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1. 发明专利

JP2011126833A Autonomic nerve regulator 审中-公开
标题翻译：自动神经调节器
公开(公告)号：JP2011126833A
公开(公告)日：2011-06-30
申请号：JP2009288305
申请日：2009-12-18
申请人： Gekkeikan Sake Co Ltd , Osaka Bioscience Institute , 月桂冠株式会社 , 財団法人大阪バイオサイエンス研究所
发明人： TSUTSUMI HIROKO , SUZUKI SACHIKO , HATA YOJI , ABE YASUHISA , URADE YOSHIHIRO , HUANG ZHI-LI , MATSUMOTO NAOMI , MASAKI MIKA
IPC分类号： A61K36/00 , A23L1/30 , A23L2/38 , A23L2/52 , A61K36/899 , A61P25/02
摘要： PROBLEM TO BE SOLVED: To provide an autonomic nerve regulator utilizing an intermediate, a final product and their processed materials yielded at the production processes of sake, such as a sake lees-processed material.
SOLUTION: This autonomic nerve regulator includes the sake lees-processed material yielded by the liquefied preparation of sake. The sake lees-processed material is obtained by performing at least one treatment selected from the group consisting of the following (1) to (3) on the sake lees. In (1) protease treatment, (2) cellulase treatment, and (3) lactobacillus fermentation treatment, and it is preferable to use a neutral protease or an acidic protease in the protease treatment, to use endoglucanase or cellobiohydrolase in the cellulase treatment, and to use Lactobacillus brevis, Lactobacillus bulgaricus, etc., in the lactobacillus fermentation treatment.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供利用中间体，最终产品及其在清酒生产过程中产生的最终产品及其加工材料的自主神经调节剂，例如酒精加工材料。
解决方案：这种自主神经调节剂包括由液化液制成的清酒产品。通过在清酒桶中进行选自由以下（1）至（3）组成的组中的至少一种处理，从而获得食品加工材料。在（1）蛋白酶处理，（2）纤维素酶处理和（3）乳酸杆菌发酵处理中，优选在蛋白酶处理中使用中性蛋白酶或酸性蛋白酶，在纤维素酶处理中使用内切葡聚糖酶或纤维二糖水解酶，在乳杆菌发酵处理中使用短乳杆菌（Lactobacillus brevis），保加利亚乳杆菌（Lactobacillus bulgaricus）等。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2008266289A Protein of rice origin or rice material brewed food origin, lipid metabolism ameliorating agent, and food material 有权
标题翻译：稻米原料或米料原料，原料，脂肪代谢品，食品原料
公开(公告)号：JP2008266289A
公开(公告)日：2008-11-06
申请号：JP2007302909
申请日：2007-11-22
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , ASHIDA YUKO , ISHIDA HIROKI , HISADA HIROMOTO
IPC分类号： C07K14/415 , A23L1/305 , A61K35/74 , A61K36/899 , A61K38/00 , A61P3/06 , C12P21/00
摘要： PROBLEM TO BE SOLVED: To provide a protein which is a protein of a rice origin or rice material brewed food origin and excellent in the lipid metabolism ameliorating effectiveness. SOLUTION: The protein is a protein of a rice origin or a rice material brewed food origin and is characterized by having the following physicochemical properties from (a) to (c) in the followings. (a) The protein has insolubility or poor solubility to water, an organic solvent, a salt aqueous solution, and an alkali solution. (b) The protein has poor hydrolyzability to cellulase, hemicellulase, mannanase, and protease, and is indigestible to pepsin and pancreatin. (c) The protein has a molecular weight in the range of 8 kDa to 15 kDa. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种蛋白质，其是水稻来源的蛋白质或大米材料酿造的食物来源，并且具有优异的脂质代谢改善效果。解决方案：蛋白质是水稻来源的蛋白质或大米材料酿造的食品来源，其特征在于以下从（a）至（c）具有以下物理化学性质。（a）蛋白质具有不溶性或对水，有机溶剂，盐水溶液和碱溶液的溶解性差。（b）蛋白质对纤维素酶，半纤维素酶，甘露聚糖酶和蛋白酶具有差的水解性，对胃蛋白酶和胰酶消化不良。（c）蛋白质的分子量范围为8kDa至15kDa。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2005225874A Iron supplement and utilization of the same 有权
标题翻译：铁的补充和利用
公开(公告)号：JP2005225874A
公开(公告)日：2005-08-25
申请号：JP2005006829
申请日：2005-01-13
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , FUKUDA KATSUHARU , IRIE MOTOKO , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： A23L2/52 , A23L1/304 , A61K31/395 , A61K33/26 , A61K36/06 , A61P7/06
摘要： PROBLEM TO BE SOLVED: To obtain an iron supplement exhibiting a high iron absorption rate into a living body, a preventing or treating agent of iron-deficiency anemia, a food additive and a food composition. SOLUTION: This iron supplement, the preventing or treating agent of the iron deficiency anemia, the food additive or the food composition contains siderophore and ferric ion preferably as a chelate complex form. The chelate complex of the siderophore with ferric ion has a high absorption rate into the living body, increases hemoglobin concentration in blood, iron concentration in serum and stored iron concentration in liver by being absorbed in the living body and does not give any adverse effect on living body functions. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得在生物体中表现出高的铁吸收率的铁补充剂，缺铁性贫血的预防或治疗剂，食品添加剂和食物组合物。解决方案：该铁补充剂，缺铁性贫血的预防或治疗剂，食品添加剂或食物组合物优选含有铁螯合物和铁离子作为螯合络合物形式。铁载体与铁离子的螯合物对人体的吸收率高，血液中血红蛋白浓度升高，血液中铁浓度升高，肝脏中铁浓度被吸收在生物体内，不会对生物体产生不利影响活体功能。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2008247888A Hypotensive composition using koji 审中-公开
标题翻译：使用KOJI的HYPOTENSIVE组合物
公开(公告)号：JP2008247888A
公开(公告)日：2008-10-16
申请号：JP2008039965
申请日：2008-02-21
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , ISHIDA HIROKI
IPC分类号： C07K5/103 , A61K36/06 , A61K38/00 , A61P9/12 , A61P43/00 , C12N9/99 , C12P21/06
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an angiotensin converting enzyme inhibitor which is available at a low cost and does not cost much labor since the use of the angiotensin converting enzyme inhibitor as a medical treatment drug has to be based on the prescription of a doctor and furthermore, its cost is high and, in the case of using an angiotensin converting enzyme inhibiting peptide, a treatment such as hydrolysis of each peptide is required and extraction and the like cost much labor. SOLUTION: It is found that the angiotensin converting enzyme inhibition activity exists in koji and the extract of koji with water and it is found that the angiotensin converting enzyme inhibition activity showing digestive enzyme resistance also exists in a peptide obtained by partially decomposing proteins present in koji and the peptide has been identified. Further, the blood-pressure reduction by intake of koji has been confirmed in the human monitoring test. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种以低成本获得并且不会花费太多劳动的血管紧张素转化酶抑制剂，因为使用血管紧张素转换酶抑制剂作为医疗治疗药物必须基于医生，此外，其成本高，并且在使用血管紧张素转化酶抑制肽的情况下，需要诸如各种水解的处理，并且提取等费用昂贵。解决方案：发现血管紧张素转换酶抑制活性存在于曲和曲水提取物中，发现显示消化酶抗性的血管紧张素转换酶抑制活性也存在于通过部分分解蛋白获得的肽存在于曲和肽已被鉴定。此外，在人体监测试验中已经确认了通过摄入曲调的血压降低。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2004261119A Functional health food or beverage 有权
公开(公告)号：JP2004261119A
公开(公告)日：2004-09-24
申请号：JP2003055972
申请日：2003-03-03
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： OURA ARATA , SUZUKI SACHIKO , KANAMORI YOJI , HATA YOJI , KAWATO SHOJI , ABE YASUHISA
IPC分类号： A23L2/38 , A23L1/30 , A23L2/52 , A61K36/06 , A61K36/899 , A61P3/04 , A61P3/06 , A61P9/12 , A61P25/28 , A61K35/70 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To develop a health food or beverage having excellent functionalities such as an antiobestic property. SOLUTION: The functional health food or beverage comprises lees of rice wine and rice bran, and as necessary, further, a sweetener such as sugar, honey bee, starch syrup, an acidulant such as lactic acid, tartaric acid or gluconic acid, a flavoring agent, a coloring agent and various components such as common salt, starch, ginger and water. The health food or beverage is not directly used only for drinking or eating, but can be used also as a foodstuff for food products and beverage products and is effective for suppression of obesity, improvement of blood lipid, vasodepressor and suppression of amnesia and has no problem on safety. As a result, the food or beverage can not only be taken in human bodies for a long period for medical application, but also for health application. COPYRIGHT: (C)2004,JPO&NCIPI

6. 发明专利

JP2007099731A Health functional composition 审中-公开
标题翻译：健康功能成分
公开(公告)号：JP2007099731A
公开(公告)日：2007-04-19
申请号：JP2005294699
申请日：2005-10-07
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , OURA ARATA , IRIE MOTOKO , HATA YOJI
IPC分类号： A61K36/899 , A23K1/00 , A23K1/06 , A23K1/18 , A23L1/30 , A23L2/38 , A23L2/52 , A61K8/97 , A61K36/18 , A61K36/81 , A61P3/00 , A61P3/04 , A61P3/06 , A61P17/14 , A61P25/00 , A61Q7/00 , C12G3/02
CPC分类号： Y02P60/873
摘要： PROBLEM TO BE SOLVED: To provide a composition having more physiological activities than those of sake lees which are said to have various physiological activities. SOLUTION: This health functional composition is provided by noticing liquefied lees produced from liquefied liquid preparation, further fermenting the same by lactobacillus to prepare lactobacillus-fermented liquefied lees, and by using the same in experiments using mice and rats, a body weight increase inhibitory effect, the accumulation inhibitory effect of peritoneal white fat tissue, a lipid in blood (neutral fat in serum)-improving effect, an amnesia inhibitory effect and a hair loss inhibitory effect are found out to reveal that the lactobacillus-fermented liquefied lees are the composition having such physiological activities. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有比具有各种生理活性的清酒的生理活性更多的组合物。解决方案：该健康功能组合物通过注意由液化液制剂产生的液化酒，通过乳杆菌进一步发酵以制备乳杆菌发酵液化酒糟，并在使用小鼠和大鼠的实验中使用该健康功能组合物，体重增加抑制作用，发现腹膜白脂肪组织的积聚抑制作用，血液中的脂质（血清中的中性脂肪） - 改善作用，健忘症抑制作用和脱发抑制作用，揭示出乳杆菌发酵液化酒糟是具有这种生理活性的组合物。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2007091711A Preventing or improving agent of fatigue 有权
标题翻译：防止或改善疲劳剂
公开(公告)号：JP2007091711A
公开(公告)日：2007-04-12
申请号：JP2006180060
申请日：2006-06-29
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , FUKUDA KATSUHARU , IRIE MOTOKO , HATA YOJI , KAWATO SHOJI , ABE YASUHISA , YASUI HIROYUKI , SAKURAI HIROSHI
IPC分类号： A61K35/66 , A23L1/304 , A23L1/305 , A61K33/26 , A61K38/00 , A61K38/16 , A61P3/02
摘要： PROBLEM TO BE SOLVED: To provide a preventing or improving agent of muscular fatigue, capable of improving the durability of the muscle, the preventing or improving agent of fatigue caused by the lack of iron and a food composition. SOLUTION: In the case that siderophore or a chelate complex of the siderophore with ferric ion is orally administered, it is found out each of the facts that the iron is absorbed in a good efficiency in a living body and distributes much in the muscle, and that the distribution rate in the muscle is very high as compared with that of inorganic iron. Also, by the oral administration of the siderophore or the chelate complex of the siderophore with ferric ion, it is found out that as compared with the administration of the inorganic iron, the durability of the muscle becomes higher, the stored amount of iron in the living body is increased as the content of iron in the muscle tissue increases, prevention and improvement of anemia, improvement of stamina and alleviation effects of tiredness or weariness are obtained. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：解决问题：提供肌肉疲劳的预防或改善剂，能够提高肌肉的耐久性，防止或改善缺乏铁和食物组合物引起的疲劳。
解决方案：在铁载体与铁离子的螯合络合物口服给药的情况下，发现铁在生物体中以良好的效率吸收的各种事实，并且分布在肌肉，与无机铁相比，肌肉中的分布率非常高。此外，通过口服铁载体的铁载体或螯合络合物与铁离子的配合，发现与无机铁的施用相比，肌肉的耐久性变高，铁的存储量随着肌肉组织中铁含量的增加，活体的增加，贫血的预防和改善，耐力的提高和疲劳或疲劳的缓解作用得到改善。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2009292785A Immunomodulator and antiallergic agent containing the same 有权
标题翻译：免疫调节剂和含有该抗体的抗微生物剂
公开(公告)号：JP2009292785A
公开(公告)日：2009-12-17
申请号：JP2008149762
申请日：2008-06-06
申请人： Gekkeikan Sake Co Ltd , National Agriculture & Food Research Organization , 月桂冠株式会社 , 独立行政法人農業・食品産業技術総合研究機構
发明人： SUZUKI SACHIKO , HATA YOJI , ISHIKAWA YUKO , GOTO MASANARI
IPC分类号： A61K36/899 , A61K31/197 , A61K35/74 , A61K36/06 , A61P37/02 , A61P37/04 , A61P37/08 , A61P43/00
CPC分类号： Y02A50/481
摘要： PROBLEM TO BE SOLVED: To provide a novel immunomodulator which can be used in the prevention and treatment of allergies and excels in safety.
SOLUTION: A composition comprising a product brewed from rice as a raw material is provided as an immunomodulator. It is preferred that the above product brewed from rice as a raw material has further undergone fermentation treatment, and particularly has undergone the fermentation treatment in the presence of rice bran. Such fermentation treatments can increase the content of γ-aminobutyric acid in the product brewed from rice as a raw material and exhibits superior modulability. For example, the immunomodulator is useful as a Th1/Th2 balance modulator for modulating the Th1/Th2 balance and an antiallergic agent.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种可用于预防和治疗过敏症并且安全性优异的新型免疫调节剂。解决方案：作为免疫调节剂提供包含从米制成的作为原料的产品的组合物。优选以水稻为原料酿造的上述产品进一步进行发酵处理，特别是在米糠存在下进行发酵处理。这样的发酵处理可以提高从水稻作为原料制成的产品中的γ-氨基丁酸的含量，并表现出优异的可调性。例如，免疫调节剂可用作用于调节Th1 / Th2平衡的Th1 / Th2平衡调节剂和抗过敏剂。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2008050269A Oral ingestion material 审中-公开
标题翻译：口腔材料
公开(公告)号：JP2008050269A
公开(公告)日：2008-03-06
申请号：JP2006224999
申请日：2006-08-22
申请人： Gekkeikan Sake Co Ltd , 月桂冠株式会社
发明人： SUZUKI SACHIKO , OURA ARATA , FUKUDA KATSUHARU , IRIE MOTOKO
IPC分类号： A61K31/197 , A23L1/30 , A61K35/74 , A61K36/899 , A61K38/55 , A61P9/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain a composition of natural raw material effective for treatment of hypertension and having no adverse effect in which γ-aminobutyric acid being a kind of an amino acid existing in the natural world is a material having a noticeable effect as antihypertensive agent and even a low γ-aminobutyric acid content, more enhances high hypotensive effect of γ-aminobutyric acid. SOLUTION: The composition containing γ-aminobutyric acid is obtained by reacting by-product of refined rice wine brewing as a raw material with lactic acid bacterium. The raw material may comprise rice bran and/or glutamic acid or its salt. The composition exhibits a strong hypotensive effect more than a case of ingesting only γ-aminobutyric acid alone. When both the composition and an ACE (angiotensin converting enzyme) inhibitory peptide are used, even the amount of each component is small, it is found that a synergistic effect is obtained and a strong hypotensive effect is exhibited. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了获得有效治疗高血压的天然原料的组合物，并且不存在γ-氨基丁酸作为存在于天然世界中的一种氨基酸的不利影响的物质是具有明显的物质作为抗高血压药物甚至低γ-氨基丁酸的含量，更能增强γ-氨基丁酸的高血压降低作用。解决方案：含有γ-氨基丁酸的组合物通过将精制米酒酿造作为原料的副产物与乳酸菌反应而获得。原料可以包含米糠和/或谷氨酸或其盐。与单独摄入γ-氨基丁酸的情况相比，该组合物具有强烈的降血压作用。当使用组合物和ACE（血管紧张素转换酶）抑制肽两者时，即使每种组分的量都很小，发现获得了协同效应并且表现出强烈的降血压作用。版权所有（C）2008，JPO＆INPIT

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