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1. 发明公开

EP4361579A1 A SENSOR ARRANGEMENT 审中-公开
公开(公告)号：EP4361579A1
公开(公告)日：2024-05-01
申请号：EP22204499.2
申请日：2022-10-28
申请人： Biotage AB
发明人： FRÖJDH, Håkan , FORSLUND, David , JOHANSSON, Elias
IPC分类号： G01F23/284 , B01D15/10 , G01S13/88
CPC分类号： B01D15/10 , G01S13/88 , G01F23/284 , G01N30/02
摘要： A method for detecting a position of a liquid surface in a container and a sensor arrangement 1; 1' configured to be attached to a top opening 11; 11' of a container 13; 13' used for storing liquid in a bench top fluid handling system 101. Said sensor arrangement 1; 1' comprises a mmWave radar sensor 21, a sensor housing 24 comprising said radar sensor 21 and a container attaching part 23; 23' connected to said sensor housing 24 and configured for attaching the sensor arrangement 1; 1' to the top opening 11; 11' of the container 13; 13' such that the radar sensor 21 can be provided in an operating position for detecting a position of a liquid surface in the container 13; 13'.

2. 发明公开

EP3404408A1 UNIT FOR NON-CONTINUOUS SAMPLE FRACTIONATION AND INTEGRATION, AND DUAL ONLINE MULTIFUNCTIONAL LIQUID CHROMATOGRAPHY DEVICE HAVING SAME 审中-实审
公开(公告)号：EP3404408A1
公开(公告)日：2018-11-21
申请号：EP16885222.6
申请日：2016-10-31
申请人： Korea University Research and Business Foundation
发明人： LEE, Sang-Won , LEE, Hangyeore
IPC分类号： G01N30/02 , G01N30/34 , G01N30/82 , G01N30/89
CPC分类号： G01N30/02 , G01N30/34 , G01N30/82 , G01N30/89
摘要： Disclosed are a unit for non-continuous sample fractionation and integration and a dual online multifunctional liquid chromatography device having the same. The unit for non-continuous sample fractionation and integration according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and integrates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.

3. 发明授权

EP3154993B1 PROCESS FOR THE PURIFICATION OF L-ALPHA-GLYCEROPHOSPHORYLCHOLINE 有权
公开(公告)号：EP3154993B1
公开(公告)日：2018-08-15
申请号：EP15732957.4
申请日：2015-06-09
申请人： Chemi SPA
发明人： DE FERRA, Lorenzo , ANIBALDI, Mauro , ZENONI, Maurizio , COCCHI, Fabrizio
IPC分类号： C07F9/10
CPC分类号： C07F9/103 , B01D15/08 , C07F9/091 , C07F9/106 , C07F9/65742 , G01N21/49 , G01N30/02 , G01N2030/027
摘要： A process for the purification of L-α-glycerophosphorylcholine is described, wherein L-α-glycerophosphorylcholine is crystallized from DMSO or from a mixture of DMSO with at least another solvent, preferably selected from water, alcohol, halogenated solvents, ethers, esters and/or amides. Such a process allows to obtain L-α-glycerophosphorylcholine having a purity greater than 99.5%, preferably greater than 99.7%, even more preferably greater than or equal to 99.9%. A method for determining the purity of L-α-glycerophosphorylcholine is also described, comprising the elution of L-α-glycerophosphorylcholine through an HPLC column having an amino stationary phase, and subsequent detection of L-α-glycerophosphorylcholine itself, and any impurity thereof, by means of an Evaporative Light Scattering Detector type.

4. 发明公开

EP3341720A1 METHODS FOR IMPROVING DIABETES MANAGEMENT 审中-公开
公开(公告)号：EP3341720A1
公开(公告)日：2018-07-04
申请号：EP16842439.8
申请日：2016-08-29
申请人： PreventAGE Healthcare, LLC
发明人： BEISSWENGER, Paul, J.
IPC分类号： G01N30/02 , G01N30/72 , G01N33/48
CPC分类号： G01N33/487 , G01N30/02 , G01N30/72 , G01N30/7233 , G01N33/50 , G01N33/6848 , G01N2030/8822 , G01N2800/042
摘要： The present invention provides methods for determining in a subject suffering from either type 1 diabetes mellitus or type 2 diabetes mellitus the risk of developing, and/or the rate of progression of certain diabetes associated complications (e.g., diabetic nephropathy and other associated disorders) resulting from angiopathic changes in the subject such as microvascular and/or macrovascular damage. The present invention also provides methods for handling, storing, and preserving, biological samples (e.g., blood, plasma, urine) from a subject having either Type 2 or Type 1 diabetes. Further provided are methods for analyzing biological samples from a subject to determine the quantities of one or more biomarkers of interest in comparison to results obtained from previous samples from the subject and/or to results obtained from aggregated samples, or to standards. Further provided are materials that will allow health care professionals to improve diabetes management in a subject or group of subjects based upon analysis of the risks of developing, and/or the rates of progression of certain diabetes associated complications.

5. 发明公开

EP3330324A1 NOVEL MARKERS FOR AQUEOUS COMPOSITIONS 有权
公开(公告)号：EP3330324A1
公开(公告)日：2018-06-06
申请号：EP17203068.6
申请日：2017-11-22
申请人： Dow Global Technologies Llc , Rohm and Haas Company
发明人： YANG, Peilin , GREYSON, Eric C. , FU, Zhenwen , ASIF, Zahid
IPC分类号： C09D5/02 , C09D7/63 , C09D5/33 , G01N33/32 , E01F9/518 , G01N30/02
CPC分类号： C08K5/06 , C09D5/004 , C09D5/024 , C09D7/63 , C09D133/12 , G01N30/02 , G01N30/7206 , G01N33/32
摘要： The present invention provides aqueous polymer compositions containing one or more, or, preferably, two or more markers selected from a C 1 -C 12 alkyl phenyl ether having a formula Ph(R 2 ) m (OR 1 ) n , wherein Ph is an aromatic ring containing group having from six to nine carbon atoms, R 1 is a C 1 -C 12 alkyl group, R 2 is a C 1 -C 12 alkyl group, m is an integer of from 0 to 5, n is an integer of from 1 to 3, and (m +n) is an integer of from 1 to 6. The markers are readily detectable, such as by mass spectroscopy, upon solvent extraction and separation from the aqueous polymer compositions, or from dried or cured coatings, film or layers thereof.

6. 发明授权

EP2344873B1 COLLECTION SYSTEM FOR PURIFICATION FLOWSTREAMS 有权转让
公开(公告)号：EP2344873B1
公开(公告)日：2018-05-30
申请号：EP09756585.7
申请日：2009-11-12
申请人： Waters Technologies Corporation
发明人： SIDHU, Harbaksh , WANG, Ziqiang , ZULLI, Steven, L.
IPC分类号： G01N30/82
CPC分类号： B01D15/10 , G01N30/02 , G01N30/82 , G01N2030/324 , B01D15/40
摘要： A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure. A collection system for HPLC is also provided, as well as a process for collection of samples from a flowstream.

7. 发明公开

EP3210012A4 GAS TESTING UNIT AND METHOD 有权转让
公开(公告)号：EP3210012A4
公开(公告)日：2018-05-23
申请号：EP15853236
申请日：2015-10-21
申请人： LANZATECH NEW ZEALAND LTD
发明人： HEIJSTRA BJORN DANIEL , SIMPSON SEAN DENNIS , BOURDAKOS NICHOLAS , BROMLEY JASON CARL , YAP KAI-MING
IPC分类号： G01N30/86 , C12M1/34 , C12M3/00 , C12N1/20 , C12P7/06 , C12R1/145 , G01N30/62 , G01N30/88 , G01N33/00
CPC分类号： C12Q1/02 , C12M21/04 , C12M21/12 , C12M23/44 , C12M29/18 , C12M41/00 , C12M41/12 , C12M41/26 , C12M41/34 , C12P7/065 , G01N30/02 , G01N30/462 , G01N30/8658 , G01N30/88 , G01N2030/0095 , Y02E50/343
摘要： Apparatuses and associated methods are described for the efficient evaluation of Cl-containing substrates, and especially for such evaluation conducted locally, or on-site, at a prospective facility for implementation of a biological conversion process for desired end product using a Cl carbon source. The exact composition of a given, industrial Cl-containing substrate, as well as the range in composition fluctuations, are generally difficult to reproduce at a remote facility (e.g., a laboratory or a pilot-scale or demonstration-scale process), as required for the accurate prediction/modeling of com′mercial performance to justify large capital expenditures for commercial scale-up.

8. 发明公开

EP3306312A1 ELEMENTAL ANALYSER 有权
标题翻译：元素分析仪
公开(公告)号：EP3306312A1
公开(公告)日：2018-04-11
申请号：EP16425096.1
申请日：2016-10-10
申请人： Thermo Fisher Scientific S.p.A
发明人： Galotta, Walter , Magni, Andrea , Krotz, Liliana , Leone, Francesco
IPC分类号： G01N31/12 , G01N30/66
CPC分类号： G01N30/66 , G01N30/02 , G01N30/20 , G01N31/12 , G01N2030/025 , G01N2030/8405
摘要： The invention relates to elemental analysers and, in particular, but not exclusively, organic elemental analysers and isotope ratio mass spectrometry (IRMS) elemental analysers.
An analysis system for analysing the constituents of a sample of material, the system comprising: a reference supply conduit (2) for supplying a source of a first gas (70a); a carrier supply conduit (4) for supplying a source of the first (70a) or a second gas (70b); first (30a) and second (30b) reactors; a first auto-sampler (20a) for providing one or more samples of material, the first auto-sampler (20a) having an inlet (22a) for receiving gas and an outlet (23a) for providing the received gas and a sample to the first reactor (30a); a second auto-sampler (20b) for providing one or more samples of material, the second auto-sampler (20b) having an inlet (22b) for receiving gas and an outlet (23b) for providing the received gas and a sample to the second reactor (30b); a thermal conductivity detector (10) having first (15) and second channels (13) for identifying the relative conductivity of the gases in each channel, characterised in that: the system further comprises a valve system (80, 100) arranged to control the flow of gas from the supply conduits (2,4) to the inlets (22a, 22b) of the first (20a) and second (20b) auto-samplers; the analysis system has a first mode of operation in which:
• the valve system (80, 100) connects the carrier supply conduit (4) with the first auto-sampler (20a);
• the first auto-sampler (20a) delivers the received gas and a sample to the first reactor (30a);
• the first reactor (30a) delivers at least one reaction product to one channel of the thermal conductivity detector; and
• the valve system (80, 100) connects the reference supply conduit (2) to the other channel of the thermal conductivity detector (10); and
the analysis system has a second mode of operation in which:
• the valve system (105) connects the carrier supply conduit (4) with the second auto-sampler (20b);
• the second auto-sampter (20b) delivers the received gas and a sample to the second reactor (30b);
• the second reactor (30b) delivers at least one reaction product to one channel of the thermal conductivity detector (10); and
• the valve system (80, 100) connects the reference supply conduit (2) to the other channel of the thermal conductivity detector (10).
摘要翻译：本发明涉及元素分析仪，尤其涉及但不限于有机元素分析仪和同位素比质谱（IRMS）元素分析仪。一种用于分析材料样品成分的分析系统，该系统包括：用于供应第一气体源（70a）的参考供应管道（2）用于供应第一气体（70a）或第二气体（70b）的源的载体供应导管（4）; 第一（30a）和第二（30b）反应器; （20a），其用于提供一个或多个材料样本，所述第一自动采样器（20a）具有用于接收气体的入口（22a）和用于向所述第一自动采样器（20a）提供所接收的气体和样本的出口（23a）第一反应器（30a）; 用于提供一个或多个材料样本的第二自动采样器（20b），所述第二自动采样器（20b）具有用于接收气体的入口（22b）和用于将所接收的气体和样本提供给第二反应器（30b）; 具有用于识别每个通道中的气体的相对电导率的第一通道（15）和第二通道（13）的热导率检测器（10），其特征在于：所述系统还包括阀系统（80,100），所述阀系统气体从第一（20a）和第二（20a）和第二（20b）自动采样器的供应导管（2,4）流入入口（22a，22b）分析系统具有第一操作模式，其中：·阀系统（80,100）将载体供应导管（4）与第一自动采样器（20a）连接; ·第一自动采样器（20a）将所接收的气体和样品输送到第一反应器（30a）; ·第一反应器（30a）将至少一种反应产物输送到热导检测器的一个通道; 以及·阀系统（80,100）将参考供应导管（2）连接到热导检测器（10）的另一通道; 并且分析系统具有第二操作模式，其中：·阀系统（105）将载体供应导管（4）与第二自动采样器（20b）连接; ·第二自动采样器（20b）将所接收的气体和样本输送到第二反应器（30b）; ·第二反应器（30b）将至少一种反应产物输送到热导检测器（10）的一个通道; 和·阀门系统（80,100）将参考供应管道（2）连接到热导检测器（10）的另一个通道。

9. 发明授权

EP2883058B1 BIOMARKERS FOR TYPE 2 DIABETES 有权
标题翻译： 2型糖尿病的生物标志物
公开(公告)号：EP2883058B1
公开(公告)日：2018-01-03
申请号：EP13748063.8
申请日：2013-08-13
申请人： Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Deutsche Diabetes-Forschungsgesellschaft E.V. - Träger Des Deutschen Diabetes-Zentrums Düsseldorf , Eberhard Karls Universität Tübingen Medizinische Fakultät
发明人： RATHMANN, Wolfgang , HERDER, Christian , ILLIG, Thomas , ADAMSKI, Jerzy , WANG-SATTLER, Rui , YU, Zhongao , WICHMANN, H.-Erich , HÄRING, Hans-Ulrich , PETERS, Annette , MEISINGER, Christine , HRABÉ DE ANGELIS,Martin , RODEN, Michael , MEITINGER, Thomas
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/487 , G01N24/08 , G01N30/02 , G01N30/72 , G01N30/7206 , G01N33/49 , G01N33/6893 , G01N33/92 , G01N2030/025 , G01N2030/027 , G01N2030/8813 , G01N2500/10 , G01N2800/042 , G01N2800/50
摘要： The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric metabolite having the same molecular weight as acetylcarnitine C2 but different chemical formula; wherein a decrease in the amount of a metabolite selected from said first group or an increase in the amount of a metabolite selected from said second group as compared to the amount of the corresponding metabolite(s) of a control is indicative of a predisposition to develop type 2 diabetes mellitus. Further, the invention relates to a method of identifying a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith or serving as a lead compound for developing a compound capable of preventing type 2 diabetes mellitus and diseases associated therewith and a method of selecting a therapy to prevent type 2 diabetes mellitus. Also, the invention relates to a kit.

10. 发明公开

EP3255058A1 PROTEIN HAVING AFFINITY TO IMMUNOGLOBULIN, AND AFFINITY SEPARATION MEDIUM AND COLUMN FOR LIQUID CHROMATOGRAPHY USING SAME 有权
标题翻译：蛋白质对免疫球蛋白具有亲和力，亲和分离介质和液相色谱柱使用相同
公开(公告)号：EP3255058A1
公开(公告)日：2017-12-13
申请号：EP16746642.4
申请日：2016-02-02
申请人： Mitsubishi Chemical Corporation
发明人： YODA, Shoya , MISAWA, Satoru , NAKATA, Risa
IPC分类号： C07K14/31 , B01D15/08 , B01J20/24 , C07K1/22 , C07K17/12 , C12N15/09
CPC分类号： B01D15/08 , B01D15/3809 , B01J20/24 , C07K1/00 , C07K1/22 , C07K14/31 , C07K17/12 , C12N15/00 , C12N15/09 , G01N30/02
摘要： An object of the present invention is to provide a protein which has resistance to a serine protease or thermolysin, has an immunoglobulin-binding activity, and can be favorably used as an affinity ligand. One embodiment of the present invention is a protein having affinity for an immunoglobulin, which is a protein having two or more domains derived from any of the amino acid sequences of E, D, and A domains of protein A, and in the amino acid sequence of at least one of the domains, one or more lysines are included, and the C-terminal lysine is deleted or substituted, or a protein having affinity for an immunoglobulin, which is a protein having two or more domains derived from any of B, C, and Z domains of protein A, and in the amino acid sequence of at least one of the domains, one or more lysines are included, and lysine at position 4 and the C-terminal lysine are deleted or substituted.
摘要翻译：本发明的目的是提供一种对丝氨酸蛋白酶或嗜热菌蛋白酶具有抗性，具有免疫球蛋白结合活性，并可有利地用作亲和配体的蛋白质。本发明的一个实施方式是对免疫球蛋白具有亲和性的蛋白质，所述免疫球蛋白是具有来自蛋白质A的E，D和A结构域的任一氨基酸序列的两个或更多个结构域的蛋白质，并且在氨基酸序列的至少一个结构域，包含一个或多个赖氨酸，并且C-末端赖氨酸缺失或被取代的蛋白质，或对免疫球蛋白具有亲和性的蛋白质，所述免疫球蛋白是具有两个或更多来源于B， C和Z结构域，并且在至少一个结构域的氨基酸序列中，包括一个或多个赖氨酸，并且位置4上的赖氨酸和C-末端赖氨酸被缺失或取代。

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