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1. 发明专利

JP2011126833A Autonomic nerve regulator 审中-公开
标题翻译：自动神经调节器
公开(公告)号：JP2011126833A
公开(公告)日：2011-06-30
申请号：JP2009288305
申请日：2009-12-18
申请人： Gekkeikan Sake Co Ltd , Osaka Bioscience Institute , 月桂冠株式会社 , 財団法人大阪バイオサイエンス研究所
发明人： TSUTSUMI HIROKO , SUZUKI SACHIKO , HATA YOJI , ABE YASUHISA , URADE YOSHIHIRO , HUANG ZHI-LI , MATSUMOTO NAOMI , MASAKI MIKA
IPC分类号： A61K36/00 , A23L1/30 , A23L2/38 , A23L2/52 , A61K36/899 , A61P25/02
摘要： PROBLEM TO BE SOLVED: To provide an autonomic nerve regulator utilizing an intermediate, a final product and their processed materials yielded at the production processes of sake, such as a sake lees-processed material.
SOLUTION: This autonomic nerve regulator includes the sake lees-processed material yielded by the liquefied preparation of sake. The sake lees-processed material is obtained by performing at least one treatment selected from the group consisting of the following (1) to (3) on the sake lees. In (1) protease treatment, (2) cellulase treatment, and (3) lactobacillus fermentation treatment, and it is preferable to use a neutral protease or an acidic protease in the protease treatment, to use endoglucanase or cellobiohydrolase in the cellulase treatment, and to use Lactobacillus brevis, Lactobacillus bulgaricus, etc., in the lactobacillus fermentation treatment.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供利用中间体，最终产品及其在清酒生产过程中产生的最终产品及其加工材料的自主神经调节剂，例如酒精加工材料。
解决方案：这种自主神经调节剂包括由液化液制成的清酒产品。通过在清酒桶中进行选自由以下（1）至（3）组成的组中的至少一种处理，从而获得食品加工材料。在（1）蛋白酶处理，（2）纤维素酶处理和（3）乳酸杆菌发酵处理中，优选在蛋白酶处理中使用中性蛋白酶或酸性蛋白酶，在纤维素酶处理中使用内切葡聚糖酶或纤维二糖水解酶，在乳杆菌发酵处理中使用短乳杆菌（Lactobacillus brevis），保加利亚乳杆菌（Lactobacillus bulgaricus）等。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2014024774A Sleep quality improving agent 审中-公开
标题翻译：休闲质量改进剂
公开(公告)号：JP2014024774A
公开(公告)日：2014-02-06
申请号：JP2012164926
申请日：2012-07-25
申请人： Lion Corp , ライオン株式会社 , Osaka Bioscience Institute , 公益財団法人大阪バイオサイエンス研究所
发明人： URADE YOSHIHIRO , KAMATA IKUKO , GOKITA TOMOO , SUZUKI KIWAMU , KAMIBAYASHI HIROAKI , MURAKOSHI TOMOAKI
IPC分类号： A61K31/05 , A61K31/352 , A61K31/7034 , A61K31/7048 , A61K36/00 , A61K36/18 , A61P25/20
CPC分类号： A61K36/87 , A61K31/05 , A61K31/7048 , A61K36/13 , A61K36/17 , A61K36/63 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide a sleep quality improving agent sufficiently displaying sleep quality improving effects, exhibiting the effects by oral administration regardless of the dosage form, and ensuring safety of the body.SOLUTION: The present invention provides a sleep quality improving agent with a stilbene-based compound and/or an olive extract as an active ingredient and a sleep quality improving composition containing the sleep quality improving agent.
摘要翻译：要解决的问题：提供充分显示睡眠质量改善效果的睡眠质量改进剂，不管剂型如何，通过口服显示效果，并确保身体的安全性。解决方案：本发明提供了一种睡眠质量改善剂，其具有作为活性成分的芪类化合物和/或橄榄提取物，以及含有睡眠质量改善剂的睡眠质量改善组合物。

3. 发明专利

JP2005098805A Method for determining and predicting degree of severity of gestosis and method for evaluating fetus/placenta function in gestosis 有权
标题翻译：用于确定和预测镰刀菌严重程度的方法和评估G虫中的FETUS / PLACENTA功能的方法
公开(公告)号：JP2005098805A
公开(公告)日：2005-04-14
申请号：JP2003332084
申请日：2003-09-24
申请人： Maruha Corp , Osaka Bioscience Institute , マルハ株式会社 , 財団法人大阪バイオサイエンス研究所
发明人： ODA KOJI , SEIKI KOSUKE , SHIINA YASUHIKO , SATO NOBUYUKI , TAKEDA SHO , EGUCHI NAOMI , URADE YOSHIHIRO
IPC分类号： G01N33/573 , C12Q1/25 , C12Q1/533 , G01N33/68
CPC分类号： C12Q1/533 , G01N33/689 , G01N2800/368
摘要： PROBLEM TO BE SOLVED: To provide a method for predicting the crisis of gestosis by accurately detecting anomalies prior to the crisis of gestosis, which has not been detected by various conventional test means to gestosis, without having to burden subjects much and to provide a method for evaluating fetus/placenta functions in gestosis.
SOLUTION: Human lipocalin-type prostaglandin D synthase (L-PGDS) in a bodily fluid sample collected from a subject is measured in the gestosis detection method.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种通过准确检测葛参危机之前的异常情况来预测呕血症危险的方法，这种异常尚未被各种常规检测手段检测到，而不必对受试者负担多提供一种评估睾丸激素的胎儿/胎盘功能的方法。解决方案：在睾丸检测方法中测量从受试者收集的体液样品中的人类脂质运载蛋白型前列腺素D合成酶（L-PGDS）。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004194581A Three-dimensional conformation of lipocine-type prostaglandin d synthetase and use thereof 审中-公开
公开(公告)号：JP2004194581A
公开(公告)日：2004-07-15
申请号：JP2002368112
申请日：2002-12-19
申请人： Institute Of Physical & Chemical Research , Osaka Bioscience Institute , 独立行政法人理化学研究所 , 財団法人大阪バイオサイエンス研究所
发明人： MIYANO MASASHI , YAMAMOTO MASAKI , KUMASAKA TAKASHI , AGO HIDEO , URADE YOSHIHIRO , IRIKURA DAISUKE , ARITAKE KOSUKE
IPC分类号： G01N33/50 , A61K31/454 , A61P43/00 , C07D401/06 , C12N9/02 , C12N9/90 , C12N9/99 , C12N15/09 , C12Q1/533 , G01N33/15 , G01N33/68
CPC分类号： C12N9/0004 , C07K2299/00 , C12Q1/533
摘要： PROBLEM TO BE SOLVED: To provide a crystal structure of a lipocine-type prostaglandin D synthetase, and to provide an inhibitor thereof. SOLUTION: The crystal of the lipocine-type prostaglandin D synthetase is formed, and the three-dimensional space structure of the enzyme is obtained from the X-ray diffraction to enable the inhibitor to be designed and selected. The inhibitor of the enzyme and the screening method thereof are also provided. COPYRIGHT: (C)2004,JPO&NCIPI

5. 发明专利

JP2011019446A Lesion model animal of myodegeneration disease, and method for producing the same 审中-公开
标题翻译：麻醉模型动物模型及其生产方法
公开(公告)号：JP2011019446A
公开(公告)日：2011-02-03
申请号：JP2009166960
申请日：2009-07-15
申请人： Osaka Bioscience Institute , 財団法人大阪バイオサイエンス研究所
发明人： URADE YOSHIHIRO , ARITAKE KOSUKE , MICHAEL LAZARUS , MITAMURA ELIZABETH KO , ENOMOTO TETSUO
IPC分类号： A01K67/027 , C12N15/09 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a lesion model animal of myodegeneration disease, especially muscular dystrophy; to provide a method for producing the model animal; and to provide a method for screening a therapeutic agent or a prophylactic agent of the myodegeneration disease by using the lesion model animal.
SOLUTION: There is provided the method for producing the lesion model animal of the myodegeneration disease in which a dystrophin gene is knocked down or knocked out, and a hematogenous organ-type prostaglandin D synthetase (H-PGDS) is highly expressed. The method for screening the therapeutic agent or the prophylactic agent of the myodegeneration disease by using the lesion model animal of the myodegeneration disease is also provided.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种病变模型动物的特征性肌营养不良症，特别是肌营养不良症; 提供生产模型动物的方法; 并且提供通过使用病变模型动物来筛选病毒性疾病的治疗剂或预防剂的方法。提供了产生肌营养不良蛋白基因被敲低或敲除的重症病变病变模型动物的方法，并且高度表达血源性器官型前列腺素D合成酶（H-PGDS）。还提供了通过使用转移性疾病的病变模型动物筛选治疗剂或预防药物的方法。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2008137941A Sleep improving composition 审中-公开
标题翻译：睡眠改善组合物
公开(公告)号：JP2008137941A
公开(公告)日：2008-06-19
申请号：JP2006325392
申请日：2006-12-01
申请人： Mitsukan Group Honsha:Kk , Osaka Bioscience Institute , 株式会社ミツカングループ本社 , 財団法人大阪バイオサイエンス研究所
发明人： URADE YOSHIHIRO , NISHIMURA RYOKO
IPC分类号： A61K35/74 , A61P25/20
摘要： PROBLEM TO BE SOLVED: To provide a sleep improving agent to induce natural and high-quality deep sleep and having high safety.
SOLUTION: The sleep improving composition comprises a disintegrated product of the cell of a microorganism belonging to Bacillus subtilis such as Bacillus natto as an active component. The invention further provides the above sleep improving composition containing the disintegrated cell of the microorganism in an amount of 2.5-100,000 mg per daily dose of the composition. It is used for improving the sleeping state of a person suffered by a poor sleeping state caused by excessive stress.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供睡眠改善剂以诱导天然和高质量的深度睡眠并具有高安全性。解决方案：睡眠改善组合物包含属于枯草芽孢杆菌的细胞的崩解产物，例如纳豆芽孢杆菌作为活性成分。本发明还提供了含有该组合物每日剂量2.5-100,000mg的微生物分解细胞的上述睡眠改善组合物。用于改善由过度压力引起的睡眠状态不佳所造成的睡眠状态。版权所有（C）2008，JPO＆INPIT

7. 发明专利

JP2005232193A Prognostic improver for cerebral injury and method for screening the same 审中-公开
标题翻译：胚胎损伤的预防性改善及其筛选方法
公开(公告)号：JP2005232193A
公开(公告)日：2005-09-02
申请号：JP2005144121
申请日：2005-05-17
申请人： Japan Science & Technology Agency , Osaka Bioscience Institute , Taiho Yakuhin Kogyo Kk , 大鵬薬品工業株式会社 , 独立行政法人科学技術振興機構 , 財団法人大阪バイオサイエンス研究所
发明人： URADE YOSHIHIRO , EGUCHI NAOMI , ARITAKE KOSUKE , SATO AKIRA , SUMIYAMA KEIICHI , TANIIKE MASAKO
IPC分类号： A61K45/00 , A61K31/185 , A61K31/41 , A61K31/4196 , A61K31/428 , A61P9/10 , A61P17/02 , A61P25/00 , A61P25/28
摘要： PROBLEM TO BE SOLVED: To provide a compound for treating or preventing cerebral injury caused by diseases such as cerebrovasular disease, cerebral degeneration disease, and demyelinating disease, and to provide a method for screening the compound.
SOLUTION: A medicinal composition comprising as an active ingredient an inhibitor for hematopoietic organ type prostaglandin D synthetase is provided. Compounds having the pharmacodynamic actions are easily screened by using a transgenic mouse expressing much human hematopoietic organ type prostaglandin D synthetase.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种用于治疗或预防由诸如脑血管病，脑变性疾病和脱髓鞘疾病的疾病引起的脑损伤的化合物，并提供筛选化合物的方法。解决方案：提供一种包含造血器官型前列腺素D合成酶抑制剂作为活性成分的药物组合物。通过使用表达大量人类造血器官型前列腺素D合成酶的转基因小鼠容易地筛选具有药效学作用的化合物。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2004129605A Flavoprotein of trypanosoma cruzi, and anthelmintic screening method and diagnostic using the same protein 审中-公开
公开(公告)号：JP2004129605A
公开(公告)日：2004-04-30
申请号：JP2002299284
申请日：2002-10-11
申请人： National Institute Of Infectious Diseases , Osaka Bioscience Institute , 国立感染症研究所長 , 財団法人大阪バイオサイエンス研究所
发明人： URADE YOSHIHIRO , BRUNO KILUNGA KUBATA , KABUTUTU ZAKAYI , NOZAKI TOMOYOSHI
IPC分类号： G01N33/50 , A61K38/00 , C07K16/20 , C07K16/40 , C12N9/02 , C12N15/09 , C12N15/53 , C12Q1/26 , C12Q1/32 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/569
CPC分类号： C12N9/0004 , A61K38/00 , C07K16/20 , C12Q1/32 , C12Q1/6893 , C12Q2600/136 , G01N33/56905 , G01N2500/00
摘要： PROBLEM TO BE SOLVED: To provide a method for screening an antithelmintic agent for Trypanosoma cruzi which is a pathogen of Chagas' disease and diagnosing Chagas' disease infection. SOLUTION: The antithelmintic agent effective against Trypanosoma cruzi is screened by using a flavoprotein TcOYE which is specific to Trypanosoma cruzi. Trypanosoma cruzi infection is diagnosed by using a genetic sequence and antibody of TcOYE. COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2004026689A New antimalarial agent 审中-公开
公开(公告)号：JP2004026689A
公开(公告)日：2004-01-29
申请号：JP2002182969
申请日：2002-06-24
申请人： Osaka Bioscience Institute , 財団法人大阪バイオサイエンス研究所
发明人： URADE YOSHIHIRO , BRUNO KILUNGA KUBATA , MURAKAMI KEIJU , HORII TOSHIHIRO
IPC分类号： A61K31/352 , A61P33/06 , C07D311/32
CPC分类号： C07D311/32
摘要： PROBLEM TO BE SOLVED: To obtain a new antimalarial agent which is effective for the treatment of malaria resistant to conventional antimalarial agents.
SOLUTION: A medicinal composition used for the treatment of the malaria comprises a compound represented by formula (I) (R
1 to R
12 are each independently H, a halogen atom, hydroxy, an alkyl, an alkoxy, amino, or an acylamino) and a pharmaceutically acceptable carrier.
COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2011195482A Sleep improver 审中-公开
标题翻译：睡眠改善
公开(公告)号：JP2011195482A
公开(公告)日：2011-10-06
申请号：JP2010062620
申请日：2010-03-18
申请人： Doshisha , Kurei Okinawa:Kk , Osaka Bioscience Institute , 学校法人同志社 , 株式会社クレイ沖縄 , 財団法人大阪バイオサイエンス研究所
发明人： OGAWA YUKO , KONISHI TENJI , URADE YOSHIHIRO , HUANG ZHI-LI , MATSUMOTO NAOMI
IPC分类号： A61K31/198 , A61K31/341 , A61K31/7048 , A61P25/20
摘要： PROBLEM TO BE SOLVED: To provide a sleep improver that improves sleep qualities.SOLUTION: The sleep improver comprises any of compounds represented by formulas (1)-(3) or its salt as an active ingredient. The sleep improver comprises the compound represented by formula (1) or its salt as an active ingredient and shortens an amount of awakening and/or increases an amount of NREM sleep.
摘要翻译：要解决的问题：提供改善睡眠质量的睡眠改进剂。解决方案：睡眠改善剂包含由式（1） - （3）表示的任何化合物或其盐作为活性成分。睡眠改善剂包含由式（1）表示的化合物或其盐作为活性成分，并缩短了一定量的觉醒和/或增加NREM睡眠的量。

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