专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2971158B1 DETECTION OF BISULFITE CONVERTED NUCLEOTIDE SEQUENCES 有权
公开(公告)号：EP2971158B1
公开(公告)日：2018-11-14
申请号：EP14769555.5
申请日：2014-02-21
申请人： Abbott Molecular Inc.
发明人： HUANG, Shihai, X. , GRANADOS, Edward, N.
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q1/6858 , C12Q2600/154 , C12Q2523/125 , C12Q2531/113 , C12Q2535/125 , C12Q2535/131 , C12Q2537/163 , C12Q2561/113
摘要： The invention is to improved compositions and methods for the detection of target bisulfite converted methylated nucleotide sequences.

2. 发明公开

EP3346016A1 HIGHLY SELECTIVE NUCLEIC ACID AMPLIFICATION PRIMERS 有权
公开(公告)号：EP3346016A1
公开(公告)日：2018-07-11
申请号：EP18156307.3
申请日：2014-02-07
申请人： Rutgers, the State University of New Jersey
发明人： MARRAS, Salvatore , VARGAS-GOLD, Diana , TYAGI, Sanjay , KRAMER, Fred, Russell
IPC分类号： C12Q1/686 , C07H21/04 , C12Q1/6858
CPC分类号： C12P19/34 , C12Q1/6858 , C12Q1/686 , C12Q2525/161 , C12Q2525/191 , C12Q2535/125 , C12Q2535/131
摘要： This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.

3. 发明授权

EP2447377B1 Primer set for detecting EGFR exon 21 polymorphism and application thereof 有权转让
标题翻译：用于检测EGFR外显子21多态性的引物组及其应用
公开(公告)号：EP2447377B1
公开(公告)日：2017-12-13
申请号：EP11187129.9
申请日：2011-10-28
申请人： ARKRAY, Inc.
发明人： Iguchi, Aki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2525/161 , C12Q2535/125 , C12Q2600/156
摘要： The invention provides a primer set for detecting a polymorphism in EGFR exon 21 1 L858R. The primer set has a P1 oligonucleotide and a P2 oligonucleotide and can perform amplification by using a region including the 172792nd base of SEQ ID NO: 1 as a template. As a base that is complementary to the 172792nd base of SEQ ID NO: 1, the P1 oligonucleotide has cytosine and the P2 oligonucleotide has adenine. The melting temperature of the P1 oligonucleotide is higher than the melting temperature of the P2 oligonucleotide, and/or the P1 oligonucleotide is one or more bases longer than the P2 oligonucleotide. The invention further provides a polymorphism detection primer, a polymorphism detection method using the primer set, a method of evaluating a EGFR tyrosine kinase inhibitor using the primer set, a primer used in the polymorphism detection method, and a kit including the primer set.

4. 发明公开

EP3049539A4 METHODS FOR DETECTING NUCLEIC ACID FRAGMENTS 有权
标题翻译： VERFAHRENFÜRDEN NACHWEIS VON NUKLEINS -UREFRAGMENTEN
公开(公告)号：EP3049539A4
公开(公告)日：2017-08-23
申请号：EP14850060
申请日：2014-09-25
申请人： BIO-ID DIAGNOSTIC INC
发明人： VINAYAGAMOORTHY THURAIAYAH
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6853 , C12Q1/6858 , C12Q1/6886 , C12Q2600/156 , C12Q2525/186 , C12Q2525/207 , C12Q2525/307 , C12Q2531/113 , C12Q2535/122 , C12Q2535/125
摘要： Provided are methods for detecting and analyzing polynucleotides in a biological sample or sample derived therefrom for example, using a synthetic template polynucleotide. In some aspects, a target polynucleotide in the sample hybridizes to the template polynucleotide and is extended by a polymerase, generating an extended target polynucleotide. In some examples, the extended target polynucleotide is amplified, for example, by polymerase chain reaction, and sequences of the target polynucleotide determined, for example, by priming in the region of the extended target polynucleotide generated by extension and sequencing towards the region having identity to the target polynucleotide. In some aspects, the target polynucleotide is thereby detected in the sample and its sequence identified. In some aspects, the provided methods can be used to capture polynucleotide fragments in a biological sample, for example, plasma, and determine respective biomarkers they carry, for example, for cancer diagnosis and prognosis.
摘要翻译：提供了用于检测和分析生物样品或由其衍生的样品中的多核苷酸的方法，例如使用合成模板多核苷酸。在一些方面，样品中的靶多核苷酸与模板多核苷酸杂交并且被聚合酶延伸，产生延伸的靶多核苷酸。在一些实例中，例如通过聚合酶链式反应扩增延伸的靶多核苷酸，并且靶多核苷酸的序列例如通过在延伸和测序产生的延伸的靶多核苷酸的区域中引发朝向具有相同性的区域到目标多核苷酸。在一些方面，由此在样品中检测到靶多核苷酸并鉴定其序列。在一些方面，所提供的方法可用于捕获生物样品（例如血浆）中的多核苷酸片段，并确定它们携带的各自的生物标志物，例如用于癌症诊断和预后。

5. 发明授权

EP2744912B1 COMPOSITIONS AND METHODS FOR DETECTING ALLELIC VARIANTS 有权
标题翻译：组合物和方法等位基因变异的检测
公开(公告)号：EP2744912B1
公开(公告)日：2016-11-02
申请号：EP12753322.2
申请日：2012-08-17
申请人： Nestec S.A.
发明人： PRINCEN, Fred , SELVARAJ, Fabiyola , SINGH, Sharat
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2525/107 , C12Q2525/186 , C12Q2535/125 , C12Q2537/163

6. 发明公开

EP2953958A4 HIGHLY SELECTIVE NUCLEIC ACID AMPLIFICATION PRIMERS 有权
标题翻译：高液体核酸扩增仪
公开(公告)号：EP2953958A4
公开(公告)日：2016-08-17
申请号：EP14748774
申请日：2014-02-07
申请人： UNIV RUTGERS
发明人： MARRAS SALVATORE , VARGAS-GOLD DIANA , TYAGI SANJAY , KRAMER FRED RUSSELL
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12P19/34 , C12Q1/6858 , C12Q1/686 , C12Q2525/161 , C12Q2525/191 , C12Q2535/125 , C12Q2535/131
摘要： This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.

7. 发明公开

EP3049539A1 METHODS FOR DETECTING NUCLEIC ACID FRAGMENTS 有权
标题翻译： VERFAHRENFÜRDEN NACHWEIS VONNUKLEINSÄUREFRAGMENTEN
公开(公告)号：EP3049539A1
公开(公告)日：2016-08-03
申请号：EP14850060.6
申请日：2014-09-25
申请人： Bio-Id Diagnostic Inc.
发明人： VINAYAGAMOORTHY, Thuraiayah
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6853 , C12Q1/6858 , C12Q1/6886 , C12Q2600/156 , C12Q2525/186 , C12Q2525/155 , C12Q2525/161 , C12Q2525/207 , C12Q2525/307 , C12Q2531/113 , C12Q2535/122 , C12Q2535/125
摘要： Provided are methods for detecting and analyzing polynucleotides in a biological sample or sample derived therefrom for example, using a synthetic template polynucleotide. In some aspects, a target polynucleotide in the sample hybridizes to the template polynucleotide and is extended by a polymerase, generating an extended target polynucleotide. In some examples, the extended target polynucleotide is amplified, for example, by polymerase chain reaction, and sequences of the target polynucleotide determined, for example, by priming in the region of the extended target polynucleotide generated by extension and sequencing towards the region having identity to the target polynucleotide. In some aspects, the target polynucleotide is thereby detected in the sample and its sequence identified. In some aspects, the provided methods can be used to capture polynucleotide fragments in a biological sample, for example, plasma, and determine respective biomarkers they carry, for example, for cancer diagnosis and prognosis.
摘要翻译：提供了用于检测和分析生物样品或其衍生的样品中的多核苷酸的方法，例如使用合成模板多核苷酸。在一些方面，样品中的靶多核苷酸与模板多核苷酸杂交，并被聚合酶延伸，产生延伸的靶多核苷酸。在一些实例中，扩增的靶多核苷酸例如通过聚合酶链式反应进行扩增，并且靶多核苷酸的序列例如通过在延伸和测序产生的延伸的靶多核苷酸的区域中引发到具有同一性的区域到靶多核苷酸。在一些方面，因此在样品中检测到靶多核苷酸，并鉴定其序列。在一些方面，提供的方法可用于捕获生物样品（例如血浆）中的多核苷酸片段，并确定它们携带的各自的生物标志物，例如癌症诊断和预后。

8. 发明公开

EP2953958A1 HIGHLY SELECTIVE NUCLEIC ACID AMPLIFICATION PRIMERS 有权
标题翻译：高度选择性的核酸扩增引物
公开(公告)号：EP2953958A1
公开(公告)日：2015-12-16
申请号：EP14748774.8
申请日：2014-02-07
申请人： Rutgers, the State University of New Jersey
发明人： MARRAS, Salvatore , VARGAS-GOLD, Diana , TYAGI, Sanjay , KRAMER, Fred, Russell
IPC分类号： C07H21/04
CPC分类号： C12P19/34 , C12Q1/6858 , C12Q1/686 , C12Q2525/161 , C12Q2525/191 , C12Q2535/125 , C12Q2535/131
摘要： This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same.
摘要翻译：本发明公开了用于引物依赖性核酸扩增方法的多部分引物。还公开了引物依赖性核酸扩增反应，特别是DNA扩增反应，用于这种反应的反应混合物和试剂盒。本发明涉及引物依赖性核酸扩增反应，特别是DNA扩增反应如PCR，以及用于这些反应的引物，反应混合物和试剂盒以及使用它们的分析。

9. 发明公开

EP2917368A1 METHODS AND SYSTEMS FOR IDENTIFYING CONTAMINATION IN SAMPLES 审中-公开
标题翻译：方法和系统，用于确定污染样品
公开(公告)号：EP2917368A1
公开(公告)日：2015-09-16
申请号：EP13792832.1
申请日：2013-11-06
申请人： Good Start Genetics, Inc.
发明人： UMBARGER, Mark , PORRECA, Gregory
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6848 , C12Q1/6881 , C12Q2600/156 , C12Q2535/125 , C12Q2537/165
摘要： Methods and systems for determining if a sample has been contaminated with other genetic material, for example, from another sample in a parallel workflow. The methods and systems compare measured allele fractions to predetermined distributions of allele fractions in order to calculate a likelihood that the sample has been contaminated.

10. 发明授权

EP2391736B1 METHOD FOR QUANTIFICATION OF SMALL RNA SPECIES 有权转让
标题翻译：方法定量小RNA物种
公开(公告)号：EP2391736B1
公开(公告)日：2015-04-08
申请号：EP10706492.5
申请日：2010-02-02
申请人： Exiqon A/S
发明人： BUSK, Peter, Kamp
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6858 , C12Q2535/125 , C12Q2525/207 , C12Q2525/113 , C12Q2525/173 , C12Q2533/10

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式