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1. 发明授权

EP2401502B1 AUTOMATED DILUTION FOR LIQUID CHROMATOGRAPHY 有权
公开(公告)号：EP2401502B1
公开(公告)日：2018-10-31
申请号：EP10746644.3
申请日：2010-02-17
申请人： Waters Technologies Corporation
发明人： CORMIER, Sylvain , ANDREWS, Richard, W. , TACCONI, Robert , DOBBS, Craig, H.
IPC分类号： F04B13/02 , F04B23/06 , G01N1/38 , G01N1/40 , G01N30/20
CPC分类号： F04B13/02 , F04B23/06 , G01N1/38 , G01N1/40 , G01N30/20
摘要： Described are a method and system for diluting a sample in a liquid chromatography system. A sample flowing at a first flow rate is combined for a predetermined time with a diluent flowing at a second flow rate to generate a volume of diluted sample. The diluted sample has a dilution ratio determined according to the two flow rates. A portion of the volume is loaded into a sample loop of an injection valve and subsequently injected into a mobile phase flowing to a chromatography column. The method eliminates the need to have a technician available to perform dilutions or to transfer the sample to a remote location for dilution. Advantageously, manufacturing or processing downtime to perform the dilution is not required and the amount of sample flowing to waste is reduced.

2. 发明授权

EP2459913B1 ROTARY SHEAR INJECTOR VALVE WITH COATED STATOR SURFACE 有权
公开(公告)号：EP2459913B1
公开(公告)日：2018-09-05
申请号：EP10804908.1
申请日：2010-07-23
申请人： Waters Technologies Corporation
发明人： MOELLER, Mark, W. , KIRBY, Peter , CIOLKOSZ, Theodore, D. , JENCKS, Robert, A.
IPC分类号： F16K25/04 , F16K3/08 , F16K25/00 , G01N30/20
CPC分类号： F16K3/08 , F16K25/005 , G01N30/20 , G01N2030/202 , Y10T29/49405 , Y10T137/7036
摘要： A valve includes a rotor and a stator. The rotor and the stator each have seal surfaces for contacting and sliding against one another during operation of the valve. Either or both of the rotor and the stator have a seal-surface coating formed by depositing an at least partially amorphous interlayer on a substrate and depositing a surface layer, including diamond-like carbon, on the interlayer. The surface layer requires no mechanical polishing.

3. 发明公开

EP3346252A1 PRE-PROCESSING DEVICE FOR GAS ANALYSIS 有权
公开(公告)号：EP3346252A1
公开(公告)日：2018-07-11
申请号：EP16844329.9
申请日：2016-09-06
申请人： Japan Agency for Marine-Earth Science and Technology
发明人： SAKAI Saburo
IPC分类号： G01N1/22 , G01N1/00 , G01N31/00
CPC分类号： G01N1/2226 , G01N1/00 , G01N1/22 , G01N30/20 , G01N31/00 , G01N33/0047 , G01N2030/025 , G01N2030/121
摘要： Provided herein is a preprocessing apparatus for gas analysis that enables preprocessing for gas analysis to be performed without requiring a cryogen. A preprocessing apparatus for gas analysis 101 mainly includes a gas flow path 103, a cooling portion 105, and a plurality of valves V101 to V105 that serve as gas flow path connection changing means for changing the gas flow path. The cooling portion 105 is operable to cool the collecting portion 113, and is constituted from a heat conductor 121, a cooling device 127, and a sealed structure 129. The cooling device 127 can cooled a contact cooling section 131 to an extremely low temperature by utilizing electrical energy. The cooling device 127 is used to bring the collecting portion 113 to a first temperature at which the target gas to be analyzed is solidified, and to thereafter bring the collecting portion 113 to a second temperature at which only the target gas to be analyzed is gasified. By performing such processes, the target gas to be analyzed can be extracted by removing gases of impurities from a mixed gas.

4. 发明公开

EP3335038A1 STACKED LAYER-TYPE MEMBER WITH INTEGRATED FUNCTIONAL COMPONENT 审中-公开
公开(公告)号：EP3335038A1
公开(公告)日：2018-06-20
申请号：EP16757346.8
申请日：2016-08-02
申请人： Agilent Technologies, Inc.
发明人： STEINKE, Armin
IPC分类号： G01N30/20 , F16K1/14 , G01N30/60 , F16K99/00 , B01D15/14
CPC分类号： G01N30/20 , B01L3/502738 , B01L2400/0478 , B01L2400/0616 , F16K99/0023 , F16K99/0042 , G01N30/6095 , G01N2030/204
摘要： A fluidic valve for a sample separation apparatus for separating a fluid, wherein the fluidic valve comprises a stack of connected layer structures, a first conduit within the stack, a second conduit within the stack, a movable body within the stack, and an actuator configured for actuating the movable body to selectively bring the movable body into a flow enabling configuration in which flow of fluid between the first conduit and the second conduit is enabled, or into a flow disabling configuration in which flow of fluid between the first conduit and the second conduit is disabled.

5. 发明授权

EP3043178B1 AUTOMATED SAMPLING AND REACTION SYSTEM FOR HIGH PRESSURE LIQUID CHROMATOGRAPHY AND OTHER TYPES OF DETECTION 有权
标题翻译：高压液相色谱和其他检测类型的自动采样和反应系统
公开(公告)号：EP3043178B1
公开(公告)日：2018-04-25
申请号：EP16150281.0
申请日：2016-01-06
申请人： Waters Technologies Corporation
发明人： HEWITSON, HILLARY , CORMIER, SYLVAIN , PHOEBE, CHARLES , PHOEBE, AARON
IPC分类号： G01N30/06 , G01N30/20 , G01N35/10 , G01N30/24 , G01N35/00
CPC分类号： G01N30/20 , G01N30/06 , G01N30/24 , G01N35/1097 , G01N2030/067 , G01N2030/207 , G01N2035/00514 , G01N2035/1032
摘要： Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.

6. 发明公开

EP3306312A1 ELEMENTAL ANALYSER 有权
标题翻译：元素分析仪
公开(公告)号：EP3306312A1
公开(公告)日：2018-04-11
申请号：EP16425096.1
申请日：2016-10-10
申请人： Thermo Fisher Scientific S.p.A
发明人： Galotta, Walter , Magni, Andrea , Krotz, Liliana , Leone, Francesco
IPC分类号： G01N31/12 , G01N30/66
CPC分类号： G01N30/66 , G01N30/02 , G01N30/20 , G01N31/12 , G01N2030/025 , G01N2030/8405
摘要： The invention relates to elemental analysers and, in particular, but not exclusively, organic elemental analysers and isotope ratio mass spectrometry (IRMS) elemental analysers.
An analysis system for analysing the constituents of a sample of material, the system comprising: a reference supply conduit (2) for supplying a source of a first gas (70a); a carrier supply conduit (4) for supplying a source of the first (70a) or a second gas (70b); first (30a) and second (30b) reactors; a first auto-sampler (20a) for providing one or more samples of material, the first auto-sampler (20a) having an inlet (22a) for receiving gas and an outlet (23a) for providing the received gas and a sample to the first reactor (30a); a second auto-sampler (20b) for providing one or more samples of material, the second auto-sampler (20b) having an inlet (22b) for receiving gas and an outlet (23b) for providing the received gas and a sample to the second reactor (30b); a thermal conductivity detector (10) having first (15) and second channels (13) for identifying the relative conductivity of the gases in each channel, characterised in that: the system further comprises a valve system (80, 100) arranged to control the flow of gas from the supply conduits (2,4) to the inlets (22a, 22b) of the first (20a) and second (20b) auto-samplers; the analysis system has a first mode of operation in which:
• the valve system (80, 100) connects the carrier supply conduit (4) with the first auto-sampler (20a);
• the first auto-sampler (20a) delivers the received gas and a sample to the first reactor (30a);
• the first reactor (30a) delivers at least one reaction product to one channel of the thermal conductivity detector; and
• the valve system (80, 100) connects the reference supply conduit (2) to the other channel of the thermal conductivity detector (10); and
the analysis system has a second mode of operation in which:
• the valve system (105) connects the carrier supply conduit (4) with the second auto-sampler (20b);
• the second auto-sampter (20b) delivers the received gas and a sample to the second reactor (30b);
• the second reactor (30b) delivers at least one reaction product to one channel of the thermal conductivity detector (10); and
• the valve system (80, 100) connects the reference supply conduit (2) to the other channel of the thermal conductivity detector (10).
摘要翻译：本发明涉及元素分析仪，尤其涉及但不限于有机元素分析仪和同位素比质谱（IRMS）元素分析仪。一种用于分析材料样品成分的分析系统，该系统包括：用于供应第一气体源（70a）的参考供应管道（2）用于供应第一气体（70a）或第二气体（70b）的源的载体供应导管（4）; 第一（30a）和第二（30b）反应器; （20a），其用于提供一个或多个材料样本，所述第一自动采样器（20a）具有用于接收气体的入口（22a）和用于向所述第一自动采样器（20a）提供所接收的气体和样本的出口（23a）第一反应器（30a）; 用于提供一个或多个材料样本的第二自动采样器（20b），所述第二自动采样器（20b）具有用于接收气体的入口（22b）和用于将所接收的气体和样本提供给第二反应器（30b）; 具有用于识别每个通道中的气体的相对电导率的第一通道（15）和第二通道（13）的热导率检测器（10），其特征在于：所述系统还包括阀系统（80,100），所述阀系统气体从第一（20a）和第二（20a）和第二（20b）自动采样器的供应导管（2,4）流入入口（22a，22b）分析系统具有第一操作模式，其中：·阀系统（80,100）将载体供应导管（4）与第一自动采样器（20a）连接; ·第一自动采样器（20a）将所接收的气体和样品输送到第一反应器（30a）; ·第一反应器（30a）将至少一种反应产物输送到热导检测器的一个通道; 以及·阀系统（80,100）将参考供应导管（2）连接到热导检测器（10）的另一通道; 并且分析系统具有第二操作模式，其中：·阀系统（105）将载体供应导管（4）与第二自动采样器（20b）连接; ·第二自动采样器（20b）将所接收的气体和样本输送到第二反应器（30b）; ·第二反应器（30b）将至少一种反应产物输送到热导检测器（10）的一个通道; 和·阀门系统（80,100）将参考供应管道（2）连接到热导检测器（10）的另一个通道。

7. 发明公开

EP3278098A1 A ROTARY VALVE AND A CHROMATOGRAPHY SYSTEM 有权转让
标题翻译：旋转阀和色谱系统
公开(公告)号：EP3278098A1
公开(公告)日：2018-02-07
申请号：EP16711305.9
申请日：2016-03-23
申请人： GE Healthcare Bio-Sciences AB
发明人： OLOVSSON, Bjorn, Markus
IPC分类号： G01N30/20 , F16K11/074 , B01D15/14
CPC分类号： G01N30/20 , F16K11/0743 , G01N2030/202
摘要： The present invention relates to a rotary valve and to a chromatography system comprising such a rotary valve. The rotary valve comprising a stator with an inner stator face, and a rotor with an inner rotor face arranged in sealing contact with the inner stator face, the rotor (1) is rotatably movable to a plurality of rotor positions about a rotational axis (RA) relative to the inner stator face (202), wherein the stator comprises ports and orifices and the rotor comprises two or more rotor interconnection paths for selective fluidic interconnection of said orifices with respect to the rotor position and wherein the rotor interconnection paths are arranged to in a rotary position connect the first orifice (S) to the fourth orifice (LF), the second orifice (W) to the third orifice (LE). And in a rotary position connect the eight orifice (SP) to the seventh orifice (PCFP). And in a rotary position connect the eight orifice (SP) to the fifth orifice (TC), the sixth orifice (FC) to the seventh orifice (PCFP). And in a rotary position connect the eight orifice (SP) to the third orifice (LE), the fourth orifice (LF) to the fifth orifice (TC), the sixth orifice (FC) to the seventh orifice (PCFP).

8. 发明授权

EP1996930B1 DEVICE AND METHODS FOR REDUCING PRESSURE AND FLOW PERTURBATIONS IN A CHROMATOGRAPHIC SYSTEM 有权
标题翻译：用于降低色谱系统中的压力和流动扰动的装置和方法
公开(公告)号：EP1996930B1
公开(公告)日：2018-01-10
申请号：EP07758679.0
申请日：2007-03-16
申请人： Waters Technologies Corporation
发明人： FADGEN, Keith , USOWICZ, James, E. , SOARES, Miguel
IPC分类号： G01N30/02 , G01N30/20
CPC分类号： G01N30/20 , G01N30/22 , G01N2030/201 , G01N2030/202 , G05D7/0688 , G05D16/208
摘要： Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

9. 发明授权

EP1856501B1 METHOD AND APPARATUS FOR SAMPLE INJECTION IN LIQUID CHROMATOGRAPHY 有权转让
标题翻译：用于液相色谱中样品注射的方法和设备
公开(公告)号：EP1856501B1
公开(公告)日：2017-12-20
申请号：EP06719892.9
申请日：2006-01-31
申请人： Waters Technologies Corporation
发明人： DOURDEVILLE, Theodore A. , KEENE, Russell L. , CIOLKOSZ, Theodore D. , USOWICZ, James E.
IPC分类号： G01N1/00 , G01N30/22
CPC分类号： G01N30/20 , G01N30/22 , G01N2030/202 , Y10T137/0396 , Y10T137/4636 , Y10T137/86863
摘要： The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

10. 发明公开

EP3252464A1 SAMPLE INJECTION WITH FLUDIC CONNECTION BETWEEN FLUID DRIVE UNIT AND SAMPLE ACCOMODATION VOLUME 有权
标题翻译：在流体驱动装置和样品容积体积之间进行流体连接的样品注射
公开(公告)号：EP3252464A1
公开(公告)日：2017-12-06
申请号：EP17172865.2
申请日：2017-05-24
申请人： Agilent Technologies, Inc. (A Delaware Corporation)
发明人： Thielsch, Daniel , Ortmann, Thomas
IPC分类号： G01N30/20 , G01N30/32
CPC分类号： G01N30/06 , F16K11/074 , G01N30/20 , G01N30/22 , G01N30/32 , G01N2030/201 , G01N2030/202 , G01N2030/207
摘要： Injector (40) for injecting a fluidic sample into a flow path (104) between a fluid drive (20) and a separation unit (30) of a sample separation apparatus (10), wherein the injector (40) comprises a sample accommodation volume (100) for accommodating the fluidic sample prior to injecting, a sample drive (102) configured for intaking the fluidic sample into the sample accommodation volume (100), a fluidic valve (95) switchable between multiple switching states to thereby selectively couple the sample accommodation volume (100) with the flow path (104) or decouple the sample accommodation volume (100) from the flow path (104), wherein in an injection switching state of the fluidic valve (95), the fluid drive (20), the separation unit (30) and the sample drive (102) are fluidically coupled by the fluidic valve (95) so that fluid driven by the sample drive (102) and flowing from the sample accommodation volume (100) to the separation unit (30) and further fluid driven by the fluid drive (20) and flowing from the fluid drive (20) to the separation unit (30) are combined at a fluidic connection (108) upstream of the separation unit (30), and a control unit (70) configured for controlling a pressure of at least one of the group consisting of the fluid driven by the sample drive (102), the further fluid driven by the fluid drive (20), and the combined fluid) during injecting fluidic sample from the sample accommodation volume (100) into the flow path (104).
摘要翻译：用于将流体样本注入样本分离装置（10）的流体驱动器（20）和分离单元（30）之间的流动路径（104）中的注射器（40），其中注射器（40）包括样本容纳容积（100），用于在注入之前容纳流体样本，配置成用于将流体样本吸入到样本容纳空间（100）中的样本驱动器（102），可在多个切换状态之间切换的流体阀（95），从而选择性地将样本（100）与所述流动路径（104）分离或将所述样品容纳空间（100）与所述流动路径（104）分离，其中在所述流体阀（95）的注射切换状态中，所述流体驱动器（20）分离单元（30）和样品驱动器（102）通过流体阀（95）流体耦合，使得由样品驱动器（102）驱动并从样品容纳空间（100）流向分离单元（30 ）和由流体驱动装置（2）驱动的另外的流体 0）并且从流体驱动器（20）流到分离单元（30）的流体在分离单元（30）上游的流体连接部（108）处结合;以及控制单元（70），配置用于控制在将来自样本容纳空间（100）的流体样本注入到流体中的过程中由样本驱动器（102）驱动的流体，由流体驱动器（20）驱动的另外流体以及组合流体）组成的组中的至少一个路径（104）。

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