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1. 发明公开

EP3309179A1 HYDROXYALKYL ALKYL CELLULOSE, METHOD FOR PRODUCING THE SAME, AND SOLID PREPARATION 有权转让
标题翻译：羟烷基烷基纤维素，其制备方法和固体制剂
公开(公告)号：EP3309179A1
公开(公告)日：2018-04-18
申请号：EP17195310.2
申请日：2017-10-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： YOKOSAWA, Takuya , KITAGUCHI, Taishi , HIRAMA, Yasuyuki , KITAMURA, Akira
IPC分类号： C08B11/193
CPC分类号： C08B3/08 , A61K9/146 , A61K9/2054 , A61K47/38 , C08B3/14 , C08B11/193 , C08L1/32 , C09D101/30 , G01N15/0211 , G01N2021/479
摘要： There is provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, provided are a hydroxyalkyl alkyl cellulose having a volume-based average particle diameter, determined by dry laser diffractometry, of 50 to 100 µm, and having, on a basis of a dynamic image analysis to divide all particles into fine particles, spherical particles and fibrous particles, a volume fraction of the fibrous particles consisting of long and short fibrous particles relative to all of the particles of 45 to 70%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.
摘要翻译：提供了显示良好流动性和高可压缩性的羟烷基烷基纤维素。更具体而言，提供通过干式激光衍射法测定的体积基准平均粒径为50〜100μm的羟烷基烷基纤维素，并且基于动态图像分析将全部颗粒分成细颗粒，球形颗粒和纤维状颗粒，由相对于所有颗粒的长和短纤维颗粒组成的纤维状颗粒的体积分数为45-70％，并且细颗粒相对于所有颗粒的体积分数小于2.0％ ; 包含羟烷基烷基纤维素的固体制剂; 和别的。

2. 发明公开

EP3279637A1 METHOD FOR ON-LINE IMAGING OF MESOPHASE PARTICLES 有权
标题翻译：中性粒子在线成像的方法
公开(公告)号：EP3279637A1
公开(公告)日：2018-02-07
申请号：EP17181995.6
申请日：2017-07-18
申请人： Honeywell Limited
发明人： KELLOMAKI, Markku M.
IPC分类号： G01N15/02 , C10G47/00 , C10G47/36 , G01N21/21 , G01N21/53 , G01N33/28 , G01N15/00 , G01N21/47
CPC分类号： C10G47/36 , C10G47/00 , C10G47/02 , C10G47/26 , G01N15/0205 , G01N15/0227 , G01N15/06 , G01N21/21 , G01N21/23 , G01N33/2823 , G01N2015/0053 , G01N2015/0693 , G01N2021/216 , G01N2021/479 , G01N2021/4792 , G01N2201/0612 , G01N2201/0697
摘要： On-line detection of mesophase particles employs a laser diode light source to illuminate a target area with a pulsed laser linearly or circularly polarized probe beam. Analysis of images determines extent of presence the birefringent mesophase particles, which are precursors to coking in catalytic hydrocracking processes. The inherently polarized low-coherence, unfocused but sufficiently collimated, pulsed laser beam yield sharp imaging with high depth of field of very small mesophase particles that are present in a moving, dark reactor liquid environment.
摘要翻译：中间相粒子的在线检测采用激光二极管光源以脉冲激光线性或圆极化探测光束照射目标区域。图像分析决定了双折射中间相颗粒的存在程度，所述双折射中间相颗粒是催化加氢裂化过程中焦化的前体。固有偏振的低相干性，未聚焦但是充分准直的脉冲激光束产生具有非常小中间相粒子的高景深的清晰成像，所述中间相粒子存在于移动的黑暗反应堆液体环境中。

3. 发明公开

EP3149490A1 OPTICAL THROMBOELASTOGRAPHY SYSTEMS AND METHODS 审中-实审
标题翻译：光学血管造影系统和方法
公开(公告)号：EP3149490A1
公开(公告)日：2017-04-05
申请号：EP15799372.6
申请日：2015-06-01
申请人： The General Hospital Corporation
发明人： NADKARNI, Seemantini, K. , HAJJARIAN, Zeinab , TRIPATHI, Markandey , TSHIKUDI, Diane
IPC分类号： G01N33/86
CPC分类号： G01N33/4905 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , B01L2400/0688 , G01N11/00 , G01N15/00 , G01N21/272 , G01N21/51 , G01N21/82 , G01N33/86 , G01N2015/0092 , G01N2015/0222 , G01N2021/479 , G01N2021/825 , G01N2201/0221 , G01N2203/0094
摘要： Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensities associated with portions of a blood sample delivered through a fluid switch to analysis chambers of a cartridge of the sensor, and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage.
摘要翻译：手持式光学血栓弹性成像传感器及其使用方法用于同时评估护理点的血液凝固的多个参数。所述传感器包括光学系统，所述光学系统将与通过流体开关递送到血液样本的部分相关联的激光散斑强度记录到所述传感器的盒的分析腔室，并且数据处理电路被编程为从散斑强度导出所述多个参数。该电路可以是被配置为在没有与中央服务器和/或数据存储器通信的情况下操作的移动设备的一部分。

4. 发明授权

EP1973467B1 Systems and process for providing speckle reduction using a wave front modulation for optical coherence tomography 有权
标题翻译：用于通过对光学相干断层扫描的波前调制提供散斑减少的系统和方法
公开(公告)号：EP1973467B1
公开(公告)日：2013-10-16
申请号：EP07756376.5
申请日：2007-01-18
申请人： The General Hospital Corporation
发明人： PARK, Boris Hyle , DE BOER, Johannes F.
IPC分类号： A61B5/00 , G01N21/47 , G01B9/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N2021/1787 , G01N2021/479

5. 发明公开

EP1664744A1 PROCEDE ET DISPOSITIF D’ANALYSE DU MOUVEMENT DANS UN MILIEU DIFFUSANT 有权
标题翻译：方法和装置运动的散射介质中分析
公开(公告)号：EP1664744A1
公开(公告)日：2006-06-07
申请号：EP04787434.2
申请日：2004-09-24
申请人： Formulaction
发明人： SNABRE, Patrick , BRUNEL, Laurent
IPC分类号： G01N21/47 , G01N15/02 , G01P5/00 , G01P3/36
CPC分类号： G01N15/0227 , G01N21/4795 , G01N2015/0216 , G01N2021/479
摘要： The invention relates to a method of detecting and analysing movement in a scattering medium. The inventive method consists in: projecting a coherent light (1) towards the scattering medium (5); performing a spatial and temporal sampling of the electromagnetic field of the light (6) scattered by the scattering medium, in order to obtain a plurality of images of said electromagnetic field; and analysing the speckle grains resulting from the images obtained from the spatial and temporal sampling of the electromagnetic field of the scattered light, in order to detect and analyse a movement in the scattering medium, said speckle grain analysis step comprising a step consisting in analysing the inter-image distance. The invention also relates to a device for detecting and analysing movement in a scattering medium. The inventive device comprises: means (1) for projecting a coherent light towards the scattering medium (5); matrix sensor means (2) which can be used to perform a spatial and temporal sampling of the electromagnetic field of the light (6) scattered by the scattering medium, in order to obtain a plurality of images of the electromagnetic field; means (3) for observing the images of the electromagnetic field of the scattered light; means (4) for analysing the speckle grains resulting from said images; and means for analysing the inter-image distance.

6. 发明公开

EP1576355A2 ILLUMINATION SYSTEM FOR OPTICAL INSPECTION 审中-公开
标题翻译：照明系统用于光学检查
公开(公告)号：EP1576355A2
公开(公告)日：2005-09-21
申请号：EP03799276.5
申请日：2003-09-08
申请人： Applied Materials Israel Ltd. , APPLIED MATERIALS, INC.
发明人： NAFTALI, Ron , GUETTA, Avishay , FELDMAN, Haim , SHOHAM, Doron , BLAI, Gil
IPC分类号： G01N21/00
CPC分类号： G01N21/8806 , G01N21/47 , G01N21/4788 , G01N21/94 , G01N21/9501 , G01N21/95607 , G01N21/95623 , G01N2021/1772 , G01N2021/4711 , G01N2021/4735 , G01N2021/479 , G01N2021/4792 , G01N2021/8822 , G01N2021/8845 , G01N2201/0697
摘要： Apparatus for generating optical radiation includes a laser, which is configured to operate in multiple transverse modes simultaneously so as to generate an input beam, which is characterized by a first speckle contrast. The transverse modes of the input beam are optically mixed so as to generate an output beam have a second speckle contrast, which is substantially less than the first speckle contrast.

7. 发明公开

EP1389060A1 IMAGING OF A REGION IN A SCATTERING MEDIUM 审中-公开
标题翻译：一个地区的一只走失的介质例证
公开(公告)号：EP1389060A1
公开(公告)日：2004-02-18
申请号：EP02761950.1
申请日：2002-04-08
申请人： Israel, Henry
发明人： Israel, Henry
IPC分类号： A61B5/00 , G01N21/17
CPC分类号： G01N21/4795 , A61B5/0051 , A61B5/0073 , C07K14/365 , C12N15/52 , G01N2021/479
摘要： A method for imaging a region in a scattering medium, comprising modulating a beam of energy passing through a region of a scattering medium by at least two ultrasonic energy waves having different spatial relationships with said beam of energy so as to form at least two different modulated energy patterns, and detecting and processing said modulated energy patterns to form an image of said region.

8. 发明公开

EP0266461A1 Methods for the detection and quantitation of immunological substances 失效
标题翻译： Verfahren zum Nachweis und zur Quantitativbestimmung von immunologischen Stoffen。
公开(公告)号：EP0266461A1
公开(公告)日：1988-05-11
申请号：EP86308568.4
申请日：1986-11-03
申请人： THE CENTER FOR IMMUNOLOGICAL STUDIES
发明人： Wyatt, Philip J. , Lopapa, Alberto F.
IPC分类号： G01N33/543
CPC分类号： G01N21/47 , G01N33/54373 , G01N2021/479 , Y10S436/805 , Y10S436/807
摘要： Chemical substances, particularly immunological substances can be detected and quantified by:

a) affixing to a surface a reactant material known to interact and to bind to, or to have a relatively high affinity for, the immunological substance to be detected, the substance being present in at least one medium;
b) impinging the affixed surface with a source of coherent radiation;
c) measuring a pattern of radiation scattered from the affixed surface;
d) reacting the affixed surface with at least one medium containing the immunological substance;
e) impinging the reacted affixed surface with substantially the same coherent radiation at substantially the same aspect and orientation utilized to perform step b);
f) measuring a pattern of radiation scattered from the reacted affixed surface; and
g) comparing the patterns of radiation derived from steps b) and f) to determine any differentiations therebetween. Unique instrumentation provides a complete system for convenient, precise quantitative measurement of immunological substances. The methods and instrumentation provide an extremely sensitive, yet relatively rapid, means for quantitative and qualitative analyses which has application to a broad range of biological fields.
摘要翻译：可以通过以下方式来检测和量化化学物质，特别是免疫学物质：a）将已知与待检测的免疫物质结合或结合或具有相对高的亲和力的反应物材料固定在表面上，该物质存在在至少一种培养基中; b）用固体辐射源撞击固定的表面; c）测量从固定表面散射的辐射图; d）使固定表面与至少一种含有免疫物质的培养基反应; e）以基本上相同的方面和取向冲击具有基本上相同的相干辐射的反应的固定表面，以执行步骤b）; f）测量从反应的固定表面散射的辐射图; 以及g）比较从步骤b）和f）得到的辐射模式以确定它们之间的任何差异。独特的仪器提供了一个完整的系统，方便，精确地定量测量免疫物质。方法和仪器为定量和定性分析提供了极其灵敏但相对较快的方法，可用于广泛的生物领域。

9. 发明公开

EP3335001A1 VERFAHREN UND VORRICHTUNG ZUM ABLICHTEN WENIGSTENS EINER SCHNITTFLÄCHE IM INNERN EINES LICHT STREUENDEN OBJEKTS 有权转让
公开(公告)号：EP3335001A1
公开(公告)日：2018-06-20
申请号：EP16756634.8
申请日：2016-08-09
申请人： Thorlabs GmbH , Medizinisches Laserzentrum Lübeck GmbH
发明人： KOCH, Peter , FRANKE, Gesa , SPAHR, Hendrik , SUDKAMP, Helge , HÜTTMANN, Gereon , HILLMANN, Dierck , BIRNGRUBER, Reginald
IPC分类号： G01B9/02 , A61B3/10 , A61B5/00 , G01N21/47 , G03H1/04 , G03H1/06
CPC分类号： A61B3/102 , A61B3/12 , A61B5/0035 , A61B5/0066 , A61B5/0073 , G01B9/02032 , G01B9/02054 , G01B9/02077 , G01B9/02082 , G01B9/02084 , G01B9/02091 , G01N21/4795 , G01N2021/479 , G03H1/0443 , G03H1/0465 , G03H1/06 , G03H2001/0445 , G03H2001/0467 , G03H2222/24 , G03H2223/26
摘要： The invention relates to an interferometric method in which the sample light which is scattered by an object is imaged onto an electronic camera, wherein a sample light portion is assigned to scattering locations on a sectional face in the interior of the object. This sample light portion can be separated from the contributions of the other sample light portions by processing the camera image, and gives rise to a sectional image. A particular advantage of the invention is that a plurality of sectional faces running in parallel at predetermined distances from one another in the interior of the object can be exposed one after another. Such a sequence of sectional images can be used to calculate a volume model of the object. The invention can be applied, in particular, to the living retina and permits a three-dimensional retina scan within several seconds using a cost-effective and, under certain circumstances, hand-held device. Application possibilities are ophthalmology and biometry.

10. 发明公开

EP3265779A1 VERFAHREN UND VORRICHTUNG ZUR OPTISCHEN DETEKTION EINER BEWEGUNG IN EINER BIOLOGISCHEN PROBE MIT RÄUMLICHER AUSDEHNUNG 有权转让
标题翻译：在空间扩展的生物样本中光学检测运动的方法和装置
公开(公告)号：EP3265779A1
公开(公告)日：2018-01-10
申请号：EP16708082.9
申请日：2016-03-02
申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V. , Universität des Saarlandes
发明人： ZIMMERMANN, Heiko , STRACKE, Frank , LE HARZIC, Ronan
IPC分类号： G01N21/21 , G01P13/00 , G01N21/47 , G01N33/50 , G01N21/49
CPC分类号： G01N33/5005 , G01N21/21 , G01N21/4788 , G01N21/49 , G01N33/15 , G01N2021/479 , G01N2021/4792 , G01P13/00
摘要： The invention relates to a method and a device for optical in vitro detection of a movement in a biological sample with a spatial extent in the form of a three-dimensional cell and/or tissue culture or a cell cluster or a sample made of freely swimming microorganisms. The method comprises the following steps: (a) providing a receptacle for the sample (1), a light beam source (6), an optical unit (7, 8) and a detector (2), (a1) wherein the optical unit (7, 8) is embodied to illuminate the whole sample (1) in the receptacle with radiation emanating from the light beam source and to guide at least some of the radiation (11) of the light beam source (6), which is changed at any point within the sample (1) by an interaction with the sample (1) in terms of the beam direction thereof, the polarization state thereof and/or the diffraction pattern thereof, to a detection surface (2a) of the detector (2), and (a2) wherein the detector (2) is embodied to generate a measurement signal (9) in a manner dependent on the detected radiation, the time profile of which measurement signal specifies a time profile of an intensity of the detected radiation (11) and/or from which the time profile of the intensity of the detected radiation (11) is derivable; (b) illuminating the sample (1) with radiation from the light beam source; and (c) detecting a movement in the biological sample (1) in a manner dependent on a temporal change in the measurement signal (9).

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