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1. 发明授权

EP3901628B1 METHOD FOR TARGETED MASS SPECTRAL PROTEOMIC ANALYSES 有权
公开(公告)号：EP3901628B1
公开(公告)日：2024-05-01
申请号：EP21169577.0
申请日：2021-04-21
IPC分类号： G01N30/86 , G01N30/72
CPC分类号： G01N30/8679 , G01N30/7233 , G01N2030/883120130101 , G01N30/8675 , G01N2458/1520130101

2. 发明授权

EP2185167B1 SYSTEM AND METHOD FOR ASSESSING TRADITIONAL MEDICINES 有权转让
公开(公告)号：EP2185167B1
公开(公告)日：2018-07-04
申请号：EP08830472.0
申请日：2008-09-12
申请人： PHYTO CZ, s.r.o. , Pennyroyal, Greg A.
发明人： LEUNG, Albert Y. , PENNYROYAL, Greg A.
IPC分类号： A61K36/00 , G01N30/86 , G01N33/15 , G01N1/28
CPC分类号： A61K36/00 , G01N30/8675 , G01N33/15 , G01N2001/2893 , Y10T436/10
摘要： Methods of defining a standard for a traditional medicine are provided. A method can comprise obtaining at least two samples of the traditional medicine that have been authenticated by qualitative profiling as representing a control positive; quantitatively profiling each of the at least two samples using at least two physicochemical analyses; blending the at least two samples to form the standard; and creating a quantitative profile for the standard using at least two physicochemical analyses, wherein the quantitative profile for the standard defines the standard. Methods of certifying a test sample of a traditional medicine are also provided. A method can comprise creating a quantitative profile for the test sample using at least two physicochemical analyses; providing a standard; and comparing the quantitative profile for the standard to the quantitative profile for the test sample. A certified traditional medicine comprises a traditional medicine certified by these methods.

3. 发明公开

EP3289085A1 COMPOUND IMPURITIES AND METHODS OF DETECTING SAME 有权转让
标题翻译：复杂杂质和检测方法
公开(公告)号：EP3289085A1
公开(公告)日：2018-03-07
申请号：EP16787302.5
申请日：2016-05-02
申请人： Aegerion Pharmaceuticals, Inc.
发明人： GELORMINI, Ann
IPC分类号： C12N15/113 , A61K31/4468 , A61K31/192 , A61K39/39
CPC分类号： A61K31/4468 , A61K9/2004 , A61P3/06 , G01N24/087 , G01N30/8675 , G01N2030/027 , H01J49/164
摘要： The present disclosure relates to compositions comprising impurities (e.g., carbamate and/or hydrolysis products) in a lomitapide sample and methods of detecting such impurities.

4. 发明公开

EP3243073A1 VERFAHREN ZUR STEUERUNG KONTINUIERLICHER CHROMATOGRAPHIE UND MULTISÄULEN-CHROMATOGRAPHIE-ANORDNUNG 有权
标题翻译：控制连续色谱和多柱色谱安排的方法
公开(公告)号：EP3243073A1
公开(公告)日：2017-11-15
申请号：EP16825323.5
申请日：2016-11-25
申请人： Karlsruher Institut für Technologie
发明人： HUBBUCH, Jürgen , BRESTRICH, Nina , RÜDT, Matthias , ROLINGER, Laura
IPC分类号： G01N30/86 , G01N30/88 , G01N30/46
CPC分类号： B01D15/1871 , B01D15/1814 , G01N30/46 , G01N30/74 , G01N30/78 , G01N30/86 , G01N30/8658 , G01N30/8675 , G01N2030/8831 , G01N2201/129
摘要： In summary, the invention relates to a method the controlling at least one multi-column chromatography arrangement for the continuous process of purifying in particular biopharmaceuticals, comprising: introducing a first multi-component mixture into a column of the multi-column chromatography arrangement; detecting at least one multivariate signal by means of at least one detector; calculating at least one process parameter on the basis of the multivariate signal by means of at least one data-processing program of a computing unit via application of a chemometric method; controlling the purification process via control of at least one controllable control element on the basis of the at least one process parameter, and a multi-column chromatography arrangement.

5. 发明公开

EP3165912A1 MASS-SPECTROMETRY-DATA PROCESSING DEVICE 审中-公开
标题翻译：质谱 - 数据处理设备
公开(公告)号：EP3165912A1
公开(公告)日：2017-05-10
申请号：EP15815598.6
申请日：2015-01-13
申请人： Shimadzu Corporation
发明人： KAGEYAMA, Tetsuya , UMEMURA, Yoshikatsu
IPC分类号： G01N27/62
CPC分类号： G01N30/8675 , G01N27/62 , G01N30/7233 , G01N2030/027 , G06F19/703 , H01J49/004 , H01J49/26
摘要： Nonuse-indication information can be set for each peak on a mass spectrum collected in a compound database (33), as attribute information, the nonuse-indication information allowing the selection of whether to be used in a database search. For example, nonuse-indication information is set in advance to a noise peak mixed in actual measurement, an impurity-originated peak, and the like. In identifying a compound, when nonuse-indication information is read from the database (33) for a database search together with a mass spectrum, an unnecessary information deleting section (341) transmits a mass spectrum from which a peak set with the nonuse-indication information is deleted, to a compound candidate extracting section (342) and a scoring section (343). Therefore, a peak set with the nonuse-indication information is ignored in, for example, calculating the score of a compound candidate, which allows a score with a high accuracy to be calculated, resulting in an improved identification accuracy.
摘要翻译：可以为在化合物数据库（33）中收集的质谱上的每个峰值设置非使用指示信息作为属性信息，非使用指示信息允许选择是否用于数据库搜索。例如，不使用指示信息被预先设定为实际测量中混入的噪声峰值，杂质来源的峰值等。在识别化合物时，不需要信息删除单元（341）与数据库（33）一起从数据库（33）中读出不使用指示信息，并与质谱一起进行数据库检索时，发送设定为不使用指示信息被删除到复合候选提取部分（342）和评分部分（343）。因此，例如，在计算允许计算高准确度的分数的复合候选的分数中忽略用非使用指示信息设置的峰值，导致提高的识别准确度。

6. 发明授权

EP1886134B1 METHODS FOR FRACTIONATION-BASED CHEMICAL ANALYSES 有权转让
标题翻译： VERFAHRENFÜRAUF FRAKTIONIERUNG BERUHENDE化学分析仪
公开(公告)号：EP1886134B1
公开(公告)日：2017-01-18
申请号：EP06760687.1
申请日：2006-06-05
申请人： Waters Technologies Corporation
发明人： GORENSTEIN, Marc, V. , GEROMANOS, Scott, J. , SILVA, Jeffrey, Cruz , LI, Guo-Zhong
IPC分类号： G01N30/88 , G01N30/86 , G01N30/72
CPC分类号： H01J49/04 , C12Q1/37 , G01N27/62 , G01N30/72 , G01N30/7233 , G01N30/8665 , G01N30/8675 , G01N30/8679 , G01N33/6848 , G01N2030/042 , G01N2030/067

7. 发明公开

EP2989461A4 SYSTEMS AND METHODS TO DETERMINE BODY DRUG CONCENTRATION FROM AN ORAL FLUID 有权转让
标题翻译：系统和方法确定口服液活性浓度的体
公开(公告)号：EP2989461A4
公开(公告)日：2017-01-04
申请号：EP14787669
申请日：2014-04-21
申请人： CORDANT RES SOLUTIONS LLC
发明人： STRIPP RICHARD
IPC分类号： G01N33/50 , A61B10/00 , G01N21/80 , G01N30/00 , G01N30/08 , G01N30/72 , G01N30/86 , G01N33/487 , G01N33/84
CPC分类号： G01N30/86 , A61B10/0051 , A61B10/0096 , A61B2010/0006 , A61B2010/0009 , G01N30/7233 , G01N30/8675 , G01N33/48714 , G01N2030/009 , G01N2030/085
摘要： Oral fluid for drug testing has several advantages over other specimens: (1) It may be collected noninvasively and under direct supervision; (2) its drug concentration reflects blood-drug concentrations; and (3) it can be processed by conventional drug screening and confirmation methods. This technology provides a system that measures the quantity of a drug (without needing a priori knowledge of the drug) in an oral fluid specimen and translates this level to a blood plasma drug concentration. The method first measures the concentration of a drug in an oral fluid sample. Next, a processor calculates the blood plasma concentration from the measured oral fluid drug concentration. Finally, this blood plasma drug level is utilized to calculate a total body drug concentration.

8. 发明公开

EP2818859A1 Chromatographic Device and Method 审中-公开
标题翻译： Chromatografievorrichtung und Verfahren
公开(公告)号：EP2818859A1
公开(公告)日：2014-12-31
申请号：EP13003300.4
申请日：2013-06-28
申请人： Ruprecht-Karls-Universität Heidelberg
发明人： Trapp, Oliver , Siegle, Alexander F.
IPC分类号： G01N30/16 , G01N30/86
CPC分类号： G01N30/16 , G01N24/08 , G01N30/86 , G01N30/8658 , G01N30/8675 , G01N30/8696 , G01N2030/027 , G01R33/448
摘要： A chromatographic device (10) for analysing multiple samples comprises a separator (22) for separating the multiple samples, an injector unit (15) for injecting the multiple samples into the separator (22), the injector unit (15) being provided as regular injector unit for single-sample chromatography, a detector (24) for detecting signals of the multiple samples after they are separated by the separator (22), a sequence generator (12) for generating a specific binary sequence for each of the multiple samples, a controller (12) that controls the injector unit (15) so that each of the multiple samples is injected into the separator (22) in pulses corresponding to its specific binary sequence, and a decomposer (12) for decomposing the detected signals of the multiple samples by identifying the specific binary sequences in the detected signals.
摘要翻译：用于分析多个样品的色谱装置（10）包括用于分离多个样品的分离器（22），用于将多个样品注入分离器（22）的注射器单元（15），喷射器单元（15）被提供为常规用于单样本层析的注射器单元，用于在被分离器（22）分离之后检测多个样品的信号的检测器（24），用于为多个样品中的每一个生成特定二进制序列的序列发生器（12）控制器（12），其控制所述喷射器单元（15），使得所述多个样品中的每一个以与其特定二进制序列相对应的脉冲注入到所述分离器（22）中;以及分解器（12），用于分解所检测的信号通过识别检测信号中的特定二进制序列来获得多个样本。

9. 发明公开

EP2717045A4 CREATION METHOD, CREATION PROGRAM, AND CREATION DEVICE FOR CHARACTERISTIC AMOUNT OF PATTERN OR FP 有权
标题翻译：方法，程序和设备，用于创建图案或FP的特征参量
公开(公告)号：EP2717045A4
公开(公告)日：2014-11-26
申请号：EP12791963
申请日：2012-05-31
申请人： TSUMURA & CO
发明人： TESHIMA SHOICHI , MORI YOSHIKAZU , NODA KEIICHI
IPC分类号： G01N30/86 , G01N30/88
CPC分类号： G06F19/70 , G01N30/86 , G01N30/8675

10. 发明公开

EP2793020A1 Data processing device for gas chromatograph, data processing method, and data processing program 审中-公开
标题翻译：用于气体色谱仪数据处理装置，数据处理方法和数据处理程序
公开(公告)号：EP2793020A1
公开(公告)日：2014-10-22
申请号：EP14001358.2
申请日：2014-04-14
申请人： Horiba Stec, Co., Ltd.
发明人： Kono, Nanako , Sasaki, Tomohiro
IPC分类号： G01N30/86 , G01N30/30
CPC分类号： G01N30/8675 , G01N30/8658 , G01N30/8668 , G01N30/8693 , G01N2030/3084
摘要： A data processing device for gas chromatograph includes an actually measured retention time storage part, a predicted retention time storage part, and an actual temperature condition estimation part configured to estimate an actual temperature condition in the column on the basis of an actually measured retention time and a predicted retention time.
摘要翻译：用于气相色谱仪的数据处理装置包括：在实际测量的保留时间存储部，预测的保留时间的存储部分，并且在被配置在实际温度条件在列来估计的实际测量的保留时间的基础上，实际温度状况估计部和预测保留时间。

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