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1. 发明公开

EP3370056A1 PREPROCESSING APPARATUS AND ANALYSIS SYSTEM COMPRISING THE PREPROCESSING APPARATUS 有权
公开(公告)号：EP3370056A1
公开(公告)日：2018-09-05
申请号：EP18000194.3
申请日：2018-02-27
申请人： Shimadzu Corporation
发明人： Hanafusa, Nobuhiro
IPC分类号： G01N1/40 , G01N35/04 , G01N1/28 , G01N30/06 , G01N35/00 , G01N35/10 , B01L3/00 , G01N30/00
CPC分类号： G01N30/06 , B01L3/502 , B01L2200/0631 , B01L2300/0681 , B01L2400/049 , G01N1/28 , G01N1/40 , G01N1/4005 , G01N1/405 , G01N33/49 , G01N35/00584 , G01N35/04 , G01N35/10 , G01N2001/288 , G01N2001/4011 , G01N2030/009 , G01N2030/027 , G01N2030/062 , G01N2035/00485 , G01N2035/00524 , G01N2035/0441 , G01N2035/0443
摘要： Disclosed herein is a preprocessing apparatus that makes it possible to highly efficiently analyze specimens held by solid media, such as dried blood spots to be used for newborn mass screening or the like. The preprocessing apparatus includes: a preprocessing container setting part in which a preprocessing container containing a solid sample including a specimen to be analyzed and a solid medium holding the specimen is to be set; a carrying mechanism that carries the preprocessing container set in the preprocessing container setting part; and a preprocessing part that has a port for setting the preprocessing container carried by the carrying mechanism and that is configured to perform preprocessing including extraction processing for extracting the specimen from the solid sample contained in the preprocessing container set in the port.

2. 发明公开

EP3355054A1 SIMULATED INTERNAL STANDARD METHOD, DEVICE AND APPLICATION FOR MASS SPECTROMETRY QUANTITATIVE ANALYSIS 审中-公开
公开(公告)号：EP3355054A1
公开(公告)日：2018-08-01
申请号：EP16847978.0
申请日：2016-08-30
申请人： Guangdong Lianjie Biotechnology Co., Ltd.
发明人： ZHU, Janshon
IPC分类号： G01N30/88
CPC分类号： H01J49/0009 , G01N30/06 , G01N30/36 , G01N30/7233 , G01N30/8665 , G01N30/88 , G01N2030/8822
摘要： Present invention discloses a pseudo internal standard method, device and application for mass spectrometry quantitative analysis. The method comprises steps: taking a standard, and formulating same into standard solutions with different concentrations by using a blank substrate of a sample to be tested, and then taking the same standard, and formulating same into internal standard solutions with one to several concentrations by using the blank substrate of the sample to be tested; processing the standard solutions and the internal standard solutions with different concentrations, through a sample processing steps, into standard samples and internal standard samples; successively injecting the standard sample and the internal standard sample into a chromatography-mass spectrometry system to be analyzed and measured; plotting a ratio of peak areas of the standard sample and the internal standard sample against the concentrations of the standard samples to establish a calibration curve of pseudo internal standard method quantification; and processing the unknown sample by the same sample processing steps then following the same steps as standard sample analysis to inject the sample to be detected and the internal standard into the chromatography-mass spectrometry system for analysis and measurement, the peak area ratio of the sample over the internal standard is then compared with the calibration curve to determine the concentration of the unknown sample.

3. 发明授权

EP3043178B1 AUTOMATED SAMPLING AND REACTION SYSTEM FOR HIGH PRESSURE LIQUID CHROMATOGRAPHY AND OTHER TYPES OF DETECTION 有权
标题翻译：高压液相色谱和其他检测类型的自动采样和反应系统
公开(公告)号：EP3043178B1
公开(公告)日：2018-04-25
申请号：EP16150281.0
申请日：2016-01-06
申请人： Waters Technologies Corporation
发明人： HEWITSON, HILLARY , CORMIER, SYLVAIN , PHOEBE, CHARLES , PHOEBE, AARON
IPC分类号： G01N30/06 , G01N30/20 , G01N35/10 , G01N30/24 , G01N35/00
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N35/1097 , G01N2030/067 , G01N2030/207 , G01N2035/00514 , G01N2035/1032
摘要： Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.

4. 发明授权

EP2816340B1 HEADSPACE SAMPLE INTRODUCTION DEVICE 有权
标题翻译： HEADSPACE样品引入装置
公开(公告)号：EP2816340B1
公开(公告)日：2018-02-28
申请号：EP11876681.5
申请日：2011-11-30
申请人： Shimadzu Corporation
发明人： AONO, Akira , YAMAMOTO, Yoshitake
IPC分类号： G01N1/00 , G01M3/26 , G01N30/04 , G01N30/86 , G01M3/20 , G01N30/06 , G01M3/32 , G01N1/22 , G01N33/00
CPC分类号： G01N33/007 , G01M3/02 , G01M3/205 , G01M3/3272 , G01N1/2226 , G01N30/06 , G01N2001/2229
摘要： A headspace sampler includes: a sample gas collection channel F1 whose one end communicates with a needle; a pressure gas introduction channel F2 and an exhaust channel F3 that communicate with the other end of the channel F1 in parallel via a branching pipe T1; a pressure control device 61 that delivers pressure gas to the pressure gas introduction channel F2 at a predetermined pressure; solenoid valves SV1 and SV2 provided in the pressure gas introduction channel F2 and the exhaust channel F3, respectively; and switching means 20 for switching a state where a measuring pipe 30 is inserted in the sample gas collection channel F1 and a state where the measuring pipe 30 is shorted away from the channel F1, wherein a pressure sensor 70 is provided on an upstream side of the solenoid valve SV2 in the exhaust channel F3. A measured value of the pressure sensor 70 in the case where a needle 10 penetrates a sample container 11, the solenoid valve SV2 is closed and the solenoid valve SV1 is opened to introduce the pressure gas into the sample container 11, is monitored by a leak determiner 82, and whether a leak of gas from the sample container 11 occurs or not is determined based on the result.

5. 发明公开

EP3270152A1 KIT FOR PREPARING SAMPLE FOR DETECTING MONOCLONAL ANTIBODY 审中-公开
标题翻译：制备样品用于检测单克隆抗体的试剂盒
公开(公告)号：EP3270152A1
公开(公告)日：2018-01-17
申请号：EP15884711.1
申请日：2015-12-18
申请人： Shimadzu Corporation
发明人： SHIMADA Takashi , IWAMOTO Noriko
IPC分类号： G01N30/72 , G01N1/10 , G01N27/62 , G01N30/00 , G01N30/06 , C12N11/02 , C12Q1/00 , C12Q1/37
CPC分类号： G01N33/6848 , C12N11/02 , C12Q1/00 , C12Q1/37 , G01N1/10 , G01N30/06 , G01N30/7233 , G01N33/577 , G01N2030/067 , G01N2333/901
摘要： A sample preparation kit related to the present invention provides a significantly versatile analytical technique that is not affected by the diversity of antibodies, difference in species, matrix and the like. For preparing a sample to be used for detection of a monoclonal antibody through high-performance liquid chromatography-mass spectrometry (LC-MS), the kit includes a porous body for immobilizing a monoclonal antibody to be detected; nanoparticles with an immobilized protease; a reaction vessel for selectively digesting the monoclonal antibody by bringing the porous body and nanoparticles into contact; a buffer to be introduced into the reaction vessel along with the nanoparticles and porous body so that a protease reaction is carried out; and a filtration membrane to remove the porous body and nanoparticles after the proteolysis so as to extract the reaction product and the buffer.
摘要翻译：与本发明有关的样品制备试剂盒提供了不受抗体多样性，物种差异，基质等影响的显着通用的分析技术。为了制备用于通过高效液相色谱 - 质谱（LC-MS）检测单克隆抗体的样品，该试剂盒包括用于固定待检测单克隆抗体的多孔体; 具有固定化蛋白酶的纳米颗粒; 通过使多孔体和纳米颗粒接触来选择性消化单克隆抗体的反应容器; 与纳米颗粒和多孔体一起引入反应容器中的缓冲液，从而进行蛋白酶反应; 和过滤膜以在蛋白水解之后去除多孔体和纳米颗粒以提取反应产物和缓冲液。

6. 发明公开

EP3252464A1 SAMPLE INJECTION WITH FLUDIC CONNECTION BETWEEN FLUID DRIVE UNIT AND SAMPLE ACCOMODATION VOLUME 有权
标题翻译：在流体驱动装置和样品容积体积之间进行流体连接的样品注射
公开(公告)号：EP3252464A1
公开(公告)日：2017-12-06
申请号：EP17172865.2
申请日：2017-05-24
申请人： Agilent Technologies, Inc. (A Delaware Corporation)
发明人： Thielsch, Daniel , Ortmann, Thomas
IPC分类号： G01N30/20 , G01N30/32
CPC分类号： G01N30/06 , F16K11/074 , G01N30/20 , G01N30/22 , G01N30/32 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： Injector (40) for injecting a fluidic sample into a flow path (104) between a fluid drive (20) and a separation unit (30) of a sample separation apparatus (10), wherein the injector (40) comprises a sample accommodation volume (100) for accommodating the fluidic sample prior to injecting, a sample drive (102) configured for intaking the fluidic sample into the sample accommodation volume (100), a fluidic valve (95) switchable between multiple switching states to thereby selectively couple the sample accommodation volume (100) with the flow path (104) or decouple the sample accommodation volume (100) from the flow path (104), wherein in an injection switching state of the fluidic valve (95), the fluid drive (20), the separation unit (30) and the sample drive (102) are fluidically coupled by the fluidic valve (95) so that fluid driven by the sample drive (102) and flowing from the sample accommodation volume (100) to the separation unit (30) and further fluid driven by the fluid drive (20) and flowing from the fluid drive (20) to the separation unit (30) are combined at a fluidic connection (108) upstream of the separation unit (30), and a control unit (70) configured for controlling a pressure of at least one of the group consisting of the fluid driven by the sample drive (102), the further fluid driven by the fluid drive (20), and the combined fluid) during injecting fluidic sample from the sample accommodation volume (100) into the flow path (104).
摘要翻译：用于将流体样本注入样本分离装置（10）的流体驱动器（20）和分离单元（30）之间的流动路径（104）中的注射器（40），其中注射器（40）包括样本容纳容积（100），用于在注入之前容纳流体样本，配置成用于将流体样本吸入到样本容纳空间（100）中的样本驱动器（102），可在多个切换状态之间切换的流体阀（95），从而选择性地将样本（100）与所述流动路径（104）分离或将所述样品容纳空间（100）与所述流动路径（104）分离，其中在所述流体阀（95）的注射切换状态中，所述流体驱动器（20）分离单元（30）和样品驱动器（102）通过流体阀（95）流体耦合，使得由样品驱动器（102）驱动并从样品容纳空间（100）流向分离单元（30 ）和由流体驱动装置（2）驱动的另外的流体 0）并且从流体驱动器（20）流到分离单元（30）的流体在分离单元（30）上游的流体连接部（108）处结合;以及控制单元（70），配置用于控制在将来自样本容纳空间（100）的流体样本注入到流体中的过程中由样本驱动器（102）驱动的流体，由流体驱动器（20）驱动的另外流体以及组合流体）组成的组中的至少一个路径（104）。

7. 发明公开

EP3184157A1 QUICK EXTRACTION KIT FOR AGRICULTURAL PRODUCT PESTICIDE RESIDUE DETECTION PROCEDURE AND METHOD FOR OBTAINING STOCK SOLUTION OF DETECTION SOLUTION FROM AGRICULTURAL PRODUCT SAMPLE 有权
标题翻译：农产品农药残留检测程序快速提取试剂盒及农药产品检测溶液库存解决方法
公开(公告)号：EP3184157A1
公开(公告)日：2017-06-28
申请号：EP15833958.0
申请日：2015-03-11
申请人： Agricultural Chemicals And Toxic Substances Research Institute, Council Of Agriculture, Executive Yuan
发明人： LIN, Shao-Kai , CHUANG, Wei-Chen , CHEN, Jou-Wen
IPC分类号： B01D15/08 , G01N1/34
CPC分类号： B01D15/08 , B01D15/22 , G01N1/405 , G01N30/06 , G01N30/6069 , G01N30/88
摘要： A quick extraction kit for an agricultural product pesticide residue detection procedure and method for obtaining a stock solution of a detection solution from an agricultural product sample; the quick extraction kit comprises a tubular column, a first mixed powder layer and a second mixed powder layer; and the first mixed powder layer can adsorb moisture of a sample solution to buffer the pH value of the sample solution, and the second mixed powder layer can absorb remaining moisture and an impurity in the sample solution. The method comprises: acquiring a crushed powder of the agricultural product sample; adding an extraction solution to the crushed powder of the agricultural product sample to obtain the sample solution; adding the sample solution to the tubular column of the quick extraction kit; and driving the sample solution in the tubular column to flow through the tubular column and to be discharged out of the tubular column to obtain the stock solution of the detection solution. The quick extraction kit and method of use thereof solve the problem in the prior art that a pesticide residue detection result cannot be quickly obtained.
摘要翻译：一种用于农产品农药残留检测程序的快速提取试剂盒和从农产品样品获得检测溶液原液的方法; 所述快速提取套件包括管状柱，第一混合粉层和第二混合粉层，并且第一混合粉末层可以吸附样品溶液的水分以缓冲样品溶液的pH值，并且第二混合粉末层可以吸收样品溶液中的残余水分和杂质。该方法包括：获取农产品样品的粉碎粉; 向农产品样品粉碎后的粉末中加入提取液，得到样品溶液; 将样品溶液加入到快速提取试剂盒的管状柱中; 驱动管柱中的样品溶液流经管柱并排出管柱以获得检测溶液的储备溶液。该快速提取试剂盒及其使用方法解决了现有技术中无法快速获得农药残留检测结果的问题。

8. 发明授权

EP2753958B1 VERFAHREN ZUR VERIFIKATION VON ALTER-TIEFEN-BEZIEHUNGEN VON GESTEIN IN SEDIMENTBECKEN 有权
标题翻译： VERFAHREN ZUR VERIFIKATION VON ALTER-TIEFEN-BEZIEHUNGEN VON GESTEIN in SEDIMENTBECKEN
公开(公告)号：EP2753958B1
公开(公告)日：2017-06-21
申请号：EP12768704.4
申请日：2012-08-30
申请人： Geomar Helmholtz-Zentrum für Ozeanforschung Kiel
发明人： EISENHAUER, Anton , HORN, Dietrich
IPC分类号： G01V99/00
CPC分类号： G01N30/06 , G01N2030/027 , G01V5/06 , G04F13/00

9. 发明公开

EP3151003A1 DISPOSITIF ET PROCEDE D'EXTRACTION DE COMPOSES A CYCLES AROMATIQUES CONTENUS DANS UN ECHANTILLON LIQUIDE 有权
标题翻译：装置和方法与芳环的成分在液体样品套件提取
公开(公告)号：EP3151003A1
公开(公告)日：2017-04-05
申请号：EP16191669.7
申请日：2016-09-30
申请人： COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES
发明人： FOAN, Louise , VIGNOUD, Séverine , RICOUL, Florence
IPC分类号： G01N30/08 , B01J20/10 , B01J20/283 , B01D15/20 , B01L3/00 , G01N1/40 , C23C16/40
CPC分类号： G01N30/482 , B01D15/22 , B01J20/02 , B01J20/2808 , B01J20/28083 , B01J20/282 , B01J20/283 , B01J20/3214 , B01J20/3234 , B01J2220/54 , C01B32/907 , C07C7/10 , G01N1/405 , G01N30/06 , G01N30/08 , G01N30/6095 , G01N2030/027 , G01N2030/085 , G01N30/6069
摘要： Dispositif d'extraction d'analytes à cycles aromatiques, de préférence d'analytes à cycles aromatiques à coefficient de partage octanol-eau supérieur à 10 3 , lesdits analytes étant contenus dans une phase liquide, ledit dispositif d'extraction comportant un support (4) et une couche d'adsorption (7) recouvrant au moins en partie ledit support, ladite couche d'adsorption (7) étant du SiOxCyHz poreux, ledit dispositif d'extraction étant configuré pour que la phase liquide entre en contact avec la couche d'absorbtion.
摘要翻译：一种用于与芳环，优选地具有芳环的分析物的量，辛醇 - 水分配系数大于103的分析物的提取装置中，分析物被包含在液相中，提取装置包含支持体和在吸附层至少部分覆盖支承，所述吸附层是多孔SiO.sub.xC.sub.yH.sub.z.

10. 发明公开

EP3043178A1 AUTOMATED SAMPLING AND REACTION SYSTEM FOR HIGH PRESSURE LIQUID CHROMATOGRAPHY AND OTHER TYPES OF DETECTION 有权
标题翻译：自动采样及反应SYSTEM FOR PROOF高压液相色谱法和其他类型的
公开(公告)号：EP3043178A1
公开(公告)日：2016-07-13
申请号：EP16150281.0
申请日：2016-01-06
申请人： Waters Technologies Corporation
发明人： HEWITSON, HILLARY , CORMIER, SYLVAIN , PHOEBE, CHARLES , PHOEBE, AARON
IPC分类号： G01N30/06 , G01N30/20 , G01N35/10 , G01N30/24
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N35/1097 , G01N2030/067 , G01N2030/207 , G01N2035/00514 , G01N2035/1032
摘要： Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.
摘要翻译：提供自动取样和反应系统，并使用相同的方法。自动化取样和反应系统具有流体连通的微反应器与外部采样阀。外部采样阀被连接到一个起动阀，并且可以被配置为从一个反应器或反应器流绘制样品。微型反应器连接到试剂阀和喷射阀。试剂阀可被配置为从试剂贮存试剂吸取和排出试剂的微反应器与样品反应。灌注阀可被构造成将来自洗蓄水池和排出洗涤到外部采样阀洗涤以从外部采样阀的微反应器移动样品。喷射阀与一列或检测器流体连通并排出次级样品在溶剂中的组合物的流。

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