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1. 发明授权

EP2751089B1 COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H 有权
公开(公告)号：EP2751089B1
公开(公告)日：2018-11-14
申请号：EP12772562.0
申请日：2012-08-31
申请人： Promega Corporation
发明人： BENINK, Helene A. , CALI, James, J. , DUELLMAN, Sarah , KLAUBERT, Dieter , LEIPPE, Donna , O'BRIEN, Martha , SHULTZ, John , VIDUGIRIENE, Jolanta , ZHOU, Wenhui , SOBOL, Mary
IPC分类号： C07D497/10 , C07F9/6558 , C07F9/6561 , C12Q1/32 , G01N21/76 , G01N33/50 , G01N33/573 , C07D277/68 , C07D487/04 , C12Q1/66 , G01N33/58
CPC分类号： C12Q1/32 , C07D277/68 , C07D417/04 , C07D487/04 , C07D493/10 , C07D497/10 , C07F9/65583 , C07F9/6561 , C12Q1/66 , G01N21/763 , G01N33/5038 , G01N33/5735 , G01N33/582
摘要： The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.

2. 发明公开

EP3230719A4 LIQUID AND PLATE SENSORS FOR MICROPLATE INJECTOR SYSTEM 有权转让
公开(公告)号：EP3230719A4
公开(公告)日：2018-07-11
申请号：EP15868139
申请日：2015-12-08
申请人： MOLECULAR DEVICES LLC
发明人： ATZLER JOSEF J , KATZLINGER MICHAEL , KRONBERGER GEORG , SCHINWALD BERNHARD
IPC分类号： G01N21/76 , G01J3/02 , G01N21/01 , G01N21/15 , G01N21/25 , G01N27/02 , G01N35/02 , G01N35/10
CPC分类号： G01N21/76 , G01J3/02 , G01N21/15 , G01N21/253 , G01N21/763 , G01N27/223 , G01N35/028 , G01N2021/015 , G01N2021/155 , G01N2035/1025 , G01N2201/0225 , G01N2201/0245 , G01N2201/0446 , G01N2201/0806
摘要： In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.

3. 发明公开

EP3268721A2 LIGHT DETECTION SYSTEM AND METHOD OF USING SAME 有权转让
标题翻译：光检测系统及其使用方法
公开(公告)号：EP3268721A2
公开(公告)日：2018-01-17
申请号：EP16711400.8
申请日：2016-02-26
申请人： 3M Innovative Properties Company
发明人： THAO, Fusu , BOMMARITO, Giuseppe M. , DEWEY, Thomas E., Jr. , STENERSEN, Kathleen M. , FRITCHER, Beth A. , ALEXANDER, Stephen R. , BOLEA, Phillip A. , WALDNER, Michele A.
IPC分类号： G01N21/01 , G01N21/76 , C12Q1/00 , C12Q1/66 , E05D3/00 , G01J1/42 , G01N21/94
CPC分类号： G01J1/0271 , G01J1/0233 , G01N21/01 , G01N21/645 , G01N21/763 , G01N21/94 , G01N2201/021 , G01N2201/0221 , G01N2201/064 , G01N2201/0646
摘要： Various embodiments of a light detection device and a method of using such device are disclosed. In one or more embodiments, the light detection device can include a housing including a top surface and a bottom surface, where the housing extends along a housing axis between the top surface and the bottom surface; and a support member connected to the housing and adapted to be selectively moved from a closed position to an open position. The support member is further adapted to maintain the light detection device in an upright position when the bottom surface and the support member are in contact with a working surface and the support member is in the open position.

4. 发明公开

EP2480876A4 METHOD AND SYSTEM FOR OPTICAL DATA ACQUISITION AND TOMOGRAPHY IMAGING OF A TURBID MEDIUM OBJECT 有权转让
公开(公告)号：EP2480876A4
公开(公告)日：2017-10-25
申请号：EP10818176
申请日：2010-09-22
申请人： POLYVALOR LTD PARTNERSHIP
发明人： LESAGE FRÉDÉRIC , BÉLANGER SAMUEL , ABRAN MAXIME , PROVOST JEAN
IPC分类号： G01N21/49 , A61B5/00 , A61B6/00 , G01N21/17 , G01N21/47 , G01N21/64 , G01N21/76
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , G01N21/6456 , G01N21/763 , G01N2021/1787 , G01N2021/479 , G01N2201/0675

5. 发明公开

EP3132052A1 METHODS AND DEVICES FOR DETECTION OF RESISTANCE TO AN ENZYME INHIBITOR 审中-公开
标题翻译： VERFAHREN UND VORRICHTUNGEN ZUM NACHWEIS DER RESISTENZGEGENÜBEREINEM ENZYMINHIBITOR
公开(公告)号：EP3132052A1
公开(公告)日：2017-02-22
申请号：EP15780015.2
申请日：2015-04-13
申请人： Cellex, Incorporated
发明人： LI, Xingxiang
IPC分类号： C12Q1/34 , C12Q1/37 , C12M1/34 , C12Q1/02
CPC分类号： C12Q1/34 , G01N21/64 , G01N21/76 , G01N21/763 , G01N2333/11 , G01N2333/986
摘要： Embodiments described herein relate to assay methods and kits for detecting resistance of any enzyme to its inhibitor due to functional alteration of the enzyme, comprising, conducting two or more reactions with two or more reagent mixes optionally containing substrates for the enzyme. The mixes are substantially similar, except that one contains no enzyme inhibitor whereas the others contain an enzyme inhibitor being tested for resistance. The ratio of the signal from the reaction with an inhibitor to that from a reaction without an inhibitor is used to indicate whether the enzyme is resistant to the enzyme inhibitor and also determine the susceptibility or resistance of the enzyme to various inhibitors and further identify enzyme variants. Embodiments further relate to assay methods comprising only two reactions- one conducted in a mix containing the inhibitor and the other without the inhibitor. Further included are devices for conducting such assays.
摘要翻译：本文描述的实施方案涉及用于检测由于酶的功能性改变而导致的任何酶对其抑制剂的耐药性的测定方法和试剂盒，其包括用任选含有酶底物的两种或多种试剂混合物进行两次或多次反应。混合物基本上相似，除了不含酶抑制剂，而其它物质含有测试抗性的酶抑制剂。来自与抑制剂的反应的信号与来自不含抑制剂的反应的信号的比率用于指示酶是否对酶抑制剂具有抗性，并且还确定酶对各种抑制剂的敏感性或抗性，并进一步鉴定酶变体。实施方案进一步涉及仅包含两个反应的测定方法 - 一个在含有抑制剂的混合物中进行，另一个不含抑制剂。还包括用于进行这种测定的装置。

6. 发明公开

EP2972354A1 SYSTEMS AND METHODS FOR DETECTION OF CELLS USING ENGINEERED TRANSDUCTION PARTICLES 有权
标题翻译：系统VERFAHREN ZUR DETEKTION VON ZELLEN MITHILFE MANIPULERERTER TRANSDUKTIONSPARTIKEL
公开(公告)号：EP2972354A1
公开(公告)日：2016-01-20
申请号：EP14779477.0
申请日：2014-03-11
申请人： Geneweave Biosciences Inc.
发明人： REY, Diego Ariel , ROY, Shaunak , TEIXEIRA, Leonardo M. , GRISWOLD, Ryan C. , MATTHEWS, Damian S. , OLSON, Kenneth G. , RICHARDSON, Bruce J. , STELLMACHER, Rick V. , YEE, Victor H.
IPC分类号： G01N33/53 , G01N33/542 , C12P19/34
CPC分类号： C12Q1/6897 , B01L3/502 , B01L3/50825 , B01L3/52 , B01L3/523 , B01L3/54 , B01L3/545 , B01L7/00 , B01L2200/028 , B01L2200/16 , B01L2300/021 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0672 , B01L2400/0478 , B01L2400/06 , B01L2400/0683 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/10 , C12Q1/14 , C12Q1/66 , G01J1/00 , G01N21/01 , G01N21/03 , G01N21/13 , G01N21/76 , G01N21/763 , G01N2035/00346 , G01N2035/0405 , G01N2333/195
摘要： Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.
摘要翻译：本文描述了使用工程改造的转导颗粒检测和/或鉴定靶细胞（例如细菌）的系统和方法。在一些实施方案中，一种方法包括将一定量的转导颗粒混合在样品内。转导颗粒与靶细胞相关联。转导颗粒是非复制型的，并被工程化以包括配制成使靶细胞产生一系列报道分子的核酸分子。当样品中存在靶细胞时，保持样品和转导颗粒以表达一系列报告分子。接收与一定量的报道分子相关的信号。在一些实施例中，信号的幅度与高于预定量的转导颗粒的数量无关。

7. 发明授权

EP1889470B1 STRUCTURED LIGHT IMAGING APPARATUS 有权转让
标题翻译：结构光成像装置
公开(公告)号：EP1889470B1
公开(公告)日：2015-09-09
申请号：EP06759546.2
申请日：2006-05-09
申请人： Xenogen Corporation
发明人： RICE, Bradley, W. , CABLE, Michael, D. , NILSON, David , KEARNEY, Kevin
IPC分类号： H04N5/222 , A61B5/00 , A61B5/107 , G01B11/25 , G01N21/64 , G01N21/76 , G06T7/00 , H04N13/02
CPC分类号： G01B11/2513 , A61B5/0059 , A61B5/0064 , A61B5/107 , A61B5/6888 , A61B2503/40 , G01B11/2518 , G01N21/6456 , G01N21/763 , G06T7/521 , H04N13/254
摘要： The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.

8. 发明公开

EP2910931A1 METHOD FOR QUANTITATIVE DETERMINATION OF BIOSUBSTANCE AND INSTRUMENT FOR QUANTITATIVE DETERMINATION OF BIOSUBSTANCE 审中-公开
标题翻译：方法为生物材料的定量测定生物材料的定量测定与仪器
公开(公告)号：EP2910931A1
公开(公告)日：2015-08-26
申请号：EP13847533.0
申请日：2013-10-18
申请人： Hitachi, Ltd.
发明人： NAKATSUKA, Yuta , MORI, Shuichi , MIYASHITA, Noe
IPC分类号： G01N21/76 , C12Q1/02 , G01N33/18 , G01N33/50
CPC分类号： G01N21/6428 , C12Q1/008 , C12Q1/02 , G01N21/763 , G01N33/52 , G01N2201/0636
摘要： The present invention is a device (1) for quantifying biological material (ATP) of cells contained in a liquid sample (8a) as a sample. The device (1) includes a controller (34) that calculates an amount of the biological material of cells contained in the liquid sample (8a), based on a differential amount of luminescence between an amount of luminescence when an ATP luminescence reagent (8b) as a luminescent reagent for biological material is reacted with the the biological material (ATP) that is separated and extracted from cells contained in the liquid sample (8a) by bringing an ATP extraction reagent (8c) as a processing reagent into contact with the liquid sample (8a), and an amount of luminescence when the ATP luminescent reagent (8b) is reacted with the ATP extraction reagent (8c).
摘要翻译：本发明是用于量化包含在液体样品（8A），其为样品中的细胞的生物材料（ATP）的装置（1）。所述装置（1）包括控制器（34）那样，计算对包含在液体样品（8）中的细胞的生物材料的量，间基于发光的差分量发光量时的ATP发光试剂（8b）的作为生物材料的发光试剂进行反应与生物材料（ATP）并分离并从通过使上ATP提取试剂（图8c），其为处理试剂接触到液体容纳在液体试样（8A）在细胞中提取样品（8A），而在发光量当ATP发光试剂（图8b）反应与ATP提取试剂（8C）。

9. 发明公开

EP2530456A4 METHOD OF WASHING PIPE OF LIGHT-EMISSION MEASURING DEVICE AND MECHANISM FOR WASHING PIPE OF LIGHT-EMISSION MEASURING DEVICE 审中-公开
标题翻译：方法的用于管道的LIGHT清洁EMITTING测量装置和机制用于清理管道中的发光测量装置
公开(公告)号：EP2530456A4
公开(公告)日：2014-02-26
申请号：EP11736931
申请日：2011-01-21
申请人： HITACHI PLANT TECHNOLOGIES LTD
发明人： MIYASHITA NOE
IPC分类号： G01N21/76 , A61L2/18 , B08B9/02 , B08B9/027 , C12M1/34 , G01N1/00 , G01N35/10
CPC分类号： B08B9/027 , G01N21/763 , G01N35/1004

10. 发明公开

EP2689026A1 DETECTION DE BACTERIES PRESENTANT UNE RESISTANCE AUX CARBAPENEMES 有权转让
标题翻译：保加利亚巴基斯坦NACHWEIS VON GEGEN CARBAPENEME RESSTENTEN BAKTERIEN
公开(公告)号：EP2689026A1
公开(公告)日：2014-01-29
申请号：EP12714799.9
申请日：2012-03-16
申请人： Biomérieux , Ghirardi, Sandrine
发明人： GHIRARDI, Sandrine , PERRY, John , ZAMBARDI, Gilles
IPC分类号： C12Q1/04 , C12N1/20
CPC分类号： G01N21/763 , C12N1/20 , C12N15/01 , C12Q1/04
摘要： The invention relates to a method for detecting and/or identifying, in a biological sample, bacteria having a resistance to carbapenems. The method comprises the following steps consisting in: a) bringing the sample into contact with a reaction medium containing at least one chromogenic agent and faropenem and/or doripenem; b) incubating the sample and reaction medium brought into contact in step (a), such as to allow the growth of bacteria; and c) detecting the strains having a resistance to carbapenems. The medium used in step (a) also contains cloxacillin and/or a combination of cloxacillin and PAbetaN.
摘要翻译：公开了一种用于在生物样品中检测和/或鉴定表现出对碳青霉烯类抗性的细菌的方法，包括：a）使所述样品与包含至少一种显色剂和法罗培南和/或多里必敏的反应介质接触; b）整个孵化以使细菌生长; 和c）检测显示出对碳青霉烯类抗性的菌株。步骤a）中使用的培养基还含有氯西西林和/或氯沙西林和PAbetaN的组合。

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