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1. 发明专利

JP2004180534A NEW GENE asb4 AND TRANSFORMANT THEREOF, AND METHOD FOR UTILIZING GENE PRODUCT 有权
公开(公告)号：JP2004180534A
公开(公告)日：2004-07-02
申请号：JP2002348752
申请日：2002-11-29
申请人： Gekkeikan Sake Co Ltd , National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 月桂冠株式会社 , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU , ISHIDA HIROKI , OBATA HIROSHI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12N15/09 , C12N1/15 , C12N9/48 , C12P21/04 , C12R1/69
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a peptide synthase gene associated with ferrichrome biosynthesis of Aspergillus oryzae in order to freely control the production of ferrichrome of the Aspergillus oryzae, and to provide a recombinant vector containing the gene and a transformant containing the recombinant vector. SOLUTION: Cloning of a gene encoding a peptide synthase protein associated with the ferrichrome biosynthesis of the Aspergillus oryzae is carried out to determine the base sequence thereof. The production of the transformant containing the gene transferred thereinto is confirmed by culturing the transformant, and the encoding of the enzyme protein in the cloned gene fragment asb4 is confirmed. High production or no production of the ferrichlorome bisynthesis of the Aspergillus oryzae can be carried out under limited iron and the ferrichrome production can be modified according to applications at a molecular level. COPYRIGHT: (C)2004,JPO&NCIPI

2. 发明专利

JP2004201545A New tyrosinase gene meld 有权
公开(公告)号：JP2004201545A
公开(公告)日：2004-07-22
申请号：JP2002373069
申请日：2002-12-24
申请人： Gekkeikan Sake Co Ltd , National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 月桂冠株式会社 , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU , OBATA HIROSHI , NAKAMURA YUKIHIRO , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02
摘要： PROBLEM TO BE SOLVED: To search the possibility of the presence of a browning-causing tyrosinase gene except tyrosinase genes melO and melB, and specify the gene. SOLUTION: A new tyrosinase gene melD was cloned, and its base sequence was determined. The cloned new gene was inserted into a vector to transform a host (Escherichia coli). Thereby, the gene has the activity of tyrosinase and can be used for preventing the browning of Sake malt and the coloration of a fermented food. The transformant can be cultured to produce the tyrosinase. The tyrosinase can be utilized not only as a reagent but also for screening an inhibitor. The development of a coloration-preventing substance can also be expected. COPYRIGHT: (C)2004,JPO&NCIPI

3. 发明专利

JP2004222609A ASPERGILLUS ORYZAE npgO GENE 审中-公开
公开(公告)号：JP2004222609A
公开(公告)日：2004-08-12
申请号：JP2003015123
申请日：2003-01-23
申请人： National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU , ISHIDA HIROKI , OBATA HIROSHI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12N15/09 , C07K14/38 , C12N1/15 , C12N9/10 , C12P21/02 , C12R1/66
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a phosphopantothenic acid-transferring enzyme gene of Aspergillus oryzae to freely control the production of a secondary metabolite including ferrichrome of the Aspergillus oryzae; to provide a recombinant vector containing the gene, and a transformant containing the recombinant vector; and to provide a non-ribosome type peptide produced by the transformant, and an arbitrary non-ribosome type peptide by using the strain obtained by introducing the recombinant vector to a strain highly expressing an arbitrary NRPS and PKS. SOLUTION: The base sequence of the phosphopantothenic acid-transferring enzyme gene (npgO gene) of Aspergillus oryzae is determined by cloning the gene. The npgO gene is highly expressed with a non-ribosome type peptide synthetase (NRPS) gene (e.g. a peptide synthetase gene asb2 or asb4) to carry out enhanced production of the non-ribosome type peptide (e.g. the ferrichrome of the Aspergillus oryzae) which can not be obtained by singly using the asb2 or the asb4. COPYRIGHT: (C)2004,JPO&NCIPI

4. 发明专利

JP2007068411A Strain highly producing caproic acid of yeast 有权
标题翻译：应用生产大量的YEAST
公开(公告)号：JP2007068411A
公开(公告)日：2007-03-22
申请号：JP2005255738
申请日：2005-09-02
申请人： Gekkeikan Sake Co Ltd , National Research Inst Of Brewing , 月桂冠株式会社 , 独立行政法人酒類総合研究所
发明人： NAMISE MASAHIRO , NAGAYOSHI MASANORI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA , SHIMOII HITOSHI
IPC分类号： C12N15/09 , A21D8/04 , A21D13/00 , C12C11/00 , C12G1/00 , C12G3/00 , C12N1/16 , C12N1/19 , C12R1/865
摘要： PROBLEM TO BE SOLVED: To obtain a yeast variant having improved production of caproic acid, to provide a method for producing such a variant and a method for regulating production of caproic acid of yeast. SOLUTION: The strain highly producing caproic acid of yeast is obtained by mutant treating yeast producing a fatty acid synthase having FAS1 with a partial amino acid sequence in which the amino acid of amino acid number 7 of an amino acid sequence composed of a specific sequence is glutamic acid and selecting a strain having acquired cerulenin resistance from the mutant-treated yeast. The production amount of caproic acid is regulated by conversion of the amino acid between aspartic acid and glutamic acid. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了获得具有改善的己酸生产的酵母变体，提供这种变体的制备方法和调节酵母的己酸生产的方法。解决方案：通过突变处理产生具有FAS1的脂肪酸合成酶的酵母的菌株得到，其部分氨基酸序列是氨基酸序列的氨基酸序列号7的氨基酸，由氨基酸序列组成的氨基酸序列特异性序列是谷氨酸，并且从突变体处理的酵母中选择具有获得性的苏氨酸抗性的菌株。天冬氨酸和谷氨酸之间的氨基酸转化调节己酸的产生量。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2006149398A Fucose-specific lectin 审中-公开
标题翻译： FUCOSE-SPECIFIC LECTIN
公开(公告)号：JP2006149398A
公开(公告)日：2006-06-15
申请号：JP2006005209
申请日：2006-01-12
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： ISHIDA HIROKI , MORIYA TOSHIYASU , HATA YOJI , KAWATO SHOJI , SUGINAMI KOJI , ABE YASUHISA , IMAYASU SATOSHI
IPC分类号： C12N15/09 , C07K14/38 , C12N1/15 , C12P21/02 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To efficiently produce a fucose-specific lectin derived from Aspergillus oryzae, utilizable for various industries exemplified by a reagent for research, such as a reagent for clinical test for measuring fucose, and sugar chain engineering. SOLUTION: The cloning of a fucose-specific lectin gene is carried out and the base sequence thereof is determined. A host (Aspergillus oryzae) is transformed by inserting the cloned new gene to a vector. As a result, the enzyme can be mass-produced by culturing the transformant. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了有效地制备源自米曲霉的岩藻糖特异性凝集素，可用于各种行业，例如用于测试岩藻糖的临床试验用试剂和糖链工程。解决方案：进行岩藻糖特异性凝集素基因的克隆，并测定其碱基序列。通过将克隆的新基因插入载体来转化宿主（米曲霉）。结果，可以通过培养转化体来大量生产酶。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005225874A Iron supplement and utilization of the same 有权
标题翻译：铁的补充和利用
公开(公告)号：JP2005225874A
公开(公告)日：2005-08-25
申请号：JP2005006829
申请日：2005-01-13
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , FUKUDA KATSUHARU , IRIE MOTOKO , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： A23L2/52 , A23L1/304 , A61K31/395 , A61K33/26 , A61K36/06 , A61P7/06
摘要： PROBLEM TO BE SOLVED: To obtain an iron supplement exhibiting a high iron absorption rate into a living body, a preventing or treating agent of iron-deficiency anemia, a food additive and a food composition. SOLUTION: This iron supplement, the preventing or treating agent of the iron deficiency anemia, the food additive or the food composition contains siderophore and ferric ion preferably as a chelate complex form. The chelate complex of the siderophore with ferric ion has a high absorption rate into the living body, increases hemoglobin concentration in blood, iron concentration in serum and stored iron concentration in liver by being absorbed in the living body and does not give any adverse effect on living body functions. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得在生物体中表现出高的铁吸收率的铁补充剂，缺铁性贫血的预防或治疗剂，食品添加剂和食物组合物。解决方案：该铁补充剂，缺铁性贫血的预防或治疗剂，食品添加剂或食物组合物优选含有铁螯合物和铁离子作为螯合络合物形式。铁载体与铁离子的螯合物对人体的吸收率高，血液中血红蛋白浓度升高，血液中铁浓度升高，肝脏中铁浓度被吸收在生物体内，不会对生物体产生不利影响活体功能。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2003310289A Method for producing phenylacetaldehyde 审中-公开
标题翻译：生产苯乙酮的方法
公开(公告)号：JP2003310289A
公开(公告)日：2003-11-05
申请号：JP2002118169
申请日：2002-04-19
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： OBATA HIROSHI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12P7/24
摘要： PROBLEM TO BE SOLVED: To provide a new method for producing phenylacetaldehyde, based on surprising discovery that a side chain of an aromatic ring of phenylalanine is decarboxylated and deaminated by conducting reaction in which the phenylalanine is used as a substrate and a tyrosinase is added thereto, therefore capable of efficiently producing the phenylacetaldehyde by conducting decarboxylation/deamination reaction of the phenylalanine in the presence of the tyrosinase, and further capable of easily producing the phenylacetaldehyde with high safety at a low cost by adopting at first a biochemical process which is different from synthetic processes conventionally conducted.
SOLUTION: This method for producing the phenylacetoaldehyde comprises reacting the tyrosinase (for example, monophenol, dihydroxyphenyl alanine- oxygen oxidoreductase, EC1.14.18.1; and catechol oxidase, EC1.10.3.1) with the phenylalanine.
COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供一种新的苯乙醛生产方法，基于惊人的发现，苯丙氨酸芳环的侧链脱羧并通过进行苯丙氨酸用作底物的反应脱氨，酪氨酸酶因此能够通过在酪氨酸酶的存在下进行苯丙氨酸的脱羧/脱氨反应而有效地制备苯乙醛，并且通过首先采用生物化学方法进一步能够以低成本容易地以高安全性生产苯乙醛与常规进行的合成方法不同。解决方案：该制备苯乙胺的方法包括将酪氨酸酶（例如单酚，二羟苯基丙氨酸 - 氧氧化还原酶，EC1.14.18.1;和邻苯二酚氧化酶，EC1.10.3.1）与苯丙氨酸反应。版权所有（C）2004，JPO

8. 发明专利

JP2005245335A Target protein-expressing yeast and use thereof 审中-公开
标题翻译：目标蛋白表达YEAST及其用途
公开(公告)号：JP2005245335A
公开(公告)日：2005-09-15
申请号：JP2004061399
申请日：2004-03-04
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SAWARA HIROSHI , ODAKA ATSUSHI , HISADA HIROMOTO , HATA YOJI , KAWATO SHOJI , ABE YASUHISA , UEDA ATSUMI
IPC分类号： C12N15/09 , C12N1/19 , C12P19/14 , C12P19/20
摘要： PROBLEM TO BE SOLVED: To provide a yeast that has a target protein on the cell cortex and can express the target protein in high efficiency under the industrial environment. SOLUTION: In this practical yeast, from the 5'-terminus in order, a high active promoter selected from the group consisting of yeast SED1 promoter, GAPDH promoter, PGK1 promoter and ADH1 promoter, secretion signal that functions in the yeast cells, the sequence encoding the target protein and a chromosome integration type expression vector that has a sequence encoding the plasma membrane bound area of the GPI anchoring protein are incorporated into the chromosomal DNA. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供在细胞皮层上具有靶蛋白的酵母，并且可以在工业环境下以高效率表达靶蛋白。解决方案：在该实用的酵母中，从5'-末端依次是选自酵母SED1启动子，GAPDH启动子，PGK1启动子和ADH1启动子的高活性启动子，在酵母细胞中起作用的分泌信号编码靶蛋白的序列和编码GPI锚定蛋白的质膜结合区域的序列的染色体整合型表达载体并入染色体DNA中。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2003026636A Tyrosol derivative inhibiting lipid metabolic enzyme 审中-公开
标题翻译： TYROSOL衍生抑制脂肪代谢酶
公开(公告)号：JP2003026636A
公开(公告)日：2003-01-29
申请号：JP2001209766
申请日：2001-07-10
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： OURA ARATA , ASHIDA YUKO , KANAMORI YOJI , OSHIMA TAKEHIKO , MINAZU TETSUYOSHI , KAWATO SHOJI , SUGINAMI KOJI , ABE YASUHISA
IPC分类号： A61P3/04 , A61K31/222 , A61P31/04 , A61P35/00 , A61P43/00 , C07C69/28
摘要： PROBLEM TO BE SOLVED: To provide a tyrosol derivative exhibiting a broad inhibition spectrum against lipid metabolic enzymes such as lipase, phospholipase and lipoxygenase, useful also as various preservatives and biochemical agents and easily synthesized at a low cost.
SOLUTION: The tyrosol derivative is a tyrosol ester expressed by formula (I) (A is H or COR; R is C
n H
2n+1 ; and (n) is an integer). An agent for inhibiting lipid metabolic enzyme contains the tyrosol derivative as an active component.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供对脂质代谢酶（例如脂肪酶，磷脂酶和脂氧合酶）表现出广泛抑制谱的酪醇衍生物，其也可用作各种防腐剂和生物化学试剂，并且以低成本易于合成。解决方案：酪醇衍生物是由式（I）表示的酪醇酯（A是H或COR; R是Cn H 2n + 1;和（n）是整数）。抑制脂质代谢酶的药剂含有酪醇衍生物作为活性成分。

10. 发明专利

JP2011126833A Autonomic nerve regulator 审中-公开
标题翻译：自动神经调节器
公开(公告)号：JP2011126833A
公开(公告)日：2011-06-30
申请号：JP2009288305
申请日：2009-12-18
申请人： Gekkeikan Sake Co Ltd , Osaka Bioscience Institute , 月桂冠株式会社 , 財団法人大阪バイオサイエンス研究所
发明人： TSUTSUMI HIROKO , SUZUKI SACHIKO , HATA YOJI , ABE YASUHISA , URADE YOSHIHIRO , HUANG ZHI-LI , MATSUMOTO NAOMI , MASAKI MIKA
IPC分类号： A61K36/00 , A23L1/30 , A23L2/38 , A23L2/52 , A61K36/899 , A61P25/02
摘要： PROBLEM TO BE SOLVED: To provide an autonomic nerve regulator utilizing an intermediate, a final product and their processed materials yielded at the production processes of sake, such as a sake lees-processed material.
SOLUTION: This autonomic nerve regulator includes the sake lees-processed material yielded by the liquefied preparation of sake. The sake lees-processed material is obtained by performing at least one treatment selected from the group consisting of the following (1) to (3) on the sake lees. In (1) protease treatment, (2) cellulase treatment, and (3) lactobacillus fermentation treatment, and it is preferable to use a neutral protease or an acidic protease in the protease treatment, to use endoglucanase or cellobiohydrolase in the cellulase treatment, and to use Lactobacillus brevis, Lactobacillus bulgaricus, etc., in the lactobacillus fermentation treatment.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供利用中间体，最终产品及其在清酒生产过程中产生的最终产品及其加工材料的自主神经调节剂，例如酒精加工材料。
解决方案：这种自主神经调节剂包括由液化液制成的清酒产品。通过在清酒桶中进行选自由以下（1）至（3）组成的组中的至少一种处理，从而获得食品加工材料。在（1）蛋白酶处理，（2）纤维素酶处理和（3）乳酸杆菌发酵处理中，优选在蛋白酶处理中使用中性蛋白酶或酸性蛋白酶，在纤维素酶处理中使用内切葡聚糖酶或纤维二糖水解酶，在乳杆菌发酵处理中使用短乳杆菌（Lactobacillus brevis），保加利亚乳杆菌（Lactobacillus bulgaricus）等。版权所有（C）2011，JPO＆INPIT

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