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1. 发明申请

WO2006042272A3 ARTIFICIAL CORNEAL IMPLANT 审中-公开
标题翻译：人造牙科植入物
公开(公告)号：WO2006042272A3
公开(公告)日：2007-02-08
申请号：PCT/US2005036648
申请日：2005-10-05
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
发明人： MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附在生物分子上。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

2. 发明申请

WO2007109134A3 INTRAOCULAR LENS IMPLANT 审中-公开
标题翻译：内窥镜植入物
公开(公告)号：WO2007109134A3
公开(公告)日：2008-07-03
申请号：PCT/US2007006634
申请日：2007-03-16
申请人： UNIV LELAND STANFORD JUNIOR , FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
发明人： FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
IPC分类号： A61F2/16
CPC分类号： A61L27/52 , A61F2/16 , A61F2/1635 , A61F2002/16905 , A61F2210/0061 , A61F2220/0008 , A61L2430/16
摘要： The present invention provides a hydrogel-based intraocular lens (110) capable of covalently binding to a lens capsule (130) upon implantation. The intraocular lens (1 10) is implanted through incision (120) in cornea (122) and into the lens capsule (130). The dehydrated intraocular lens (110) becomes fully swollen (114) within the capsule (130) which can then be controlled by zonules (140) to accommodate the curvature of the lens (140) to different distances.
摘要翻译：本发明提供一种在植入后能够共价结合透镜胶囊（130）的水凝胶型眼内透镜（110）。眼内透镜（110）通过切口（120）在角膜（122）中植入到晶状体囊（130）中。脱水的眼内透镜（110）在胶囊（130）内变得完全溶胀（114），然后可以通过小区（140）来控制，以将镜片（140）的曲率适应不同的距离。

3. 发明申请

WO2007133266A3 INTERPENETRATING POLYMER NETWORK HYDROGEL CORNEAL PROSTHESIS 审中-公开
标题翻译：互聚聚合物网络水力发电机
公开(公告)号：WO2007133266A3
公开(公告)日：2008-12-11
申请号：PCT/US2006047878
申请日：2006-12-14
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , TA CHRISTOPHER , FRANK CURTIS W , KOH WON-GUN , NOOLANDI JAAN
发明人： MYUNG DAVID , TA CHRISTOPHER , FRANK CURTIS W , KOH WON-GUN , NOOLANDI JAAN
IPC分类号： C08G18/34 , C08J3/24 , C08L33/24 , C12N5/071
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和耐蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

4. 发明申请

WO2007108842A3 INTERPENETRATING POLYMER NETWORK HYDROGEL CONTACT LENSES 审中-公开
标题翻译： INTERPENETRATING聚合物网络HYDROGEL接触镜
公开(公告)号：WO2007108842A3
公开(公告)日：2008-02-28
申请号：PCT/US2006047170
申请日：2006-12-08
申请人： BOARD TRUSTEES OF THE LELAND S , MYUNG DAVID , NOOLANDI JAAN , TA CHRISTOPHER , FRANK CURTIS W
发明人： MYUNG DAVID , NOOLANDI JAAN , TA CHRISTOPHER , FRANK CURTIS W
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08L51/08
摘要： The present invention, provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网络水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

5. 发明申请

WO2010068295A3 THREE-DIMENSIONALLY SHAPED INTERPENETRATING NETWORK HYDROGELS 审中-公开
标题翻译：三维形状互穿网络水凝胶
公开(公告)号：WO2010068295A3
公开(公告)日：2010-10-21
申请号：PCT/US2009006525
申请日：2009-12-11
申请人： UNIV LELAND STANFORD JUNIOR , HUIE PHILIP , WATERS DALE JON , FRANK CURTIS W , TA CHRISTOPHER N , TOM ARIANE C
发明人： HUIE PHILIP , WATERS DALE JON , FRANK CURTIS W , TA CHRISTOPHER N , TOM ARIANE C
IPC分类号： A61L27/52 , A61F2/14 , A61L27/14 , G02B1/04
CPC分类号： A61L27/52 , A61L27/26 , A61L2430/16 , G02B1/041 , C08L73/02 , C08L33/02 , C08L71/02
摘要： Three-dimensionally (3-D) shaped interpenetrating double network (IPN) hydrogel based on a first network and a second network are provided. The 3- D shape is characterized by a non-uniform distribution of the second network (e.g. carboxylic acid groups) when in hydrated state. The 3-D shape can further be characterized by changes in the radius of curvature of the shape. The 3-D IPN hydrogel is created by applying a non-uniform illumination pattern to polymerize the second network of monomers within a layer of a first network. In hydrated state, the second network causes a swelling force that is resisted by the first network. The non-uniformal distribution of the second network with the first network is responsible for the 3-D of the resulting IPN. The invention can find use in ophthalmic applications as well as non- ophthalmic applications.
摘要翻译：提供了基于第一网络和第二网络的三维（3-D）形互穿双网络（IPN）水凝胶。 3-D形状的特征在于当处于水合状态时第二网络的不均匀分布（例如羧酸基团）。 3D形状还可以通过形状的曲率半径的变化来表征。三维IPN水凝胶通过应用非均匀照明图案来聚合第一网络层内的第二单体网络而形成。在水合状态下，第二网络引起第一网络抵抗的膨胀力。第二个网络与第一个网络的非均匀分布负责所得到的IPN的3-D。本发明可以用于眼科应用以及非眼科应用。

6. 发明申请

WO2008130604A2 HYDROGEL ARTHROPLASTY DEVICE 审中-公开
公开(公告)号：WO2008130604A2
公开(公告)日：2008-10-30
申请号：PCT/US2008004976
申请日：2008-04-17
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , KOURTIS LAMPROS , HARTMANN LAURA , FRANK CURTIS W , GOODMAN STUART B , CARTER DENNIS R
发明人： MYUNG DAVID , KOURTIS LAMPROS , HARTMANN LAURA , FRANK CURTIS W , GOODMAN STUART B , CARTER DENNIS R
IPC分类号： A61F2/30 , A61L27/52
CPC分类号： A61L27/52 , A61F2/30756 , A61F2/32 , A61F2/34 , A61F2/3603 , A61F2/38 , A61F2/3859 , A61F2/389 , A61F2002/30075 , A61F2002/30077 , A61F2002/30324 , A61F2002/30616 , A61F2002/30673 , A61F2002/3092 , A61F2002/30937 , A61F2002/30971 , A61F2002/3225 , A61F2002/3491 , A61F2002/4631 , A61F2210/0061 , A61F2210/0066 , A61F2250/0036 , A61F2310/00796 , A61L27/425 , A61L27/56
摘要： An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.
摘要翻译：提供了一种具有互穿聚合物网络（IPN）水凝胶的关节成形术装置，其通过溶胀变形硬化并且适于通过符合骨几何形状在关节中保持就位。应变硬化IPN水凝胶基于两个不同的网络：（1）通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络，和（2）非硅氧烷网络的可离子化单体。第二个网络在第一个网络的存在下被聚合和化学交联，并与第一个网络形成了物理交叉连接。在IPN中，第二网络中的化学交联程度小于第一网络中的化学交联度。使用盐水溶液（中性pH）来电离和膨胀第二网络。第二个网络的肿胀受到第一个网络的限制，导致IPN内有效的物理交叉链路的增加。

7. 发明申请

WO2009134414A2 DEVICES FOR THE TREATMENT OF WOUNDS AND METHODS AND KITS THEREOF 审中-公开
标题翻译：用于治疗创伤的装置及其方法及其工具
公开(公告)号：WO2009134414A2
公开(公告)日：2009-11-05
申请号：PCT/US2009002672
申请日：2009-04-29
申请人： UNIV LELAND STANFORD JUNIOR , BECK STAYCE , MYUNG DAVID , FRANK CURTIS W , COCHRAN JENNIFER R , LONGAKER MICHAEL T , YANG GEORGE P , LY DAPHNE P , MANDEL SHIRA G
发明人： BECK STAYCE , MYUNG DAVID , FRANK CURTIS W , COCHRAN JENNIFER R , LONGAKER MICHAEL T , YANG GEORGE P , LY DAPHNE P , MANDEL SHIRA G
IPC分类号： A61L15/22 , A61L15/60
CPC分类号： A61L15/60 , A61L15/225 , C08L71/02
摘要： Interpenetrating network hydrogels are described that may be incorporated into wound dressings and/or in implants. The properties of the interpenetrating network hydrogel may be tuned to control an amount of moisture in a wound environment. The devices, methods, and kits described herein may be adapted to treat a variety of wound types at a variety of healing stages over a range of time scales. Some hydrogels may be configured to deliver one or more vulnerary agents to a wound. The interpenetrating network hydrogels may also be adapted to control a rate and/or amount of moisture uptake so that the hydrogels may be used as expandable implants to expand tissue.
摘要翻译：描述了可以并入伤口敷料和/或植入物中的互穿网络水凝胶。可以调节互穿网络水凝胶的性质以控制伤口环境中的水分量。本文描述的装置，方法和试剂盒可适用于在多个时间范围内的各种愈合阶段处理各种伤口类型。一些水凝胶可以被配置成将一种或多种弱毒剂递送到伤口。互穿网络水凝胶还可以适于控制吸湿的速率和/或量，使得水凝胶可以用作可膨胀植入物以膨胀组织。

8. 发明申请

WO2009014615A3 AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITIONS AS ANTIVIRAL AGENTS 审中-公开
标题翻译： AMPHIPATHIC ALPHA-HELICAL PEPTIDE COMPOSITION AS ANTIVIRAL AGENTS
公开(公告)号：WO2009014615A3
公开(公告)日：2009-12-03
申请号：PCT/US2008008627
申请日：2008-07-14
申请人： UNIV LELAND STANFORD JUNIOR , GLENN JEFFREY S , CHO NAM-JOON , FRANK CURTIS W , CHEONG KWANG HO
发明人： GLENN JEFFREY S , CHO NAM-JOON , FRANK CURTIS W , CHEONG KWANG HO
IPC分类号： A61K38/16 , A61L2/16 , A61L31/10
CPC分类号： A61K38/162 , A01N37/46 , A61L2/0082 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/408
摘要： The invention features methods and compositions that exploit the ability of amphipathic alpha-helical (AH) peptides to cause disruption of lipid-contaming vesicles, such as enveloped viruses, in a size-dependent manner. In a preferred embodiment, the AH peptides have an aminoacid sequence of the N-terminal amphipathic alpha-helix of the hepatitis C virus (HCV) nonstructural protein NS5A.
摘要翻译：本发明的特征在于利用两亲性α-螺旋（AH）肽以大小依赖的方式引起脂质连续囊泡如包膜病毒破坏的能力的方法和组合物。在优选的实施方案中，AH肽具有丙型肝炎病毒（HCV）非结构蛋白NS5A的N-末端两亲性α-螺旋的氨基酸序列。

9. 发明申请

WO2007142617A3 FABRICATION AND USE OF BIOCOMPATIBLE MATERIALS FOR TREATING AND REPAIRING HERNIATED SPINAL DISCS 审中-公开
标题翻译：生物化学材料的治疗和使用用于治疗和修复接受治疗的脊髓损伤
公开(公告)号：WO2007142617A3
公开(公告)日：2008-12-04
申请号：PCT/US2006018856
申请日：2006-05-15
申请人： SARATECH INC , UNIV LELAND STANFORD JUNIOR , KIM DANIEL H , FRANK CURTIS W
发明人： KIM DANIEL H , FRANK CURTIS W
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/7095 , A61B17/8836 , A61F2/441 , A61F2/4611 , A61F2002/0086 , A61F2002/009 , A61F2002/30032 , A61F2002/30062 , A61F2002/30075 , A61F2002/30224 , A61F2002/30235 , A61F2002/30583 , A61F2002/30588 , A61F2002/30601 , A61F2002/30677 , A61F2002/3092 , A61F2002/3093 , A61F2002/30932 , A61F2002/30971 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4685 , A61F2210/0004 , A61F2210/0061 , A61F2210/0085 , A61F2230/0069 , A61F2250/003 , A61L27/18 , A61L27/56 , A61L2400/06 , A61L2430/38 , C08L75/04
摘要： The present invention involves the fabrication and use of biocompatible polymers that are injected percutaneously into the inner portion of a defective region of a spinal disc and swell or expand or subsequently cure in situ to form a disc nucleus prosthesis. The polymers may be synthetic or natural (e.g., collagen), and may be provided in forms including, but not limited to hydrogels, compressible foams, cords, balloons, etc. Subsequent to injection into a target space or void within the disc, one or more cell binding agents, growth factors, and/or drugs on or within the cured polymer then interact with the remaining portion of the disc to support tissue ingrowth and to achieve a higher probability of biological mimicking.
摘要翻译：本发明涉及生物相容性聚合物的制造和使用，所述生物相容性聚合物经皮注射到脊椎盘的缺陷区域的内部并膨胀或膨胀或随后在原位固化以形成椎间盘假体。聚合物可以是合成的或天然的（例如胶原），并且可以以包括但不限于水凝胶，可压缩泡沫，帘线，气球等的形式提供。在注入到盘中的目标空间或空隙中之后，一个或更多的细胞粘附剂，生长因子和/或药物在固化的聚合物上或内部，然后与盘的剩余部分相互作用以支持组织向内生长并实现更高的生物模拟概率。

10. 发明申请

WO2006110350A3 METHOD OF FABRICATING LIPID BILAYER MEMBRANES ON SOLID SUPPORTS 审中-公开
标题翻译：在固体支撑物上制备脂质双层膜的方法
公开(公告)号：WO2006110350A3
公开(公告)日：2007-03-15
申请号：PCT/US2006012085
申请日：2006-03-29
申请人： UNIV LELAND STANFORD JUNIOR , CHO NAM-JOON , FRANK CURTIS W
发明人： CHO NAM-JOON , FRANK CURTIS W
IPC分类号： C12Q1/00
CPC分类号： G01N33/533 , B82Y5/00 , G01N33/554 , Y10T428/31678
摘要： The present invention provides a method of producing a planar lipid bilayer on a solid support. With this method, a solution of lipid vesicles is first deposited on the solid support. Next, the lipid vesicles are destabilized by adding an amphipathic peptide solution to the lipid vesicle solution. This destabilization leads to production of a planar lipid bilayer on the solid support. The present invention also provides a supported planar lipid bilayer, where the planar lipid bilayer is made of naturally occurring lipids and the solid support is made of unmodified gold or titanium oxide. Preferably, the supported planar lipid bilayer is continuous. The planar lipid bilayer may be made of any naturally occurring lipid or mixture of lipids, including but not limited to phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, cardiolipin, cholesterol, and sphingomyelin.
摘要翻译：本发明提供了一种在固体支持物上制备平面脂双层的方法。使用该方法，首先将脂质囊泡溶液沉积在固体支持物上。接下来，通过向脂质囊泡溶液中加入两亲肽溶液使脂质囊泡不稳定。这种不稳定性导致在固体支持物上产生平面脂双层。本发明还提供了一种支撑的平面脂质双层，其中平面脂质双层由天然存在的脂质制成，并且固体支持物由未改性的金或氧化钛制成。优选地，支撑的平面脂质双层是连续的。平面脂质双层可以由任何天然存在的脂质或脂质混合物制成，包括但不限于磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰丝氨酸，磷脂酰肌醇，心磷脂，胆固醇和鞘磷脂。

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