OPTICALLY ACTIVE BENZOTHIAZEPINE DERIVATIVE AND PRODUCTION OF THE SAME 失效
公开(公告)号：JPH09216875A
公开(公告)日：1997-08-19
申请号：JP32239596
申请日：1996-12-03
申请人： TANABE SEIYAKU CO
发明人： YOSHIOKA RYUZO , YAMADA SHINICHI , SHIBATANI TAKEJI
IPC分类号： C07D281/10 , A61K31/55 , A61K31/554 , A61P9/00 , C07B57/00
摘要： PROBLEM TO BE SOLVED: To obtain a high purity optically active 3-hydroxy-1,5-benzothiazepine derivative by optically resolving a racemic compound thereof by using an optically active 3-bromocamphor-9-sulfonic acid as an optically resolving agent to form a diastereomer. SOLUTION: This optically active 3-hydroxy-1,5-benzothiazepine derivative is obtained by reacting d- or 1-3-bromocamphor-9-sulfonic acid or salt thereof as an optically resolving agent with a cis-3-hydroxy-1,5-benzothiazepine derivative of formula I (rings A, B arc each a subtsitutable benzene ring; R , R are each a lower alkyl) in a solvent (e.g. methanol) at a room temperature to a boiling point of the solvent or lower to form two kinds of diastereomer salts expressed by formula II, crystallizing one of the salts having lower solubility by taking advantage of the difference in their solubilities, and separating. The separated diastereomer salt can be converted to a free base or an acid adduct salt other than the diastereomer by a commonly known method.

3. 发明专利

JPH09216874A OPTICALLY ACTIVE BENZOTHIAZEPINE DERIVATIVE AND PRODUCTION OF THE SAME 失效
公开(公告)号：JPH09216874A
公开(公告)日：1997-08-19
申请号：JP32239496
申请日：1996-12-03
申请人： TANABE SEIYAKU CO
发明人： YAMADA SHINICHI , YOSHIOKA RYUZO , SHIBATANI TAKEJI
IPC分类号： C07D281/10 , C07B57/00 , C07B63/00
摘要： PROBLEM TO BE SOLVED: To obtain an optically active 1,5-benzothiazepine derivative by optically resolving a racemic 1,5-benzothiazepine derivative slat by using a preferential crystallization method. SOLUTION: This optically active 1,5-benzothiazepine derivative is obtained by a preferential crystallization of the same by seeding a crystal of an optically active salt of 1,5-benzothiazepine derivative into a supersaturated solution of a racemic salt of 1,5-benzothiazepine derivative expressed by formula I or II (rings A, B are each a substitutable benzene ring; R , R are each a lower alkyl). Further, it is possible to add a same kind of racemic salt to the mother liquor after the preferential crystallization of the compounds of the formula I, II, and continue the optical resolution by performing the preferential crystallization. Also, by separating the optically active compounds of the formula I, II, an optically active compound of 1,5-benzothiazepine derivative of formula III can be obtained. The optically active 1,5-benzothiazepine derivative is useful as an intermediate for Diltiazem and can be obtained at a high optical purity without using an expensive optically active reagent.

4. 发明专利

JPH0975097A PRODUCTION OF D-AMINO ACID 失效
公开(公告)号：JPH0975097A
公开(公告)日：1997-03-25
申请号：JP22989995
申请日：1995-09-07
申请人： TANABE SEIYAKU CO
发明人： FURUI MASAKATSU , TAKAHASHI EIJI , SHIBATANI TAKEJI
IPC分类号： C12P41/00 , C12R1/01 , C12R1/025 , C12R1/37
摘要： PROBLEM TO BE SOLVED: To produce a D-amino acid which is useful for medicines and pigments and optical resolution by allowing a microorganism capable of asymmetrically decomposing the optically active L-isomer in a racemic body, to act on a specific racemic amino acid and separating and collecting the remaining optically active D-isomer. SOLUTION: The culture mixture or its treated product of a microorganism capable of asymmetrically decomposing the optically active L-isomer in a racemic body of such as racemic valine, racemic leucine, and racemic isoleucine, for example, Proteus vulgaris RIMD KS (IAM12003), is allowed to act on racemic amino acid consiting of these compound, or the microorganism is cultured in a culture medium containing these racemic amino acids. Then, the optically active D-isomer remaining the reaction system is separated and collected to industrially and inexpensively produce the objective D-amino acid which is useful as a raw material for medicines such as antibiotics, a synthetic intermediate or a reagent for optical resolution.

5. 发明专利

JPH0751092A PRODUCTION OF OPTICALLY ACTIVE PYRROLIDINE DERIVATIVE 失效
公开(公告)号：JPH0751092A
公开(公告)日：1995-02-28
申请号：JP19822193
申请日：1993-08-10
申请人： TANABE SEIYAKU CO
发明人： SHIBATANI TAKEJI , NISHIDA TAKUO , IWASAKI TAMEO , KONDO KAZUHIKO
IPC分类号： C07D207/24 , C07D207/273 , C07D477/00 , C12P41/00 , C12R1/01 , C12R1/07 , C12R1/10 , C12R1/13 , C12R1/15 , C12R1/365 , C12R1/385 , C12R1/40 , C12R1/425 , C12R1/465 , C12R1/645 , C12R1/66 , C12R1/80
摘要： PURPOSE:To obtain an optically active pyrrolidine derivative having oxo- or thioxo-group at the 2-position in an industrially advantageous way, by hydrolyz ing or alcholyzing one of the optically active enantiomers of a specific pyrrolidine derivative with a specific enzyme. CONSTITUTION:A pyrrolidine derivative of formula I (wherein, R is an alkyl, phenyl etc.; R is H, an acyl; X is O, S) is subjected to the action of an enzyme capable of asymmetrically hydrolyzing or alcholyzing its thioester bond (an esterase, lipase, protease etc.). One of the optically active enantiomers is hydrolyzed or alcholyzed and an optically active 4-mercaptopyrrolidine derivative is obtained.

6. 发明专利

JPH075176A METHOD AND APPARATUS FOR MEASURING ENDOTOXIN 失效
公开(公告)号：JPH075176A
公开(公告)日：1995-01-10
申请号：JP4547494
申请日：1994-03-16
申请人： TANABE SEIYAKU CO
发明人： TOSA TETSUYA , SHIBATANI TAKEJI , WATANABE TAIZO , MINOBE SATOSHI , MASUDA MAKOTO
IPC分类号： G01N33/53 , G01N33/579
摘要： PURPOSE:To provide method and apparatus for measuring endotoxin in which the operability is enhanced while facilitating automation. CONSTITUTION:The method for measuring endotoxin comprises a step for introducing an adsorbent 12 into a column 4 through an opening 1 at the tip of the column having means 3 for passing a solution specimen and holding the endotoxin adsorbent, a step for introducing the solution specimen into the column 4 through an opening at the tip thereof and discharging the solution specimen through an opening 2 at the rear end thereof to bring into contact with the adsorbent, and a step for introducing a detection reagent into the column 4 through the opening 1 to cause reaction on the endotoxin adsorbed by the adsorbent 12. The measuring apparatus comprises the column 4, a vessel 6 containing the solution specimen or the like, a column sustaining means 7, and means 11 for applying negative pressure to the column. This method and apparatus allows convenient measurement of endotoxin and facilitate automation.

7. 发明专利

JPH05307040A 失效
公开(公告)号：JPH05307040A
公开(公告)日：1993-11-19
申请号：JP6869592
申请日：1992-03-26
申请人： EIKEN CHEMICAL , UNIV OSAKA , TANABE SEIYAKU CO
发明人： ISHIBASHI KAICHIRO , ITO MASAO , YOSHIDA IWAO , TAKAMIZAWA AKIHISA , SHIBATANI TAKEJI
IPC分类号： C07K7/06 , C07K7/08 , C07K19/00 , G01N33/53 , G01N33/576
摘要： PURPOSE:To provide possibility of sensing peculiarly an antibody with a high rate of sensing for the HCV structure zone, inspect HCV infection accurately at an early stage, and prepare necessary peptide easily by chemical synthesis. CONSTITUTION:As an antibody, a peptide which includes, as a vital peptide, a specific arrangement ArgXaaGlyProArgLeuGlyArgArgPro (where Xaa represents preferably Leu, Lys, Arg) having epitope in the HCV structure zone, is used, and thereby, a reagent to inspect the antibody for C-type hepatitis is formed.

8. 发明专利

JPS58146279A PREPARATION OF POLYMERIC UROKINASE 失效
公开(公告)号：JPS58146279A
公开(公告)日：1983-08-31
申请号：JP2796882
申请日：1982-02-22
申请人： TANABE SEIYAKU CO
发明人： SENHATA ICHIROU , KAKIMOTO TOSHIO , SHIBATANI TAKEJI
IPC分类号： C12N9/72
摘要： PURPOSE:To prepare a polymeric urokinase which is homogeneous when examined by SDS-electrophoresis, economically in an industrial scale, from human urine or crude urokinase derived therefrom. CONSTITUTION:Human urine or a solution of crude urokinase derived therefrom is subjected to the adsorption and desorption treatments with an alkyldextran gel crosslinked with N,N'-methylenebisacrylamide to remove the most part of the impurities. The eluate is heated at 60-62 deg.C for 10-12hr to inactivate viruses, and made to contact with anion exchange beads obtained by introducing diethylaminoethyl group to desulfated and crosslinked agarose to adsorb and remove pyrogenic substance from the solution. The obtained solution is subjected to the adsorption and desorption treatments with 3-(p-sulfophenylamino)- 2-hydroxypropyl cellulose, and the eluate free from impurities is subjected to the gel filtration treatment using gel beads composed of polyacrylamide gel and agarose gel.

9. 发明专利

JPH11243989A PRODUCTION OF OPTICALLY ACTIVE CYCLIC BIARYL COMPOUND 失效
公开(公告)号：JPH11243989A
公开(公告)日：1999-09-14
申请号：JP5159098
申请日：1998-03-04
申请人： TANABE SEIYAKU CO
发明人： FURUYA TOSHIYUKI , SEKI MASAHIKO , YOSHIOKA RYUZO , SHIBATANI TAKEJI
IPC分类号： C07D321/00 , C12P41/00
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially profitably producing the subject compound useful as a raw material for producing an asymmetric epoxidation reaction catalyst, etc., by reacting a cyclic biaryl alcohol compound with an acyl donor in the presence of a biocatalyst having an ability to asymmetrically acylate the reactant. SOLUTION: The optically active cyclic biaryl compound comprising an optically active biaryl alcohol compound of formula I (the ring A is a non- substituted or substituted mono-tricyclic aromatic ring) and an optically active cyclic biaryl ester compound of formula II (R is an alkyl or an aryl), an ester of an antipode of the above biaryl alcohol compound, are profitably obtained by acylating a racemic cyclic biaryl alcohol compound of the formula I with an acyl donor of formula: R COOR (R is H, an alkyl, an alkenyl, an alkanoyl or an aroyl) in the presence of a biocatalyst originated from a microorganism belonging to the genus Serratia or the genus Candida, having an ability to asymmetrically acylate the reactant.

10. 发明专利

JPH09299099A PRODUCTION OF COMPOUND OF OPTICALLY ACTIVE TRANS-3-PHENYLGLYCIDAMIDES 失效
公开(公告)号：JPH09299099A
公开(公告)日：1997-11-25
申请号：JP6056997
申请日：1997-03-14
申请人： TANABE SEIYAKU CO
发明人： MATSUMAE HIROAKI , IDEI AKIKO , NISHIDA TAKUO , OZAKI YASUHIKO , SHIBATANI TAKEJI
IPC分类号： C12P41/00 , C07D281/10 , C07D303/48 , C12R1/01 , C12R1/025 , C12R1/06 , C12R1/20 , C12R1/645 , C12R1/67 , C12R1/69 , C12R1/72 , C12R1/74 , C12R1/785 , C12R1/825
摘要： PROBLEM TO BE SOLVED: To produce the subject compound useful for production, etc., of optically active 1,5-benzothiazepin derivatives by reacting a compound of racemic type trans-3-phenylglycidamides with microorganisms capable of hydrolyzing either of optical isomers thereof. SOLUTION: A compound of racemic type trans-3-phenylglycidamides represented by formula I [ring A is a (substituted)benzene ring; R1 is H or a lower alkyl] is reacted with a cultured product of a microorganism having the ability to preferentially hydrolyze either of the (2S, 3R) and the (2R, 3S) isomers of the compound or its treated substance to hydrolyze one of the optically active substances. The unreacted antipode is then separated and collected from the reactional solution to provide the objective optically active compound. Furthermore, the compound can be reacted with 2-aminothiophenols represented by formula II [ring B is a (substituted)benzene ring; R is H or a di-lower alkylamino-lower alkyl] to afford an optically active 1,5-benzothiazepine derivative represented by formula III or IV.

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