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1. 发明授权

EP2520666B1 Oligonucleotide for detection test of polymorphism of EGFR exon 19 and use thereof 有权转让
标题翻译：用于检测EGFR外显子19多态性的寡核苷酸及其用途
公开(公告)号：EP2520666B1
公开(公告)日：2018-03-07
申请号：EP12166238.1
申请日：2012-04-30
申请人： ARKRAY, Inc.
发明人： Iguchi, Aki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2600/106
摘要： An oligonucleotide for a test for detecting a polymorphism of EGFR exon 19, the oligonucleotide being at least one selected from the group consisting of a P1 oligonucleotide and a P1' oligonucleotide, the P1 oligonucleotide having a 3' end subjected to an extension inhibition treatment, which has an identity of at least 80% with respect to a base sequence including at least the 115th to the 123rd bases of the base sequence indicated in SEQ ID NO: 1 and has a length of from 9 to 80 bases; and the P1' oligonucleotide having a 3' end subjected to an extension inhibition treatment, which hybridizes under stringent conditions with the complementary strand of a base sequence including at least the 115th to the 123rd bases of the base sequence indicated in SEQ ID NO: 1 and having a length of from 9 to 80 bases.

2. 发明公开

EP3281950A1 POLYPEPTIDE SOLUTION, ARTIFICIAL POLYPEPTIDE FIBER PRODUCTION METHOD AND POLYPEPTIDE PURIFICATION METHOD USING SAME 有权
标题翻译：多肽溶液，人工多肽纤维生产方法和使用相同多肽的纯化方法
公开(公告)号：EP3281950A1
公开(公告)日：2018-02-14
申请号：EP17194459.8
申请日：2012-10-29
申请人： Spiber Inc.
发明人： SUGAHARA, Junichi , SEKIYAMA, Kaori , SATO, Ryota , ISHIKAWA, Mizuki , MURATA, Shinya , SEKIYAMA, Kazuhide , OTOMO, Kazuko
IPC分类号： C07K14/435 , D01D5/04 , D01F4/02 , C12N15/09
CPC分类号： C08K5/41 , B29D99/0078 , C07K14/43518 , C08K3/16 , C08K5/20 , D01D5/04 , D01F4/02 , D01F6/68 , Y10S530/858
摘要： A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(ii): (i) DMSO with an inorganic salt; and (ii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
摘要翻译：本发明的多肽溶液是将来自天然蜘蛛丝蛋白质的多肽溶解于溶剂中的多肽溶液。该溶剂含有选自下列（i） - （ii）中的至少一种：（i）具有无机盐的DMSO; 和（ii）DMF与无机盐。此外，在本发明中，人造多肽纤维通过以下步骤获得：使用多肽溶液作为掺杂溶液; 并将纺丝原液从喷丝头挤出到去溶剂浴中以从纺丝原液中除去溶剂并形成纤维以生产未拉伸丝。此外，在本发明中，通过对多肽溶液进行热处理，然后从中除去未溶解物质来纯化多肽。因此，本发明提供溶质溶解性高，溶剂本身成本低，并且能够在高温下溶解，安全性高的多肽溶液：人造多肽纤维的制造方法以及多肽的纯化方法。

3. 发明公开

EP3274460A1 SOYBEAN U6 SMALL NUCLEAR RNA GENE PROMOTERS AND THEIR USE IN CONSTITUTIVE EXPRESSION OF SMALL RNA GENES IN PLANTS 审中-公开
标题翻译：大豆U6小核RNA基因启动子及其在植物中小RNA基因组成本表达中的应用
公开(公告)号：EP3274460A1
公开(公告)日：2018-01-31
申请号：EP16715935.9
申请日：2016-03-21
申请人： E. I. du Pont de Nemours and Company
发明人： LI, Zhongsen
IPC分类号： C12N15/82
CPC分类号： C12N15/8216 , C12N15/8213
摘要： The invention relates to gene expression regulatory sequences from soybean, specifically to promoters of U6 small nuclear RNA genes, and fragments thereof, and their use in promoting the expression of one or more heterologous nucleic acid fragments in a constitutive manner in plants. The invention further discloses compositions, polynucleotide constructs, transformed host cells, transgenic plants and seeds containing the recombinant construct with the promoter, and methods for preparing and using the same.

4. 发明授权

EP2447377B1 Primer set for detecting EGFR exon 21 polymorphism and application thereof 有权
标题翻译：用于检测EGFR外显子21多态性的引物组及其应用
公开(公告)号：EP2447377B1
公开(公告)日：2017-12-13
申请号：EP11187129.9
申请日：2011-10-28
申请人： ARKRAY, Inc.
发明人： Iguchi, Aki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2525/161 , C12Q2535/125 , C12Q2600/156
摘要： The invention provides a primer set for detecting a polymorphism in EGFR exon 21 1 L858R. The primer set has a P1 oligonucleotide and a P2 oligonucleotide and can perform amplification by using a region including the 172792nd base of SEQ ID NO: 1 as a template. As a base that is complementary to the 172792nd base of SEQ ID NO: 1, the P1 oligonucleotide has cytosine and the P2 oligonucleotide has adenine. The melting temperature of the P1 oligonucleotide is higher than the melting temperature of the P2 oligonucleotide, and/or the P1 oligonucleotide is one or more bases longer than the P2 oligonucleotide. The invention further provides a polymorphism detection primer, a polymorphism detection method using the primer set, a method of evaluating a EGFR tyrosine kinase inhibitor using the primer set, a primer used in the polymorphism detection method, and a kit including the primer set.

5. 发明公开

EP3250711A1 METHOD AND PRODUCT FOR PREVENTING FALSE POSITIVES IN METHODS EMPLOYING DDNTP'S 审中-公开
标题翻译：用于预防使用DDNTP的方法中的假阳性的方法和产品
公开(公告)号：EP3250711A1
公开(公告)日：2017-12-06
申请号：EP16702421.5
申请日：2016-02-01
申请人： Norwegian University Of Life Sciences , Hedmark University Of Applied Sciences
发明人： RUDI, Knut , WILSON, Robert C.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6816 , C12Q1/6818 , C12Q1/6848 , C12Q2535/101 , C12Q2521/537 , C12Q2537/143 , C12Q2565/101
摘要： The present invention relates to a method which prevents undesirable binding of ddNTPs to double stranded polynucleotides when in the presence of a polymerase. Such methods may be used to prevent the appearance of false positives in methods employing ddNTPs, e.g. in sequence detection methods. The present invention also provides a method of avoiding a false Tm reading or false FRET effects (such as false positive quenching), for example in a melting curve analysis method. In particular a method is provided in which a target nucleotide sequence in a test polynucleotide is detected using a method in which a double stranded molecule is generated which may or may not comprise two labels depending on whether the target sequence is present in which the presence of the two labels is determined, preferably by performing a melting curve analysis.

6. 发明授权

EP2770051B1 METHOD FOR CULTURING PLURIPOTENCY-MAINTAINED SINGLY DISPERSED CELLS BY MEANS OF LAMINAR FLOW 有权
标题翻译：利用层流法培养具有多潜能性的维持单分散细胞的方法
公开(公告)号：EP2770051B1
公开(公告)日：2017-09-27
申请号：EP12842151.8
申请日：2012-10-22
申请人： ARKRAY, Inc.
发明人： KOTERA, Hidetoshi , TATSUMI, Kazuya , YOKOKAWA, Ryuji , TADA, Takashi , NAGATA, Shogo , OKITSU, Teru , OKONOGI, Atsuhito , NODA, Yuichiro , NAKANISHI, Naoyuki , MATSUMURA, Taku , OSUMI, Takashi
IPC分类号： C12N5/10 , C12N5/00 , C12N5/071 , C12N5/0735 , C12M3/06 , C12N5/074
CPC分类号： C12N5/0606 , C12M23/16 , C12N5/0696 , C12N2501/115 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2502/13 , C12N2521/00 , C12N2533/54

7. 发明授权

EP2657346B1 METHOD FOR DETECTING CANCER CELL 有权
标题翻译：检测癌细胞的方法
公开(公告)号：EP2657346B1
公开(公告)日：2017-08-23
申请号：EP11850491.9
申请日：2011-12-22
申请人： ARKRAY, Inc.
发明人： TAKAGI, Hidenori , ITO, Hiroshi , KOZUKA, Masahiro
IPC分类号： C12Q1/04
CPC分类号： G01N33/582 , G01N33/574 , G01N33/72

8. 发明授权

EP2848701B1 Genetic loci on maize chromosomes 3 and 4 that are associated with Fusarium ear mold resistance 有权转让
标题翻译：玉米3号和4号染色体上的基因位点与镰刀菌穗霉菌抗性相关
公开(公告)号：EP2848701B1
公开(公告)日：2017-08-02
申请号：EP14189434.5
申请日：2011-01-26
申请人： E. I. du Pont de Nemours and Company
发明人： Tomas, Adriana , Layton, Jamie Anne , Luck, Stanley
IPC分类号： C12Q1/68 , A01H1/00 , A01H1/04 , A01H5/10
CPC分类号： A01H1/04 , A01H1/00 , A01H5/10 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/172

9. 发明授权

EP2764124B1 DIAGNOSTIC ASSAY FOR TISSUE TRANSPLANTATION STATUS 有权
标题翻译：组织移植状态的诊断分析
公开(公告)号：EP2764124B1
公开(公告)日：2017-08-02
申请号：EP12839093.7
申请日：2012-10-05
申请人： Murdoch Childrens Research Institute
发明人： SLATER, Howard Robert , BRUNO, Damien Luis , GANESAMOORTHY, Devika
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q2600/118 , C12Q2600/156
摘要： The present disclosure relates generally to tissue, including organ, transplantation. Taught herein is a genetic-based diagnostic assay to ascertain the status of a tissue transplantation procedure in a recipient based on a characterization of circulating or other cell free nucleic acid material. The instant disclosure enables kits, primers and protocols for ascertaining the status of a transplantation procedure.
摘要翻译：本公开一般涉及组织，包括器官移植。在此教导的是基于遗传学的诊断测定，以基于循环或其他无细胞核酸材料的表征来确定接受者中组织移植程序的状态。本公开使得用于确定移植过程的状态的试剂盒，引物和方案成为可能。

10. 发明授权

EP2358862B1 REDUCING BYPRODUCTION OF MALONATES IN A FERMENTATION PROCESS 有权
标题翻译：在发酵过程中减少副产物的产生
公开(公告)号：EP2358862B1
公开(公告)日：2017-08-02
申请号：EP09771642.7
申请日：2009-12-15
申请人： E. I. du Pont de Nemours and Company
发明人： XUE, Zhixiong , ZHU, Quinn, Qun
IPC分类号： C12N1/19 , C12N9/00 , C12P7/64
CPC分类号： C12P7/6427 , C12N9/93 , C12P7/6472

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