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1. 发明授权

EP2460009B1 DEVICE FOR DETECTION OF ANTIGENS AND USES THEREOF 有权
标题翻译： DEVICE FOR抗原检测及其用途
公开(公告)号：EP2460009B1
公开(公告)日：2015-03-04
申请号：EP10805106.1
申请日：2010-07-30
申请人： Invisible Sentinel, Inc.
发明人： SICILIANO, Nicholas, A. , BOULIANE, Martin, Joseph
IPC分类号： G01N33/558 , G01N33/569 , G01N33/53 , B01L3/00
CPC分类号： G01N33/5302 , B01L3/5023 , B01L2200/026 , B01L2200/04 , B01L2200/10 , B01L2300/041 , B01L2300/049 , B01L2300/0636 , B01L2300/069 , B01L2300/0809 , B01L2300/087 , G01N33/56911 , G01N33/56916 , G01N33/56922 , Y10S435/81 , Y10S435/97 , Y10S436/804 , Y10S436/805 , Y10S436/807
摘要： Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.

2. 发明公开

EP2662136A3 Method for handling and mixing droplets 审中-公开
标题翻译：处理和混合液滴的方法
公开(公告)号：EP2662136A3
公开(公告)日：2013-12-25
申请号：EP13165667.0
申请日：2004-08-27
申请人： President and Fellows of Harvard College
发明人： Link, Darren , Weitz, David , Cristobal-Azkarte, Glader , Cheng, Zhengdong , Ahn, Keunho
IPC分类号： B01J19/00 , G01N15/14
CPC分类号： B01L3/5027 , B01F5/0256 , B01F5/0646 , B01F5/0655 , B01F5/0682 , B01F5/0689 , B01F13/0069 , B01F13/0071 , B01F13/0074 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00862 , B01L3/0241 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L3/502792 , B01L3/5088 , B01L2200/0636 , B01L2200/0652 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , B01L2400/0487 , C12Q2563/159 , C12Q2565/629 , G01N15/10 , G01N15/14 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/149 , Y10S436/807 , Y10T436/118339 , Y10T436/2525 , Y10T436/2575
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.
摘要翻译：本发明的各个方面涉及例如在微流体系统中的流体物质的控制和操纵。在一个方面，本发明涉及使用例如电场，机械改变，添加介入流体等来制造被液体围绕的流体液滴的系统和方法。在一些情况下，液滴可以各自具有其中的实体数量基本一致。例如，95％或更多的液滴可能每个都含有相同数量的特定物种的实体。另一方面，本发明涉及用于将流体液滴分成两个液滴的系统和方法，例如通过电荷和/或偶极子与电场的相互作用。本发明还涉及根据本发明另一方面的用于融合液滴的系统和方法，例如通过电荷和/或偶极相互作用。在一些情况下，液滴的融合可以引发或确定反应。在本发明的一个相关方面中，还提供了允许液滴内发生流体混合的系统和方法。又一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。例子包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如流体位移）来分选液滴。在一些情况下，流体液滴可以以相对高的速率分拣，例如以每秒约10个液滴或更多。本发明的另一方面提供了例如使用荧光和/或其它光学技术（例如显微镜）或电感测技术（例如电介质感测）来确定液滴或其组分的能力。

3. 发明授权

EP2204654B1 Use of devices and methods for detecting amniotic fluid in vaginal secretions 有权转让
标题翻译：使用的设备和方法，在阴道分泌物检测羊水
公开(公告)号：EP2204654B1
公开(公告)日：2012-12-12
申请号：EP10160487.4
申请日：2003-08-12
申请人： N-Dia, Inc.
发明人： Petrunin, Dimitrii D. , Fuks, Boris B. , Zaraisky, Evgeny I. , Boltovskaya, Marina N. , Nazimova, Svetlana V. , Starosvetskaya, Nelly A. , Konstantinov, Alexandr B. , Marshiskaia, Margarita I.
IPC分类号： G01N33/558 , G01N33/68 , G01N33/53
CPC分类号： G01N33/6854 , G01N33/558 , G01N33/577 , G01N33/689 , G01N2333/471 , G01N2800/36 , G01N2800/368 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/807 , Y10S436/81 , Y10S436/811 , Y10S436/815 , Y10S436/817

4. 发明公开

EP2496941A2 METHODS AND DEVICES TO ENHANCE SENSITIVITY AND EVALUATE SAMPLE ADEQUACY AND REAGENT REACTIVITY IN RAPID LATERAL FLOW IMMUNOASSAYS 有权
标题翻译： METHOD AND APPARATUS FOR提高灵敏度，并评价样品健身和REAGENZIENREAKTIVITÄTIN免疫ASSAYS具有快速侧向流
公开(公告)号：EP2496941A2
公开(公告)日：2012-09-12
申请号：EP10829126.1
申请日：2010-11-04
申请人： Buchanan, Thomas M.
发明人： Buchanan, Thomas M.
IPC分类号： G01N33/53 , G01N35/08 , G01N33/536 , G01N33/569
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/5029 , B01L2200/0605 , B01L2300/069 , B01L2300/0825 , B01L2400/0478 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/807 , Y10S436/81
摘要： Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods and devices provide for delivery of a diluted liquid sample to a single location that simultaneously directs the liquid flow along two or more separate flow paths, one that serves as a positive control to confirm that all critical reagents of the test are immunoreactive, and that the sample being tested is adequate, and the other to detect specific antibodies if present.

5. 发明授权

EP1340083B1 SIGNAL ENHANCEMENT SYSTEM WITH MULTIPLE LABELLED-MOIETIES 有权
标题翻译：具有多资金注明SIGNAL提高系统
公开(公告)号：EP1340083B1
公开(公告)日：2011-10-26
申请号：EP01998830.2
申请日：2001-11-30
申请人： Diagnostics for the Real World, Ltd
发明人： LEE, Helen, Univ. Cambridge, Dept of Haematology , HUANG, Ling , DINEVA, Magda, Anastassova , HU, Hsiang, Yun
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , Y10S435/81 , Y10S436/807 , Y10S977/70 , Y10S977/773 , Y10S977/788 , Y10S977/918
摘要： Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labelled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. the sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labelled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.

6. 发明公开

EP2250500A4 METHODS AND KIT FOR EARLY DETECTION OF ACUTE CORONARY SYNDROME AND PREDICTION OF ADVERSE CARDIAC EVENTS 有权
标题翻译：方法和试剂盒治疗急性冠脉综合征和早期发现心脏预测负性事件
公开(公告)号：EP2250500A4
公开(公告)日：2011-08-24
申请号：EP08873041
申请日：2008-06-25
申请人： RAJAPURKAR MOHAN , LELE SUHAS , SHAH SUDHIR
发明人： RAJAPURKAR MOHAN , LELE SUHAS , SHAH SUDHIR
IPC分类号： G01N33/50 , A61B5/145 , G01N33/84
CPC分类号： G01N33/20 , A61K31/4439 , G01N33/6893 , G01N33/84 , G01N2800/324 , G01N2800/325 , G01N2800/56 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/811

7. 发明公开

EP2261659A3 Method of optical detection of binding of a material component to a sensor substance due to a biological, chemical or physical interaction and apparatus for its embodiment (variant) 有权
标题翻译：的材料组分到Sensorsubstance结合光学检测的方法，由于生物，化学或物理相互作用和装置用于执行该方法
公开(公告)号：EP2261659A3
公开(公告)日：2011-02-02
申请号：EP10178220.9
申请日：2001-05-10
申请人： Nikitin, Petr Ivanovich
发明人： Nikitin, Petr Ivanovich , Gorshkov, Boris Georgievich
IPC分类号： G01N33/53 , G01N21/45
CPC分类号： G01N33/54373 , G01N21/45 , G01N21/7703 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： The invention provides a method and apparatus for detection of binding of biological and/or chemical components of liquid or gaseous mixtures and solutions, which are mainly of biological origin and/or determine parameters of living activity of biological objects, to substances that bind the said components due to a biological, chemical or physical interaction; and analysis of mixtures and solutions to determine presence of biological and/or chemical components.
Binding substances are arranged on a surface of or inside a sensor layer, which changes its thickness due to the binding being detected; the layer is affected by the light of different wavelengths; a signal due to interference on the sensor layer is registered in the reflected or transmitted light. The signal is represented by a spectrum; the sensor layer is more than 10 micrometers thick and exceeds the maximum-recorded wavelength by at least an order of magnitude; information about the binding being detected is obtained from analysis of a spectral shift of interference maximums and minimums. A plate, solid or porous, or a gap with two surfaces of a solid optical material is used as the sensor layer. As the surfaces are located at a distance of more than 10 micrometers, this allows pumping liquids through the gap at moderate pressure drops and investigating large biological objects (e.g., cells), or employment of affordable plates that are rigid enough without any substrate. The indicated thickness of the plate or the gap permits using of the superluminescent diodes or tunable semiconductor lasers as light sources, because it allows recording within their narrow spectrums a sufficient number of interference maxima and minima for precise registration of molecular binding reactions, which lead to much higher signal-to-noise ratio and sensitivity of the apparatus as compared with apparatus based on thin-film sensor layers.

8. 发明公开

EP2270508A1 Membrane assay method and kit 有权转让
标题翻译： Membran-Assay-Verfahren und Kit
公开(公告)号：EP2270508A1
公开(公告)日：2011-01-05
申请号：EP10011767.0
申请日：2003-12-24
申请人： DENKA SEIKEN Co., Ltd.
发明人： Shimizu, Hideharu, , Watanabe, Takeshi , Takizawa, Kazuyuki , Matsuda, Junji , Sato, Toshinori
IPC分类号： G01N33/569 , G01N33/48 , G01N1/10 , G01N33/53 , G01N33/543
CPC分类号： G01N1/4077 , B01L3/5023 , B01L2300/0681 , B01L2300/069 , B01L2400/0406 , G01N33/569 , G01N2001/4016 , Y10S435/805 , Y10S435/81 , Y10S436/807 , Y10S436/808 , Y10S436/81
摘要： The present invention is to provide a simple membrane assay method for detecting or quantitating an analyte in a specimen sample using an assay device equipped with a membrane bound with a capture-substance to capture the analyte, comprising the steps of filtering a specimen sample using a filter, dropping the filtrate onto said membrane and detecting the presence of the analyte in said specimen sample, as well as a simple membrane assay kit for detecting the presence of an analyte in a specimen sample, comprising (1) a filter tube, and (2) an assay device equipped with a membrane bound with a capture-substance to capture the analyte. The method or the kit can decrease the occurrence of false positivity and can provide a highly accurate detection of the analyte such as pathogen and antibody in a specimen collected in a medical scene or by an individual.
摘要翻译：本发明提供一种简单的膜测定方法，用于使用配备有与捕获物质结合的膜的测定装置来检测或定量样品样品中的分析物，以捕获分析物，包括以下步骤：使用过滤器，将滤液滴加到所述膜上并检测所述样品样品中分析物的存在，以及用于检测样品样品中分析物的存在的简单膜分析试剂盒，其包括（1）过滤管和（ 2）配备有与捕获物质结合以捕获分析物的膜的测定装置。该方法或试剂盒可以减少假阳性的发生，并且可以提供在医疗场景或个体收集的样本中的分析物如病原体和抗体的高精度检测。

9. 发明公开

EP2035541A4 ABLATION BASED LASER MACHINING OF BIOMOLECULE PATTERNS ON SUBSTRATES 审中-公开
标题翻译： ON对基质烧蚀基于激光加工的生物分子结构
公开(公告)号：EP2035541A4
公开(公告)日：2010-11-24
申请号：EP07797868
申请日：2007-05-30
申请人： UNIV JOHNS HOPKINS
发明人： HOH JAN , HEINZ WILLIAM F
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/00 , C12Q1/68 , G01N15/06 , G01N33/53 , G01N33/543 , G01N33/551
CPC分类号： G01N33/54393 , B01J19/0046 , B01J2219/00441 , B01J2219/00527 , B01J2219/00563 , B01J2219/00576 , B01J2219/00659 , B01J2219/00725 , B01J2219/0074 , Y10S436/807

10. 发明公开

EP2027466A4 DIRECTED-FLOW ASSAY DEVICE 有权
标题翻译：面向流量测试设备
公开(公告)号：EP2027466A4
公开(公告)日：2010-03-17
申请号：EP07754688
申请日：2007-03-29
申请人： QUANTUM DESIGN INC
发明人： LABORDE RONALD T , CHOW HERBERT S
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , B01L3/5023 , B01L9/52 , B01L2200/026 , B01L2300/0825 , G01N33/54326 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S436/807 , Y10S436/808 , Y10S436/81

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