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1. 发明授权

EP3010527B1 METHOD FOR ASSESSING PROTEIN IDENTITY AND STABILITY 有权
公开(公告)号：EP3010527B1
公开(公告)日：2018-08-08
申请号：EP14813186.5
申请日：2014-06-13
申请人： Armo Biosciences, Inc.
发明人： MUMM, John, Brian , VAN VLASSELAER, Peter
IPC分类号： A61K38/20 , G01N33/68
CPC分类号： G01N33/6869 , G01N27/447 , G01N33/6848 , G01N33/6851 , G01N2030/8831 , G01N2333/5428 , G01N2496/00 , G01N2560/00
摘要： The present invention relates to methods and other technologies that may be used to determine whether compositions (e.g., pharmaceutical compositions) comprising interleukin-10 molecules (e.g., pegylated interleukin-10) meet particular product-related specifications prior to being administered to a subject for the treatment and/or prevention of the diseases, disorders and conditions, and/or the symptoms thereof, described herein.

2. 发明公开

EP3318878A3 PROSTATE ANTIGEN STANDARDS AND USES THEREOF 审中-公开
公开(公告)号：EP3318878A3
公开(公告)日：2018-07-11
申请号：EP17187201.3
申请日：2016-03-25
申请人： Opko Diagnostics, LLC
发明人： Linder, Vincent , Higgins, Christina
IPC分类号： G01N33/574 , C12N9/64
CPC分类号： G01N33/57434 , C12N9/6445 , G01N2333/96455 , G01N2496/00
摘要： Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.

3. 发明公开

EP3253800A1 PROSTATE ANTIGEN STANDARDS AND USES THEREOF 有权
标题翻译：前列腺抗原标准及其应用
公开(公告)号：EP3253800A1
公开(公告)日：2017-12-13
申请号：EP16773820.2
申请日：2016-03-25
申请人： Opko Diagnostics, LLC
发明人： LINDER, Vincent , HIGGINS, Christina
IPC分类号： C07K16/30 , G01N33/573 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57434 , C12N9/6445 , G01N2333/96455 , G01N2496/00
摘要： Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.

4. 发明公开

EP2898088A4 THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY 审中-公开
标题翻译：胰蛋白酶定量法的质谱分析
公开(公告)号：EP2898088A4
公开(公告)日：2016-04-20
申请号：EP13839646
申请日：2013-09-19
申请人： QUEST DIAGNOSTICS INVEST INC
发明人： ZHANG YANNI , CLARKE NIGEL J , REITZ RICHARD E
IPC分类号： C12Q1/37 , G01N33/68
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
摘要翻译：提供了使用各种纯化步骤随后进行质谱法测定样品中甲状腺球蛋白量的方法。所述方法通常涉及纯化测试样品中的甲状腺球蛋白，消化甲状腺球蛋白以形成肽T129，纯化肽T129，电离肽T129，检测产生的肽T129离子的量，并将肽T129离子的量与原始存在的甲状腺球蛋白的量相关联在样品中。

5. 发明公开

EP2898088A1 THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY 审中-公开
标题翻译：甲基丙烯酸甲酯定量分析的质谱分析
公开(公告)号：EP2898088A1
公开(公告)日：2015-07-29
申请号：EP13839646.0
申请日：2013-09-19
申请人： Quest Diagnostics Investments Incorporated
发明人： ZHANG, Yanni , CLARKE, Nigel J. , REITZ, Richard E.
IPC分类号： C12Q1/37
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
摘要翻译：提供了使用各种纯化步骤然后质谱法测定样品中甲状腺球蛋白量的方法。该方法通常涉及纯化测试样品中的甲状腺球蛋白，消化甲状腺球蛋白以形成肽T129，纯化肽T129，电离肽T129，检测产生的肽T129离子的量，并将肽T129离子的量与最初存在的甲状腺球蛋白在样本中。

6. 发明授权

EP2238167B1 ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE 有权
标题翻译： ANTI-T.，克氏锥虫抗体和使用方法
公开(公告)号：EP2238167B1
公开(公告)日：2015-04-22
申请号：EP08868099.6
申请日：2008-12-23
申请人： ABBOTT LABORATORIES
发明人： BROPHY, Susan E. , HAWKSWORTH, David J. , SHAH, Dinesh O. , SIEGEL, Robert W. , TIEMAN, Bryan C. , TU, Bailin , ZIEMANN, Robert N. , TYNER, Joan D.
IPC分类号： C07K16/20 , G01N33/569
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00

7. 发明授权

EP2373988B1 METHODS FOR MEASURING CONCENTRATIONS OF BIOMOLECULES 有权
标题翻译：测量生物分子浓度的方法
公开(公告)号：EP2373988B1
公开(公告)日：2015-02-18
申请号：EP09831209.3
申请日：2009-12-04
申请人： C2N Diagnostics
发明人： WEST, Tim , PAOLETTI, Andrew, Corey
IPC分类号： G01N30/72 , G01N30/06 , G01N33/48 , G01N33/68
CPC分类号： G01N33/6896 , G01N33/537 , G01N33/58 , G01N2496/00

8. 发明公开

EP2818871A1 Means and methods for universal calibration of anti-Factor Xa tests 审中-公开
标题翻译： Mittel und Verfahren zur universellen Kalibrierung von anti-Faktor-Xa-Tests
公开(公告)号：EP2818871A1
公开(公告)日：2014-12-31
申请号：EP13174242.1
申请日：2013-06-28
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： The designation of the inventor has not yet been filed
IPC分类号： G01N33/86 , A61K38/48
CPC分类号： C12Q1/56 , C12Y304/21006 , G01N33/86 , G01N2333/96444 , G01N2496/00 , G01N2500/20
摘要： The present invention concerns diagnostic means and methods in the field of coagulation testing. In particular, it relates to a method for determining an anticoagulant activity elicited by a first anticoagulant in a sample of a subject comprising measuring a first Factor Xa activity in a body fluid test sample of said subject, measuring a second Factor Xa activity in at least one calibrator sample comprising a predefined anticoagulation activity for a second anticoagulant, calculating an universal parameter for the anticoagulation activity comprised in the test sample based on the first and the second measured Factor Xa activities and comparing the said parameter for the anticoagulation activity with predefined ranges of expected anticoagulation activity for at least three anticoagulants. Further provided is a computer program code assisting the method as well as a system for carrying out the said method as well as a kit.
摘要翻译：本发明涉及凝血试验领域的诊断手段和方法。具体地，本发明涉及一种用于测定受试者样品中由第一抗凝血剂引起的抗凝血活性的方法，包括测量所述受试者的体液测试样品中的第一因子Xa活性，至少测量第二因子Xa活性一个校准品样品包含针对第二抗凝血剂的预定抗凝活性，基于第一和第二测量的因子Xa活动计算包含在测试样品中的抗凝活性的通用参数，并将抗凝活性的所述参数与预定义的范围预期至少有三种抗凝剂的抗凝活性。还提供了一种辅助该方法的计算机程序代码以及用于执行所述方法的系统以及套件。

9. 发明公开

EP2238167A2 ANTI-T. CRUZI ANTIBODIES AND METHODS OF USE 有权
标题翻译： ANTI-T.，克氏锥虫抗体和使用方法
公开(公告)号：EP2238167A2
公开(公告)日：2010-10-13
申请号：EP08868099.6
申请日：2008-12-23
申请人： ABBOTT LABORATORIES
发明人： BROPHY, Susan E. , HAWKSWORTH, David J. , SHAH, Dinesh O. , SIEGEL, Robert W. , TIEMAN, Bryan C. , TU, Bailin , ZIEMANN, Robert N.
IPC分类号： C07K16/20 , G01N33/569
CPC分类号： G01N33/56905 , C07K16/20 , C07K2317/24 , C07K2317/56 , C07K2317/92 , G01N2333/44 , G01N2469/10 , G01N2469/20 , G01N2496/00
摘要： The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

10. 发明授权

EP1459075B1 NORMALISATION OF MICROARRAY DATA BASED ON HYBRIDISATION WITH AN INTERNAL REFERENCE 有权
标题翻译：基于内标杂交微器件数据标准化
公开(公告)号：EP1459075B1
公开(公告)日：2006-07-05
申请号：EP02796663.9
申请日：2002-12-17
申请人： PamGene B.V.
发明人： VAN BEUNINGEN, Marinus, Gerardus, Johannes
IPC分类号： G01N33/96 , C12Q1/68
CPC分类号： C12Q1/68 , C12M1/34 , G01N33/48 , G01N33/50 , G01N35/00594 , G01N35/00693 , G01N2035/00158 , G01N2496/00 , G06F19/00
摘要： The invention relates to methods and corresponding arrays especially suited to correct for signal errors due to variations in sample preparation. Methods and compositions for performing quantitative array-based assays are provided. In the subject methods, both a reporter and an analyte is employed, where the reporter is characterized by binding selectively to an internal reference present on the array, i.e. at least a subset of, if not all of, the spots present on the array employed in the method contain an internal reference which can be bound by the reporter.

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