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1. 发明授权

EP1825251B1 METHOD FOR ANALYZING LIPOPROTEINS 失效转让
公开(公告)号：EP1825251B1
公开(公告)日：2018-07-25
申请号：EP05811455.4
申请日：2005-11-24
申请人： Okazaki, Mitsuyo
发明人： Okazaki, Mitsuyo
IPC分类号： G01N30/86 , G01N30/88 , G01N33/92
CPC分类号： G01N30/8675 , G01N30/8679 , G01N33/92 , G01N2030/8813 , G01N2030/8831
摘要： A method of analysis of lipoproteins according to the present invention comprises the steps of: separating a plurality of classes of lipoproteins contained in a subject sample by liquid chromatography and then detecting signals derived from components included in the separated lipoproteins; and assuming that the lipoproteins are constituted of subclasses estimated from component peaks comprising anchor peaks and extra essential peaks and then calculating an approximated curve corresponding to summation of the component peaks using the above described detected signals.

2. 发明公开

EP3304382A1 TECHNIQUES FOR PROCESSING OF MASS SPECTRAL DATA 审中-公开
标题翻译：质谱数据处理技术
公开(公告)号：EP3304382A1
公开(公告)日：2018-04-11
申请号：EP16804202.6
申请日：2016-05-31
申请人： Waters Technologies Corporation
发明人： GEROMANOS, Scott, J. , CIAVARINI, Steven, J. , DEVLIN, Curt
IPC分类号： G06F19/00 , H01J49/00 , G01N30/72 , G01N30/86 , G01N33/68
CPC分类号： H01J49/0036 , G01N30/72 , G01N30/86 , G01N30/8675 , G01N33/68 , G01N33/6854 , G06F19/707 , H01J49/0027 , H01J49/0031
摘要： Techniques for performing data acquisition and analysis are described. A multi-mode acquisition strategy may be performed which iteratively selects mass isolation windows of different sizes in different scan cycles to acquire experimental data. The mass isolation windows selected may provide for acquiring elevated energy scan data for a defined set of m/z values. Single scan data analysis may be performed. Data analysis may include forming precursor charge clusters, chaining precursor charge clusters having the same mass to charge ratio to form peaks profiles, and using criteria to align precursor and product ions of the experimental data. Unsupervised and supervised clustering may be performed using a database and composite ion spectra formed from experimental data. Also described are a small molecule acquisition enhancement and additional techniques applicable for biopharmaceutical and other applications.

3. 发明授权

EP3133393B1 PROCÉDÉ D'ESTIMATION D'UNE QUANTITÉ DE PARTICULES RÉPARTIES EN CLASSES, À PARTIR D'UN CHROMATOGRAMME 失效
标题翻译：从色谱图中估算一定数量的类分布颗粒的方法
公开(公告)号：EP3133393B1
公开(公告)日：2018-03-21
申请号：EP16184771.0
申请日：2016-08-18
申请人： Commissariat à l'énergie atomique et aux énergies alternatives
发明人： HARANT, Olivier , BERTHOLON, François , GRANGEAT, Pierre
IPC分类号： G01N30/86
CPC分类号： G01N30/8693 , G01N15/06 , G01N30/8675 , G01N2030/8648

4. 发明公开

EP3155639A4 SYSTEM AND METHOD FOR ENHANCING CHARGE-STATE DETERMINATION IN ELECTROSPRAY MASS SPECTROMETRY 有权
公开(公告)号：EP3155639A4
公开(公告)日：2018-02-28
申请号：EP15807310
申请日：2015-06-12
申请人： WATERS TECH CORPORATION
发明人： GEROMANOS SCOTT J , CIAVARINI STEVEN J
IPC分类号： G01N30/86 , H01J49/00
CPC分类号： H01J49/0036 , G01N30/8675
摘要： A method of mass spectrometry comprises ionising a sample and obtaining mass spectral data relating to a plurality of ion detection events. The method then comprises applying match tolerances for mass to charge ratio (m/z), chromatographic retention time (tr), and ion mobility drift time (td), to the ion detection events in order to determine possible charge state connections. The method also comprises constructing a tentative isotope chain and querying ion detection events for a match to the tentative isotope chain. Once a tentative isotope chain has been constructed, the method further comprises determining a corresponding theoretical molecular mass and a corresponding theoretical isotopic distribution, querying one or more lookup tables and returning one or more parameters (New X, New X′, Δ New X′) related to the fractional mass to charge ratio (fm/z) and at least one of: ion mobility drift time (td); and nominal mass to charge ratio (Nm/z), of the ion detection events, and using the one or more parameters (New X, New X′, Δ New X′) to determine a unique charge state of the ions.

5. 发明公开

EP3252465A4 NOISE LEVEL ESTIMATION METHOD, MEASUREMENT DATA PROCESSING DEVICE, AND PROGRAM FOR MEASUREMENT DATA PROCESSING 审中-公开
公开(公告)号：EP3252465A4
公开(公告)日：2018-01-17
申请号：EP15879857
申请日：2015-01-26
申请人： SHIMADZU CORP
发明人： KOZAWA HIROAKI
IPC分类号： G01N30/86
CPC分类号： G01N30/861 , G01N30/8641 , G01N30/8675 , G01N30/8686
摘要： In a method for estimating a noise level representing the magnitude of a noise component from measurement data, first waveform data composed of high frequency noise components extracted from assumed noise data are divided into segments so that each section where positive values successively occur or each section where negative values successively occur in the first waveform data is defined as one segment (Step S3). A segment-width threshold is determined based on the distribution of the widths of the segments (Step S4). Second waveform data composed of high frequency noise components extracted from measurement data are divided into segments so that each section where positive values successively occur or each section where negative values successively occur in the second waveform data is defined as one segment (Step S6). Each segment having a width larger than the threshold is excluded from the segments in the second waveform data, to create a first segment group (Step S7). The noise level is determined based on the heights or areas of the plurality of segments included in the first segment group.

6. 发明公开

EP3256848A1 METHOD AND APPARATUS FOR CREATING A CLASSIFIER INDICATIVE OF A PRESENCE OF A MEDICAL CONDITION 有权
标题翻译：用于创建表示存在医疗状况的分类器的方法和设备
公开(公告)号：EP3256848A1
公开(公告)日：2017-12-20
申请号：EP16704919.6
申请日：2016-02-12
申请人： The University of Liverpool
发明人： PROBERT, Christopher Simon John , AGGIO, Raphael Bastos Mareschi
IPC分类号： G01N30/86 , G06F19/00
CPC分类号： G01N30/8675 , G01N30/8686 , G06F19/00 , G06F19/703 , G06F19/707 , G16H50/20 , G16H50/70
摘要： An embodiment of the present invention provides a method of creating a classifier indicative of a presence of a medical condition in a subject, comprising receiving chromatogram data indicative of a profile of volatile organic compounds in a sample from each of a first plurality of subjects having the medical condition and a second plurality of subjects without the medical condition, selecting one of the chromatogram data as reference chromatogram data, aligning the remaining chromatogram data in relation to the reference chromatogram data, extracting one or more features from the chromatogram data using a Mexican hat wavelet transform of one or more scales, selecting one or more features of the chromatogram data indicative of the medical condition, and constructing a classifier for determining a boundary between chromatogram data indicative of the medical condition and chromatogram data indicative of an absence of the medical condition.

7. 发明公开

EP3091354A1 METHOD FOR IDENTIFYING AN ANALYTE IN A FLUID SAMPLE 无效
标题翻译： VERFAHREN ZUR IDENTIFIZIERUNG EINES ANALYTEN IN EINERFLÜSSIGKEITSPROBE
公开(公告)号：EP3091354A1
公开(公告)日：2016-11-09
申请号：EP15305680.9
申请日：2015-05-04
申请人： ALPHA M.O.S.
发明人： Labreche, Saïd , Cabrol, Olivier , Loubet, François , Lechat, Hervé , Isz, Sandrine , Mifsud, Jean-Christophe
IPC分类号： G01N30/78 , G01N30/86 , G01N27/12
CPC分类号： G01N30/8675 , G01N30/78
摘要： The invention relates to a method (200) for the identification of an analyte in a sample fluid sensed by at least two sensors of different types. Sensors of different types may comprise gas chromatography sensors, CMOS gas sensors, or a combination thereof. In a first step, the two sensors provide a first and a second set of measured values (210) comprising at least one peak of a physical parameter representative of the concentration of the analyte, said physical parameter varying according to parameters like time, temperature, or wavelength. The method further comprises a step (220) of accessing a database of reference values, for example the NIST database. Said database contains reference values of parameters at which a peak occurs for an analyte. In the next step (230) the database is searched for reference values which are close to the measured values of the two different types of sensors and analytes whose reference values match the experimental values for two different types of sensors are identified.
摘要翻译：本发明涉及用于识别由至少两种不同类型的传感器检测的样品流体中的分析物的方法（200）。不同类型的传感器可以包括气相色谱传感器，CMOS气体传感器或其组合。在第一步骤中，两个传感器提供包括代表分析物浓度的物理参数的至少一个峰值的第一和第二组测量值（210），所述物理参数根据诸如时间，温度等参数而变化，或波长。该方法还包括访问参考值的数据库的步骤（220），例如NIST数据库。所述数据库包含对于分析物发生峰的参数的参考值。在下一步骤（230）中，搜索数据库的参考值，该参考值接近于两种不同类型的传感器和分析物的测量值，其参考值与两种不同类型的传感器的实验值相匹配。

8. 发明公开

EP3006935A1 PROCÉDÉ ET DISPOSITIF DE DÉTERMINATION D'UNE COMPOSITION D'UN ÉCHANTILLON GAZEUX TRAITÉ PAR CHROMATOGRAPHIE GAZEUSE 有权转让
标题翻译：用于确定组合物与GC气体样品的方法和装置处理BEEN
公开(公告)号：EP3006935A1
公开(公告)日：2016-04-13
申请号：EP15185873.5
申请日：2015-09-18
申请人： Commissariat à l'Énergie Atomique et aux Énergies Alternatives
发明人： BERTHOLON, François , GRANGEAT, Pierre , GERFAULT, Laurent , HARANT, Olivier , JUTTEN, Christian
IPC分类号： G01N30/86 , G01N30/64
CPC分类号： G01N30/8693 , G01N30/64 , G01N30/8675
摘要： Ce procédé de détermination d'une composition ({C j }) d'un échantillon gazeux (E) comporte les étapes suivantes : faire passer (102) l'échantillon (E) par une chaîne de traitement comportant une colonne de chromatographie gazeuse et un détecteur de gaz disposé en sortie de la colonne de chromatographie ; obtenir (104), en sortie du détecteur, un signal électrique représentatif de la composition ({C j }) ; déterminer (108) la composition gazeuse ({C j }) par traitement de ce signal électrique.
La détermination (108) de la composition de l'échantillon (E) se fait sur la base d'une combinaison d'un modèle probabiliste direct de la colonne de chromatographie, ce modèle comportant au moins une loi de probabilité définissant une probabilité à chaque instant qu'une molécule d'une espèce gazeuse sorte de la colonne de chromatographie, et d'un modèle de réponse impulsionnelle du détecteur. Elle est réalisée par inversion de cette combinaison de modèles à partir du signal électrique.
摘要翻译：一种用于确定性采矿方法的气体样品，包括以下步骤的组合物：通过运行一个处理链，其包括气相色谱柱，并在气相色谱柱的出口布置在气体检测器中的样品; 获得，在检测器中，组合物的有代表性的电信号的输出; 确定性采矿通过处理该电信号的气体组成。样品的组合物的测定进行层析柱的直接概率模型的组合的基础上，该模型包括概率定义中的至少一个法，用于至少一个气体物质容易在样品中被发现，在每个时刻的概率这样做的气体种类的分子从色谱柱排出，并且在检测器的脉冲响应模型。它执行通过反向利用的电信号模式这个组合。

9. 发明公开

EP2989461A2 SYSTEMS AND METHODS TO DETERMINE BODY DRUG CONCENTRATION FROM AN ORAL FLUID 有权转让
标题翻译：系统和方法确定口服液活性浓度的体
公开(公告)号：EP2989461A2
公开(公告)日：2016-03-02
申请号：EP14787669.2
申请日：2014-04-21
申请人： Sterling Healthcare Opco, LLC
发明人： STRIPP, Richard
IPC分类号： G01N33/50 , G01N33/84 , G01N21/80
CPC分类号： G01N30/86 , A61B10/0051 , A61B10/0096 , A61B2010/0006 , A61B2010/0009 , G01N30/7233 , G01N30/8675 , G01N33/48714 , G01N2030/009 , G01N2030/085
摘要： Oral fluid for drug testing has several advantages over other specimens: (1) It may be collected noninvasively and under direct supervision; (2) its drug concentration reflects blood-drug concentrations; and (3) it can be processed by conventional drug screening and confirmation methods. This technology provides a system that measures the quantity of a drug (without needing a priori knowledge of the drug) in an oral fluid specimen and translates this level to a blood plasma drug concentration. The method first measures the concentration of a drug in an oral fluid sample. Next, a processor calculates the blood plasma concentration from the measured oral fluid drug concentration. Finally, this blood plasma drug level is utilized to calculate a total body drug concentration.
摘要翻译：用于药物测试的口服流体具有比其它试样的几个优点：（1）它可以被非侵入性地和直接监督下收集; （2）其药物浓度反映了血液中的药物浓度; 和（3）它可以通过常规的药物筛选和确认方法进行加工。该技术提供了一个系统做的措施药物的数量（无需药物的先验知识）在口腔液样本和反鲈在这个级别的血浆药物浓度。该方法首先测量药物在口液样品的浓度。接着，处理器计算从测量的口腔流体药物浓度的血浆浓度。最后，该血浆药物水平被用于计算总体药物浓度。

10. 发明公开

EP2863216A1 Plus-fraction corrections for heavy hydrocarbon liquids 有权
$Plus-fraction corrections for heavy hydrocarbon liquids$
标题翻译：加油 - sch en en en en en en en en en en en en en en en
公开(公告)号：EP2863216A1
公开(公告)日：2015-04-22
申请号：EP14189589.6
申请日：2014-10-20
申请人： Weatherford Canada Partnership
发明人： Hu, YunFeng Y. , Thomas, F. Brent
IPC分类号： G01N30/86 , G01N30/88 , G01N33/28
CPC分类号： G01N33/28 , G01N30/00 , G01N30/8675 , G01N2030/009 , G01N2030/8854
摘要： A method of determining the plus-fraction correction for a heavy oil sample including analyzing the heavy oil sample using gas chromatography, selecting an elution ratio based on the percentage of plus-fraction elution, applying the elution ratio to provide a maximum carbon number and a plus-fraction correction to compensate for the non-elution of the plus-fraction. An elution ratio as a function of the percentage of C 60+ elution is provided. A corrected molecular weight for the C 60+ fraction (MW C60+ ) and the C 90+ fraction (MW C90+ ) as well as the total oil (MW) is provided.
摘要翻译：一种确定重油样品的加馏分校正的方法，包括使用气相色谱法分析重油样品，基于加馏分洗脱的百分比选择洗脱比，应用洗提比以提供最大碳数和加分数校正以补偿正馏分的非洗脱。提供了洗脱比作为C 60+洗脱百分比的函数。提供了C 60+级分（MW C 60 +）和C 90+级分（MW C 90+）以及总油（MW）的校正分子量。

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