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1. 发明授权

EP2757369B1 ONLINE VOLATILE ORGANIC COMPOUND ANALYZER AND USING METHOD THEREOF 失效
标题翻译：在线挥发性有机化合物分析仪及其使用方法
公开(公告)号：EP2757369B1
公开(公告)日：2017-09-27
申请号：EP12832055.3
申请日：2012-07-20
申请人： Wuhan Tianhong Instruments Co., Ltd
发明人： LI, Hongjie , HAN, Changmian , JIANG, Maogui , WANG, Pengjiao
IPC分类号： G01N33/00 , G01N30/08 , G01N30/78 , G01N1/40
CPC分类号： G01N30/06 , G01N1/2214 , G01N1/2273 , G01N30/20 , G01N30/6043 , G01N30/78 , G01N33/0016 , G01N33/0032 , G01N33/0047 , G01N2030/025 , G01N2030/045 , G01N2030/047 , G01N2030/884 , G01N2030/8854

2. 发明公开

EP2697655A2 METHOD AND APPARATUS FOR THE ANALYSIS OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：方法和设备用于生物样品分析
公开(公告)号：EP2697655A2
公开(公告)日：2014-02-19
申请号：EP12720940.1
申请日：2012-04-12
申请人： Micromass UK Limited
发明人： WILLIAMS, Jonathan Paul , HUGHES, Christopher John , GREEN, Brian , VISSERS, Johannes Petrus Cornelis
IPC分类号： G01N33/72 , G01N33/68
CPC分类号： G01N33/721 , G01N30/7233 , G01N30/8675 , G01N33/6848 , G01N33/72 , G01N2030/045 , G01N2030/8822 , G01N2560/00
摘要： A method for the detection and quantitation of analytes of interest and variants of the analyte of interest comprising the steps of: (i) providing a sample containing an analyte of interest; (ii) spiking sample with known amount of calibrant; (iii) performing an LCMS or LCMSMS analysis on the spiked sample to produce a data set; (iv) determining from said data set the relative quantity of analyte of interest to calibrant; (v) calculating the absolute quantity of the analyte of interest from said relative quantity of analyte of interest and said known amount of calibrant; (vi) searching for one or more previously identified candidate sequences for one or more known variants denoted by one or more specific peaks to identify the presence of said one or more known variants within the sample; (vii) determining the relative quantity or amount of said one or more variants to said analyte of interest; and (viii) calculating the absolute quantity or amount of any of said one or more variants present in the sample.

3. 发明公开

EP2446460A1 FUNKTIONSKONTROLLE BZW. VARIANZENKOMPENSATION IN DER MASSENSPEKTROMETRIE 审中-公开
标题翻译：功能控制或无功补偿在大体积
公开(公告)号：EP2446460A1
公开(公告)日：2012-05-02
申请号：EP10725193.6
申请日：2010-06-18
申请人： Tecan Trading AG
发明人： VOGESER, Michael , GEYER, Roland , HÄLG, Werner
IPC分类号： H01J49/00
CPC分类号： H01J49/0009 , G01N30/02 , G01N30/7233 , G01N30/8665 , G01N2030/045 , H01J49/0036
摘要： The invention relates to a test method for checking the function of a mass spectrometer (5) and a method for compensating for ion yield variances in mass spectrometry, characterized in that said method comprises mixing an eluate of a chromatographic separate system (1,2) and a target analyte solution having a known concentration, injecting said mixture into a mass spectrometer (5) having a detector providing a signal, capturing a mass spectrogram based on the detector signal, capturing an integrated mass spectrographic peak area (A) above an integration line (6) and an area (B) below the integrated peak area (A), and forming a mathematical relationship of the areas (A) and (B). The test method thereby further comprises setting a threshold value for said mathematical relationship indicating the limit of the acceptable quality of a mass spectrometric analysis, and accepting or rejecting the mass spectrometric analysis on the basis of a comparison of the mathematical relationship to the set threshold value. The compensation method thereby further comprises evaluating the mass spectrogram for compensating for variances in the ion yield in the detector (5). The invention further relates to devices for performing said test method or compensation method.

4. 发明公开

EP2438448A4 SPECIFIC ANALYSIS OF KETONE AND ALDEHYDE ANALYTES USING REAGENT COMPOUNDS LABELING STRATEGIES, AND MASS SPECTROMETRY WORKFLOW 有权转让
标题翻译：酮和醛分析物的具体分析使用物鉴别策略和试剂的质量，工作流程
公开(公告)号：EP2438448A4
公开(公告)日：2015-05-06
申请号：EP10783702
申请日：2010-06-01
申请人： DH TECHNOLOGIES DEV PTE LTD
发明人： DEY SUBHAKAR , PILLAI SASI , WILLIAMSON BRIAN L , PURKAYASTHA SUBHASISH , WEINSTOCK MICHAL
IPC分类号： G01N37/00 , G01N27/62 , G01N30/04 , G01N30/72 , G01N30/88 , G01N33/64 , G01N33/74 , H01J49/00
CPC分类号： G01N30/72 , G01N27/62 , G01N33/64 , G01N33/743 , G01N2030/045 , G01N2030/884 , H01J49/00 , H01J49/0045 , H01J49/164 , Y10T436/147777 , Y10T436/200833
摘要： Labeling reagents, sets of labeling reagents, and labeling techniques are provided for the relative quantitation, absolute quantitation, or both, of ketone or aldehyde compounds including, but not limited to, analytes comprising steroids or ketosteroids. The analytes can be medical or pharmaceutical compounds in biological samples. Methods for labeling, analyzing, and quantifying ketone or aldehyde compounds are also disclosed as are methods that also use mass spectrometry.
摘要翻译：标记试剂，套标记试剂，和标记技术被提供用于相对定量，绝对定量，或两者，酮或醛的化合物，包括但不限于，分析物包括类固醇或类固醇酮和睾酮包括。所述分析物可以是生物样品中的医用或药用化合物。因此用于标记，分析和定量酮或醛的化合物的方法是游离缺失盘如同方法都因此使用质谱法。

5. 发明公开

EP2757369A1 ONLINE VOLATILE ORGANIC COMPOUND ANALYZER AND USING METHOD THEREOF 失效
标题翻译：在线分析师FÜRFLÜCHTIGEORGANISCHE VERBINDUNGEN UND ANWENDUNGSVERFAHRENDAFÜR
公开(公告)号：EP2757369A1
公开(公告)日：2014-07-23
申请号：EP12832055.3
申请日：2012-07-20
申请人： Wuhan Tianhong Instruments Co., Ltd
发明人： LI, Hongjie , HAN, Changmian , JIANG, Maogui , WANG, Pengjiao
IPC分类号： G01N33/00 , G01N30/08 , G01N30/78
CPC分类号： G01N30/06 , G01N1/2214 , G01N1/2273 , G01N30/20 , G01N30/6043 , G01N30/78 , G01N33/0016 , G01N33/0032 , G01N33/0047 , G01N2030/025 , G01N2030/045 , G01N2030/047 , G01N2030/884 , G01N2030/8854
摘要： The present invention relates to an on-line analyzer for VOCs in gas and method of using the same, comprising: a sampling device (1), an gas-supply device (2) and a refrigerating device (3) connected to the sampling device (1) and the gas-supply device (2) respectively; the on-line analyzer for VOCs in gas with two cryo-focuses in empty tubes and two detectors also comprises a gas flow control device (4) connected to the sampling device (1) and the gas-supply device (2) respectively, an analyzing device (5) connected to the gas flow control device (4), and a data acquisition and processing device connected to the analyzing device (5). Therefore, the present invention has a following advantage: the present invention runs automatically and continuously over a long period since it uses electronic refrigeration technique to achieve cryo-refrigeration, instead of using liquid nitrogen refrigeration technique which needs frequent addition of liquid nitrogen and limits application conditions.
摘要翻译：本发明涉及一种气体中VOC的在线分析仪及其使用方法，包括：取样装置（1），气体供给装置（2）和与采样装置连接的制冷装置（3）（1）和气体供应装置（2）; 用于在空管中具有两个冷冻焦点的气体中的VOC在线分析器和两个检测器还包括分别连接到取样装置（1）和气体供应装置（2）的气体流量控制装置（4）连接到气体流量控制装置（4）的分析装置（5）以及连接到分析装置（5）的数据采集和处理装置。因此，本发明具有以下优点：本发明使用电子制冷技术来实现冷冻制冷，而是使用液氮制冷技术而不需要频繁添加液氮并限制应用的长时间自动连续运行条件。

6. 发明公开

EP2548015A1 IMPROVED MASS SPECTROMETRIC ASSAYS FOR PEPTIDES 审中-公开
标题翻译：改进的大容量测定法肽
公开(公告)号：EP2548015A1
公开(公告)日：2013-01-23
申请号：EP11756883.2
申请日：2011-03-15
申请人： Anderson Forschung Group, Inc.
发明人： ANDERSON, N., Leigh
IPC分类号： G01N33/00
CPC分类号： G01N33/6851 , C07K7/06 , C07K7/08 , C07K17/06 , C12Y304/21004 , G01N27/62 , G01N30/7233 , G01N33/6848 , G01N2030/045 , G01N2030/8831 , G01N2333/976 , G01N2458/15 , G01N2496/00 , G01N2560/00
摘要： Methods for interpretation of mass spectrometric tests for clinical biomarkers in which the amounts of internal standards are set to equal clinical evaluation thresholds, and preparations for adding stable isotope labeled peptide species to sample digests while minimizing losses and alterations in peptide stoichiometry.

7. 发明公开

EP2285461A1 ANALYTICAL METHOD TO MONITOR VACCINE POTENCY AND STABILITY 审中-公开
标题翻译：分析方法用于监测疫苗的有效性和稳定性
公开(公告)号：EP2285461A1
公开(公告)日：2011-02-23
申请号：EP09755648.4
申请日：2009-05-21
申请人： Intervet International B.V.
发明人： WILLIAMS, Mark , SLIGHTOM, James , ROERINK, Frank
IPC分类号： B01D15/08
CPC分类号： G01N30/88 , G01N21/6428 , G01N30/74 , G01N30/8679 , G01N2030/027 , G01N2030/045 , G01N2030/8831
摘要： The present invention is directed to methods of evaluating whether an antigen or vaccine has degraded over time using liquid chromatography. The methods described herein also relate to using liquid chromatography to evaluate the relative potency of a given antigen or vaccine.

8. 发明公开

EP2215460A4 INTERNAL STANDARDS AND METHODS FOR USE IN QUANTITATIVELY MEASURING ANALYTES IN A SAMPLE 审中-公开
标题翻译：内标和定量测定样品中分析物的方法
公开(公告)号：EP2215460A4
公开(公告)日：2010-12-29
申请号：EP08855298
申请日：2008-11-20
申请人： WATERS TECHNOLOGIES CORP
发明人： AMOURA MOHAMED
IPC分类号： G01N24/00 , G01N30/72
CPC分类号： G01N30/02 , G01N30/06 , G01N30/7233 , G01N2030/045 , H01J49/0009 , Y10T436/10 , Y10T436/143333 , Y10T436/25

9. 发明公开

EP2718710A1 COMPOSITIONS, METHODS, AND KITS FOR QUANTIFYING TARGET ANALYTES IN A SAMPLE 有权
标题翻译： ZUSAMMENSETZUNGEN，VERFAHREN UND KITS ZUR QUANTIFIZIERUNG VON ZIELANALYTEN IN EINER PROBE
公开(公告)号：EP2718710A1
公开(公告)日：2014-04-16
申请号：EP12727065.0
申请日：2012-06-06
申请人： Waters Technologies Corporation
发明人： COOPER, Donald, P.
IPC分类号： G01N30/86
CPC分类号： H01J49/0009 , G01N30/72 , G01N30/8665 , G01N2030/045
摘要： A method of quantifying a target analyte by mass spectrometry includes obtaining a mass spectrometer signal comprising a first calibrator signal, comprising a second calibrator signal, and potentially comprising a target analyte signal from a single sample comprising a first known quantity of a first calibrator, comprising a second known quantity of a second calibrator, and potentially comprising a target analyte. The first known quantity and the second known quantity are different, and wherein the first calibrator, the second calibrator, and the target analyte are each distinguishable in the single sample by mass spectrometry. The method also includes quantifying the target analyte in the single sample using the first calibrator signal, the second calibrator signal, and the target analyte signal.
摘要翻译：通过质谱法对目标分析物进行定量的方法包括获得包含第一校准器信号的质谱仪信号，包括第二校准器信号，潜在地包括来自包含第一已知量的第一校准器的单个样品的目标分析物信号，包括第二已知量的第二校准器，并且潜在地包含靶分析物。第一已知量和第二已知量是不同的，并且其中第一校准器，第二校准器和目标分析物在单个样品中通过质谱分别可分辨。该方法还包括使用第一校准器信号，第二校准器信号和目标分析物信号量化单个样品中的目标分析物。

10. 发明公开

EP2515107A1 METHOD FOR QUANTIFICATION OF CAROTENOID 审中-公开
标题翻译： VERFAHREN ZUR QUANTIFIZIERUNG VON CAROTINOID
公开(公告)号：EP2515107A1
公开(公告)日：2012-10-24
申请号：EP10837347.3
申请日：2010-10-15
申请人： Suntory Holdings Limited
发明人： KASAJIMA, Naoki
IPC分类号： G01N30/88 , G01N30/06 , G01N33/14
CPC分类号： G01N33/14 , G01N30/04 , G01N33/025 , G01N2030/045 , G01N2030/8813
摘要： Provided is a method for quantitative analysis of carotenoids such as β-cryptoxanthin contained in a sample such as citrus fruit or the like which enables simple and accurate quantitative analysis.
An internal standard such as lycopene or retinal is used, whereby work is facilitated and an error of a measured value is reduced. Further, a dehydrating agent is added during saponification reaction in the preparation of a sample for analysis, whereby a deviation of a measured value can be reduced.
摘要翻译：提供了一种用于定量分析类胡萝卜素的方法，例如柑橘类水果等样品中所含的β-隐黄质，其能够进行简单且准确的定量分析。使用诸如番茄红素或视网膜之类的内部标准，从而促进了工作并降低了测量值的误差。此外，在制备用于分析的样品时，在皂化反应期间加入脱水剂，由此可以降低测定值的偏差。

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