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1. 发明公开

EP4375403A2 COMPOSITE MATERIALS COMPRISING SYNTHETIC DRAGLINE SPIDER SILK 审中-公开
公开(公告)号：EP4375403A2
公开(公告)日：2024-05-29
申请号：EP24163979.8
申请日：2017-02-12
申请人： Seevix Material Sciences Ltd.
发明人： ITTAH, Shmulik , SHIMEL, Meni , SKLAN, Ella , STERN, Dganit
IPC分类号： D01F6/88
CPC分类号： C12N5/0068 , D01D5/0038 , D01F1/10 , D01F4/00 , D01F6/88 , C12N5/0602 , C12N2533/3020130101 , C12N2533/5020130101 , C07K14/43518
摘要： Composites based on a polymer and a mixture of proteins derived from a MaSp (major ampullate spidroin) protein are provides. Further, methods for preparation of same, and method of use of the composites are provided.

2. 发明授权

EP3414373B1 COMPOSITE MATERIALS COMPRISING SYNTHETIC DRAGLINE SPIDER SILK 有权
公开(公告)号：EP3414373B1
公开(公告)日：2024-04-24
申请号：EP17749991.0
申请日：2017-02-12
IPC分类号： C07K14/435 , C12N5/00 , C12N5/071 , D01D5/00 , D01F4/00 , D01F1/10 , D01F6/88
CPC分类号： C12N5/0068 , D01D5/0038 , D01F1/10 , D01F4/00 , D01F6/88 , C12N5/0602 , C12N2533/3020130101 , C12N2533/5020130101 , C07K14/43518

3. 发明公开

EP3387007A1 PROTEINACEOUS MOLECULES AND METHODS OF USE 审中-公开
公开(公告)号：EP3387007A1
公开(公告)日：2018-10-17
申请号：EP16871827.8
申请日：2016-12-09
申请人： The University of Queensland , The Florey Institute of Neuroscience and Mental Health , The Johns Hopkins University , The Regents of the University of California
发明人： PETROU, Steven , KING, Glenn , BOSMANS, Frank , JULIUS, David , OSTEEN, Jeremiah , ZHANG, Chuchu
IPC分类号： C07K14/435 , A61K38/17 , A61P25/08 , A61P25/28
CPC分类号： C07K14/43518 , A61K38/00
摘要： This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.

4. 发明公开

EP3265476A2 PROTOXIN-II VARIANTS AND METHODS OF USE 审中-公开
标题翻译： PROTOXIN-II变体和使用方法
公开(公告)号：EP3265476A2
公开(公告)日：2018-01-10
申请号：EP16759288.0
申请日：2016-02-25
申请人： Janssen Biotech, Inc.
发明人： FLINSPACH, Mack , WICKENDEN, Alan
IPC分类号： C07K14/47 , C07K14/765 , C12N15/11
CPC分类号： C07K14/47 , A61K38/00 , C07K14/43518 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31
摘要： The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.

5. 发明授权

EP2774934B1 POLYPEPTIDE SOLUTION, ARTIFICIAL POLYPEPTIDE FIBER PRODUCTION METHOD USING SAME, AND POLYPEPTIDE REFINING METHOD 有权转让
标题翻译：多肽溶液，使用该多肽的人造多肽纤维生产方法和多肽精炼方法
公开(公告)号：EP2774934B1
公开(公告)日：2017-11-29
申请号：EP12844908.9
申请日：2012-10-29
申请人： Spiber Inc.
发明人： SUGAHARA Junichi , SEKIYAMA, Kaori , SATO, Ryota , ISHIKAWA, Mizuki , MURATA, Shinya , SEKIYAMA, Kazuhide , OTOMO, Kazuko
IPC分类号： C07K14/435 , D01D5/04 , D01F4/02 , C12N15/09
CPC分类号： C08K5/41 , B29D99/0078 , C07K14/43518 , C08K3/16 , C08K5/20 , D01D5/04 , D01F4/02 , D01F6/68 , Y10S530/858
摘要： A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(ii): (i) DMSO with an inorganic salt; and (ii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.

6. 发明公开

EP2990413A4 POLYPEPTIDE POROUS BODY AND METHOD FOR PRODUCING SAME 有权
标题翻译：多孔多肽体及其生产方法
公开(公告)号：EP2990413A4
公开(公告)日：2016-10-05
申请号：EP14787816
申请日：2014-04-18
申请人： SPIBER INC
发明人： OSAWA TOSHIAKI , MORITA KEISUKE
IPC分类号： C07K14/435 , A61K8/64 , A61K47/42 , C07K1/02 , C08J9/28 , C08L89/00
CPC分类号： C07K14/43518 , A61K8/0279 , A61K8/42 , A61K8/46 , A61K8/64 , A61K8/987 , A61K9/19 , A61K47/42 , A61K2800/10 , A61K2800/56 , A61K2800/84 , A61Q19/00 , B01J20/24 , C08J9/28 , C08J2201/0484 , C08J2201/0544 , C08J2205/022 , C08J2205/028 , C08J2389/00 , C08L89/00 , C11B9/00
摘要： A polypeptide porous body of the present invention is a porous body of a polypeptide derived from spider silk proteins. The polypeptide includes a water-insoluble polypeptide. The polypeptide porous body has an apparent density of 0.1 g/cm 3 or less. A method for producing the polypeptide porous body includes: a solution production step in which the polypeptide is dissolved in at least one solvent selected from DMSO, DMF, and these with an inorganic salt, so as to obtain a solution of the polypeptide; a step in which the solution produced in the solution production step is substituted with a water-soluble solvent so as to obtain a polypeptide gel; and a step in which the polypeptide gel is dried. Thereby, the present invention provides a polypeptide porous body having excellent water absorbability and a polypeptide porous body suitable for application to a living body, and a method for producing the same.

7. 发明公开

EP2990062A1 POLYPEPTIDE HYDROGEL AND METHOD FOR PRODUCING SAME 有权
标题翻译：多米尼加共和国维多利亚州ZER HERSTELLUNG DAVON
公开(公告)号：EP2990062A1
公开(公告)日：2016-03-02
申请号：EP14788691.5
申请日：2014-04-18
申请人： Spiber Inc.
发明人： OSAWA, Toshiaki , MORITA, Keisuke
IPC分类号： A61L27/00 , C07K14/435 , C12N15/09
CPC分类号： A61K47/42 , A61K9/0087 , A61K38/1767 , A61L26/008 , A61L27/227 , A61L27/3604 , A61L27/3687 , A61L27/52 , A61L27/60 , A61L31/145 , A61L2430/06 , C07K14/43518
摘要： A polypeptide hydrogel of the present invention is a hydrogel of a polypeptide derived from spider silk proteins, and has a moisture content of 85.0 to 99.9 mass% based on 100 mass% of the polypeptide hydrogel. A method for producing the hydrogel includes: a solution production step in which a polypeptide derived from spider silk proteins is dissolved in at least one dissolving solvent selected from the group consisting of (A) dimethyl sulfoxide; (B) dimethyl sulfoxide with an inorganic salt; and (C) N, N-dimethylformamide with an inorganic salt, so as to obtain a solution of the polypeptide; and a substitution step in which the solution produced in the solution production step is substituted with a water-soluble solvent. Thus, the present invention provides a polypeptide hydrogel having excellent water retentivity and a polypeptide hydrogel suitable for application to a living body.
摘要翻译：本发明的多肽水凝胶是来自蜘蛛丝蛋白质的多肽的水凝胶，相对于100质量％的多肽水凝胶，水分含量为85.0〜99.9质量％。水凝胶的制造方法包括：将来自蜘蛛丝蛋白质的多肽溶解在选自（A）二甲基亚砜中的至少一种溶解溶剂中的溶液制备工序; （B）二甲基亚砜与无机盐; 和（C）N，N-二甲基甲酰胺与无机盐反应，得到多肽的溶液; 以及其中在溶液制备步骤中产生的溶液被水溶性溶剂代替的取代步骤。因此，本发明提供了具有优异的保水性的多肽水凝胶和适用于生物体的多肽水凝胶。

8. 发明公开

EP2940032A1 EXTRACTION METHOD FOR HYDROPHILIC RECOMBINANT PROTEIN 有权转让
标题翻译： EXTRAKTIONSVERFAHRENFÜRHYDROPHILE REKOMBINANTE PROTEINE
公开(公告)号：EP2940032A1
公开(公告)日：2015-11-04
申请号：EP13867712.5
申请日：2013-12-18
申请人： Spiber Inc.
发明人： OSAWA, Toshiaki , MORITA, Keisuke
IPC分类号： C07K1/14 , C12P21/02 , C07K14/435
CPC分类号： C07K1/145 , C07K14/43518 , C07K14/78
摘要： The present invention relates to a method for extracting a hydrophilic recombinant protein from a host expressing a hydrophilic recombinant protein. The method includes: a lysate acquisition step in which a dissolving solvent is added to the host expressing a hydrophilic recombinant protein so as to obtain a host cell lysate; and a step in which a diluting solvent is added to the host cell lysate obtained in the lysate acquisition step, an insoluble substance is separated from the obtained dilution, and a supernatant containing the hydrophilic recombinant protein is collected. The hydrophilic recombinant protein has a hydropathy index of 0 or less. The dissolving solvent is an aprotic polar solvent. The diluting solvent is an aqueous solvent.
摘要翻译：本发明涉及从表达亲水重组蛋白的宿主中提取亲水性重组蛋白的方法。该方法包括：裂解物获取步骤，其中向表达亲水重组蛋白的宿主中加入溶解溶剂以获得宿主细胞裂解物; 向裂解物获取工序中得到的宿主细胞裂解物中添加稀释溶剂的步骤，从得到的稀释液中分离不溶物质，收集含有亲水性重组蛋白质的上清液。亲水重组蛋白的亲水指数为0以下。溶解溶剂是非质子极性溶剂。稀释溶剂是水性溶剂。

9. 发明授权

EP2421890B1 METHOD OF PRODUCING POLYMERS OF SPIDER SILK PROTEINS 有权
标题翻译： PROCESS FOR蜘蛛丝蛋白的聚合物的制备
公开(公告)号：EP2421890B1
公开(公告)日：2015-08-26
申请号：EP10767397.2
申请日：2010-04-21
申请人： Spiber Technologies AB
发明人： JOHANSSON, Jan , HEDHAMMAR, My , RISING, Anna , NORDLING, Kerstin
IPC分类号： C07K14/435 , D01F4/00 , C12N15/62
CPC分类号： C07K14/43518

10. 发明授权

EP2330186B1 METHOD FOR SYNTHESIZING PROTEIN CONTAINING HIGH CONTENT OF SPECIFIC AMINO ACID THROUGH SIMULTANEOUS EXPRESSION WITH TRNA OF THE SPECIFIC AMINO ACID 有权
标题翻译：合成与特定的氨基比例较高的蛋白质BY同时表达与特定的tRNA氨基方法
公开(公告)号：EP2330186B1
公开(公告)日：2014-12-31
申请号：EP09814823.2
申请日：2009-09-22
申请人： Korea Advanced Institute of Science and Technology
发明人： LEE, Sang Yup , XIA, Xiaoxia , QIAN, Zhi Gang , BAEK, Jong Hwan
IPC分类号： C12N1/21 , C12N15/67 , C07K14/435
CPC分类号： C12N15/67 , C07K14/43518 , C07K14/43586

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