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1. 发明申请

WO2006042272A3 ARTIFICIAL CORNEAL IMPLANT 审中-公开
标题翻译：人造牙科植入物
公开(公告)号：WO2006042272A3
公开(公告)日：2007-02-08
申请号：PCT/US2005036648
申请日：2005-10-05
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
发明人： MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附在生物分子上。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

2. 发明专利

CA2485338A1 ARTIFICIAL CORNEA 未知
公开(公告)号：CA2485338A1
公开(公告)日：2003-12-24
申请号：CA2485338
申请日：2003-06-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： BLUMENKRANZ MARK , WAYMOUTH ROBERT , SMITH ALAN J , TA CHRISTOPHER , HUIE PHILIP JR , NOOLANDI JAAN
IPC分类号： A61L27/00 , A61F20060101 , A61F2/14 , A61F2/16 , A61L27/34 , A61L27/54 , A61L27/56
摘要： An artificial cornea (10) including a core/skirt construct (12). The core/skirt (12) has a central core (14) and skirt (18) joined at the core/skirt interface (22). The core (14), which has a core periphery (16), a nd skirt (18) having a skirt periphery (21), are securely attached by interface (22). Skirt (18) can be porous. The central core (14) and the skirt (18) are configured to promote the growth of cells over their surfaces.

3. 发明申请

WO2007109134A3 INTRAOCULAR LENS IMPLANT 审中-公开
标题翻译：内窥镜植入物
公开(公告)号：WO2007109134A3
公开(公告)日：2008-07-03
申请号：PCT/US2007006634
申请日：2007-03-16
申请人： UNIV LELAND STANFORD JUNIOR , FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
发明人： FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
IPC分类号： A61F2/16
CPC分类号： A61L27/52 , A61F2/16 , A61F2/1635 , A61F2002/16905 , A61F2210/0061 , A61F2220/0008 , A61L2430/16
摘要： The present invention provides a hydrogel-based intraocular lens (110) capable of covalently binding to a lens capsule (130) upon implantation. The intraocular lens (1 10) is implanted through incision (120) in cornea (122) and into the lens capsule (130). The dehydrated intraocular lens (110) becomes fully swollen (114) within the capsule (130) which can then be controlled by zonules (140) to accommodate the curvature of the lens (140) to different distances.
摘要翻译：本发明提供一种在植入后能够共价结合透镜胶囊（130）的水凝胶型眼内透镜（110）。眼内透镜（110）通过切口（120）在角膜（122）中植入到晶状体囊（130）中。脱水的眼内透镜（110）在胶囊（130）内变得完全溶胀（114），然后可以通过小区（140）来控制，以将镜片（140）的曲率适应不同的距离。

4. 发明申请

WO2006116137A2 ARTIFICIAL CORNEA 审中-公开
标题翻译：人造石
公开(公告)号：WO2006116137A2
公开(公告)日：2006-11-02
申请号：PCT/US2006015173
申请日：2006-04-21
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , TA CHRISTOPHER , FAROOQUI NABEEL , CURTIS FRANK W , KOH WON-GUN , KO JUNGMIN , NOOLANDI JAAN , CARRASCO MICHAEL R
发明人： MYUNG DAVID , TA CHRISTOPHER , FAROOQUI NABEEL , CURTIS FRANK W , KOH WON-GUN , KO JUNGMIN , NOOLANDI JAAN , CARRASCO MICHAEL R
IPC分类号： A61K35/30 , A61F2/14
CPC分类号： A61F2/142 , A61F2/15 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxy ethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
摘要翻译：本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（2-羟乙基丙烯酸酯）（PHEA）制成。在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。人造角膜植入物还可以具有相互扩散区域，其中裙部组件与芯部件互穿，反之亦然。在优选的实施方案中，生物分子连接到裙部，中心芯或两者。这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。优选地，生物分子以空间选择性方式连接。本发明还提供了一种使用光刻制造人造角膜植入物的方法。

5. 发明申请

WO03105725A2 ARTIFICIAL CORNEA 审中-公开
标题翻译：人造角
公开(公告)号：WO03105725A2
公开(公告)日：2003-12-24
申请号：PCT/US0319312
申请日：2003-06-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： NOOLANDI JAAN , TA CHRISTOPHER , HUIE PHILIP JR , SMITH ALAN J , WAYMOUTH ROBERT , BLUMENKRANZ MARK
IPC分类号： A61L27/00 , A61F20060101 , A61F2/14 , A61F2/16 , A61L27/34 , A61L27/54 , A61L27/56 , A61F
CPC分类号： B82Y30/00 , A61F2/142 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/406 , A61L2300/414 , A61L2300/43 , A61L2300/432 , C08L89/06
摘要： The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.
摘要翻译：本发明提供适合用作人造角膜的植入物，以及制造和使用这种植入物的方法。具有本发明特征的人造角膜可以是两相人造角膜，也可以是三相人造角膜。这些人造角膜具有柔性的，光学透明的中心芯和亲水的多孔裙部，两者都是生物相容的并且允许组织整合。三相人造角膜还将具有在芯部和裙部之间的界面区域。人造角膜具有高度的眼部耐受性，并且允许组织整合到裙部中并且允许在假体表面上的上皮细胞生长。生物相容材料的使用避免了角膜移植固有的疾病传播的风险，并且起作用以使术后炎症最小化，从而降低植入人工角膜后的组织坏死的机会或严重程度。

6. 发明公开

EP1809207A4 ARTIFICIAL CORNEAL IMPLANT 审中-公开
标题翻译：人工角膜植入
公开(公告)号：EP1809207A4
公开(公告)日：2010-04-28
申请号：EP05807352
申请日：2005-10-05
申请人： UNIV LELAND STANFORD JUNIOR
发明人： MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
IPC分类号： A61F2/16 , A61F2/14 , A61L27/26 , A61L27/54 , C08L33/08 , C08L71/02
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.

7. 发明申请

WO2007133266A3 INTERPENETRATING POLYMER NETWORK HYDROGEL CORNEAL PROSTHESIS 审中-公开
标题翻译：互聚聚合物网络水力发电机
公开(公告)号：WO2007133266A3
公开(公告)日：2008-12-11
申请号：PCT/US2006047878
申请日：2006-12-14
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , TA CHRISTOPHER , FRANK CURTIS W , KOH WON-GUN , NOOLANDI JAAN
发明人： MYUNG DAVID , TA CHRISTOPHER , FRANK CURTIS W , KOH WON-GUN , NOOLANDI JAAN
IPC分类号： C08G18/34 , C08J3/24 , C08L33/24 , C12N5/071
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和耐蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

8. 发明专利

AU2006239919A1 Artificial cornea 未知
公开(公告)号：AU2006239919A1
公开(公告)日：2006-11-02
申请号：AU2006239919
申请日：2006-04-21
申请人： UNIV LELAND STANFORD JUNIOR
发明人： FAROOQUI NABEEL , KOH WON-GUN , TA CHRISTOPHER , CARRASCO MICHAEL R , KO JUNGMIN , NOOLANDI JAAN , CURTIS FRANK W , MYUNG DAVID
IPC分类号： A61K35/30 , A61F2/14 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.

9. 发明专利

AU2003276137A1 ARTIFICIAL CORNEA 未知
公开(公告)号：AU2003276137A1
公开(公告)日：2003-12-31
申请号：AU2003276137
申请日：2003-06-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： NOOLANDI JAAN , TA CHRISTOPHER , HUIE PHILIP JR , SMITH ALAN J , WAYMOUTH ROBERT , BLUMENKRANZ MARK
IPC分类号： A61L27/00 , A61F20060101 , A61F2/14 , A61F2/16 , A61L27/34 , A61L27/54 , A61L27/56
摘要： The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.

10. 发明公开

EP1874234A4 ARTIFICIAL CORNEA 审中-公开
标题翻译：人工角膜
公开(公告)号：EP1874234A4
公开(公告)日：2008-06-04
申请号：EP06751038
申请日：2006-04-21
申请人： UNIV LELAND STANFORD JUNIOR
发明人： MYUNG DAVID , TA CHRISTOPHER , FAROOQUI NABEEL , CURTIS FRANK W , KOH WON-GUN , KO JUNGMIN , NOOLANDI JAAN , CARRASCO MICHAEL R
IPC分类号： A61F2/16
CPC分类号： A61F2/142 , A61F2/15 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxyethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.

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