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1. 发明公开

EP3308774A1 HYDROXYALKYL ALKYL CELLULOSE, METHOD FOR PRODUCING THE SAME, AND SOLID PREPARATION 有权转让
标题翻译：羟烷基烷基纤维素，其制备方法和固体制剂
公开(公告)号：EP3308774A1
公开(公告)日：2018-04-18
申请号：EP17195311.0
申请日：2017-10-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： KITAGUCHI, Taishi , HIRAMA, Yasuyuki , YOKOSAWA, Takuya , KITAMURA, Akira
IPC分类号： A61K9/20 , C08B11/193
CPC分类号： A61K9/2054 , A61K9/146 , A61K9/2095 , A61K47/38 , C08B11/08 , C08B11/193 , C08B11/20 , C08L1/32 , C09D101/30
摘要： Provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, there are provided a hydroxyalkyl alkyl cellulose having a volume-based average particle size, determined by dry laser diffractometry, of more than 100 µm and not more than 150 µm; and after dividing all particles into fine particles, spherical particles and fibrous particles by a dynamic image analysis, a volume fraction of the fibrous particles relative to all of the particles of more than 40% and not more than 50%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.
摘要翻译：提供了显示良好流动性和高可压缩性的羟烷基烷基纤维素。更具体而言，提供一种通过干式激光衍射法测定的体积平均粒径大于100μm且不大于150μm的羟烷基烷基纤维素; 并且通过动态图像分析将所有颗粒分成细颗粒，球形颗粒和纤维颗粒，纤维颗粒相对于所有颗粒的体积分数大于40％且不大于50％，并且体积分数为相对于所有颗粒的细颗粒小于2.0％; 包含羟烷基烷基纤维素的固体制剂; 和别的。

2. 发明授权

EP3308776B1 LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION 有权
公开(公告)号：EP3308776B1
公开(公告)日：2024-06-05
申请号：EP17195313.6
申请日：2017-10-06
IPC分类号： A61K9/20 , A61K47/38 , A61K9/14 , C08B11/193 , C09D101/30 , C08L1/32 , A61K31/167
CPC分类号： A61K47/38 , A61K9/146 , C08B11/193 , C09D101/30 , C08L1/32 , A61K31/167 , A61K9/2054

3. 发明公开

EP3308775A1 LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION 有权
标题翻译：低取代羟丙基纤维素及其生产方法和固体制剂
公开(公告)号：EP3308775A1
公开(公告)日：2018-04-18
申请号：EP17195312.8
申请日：2017-10-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： HIRAMA, Yasuyuki , TSUCHIYA, Aya
IPC分类号： A61K9/20 , C08B11/193
CPC分类号： C08B3/08 , A61K9/146 , A61K9/2054 , A61K47/38 , C08B3/14 , C08B11/193 , C08L1/32 , C09D101/30 , G01N23/20
摘要： Provided are low-substituted hydroxypropyl cellulose (L-HPC) having a hydroxypropoxy content of from 5 to 16% by weight, and having, on a basis of a dynamic image analysis to divide all particles into fine, spherical, and fibrous particles consisting of long and short fibrous particles, a volume fraction of the long fibrous particles of from 15 to 50% and a volume fraction of the short fibrous particles of from 23 to 60%; and a solid preparation containing the L-HPC. Also provided is a method for producing the L-HPC including the steps: bringing sheet-like or chip-like pulp having a length-weighted average fiber length of from 2.40 to 3.50 mm into contact with an alkali metal hydroxide solution, reacting the resulting alkali cellulose with propylene oxide, and dispersing the resulting reaction product in water containing an acid to partially dissolve it therein, followed by neutralization with an acid to precipitate crude L-HPC.
摘要翻译：提供羟基丙氧基含量为5-16重量％的低取代羟丙基纤维素（L-HPC），并且基于动态图像分析将所有颗粒分成由以下物质组成的细颗粒，球状和纤维状颗粒：长短纤维颗粒，长纤维颗粒的体积分数为15〜50％，短纤维颗粒的体积分数为23〜60％; 和含有L-HPC的固体制剂。还提供了一种生产L-HPC的方法，包括以下步骤：使长度加权平均纤维长度为2.40-3.50mm的片状或碎片状纸浆与碱金属氢氧化物溶液接触，使得到的产物将碱性纤维素与环氧丙烷混合，并将所得反应产物分散在含有酸的水中以部分溶解于其中，随后用酸中和以沉淀粗制L-HPC。

4. 发明公开

EP3309179A1 HYDROXYALKYL ALKYL CELLULOSE, METHOD FOR PRODUCING THE SAME, AND SOLID PREPARATION 有权转让
标题翻译：羟烷基烷基纤维素，其制备方法和固体制剂
公开(公告)号：EP3309179A1
公开(公告)日：2018-04-18
申请号：EP17195310.2
申请日：2017-10-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： YOKOSAWA, Takuya , KITAGUCHI, Taishi , HIRAMA, Yasuyuki , KITAMURA, Akira
IPC分类号： C08B11/193
CPC分类号： C08B3/08 , A61K9/146 , A61K9/2054 , A61K47/38 , C08B3/14 , C08B11/193 , C08L1/32 , C09D101/30 , G01N15/0211 , G01N2021/479
摘要： There is provided is a hydroxyalkyl alkyl cellulose exhibiting good flowability and high compressibility. More specifically, provided are a hydroxyalkyl alkyl cellulose having a volume-based average particle diameter, determined by dry laser diffractometry, of 50 to 100 µm, and having, on a basis of a dynamic image analysis to divide all particles into fine particles, spherical particles and fibrous particles, a volume fraction of the fibrous particles consisting of long and short fibrous particles relative to all of the particles of 45 to 70%, and a volume fraction of the fine particles relative to all of the particles of less than 2.0%; a solid preparation including the hydroxyalkyl alkyl cellulose; and others.
摘要翻译：提供了显示良好流动性和高可压缩性的羟烷基烷基纤维素。更具体而言，提供通过干式激光衍射法测定的体积基准平均粒径为50〜100μm的羟烷基烷基纤维素，并且基于动态图像分析将全部颗粒分成细颗粒，球形颗粒和纤维状颗粒，由相对于所有颗粒的长和短纤维颗粒组成的纤维状颗粒的体积分数为45-70％，并且细颗粒相对于所有颗粒的体积分数小于2.0％ ; 包含羟烷基烷基纤维素的固体制剂; 和别的。

5. 发明公开

EP3308776A1 LOW-SUBSTITUTED HYDROXYPROPYL CELLULOSE, PRODUCTION METHOD THEREOF, AND SOLID PREPARATION 有权
标题翻译：低取代羟丙基纤维素及其生产方法和固体制剂
公开(公告)号：EP3308776A1
公开(公告)日：2018-04-18
申请号：EP17195313.6
申请日：2017-10-06
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： HIRAMA, Yasuyuki
IPC分类号： A61K9/20 , C08B11/193
CPC分类号： C08B11/08 , A61K9/146 , A61K9/2054 , A61K9/2095 , A61K31/167 , A61K47/38 , C08B11/193 , C08B11/20 , C08L1/32 , C09D101/30
摘要： There are provided low-substituted hydroxypropyl cellulose (L-HPC) having good compressibility and capping-prevention performance, and others. Specifically, provided are L-HPC having a hydroxypropoxy content of 5 to 16% by weight, a volume fraction of long fibrous particles of 20 to 40% and a volume fraction of short fibrous particles of 26 to 60% with the proviso that the latter is greater than the former; and a solid preparation containing the L-HPC. Also provided is a method for producing the L-HPC including the steps of: bringing powdery pulp having a length-weighted mean width of 10 to 25 µm into contact with an alkali metal hydroxide solution, reacting the alkali cellulose with propylene oxide, and neutralizing the alkali metal hydroxide present in the reaction product with an acid to precipitate crude low-substituted hydroxypropyl cellulose in the absence of a step of dissolving a portion or all of the reaction product.
摘要翻译：提供了具有良好的压缩性和防盖性能的低取代羟丙基纤维素（L-HPC）等。具体而言，提供具有5至16重量％的羟丙氧基含量，20至40％的长纤维颗粒的体积分数和26至60％的短纤维颗粒的体积分数的L-HPC，条件是后者大于前者; 和含有L-HPC的固体制剂。还提供了生产L-HPC的方法，包括以下步骤：使长度加权平均宽度为10-25μm的粉末状纸浆与碱金属氢氧化物溶液接触，使碱性纤维素与环氧丙烷反应，并中和存在于反应产物中的碱金属氢氧化物与酸在不溶解部分或全部反应产物的步骤不存在的情况下沉淀粗制低取代羟丙基纤维素。

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