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1. 发明专利

JP2004083587A Medicinal composition 审中-公开
公开(公告)号：JP2004083587A
公开(公告)日：2004-03-18
申请号：JP2003287628
申请日：2003-08-06
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： YAMADA KOICHIRO , HIKODA MASAKATSU , KOGA YUICHI , YOSHIKAWA KOHEI , OMORI KENJI
IPC分类号： C07D471/04 , A61K31/55 , A61P9/04 , A61P9/12 , A61P13/12 , A61P15/00 , A61P15/10 , C07D519/00
摘要： PROBLEM TO BE SOLVED: To provide medicinal compositions containing a new compound having excellent PDE V inhibitory action and useful for prevention/treatment of erectile dysfunction. SOLUTION: The medicinal composition contains a pyridopyrimidine or a naphthyridine derivative shown by general formula (I) or their pharmacologically acceptable salt as an effective ingredient, wherein R 1 represents an optionally substituted nitrogen containing heterocyclic group or the like, R 2 represents H or a lower alkyl group, R 3 represents H, an optionally substituted lower alkyl group or the like, R 4 represents H, a lower alkyl group, COOH or the like, R 5 represents H, an optionally substituted aryl group or the like, X and Y represent one CH and the other N or both N. COPYRIGHT: (C)2004,JPO

2. 发明专利

JPH11276172A Abc transporter gene 失效
标题翻译： ABC运输基因
公开(公告)号：JPH11276172A
公开(公告)日：1999-10-12
申请号：JP8059798
申请日：1998-03-27
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： SHIBATANI TAKEJI , OMORI KENJI , AKATSUKA HIROYUKI , KAWAI ERI , IDEI AKIKO
IPC分类号： C12N15/09 , C12N1/21 , C12N9/20
摘要： PROBLEM TO BE SOLVED: To obtain a new ABC transporter gene encoding a polypeptide constituting an ATP-binding cassette transporter of Pseudomonas fluorescens and capable of efficiently producing useful proteins, e.g. lipase, by microbes.
SOLUTION: This new ABC transporter gene is such one as to encode a polypeptide constituting an ATP-binding cassette transporter of Pseudomonas fluorescens, consisting of e.g. a polypeptide having the amino acid sequence described in formula I to III, or a polypeptide having an amino acid sequence wherein one or several amino acid residue(s) is (are) added, deleted or substituted in the above amino acid sequence and to efficiently produce useful proteins, e.g. lipase through the function of secreting proteins extracellularly. This gene is obtained by separating a chromosomal DNA from the Pseudomonas fluorescens No.33 strain and conducting PCR using a primer consisting of a partial sequence of the ABC transporter gene.
COPYRIGHT: (C)1999,JPO
摘要翻译：要解决的问题：获得编码构成荧光假单胞菌的ATP结合盒转运蛋白的多肽的新的ABC转运蛋白基因，并能够有效地产生有用的蛋白质，例如，脂肪酶，微生物。解决方案：这种新的ABC转运蛋白基因是编码构成荧光假单胞菌（Pseudomonas fluorescens）的ATP结合盒转运蛋白的多肽的一种。具有式I至III中描述的氨基酸序列的多肽或具有氨基酸序列的多肽，其中在上述氨基酸序列中添加，缺失或取代一个或多个氨基酸残基并有效地产生有用的蛋白质，例如脂肪酶通过细胞外分泌蛋白质的功能。通过从荧光假单胞菌No.33菌株中分离染色体DNA并使用由ABC转运蛋白基因的部分序列组成的引物进行PCR获得该基因。

3. 发明专利

JP2006166706A Phosphodiesterase of plasmodium protozoa, nucleic acid encoding the same and treatment of malaria using inhibitor of the same 审中-公开
标题翻译： PLASMODIUM PROTOZOA的磷酸二酯酶，编码它们的核酸和使用其抑制剂治疗疟疾
公开(公告)号：JP2006166706A
公开(公告)日：2006-06-29
申请号：JP2002330382
申请日：2002-11-14
申请人： Tanabe Seiyaku Co Ltd , 田辺製薬株式会社
发明人： YUASA KEIZO , OMORI KENJI , SAKURAI NAOKI , KITA KIYOSHI
IPC分类号： C12N15/09 , A61K31/519 , A61K45/00 , A61P33/06 , A61P43/00 , C07D487/04 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12Q1/44 , C12R1/90
CPC分类号： Y02A50/411
摘要： PROBLEM TO BE SOLVED: To provide a new PDE (cyclic nucleotide phosphodiesterase) of a Plasmodium protozoa and to provide a nucleic acid encoding the same and a method for characterizing, identifying and selecting an inhibitor of the PDE of the Plasmodium protozoa. SOLUTION: A polypeptide composed of a specific amino acid sequence derived from the protozoa, a conservative substitution variant or a naturally occurring allelic variant thereof, etc., are provided. A nucleic acid encoding the polypeptide or a complement thereof is provided. A recombinant vector containing the nucleic acid, a host cell in which the recombinant vector is introduced and a method for producing a polypeptide comprising culturing the host cell are provided. A method for characterizing, identifying or selecting the PDE inhibitor comprising using the polypeptide is provided. A pharmaceutical composition for treating malaria and a therapeutic method, etc., comprising a compound having an inhibitory activity against the PDE of the Plasmodium protozoa as an active ingredient are provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供原生动物的新的PDE（环状核苷酸磷酸二酯酶），并提供编码它的核酸和表征，鉴定和选择原生动物疟原虫的PDE的抑制剂的方法。解决方案：提供由源自原生动物的特定氨基酸序列组成的多肽，保守取代变体或其天然存在的等位基因变体等。提供了编码多肽或其互补序列的核酸。提供了含有核酸的重组载体，其中引入重组载体的宿主细胞和包含培养宿主细胞的产生多肽的方法。提供了用于表征，鉴定或选择包含使用该多肽的PDE抑制剂的方法。提供了一种用于治疗疟疾的药物组合物和治疗方法等，其包含对原生动物原生动物PDE具有抑制活性的化合物作为活性成分。版权所有（C）2006，JPO＆NCIPI

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