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1. 发明专利

JP2004180534A NEW GENE asb4 AND TRANSFORMANT THEREOF, AND METHOD FOR UTILIZING GENE PRODUCT 有权
公开(公告)号：JP2004180534A
公开(公告)日：2004-07-02
申请号：JP2002348752
申请日：2002-11-29
申请人： Gekkeikan Sake Co Ltd , National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 月桂冠株式会社 , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU , ISHIDA HIROKI , OBATA HIROSHI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12N15/09 , C12N1/15 , C12N9/48 , C12P21/04 , C12R1/69
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a peptide synthase gene associated with ferrichrome biosynthesis of Aspergillus oryzae in order to freely control the production of ferrichrome of the Aspergillus oryzae, and to provide a recombinant vector containing the gene and a transformant containing the recombinant vector. SOLUTION: Cloning of a gene encoding a peptide synthase protein associated with the ferrichrome biosynthesis of the Aspergillus oryzae is carried out to determine the base sequence thereof. The production of the transformant containing the gene transferred thereinto is confirmed by culturing the transformant, and the encoding of the enzyme protein in the cloned gene fragment asb4 is confirmed. High production or no production of the ferrichlorome bisynthesis of the Aspergillus oryzae can be carried out under limited iron and the ferrichrome production can be modified according to applications at a molecular level. COPYRIGHT: (C)2004,JPO&NCIPI

2. 发明专利

JP2004201545A New tyrosinase gene meld 有权
公开(公告)号：JP2004201545A
公开(公告)日：2004-07-22
申请号：JP2002373069
申请日：2002-12-24
申请人： Gekkeikan Sake Co Ltd , National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 月桂冠株式会社 , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU , OBATA HIROSHI , NAKAMURA YUKIHIRO , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02
摘要： PROBLEM TO BE SOLVED: To search the possibility of the presence of a browning-causing tyrosinase gene except tyrosinase genes melO and melB, and specify the gene. SOLUTION: A new tyrosinase gene melD was cloned, and its base sequence was determined. The cloned new gene was inserted into a vector to transform a host (Escherichia coli). Thereby, the gene has the activity of tyrosinase and can be used for preventing the browning of Sake malt and the coloration of a fermented food. The transformant can be cultured to produce the tyrosinase. The tyrosinase can be utilized not only as a reagent but also for screening an inhibitor. The development of a coloration-preventing substance can also be expected. COPYRIGHT: (C)2004,JPO&NCIPI

3. 发明专利

JP2005176602A Koji mold gene 审中-公开
标题翻译： KOJI模具基因
公开(公告)号：JP2005176602A
公开(公告)日：2005-07-07
申请号：JP2002383868
申请日：2002-12-26
申请人： National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , TAKEUCHI MICHIO , OGASAWARA NAOKI , KUHARA SATORU
IPC分类号： C12N15/09 , C07K14/38
摘要： PROBLEM TO BE SOLVED: To provide an effective method for utilizing a safe gene resource in the food industry such as production of substances utilizing biotechnologies by elucidating the genomic DNA information about a Koji mold and functions such as genes encoded thereby, and to provide information useful for screening the various kinds of genes in agrochemical and medical fields. SOLUTION: There are provided the following a mold, especially a DNA derived from Aspergillus oryzae and a primer set for amplifying a mold gene of a GRAS (generally recognized as safe) grade composed of a nucleotide sequence prepared from the DNA and a probe for detecting the mold gene. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种利用生物技术生产物质生产食品工业中的安全基因资源的有效方法，通过阐明关于Koji霉菌的基因组DNA信息和诸如由其编码的基因等功能，以及提供有助于筛选农业和医疗领域各种基因的信息。提供以下模具，特别是衍生自米曲霉的DNA，以及用于扩增由DNA制备的核苷酸序列组成的GRAS（通常被认为是安全）级的模具基因的引物组，用于检测霉菌基因的探针。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2007014245A GENES OF β-1,6-GLUCANASE DERIVED FROM ASPERGILLUS ORYZAE AND NEW LECTIN, AND METHOD FOR PRODUCING THE ENZYME OR THE LECTIN 审中-公开
标题翻译：从ASPERGILLUS ORYZAE和NEW LECTIN衍生的β-1,6-GLUCANASE的基因，以及生产酶或LECTIN的方法
公开(公告)号：JP2007014245A
公开(公告)日：2007-01-25
申请号：JP2005197595
申请日：2005-07-06
申请人： National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： TAMANO KOICHI , MACHIDA MASAYUKI , TERABAYASHI YASUNOBU , ABE TAKAYOSHI , GOMI KATSUYA , NAKAJIMA YU , ASAI KIYOSHI , KIN DAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , OGASAWARA NAOKI , KUHARA SATORU , AKITA OSAMU
IPC分类号： C12N15/09 , C08B37/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/24 , C12P21/02
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide genes encoding a new β-1,6-glucanase and lectin, a microorganism in which the expression of the gene is enhanced, and a method for producing a sugar chain having a new structure or function by using the protein. SOLUTION: The gene encoding any one of proteins shown in the following: (a) a protein comprising a specific amino acid sequence; (b) a protein comprising an amino acid sequence obtained by substituting, deleting, inserting or transferring one or several amino acid residues in, from or to the amino acid sequence, and having β-1,6-glucanase activities; and (c) a protein containing an amino acid sequence exhibiting ≥80% sequence identity with the amino acid sequence, or a partial fragment thereof, and having the β-1,6-glucanase activities. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供编码新的β-1,6-葡聚糖酶和凝集素的基因，其中基因表达增强的微生物和具有新结构或功能的糖链的制备方法通过使用蛋白质。解决方案：编码以下所示蛋白质的任何一种的基因：（a）包含特定氨基酸序列的蛋白质; （b）包含通过用氨基酸序列取代，缺失，插入或转移一个或多个氨基酸残基而获得并具有β-1,6-葡聚糖酶活性的氨基酸序列的蛋白质; 和（c）含有与氨基酸序列或其部分片段≥80％序列同一性且具有β-1,6-葡聚糖酶活性的氨基酸序列的蛋白质。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2005034146A Gene of new cell wall decomposing enzyme derived from aspergillus oryzae and method for producing the enzyme 有权
标题翻译：来自ASPERGILLUS ORYZAE的新细胞壁分解酶的基因和用于生产酶的方法
公开(公告)号：JP2005034146A
公开(公告)日：2005-02-10
申请号：JP2004188849
申请日：2004-06-25
申请人： National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , SANO MOTOAKI , SUNAKAWA MISAO , NAKAJIMA YU , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU
IPC分类号： A23L1/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/24 , C12N15/09 , C12P19/14
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To obtain a new gene encoding an exo- and endo-β-1,3-glucanase, to obtain a microorganism enhanced in expression of the gene, and to decrease a molecular weight of β-1,3-glucan by using a specified protein. SOLUTION: This exo- and endo-β-1,3-glucanase encoding gene derived from Aspergillus oryzae, a recombinant vector containing the gene, a microorganism transformed by the vector (transformant), a method for decreasing the molecular weight of the β-1,3-glucan by acting the microorganism, a cultured product of the same, and/or the specified protein on the glucan, and a food containing the same are provided, respectively. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题为了获得编码外切-β-1,3-葡聚糖酶的新基因，为了获得增强基因表达的微生物，降低β-1的分子量， 3-葡聚糖。解决方案：来自米曲霉的外切和内切-β-1,3-葡聚糖酶编码基因，含有该基因的重组载体，由载体转化的微生物（转化体），降低分子量的方法分别提供通过作用微生物的β-1,3-葡聚糖，其培养产物和/或葡聚糖上的特定蛋白质和含有该蛋白质的食物。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2004222609A ASPERGILLUS ORYZAE npgO GENE 审中-公开
公开(公告)号：JP2004222609A
公开(公告)日：2004-08-12
申请号：JP2003015123
申请日：2003-01-23
申请人： National Institute Of Advanced Industrial & Technology , National Institute Of Technology & Evaluation , National Research Inst Of Brewing , 独立行政法人産業技術総合研究所 , 独立行政法人製品評価技術基盤機構 , 独立行政法人酒類総合研究所
发明人： MACHIDA MASAYUKI , ABE TAKAYOSHI , GOMI KATSUYA , ASAI KIYOSHI , SANO MOTOAKI , KIN TAISHIN , NAGASAKI HIDEKI , HOSOYAMA SATORU , AKITA OSAMU , OGASAWARA NAOKI , KUHARA SATORU , ISHIDA HIROKI , OBATA HIROSHI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： C12N15/09 , C07K14/38 , C12N1/15 , C12N9/10 , C12P21/02 , C12R1/66
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a phosphopantothenic acid-transferring enzyme gene of Aspergillus oryzae to freely control the production of a secondary metabolite including ferrichrome of the Aspergillus oryzae; to provide a recombinant vector containing the gene, and a transformant containing the recombinant vector; and to provide a non-ribosome type peptide produced by the transformant, and an arbitrary non-ribosome type peptide by using the strain obtained by introducing the recombinant vector to a strain highly expressing an arbitrary NRPS and PKS. SOLUTION: The base sequence of the phosphopantothenic acid-transferring enzyme gene (npgO gene) of Aspergillus oryzae is determined by cloning the gene. The npgO gene is highly expressed with a non-ribosome type peptide synthetase (NRPS) gene (e.g. a peptide synthetase gene asb2 or asb4) to carry out enhanced production of the non-ribosome type peptide (e.g. the ferrichrome of the Aspergillus oryzae) which can not be obtained by singly using the asb2 or the asb4. COPYRIGHT: (C)2004,JPO&NCIPI

7. 发明专利

JP2009060877A Method for producing solid culture-specific gene product by liquid culture utilizing new transcription-regulatory gene 审中-公开
标题翻译：通过使用新的转录调节基因的液体培养生产实体文化特异性基因产物的方法
公开(公告)号：JP2009060877A
公开(公告)日：2009-03-26
申请号：JP2007233553
申请日：2007-09-10
申请人： Kanazawa Inst Of Technology , National Institute Of Advanced Industrial & Technology , 学校法人金沢工業大学 , 独立行政法人産業技術総合研究所
发明人： SANO MOTOAKI , KOBAYASHI AKIKO , OHASHI SHINICHI , MACHIDA MASAYUKI
IPC分类号： C12N15/09 , C07K4/06 , C12N1/14
摘要： PROBLEM TO BE SOLVED: To enable an intracellular protein encoded by a solid culture-specific gene to be expressed in a liquid culture to facilitate the extraction by identifying a transcription regulatory gene enabling the solid culture-specific gene to be expressed in a liquid culture system, and enabling the transcription regulatory gene to be expressed highly. SOLUTION: The gene encodes a protein including a specific amino acid sequence and having the transcription regulatory factor activities of the solid culture-specific gene of Aspergillus oryzae. The method for producing the gene product includes liquid-culturing the Aspergillus oryzae transformed by the gene to enable the solid culture-specific gene of the Aspergillus oryzae to be expressed, and collecting the gene product. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了使得由固体培养物特异性基因编码的细胞内蛋白质能够在液体培养物中表达，以促进通过鉴定能够使固体培养物特异性基因在液体培养体系，使得能够高度表达转录调控基因。解决方案：该基因编码包含特定氨基酸序列的蛋白质，并具有米曲霉的固体培养物特异性基因的转录调节因子活性。生产该基因产物的方法包括液体培养由该基因转化的米曲霉，使得能够表达米曲霉的固体培养特异性基因，并收集该基因产物。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2006275858A Fluorescence detecting method, method of manufacturing fluorescence detecting beads and fluorescence detecting beads 有权
标题翻译：荧光检测方法，制造荧光检测珠和荧光检测珠的方法
公开(公告)号：JP2006275858A
公开(公告)日：2006-10-12
申请号：JP2005097183
申请日：2005-03-30
申请人： Mitsui Eng & Shipbuild Co Ltd , National Institute Of Advanced Industrial & Technology , 三井造船株式会社 , 独立行政法人産業技術総合研究所
发明人： MACHIDA MASAYUKI , ITO AKIHIDE , YOSHIDA TAKASATO
IPC分类号： G01N21/64 , G01N21/78 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To discriminate between several-hundred kinds of beads by one measurement by increasing the kinds of the beads capable of being discriminated on the basis of fluorescence when the kinds of the beads are discriminated using the fluorescences emitted from the beads having probes on their surfaces.
SOLUTION: Microbeads 12 are preliminarily dyed with a mixture of two kinds of fluorescent coloring matters different in fluorescence relaxation time constant and, at the time of detection of fluorescence, the fluorescences of the microbeads 12 wherein a bio-substance or the like is bonded to the probes to measure the fluorescence relaxation time constant to discriminate between the kinds of the microbeads 12 to which the bio-substance is bonded. Fluorescent coloring matter of a kind different from that of the fluorescent coloring matter used for dying the microbeads 12 is provided to the bio-substance and, upon detection of fluorescence, the microbeads 12 are irradiated with a laser beam and the fluorescence emitted upon irradiation is filtered not only to detect the fluorescence of the fluorescent coloring matter provided to the bio-substance but also to measure the fluorescence relaxiation time constant of the fluorescent coloring matter of the microbeads 12.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过一次测量来鉴别几百种珠粒，通过使用从荧光发射的荧光鉴别珠粒的种类，通过增加基于荧光来鉴别的珠粒的种类来区分几种珠粒珠在其表面上具有探针。解决方案：微珠12用荧光松弛时间常数不同的两种荧光着色剂的混合物预先染色，并且在荧光检测时，其中生物物质等的微珠12的荧光与探针结合以测量荧光弛豫时间常数，以区分生物物质结合的微珠12的种类。向生物物质提供与用于染色微珠12的荧光色素不同的荧光色素，并且在检测到荧光时，用激光束照射微珠12，并且照射时发射的荧光是过滤不仅用于检测提供给生物物质的荧光色素的荧光，而且还测量微珠12的荧光色素的荧光松弛时间常数。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2007153821A Carrier for protein capture and protein capturing and treating method 审中-公开
标题翻译：蛋白质捕获和蛋白质捕获和处理方法的载体
公开(公告)号：JP2007153821A
公开(公告)日：2007-06-21
申请号：JP2005352695
申请日：2005-12-06
申请人： National Institute Of Advanced Industrial & Technology , Precision System Science Co Ltd , プレシジョン・システム・サイエンス株式会社 , 独立行政法人産業技術総合研究所
发明人： MACHIDA MASAYUKI , KIN UKUTO , NIIMA YOICHI , HAGIWARA HISAKO , TAJIMA HIDEJI
IPC分类号： C07K14/42 , B01J20/24 , B03C1/00 , C07K1/22 , C07K16/40 , C12N9/36 , C12N11/14
摘要： PROBLEM TO BE SOLVED: To provide a protein-capturing carrier and a protein capturing and treating method enabling efficient and quick production of a protein from a living body such as cell and automatic integral formation of a protein from a living body such as cell. SOLUTION: The protein-capturing carrier is composed of a living body capturing molecule capable of capturing a living body, a protein-capturing molecule capable of capturing the target protein expressed in the living body, and a particulate carrier having the living body capturing molecule and the protein-capturing molecule on the surface. COPYRIGHT: (C)2007,JPO&INPIT

10. 发明专利

JP2007137841A Peptide derived from decorin 有权
标题翻译：从DECORIN衍生的肽
公开(公告)号：JP2007137841A
公开(公告)日：2007-06-07
申请号：JP2005336110
申请日：2005-11-21
申请人： Chiba Univ , National Institute Of Advanced Industrial & Technology , 国立大学法人千葉大学 , 独立行政法人産業技術総合研究所
发明人： TAKIGUCHI MASAKI , MACHIDA MASAYUKI , TAMURA YUTAKA , HIWASA SHIGEKI , SHIMOIDE MASAYOSHI
IPC分类号： A61K38/00 , A61P17/00 , A61P19/04 , A61P25/28 , A61P35/00 , A61P43/00 , C07K14/47 , C12N5/079 , C12N5/09
摘要： PROBLEM TO BE SOLVED: To obtain a new cell growth regulator comprising a peptide having a regulatory action on cell growth. SOLUTION: The human cancer cell proliferation inhibitor and the fibroblast growth promoter each comprise a peptide represented by formula Cys Pro X1 Arg Cys Gln Cys His Leu Arg Val Val Gln Cys (sequence number 1) [X1 is Phe or Tyr; first Cys and seventh Cys are bound and fifth Cys and 14th Cys are bound by a disulfide bond, respectively] or represented by formula Cys X2 X3 Pro Gly His X4 X5 X6 Lys Ala Ser Tyr Ser Gly Val Cys (sequence number 2) [X2 is Pro or Arg; X3 is Pro or Ala; X4 is Asn or Pro; X5 is Thr or Ser; X6 is Lys or Arg; first Cys and 16th Cys are bound by a disulfide bond] as an active ingredient. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：获得包含对细胞生长具有调节作用的肽的新细胞生长调节剂。解决方案：人类癌细胞增殖抑制剂和成纤维细胞生长促进剂各自包含由式Cys Pro X1 Arg Cys Gln Cys His Leu Arg Val Val Gln Cys（序列号1）表示的肽[X1是Phe或Tyr; 分别表示Cys和Cys与第七个Cys结合，第五个Cys和第十四个Cys分别被二硫键结合）或由式Cys X2 X3 Pro Gly His X4 X5 X6 Lys Ala Ser Tyr Ser Gly Val Cys（序列号2）[X2 是Pro或Arg; X3是Pro或Ala; X4是Asn或Pro; X5是Thr或Ser; X6为Lys或Arg; 第一个Cys和第十六个Cys被二硫键结合]作为活性成分。版权所有（C）2007，JPO＆INPIT

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