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    • 3. 发明申请
    • HYDROGEL-METAL ASSEMBLY
    • 氢化金属组件
    • WO2008097616A1
    • 2008-08-14
    • PCT/US2008/001642
    • 2008-02-06
    • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYMYUNG, DavidMUIR, Beinn, V.O.FRANK, Curtis, W.
    • MYUNG, DavidMUIR, Beinn, V.O.FRANK, Curtis, W.
    • B32B15/04
    • A61L27/34A61L27/06A61L2400/18B32B15/04Y10T428/24355Y10T428/269Y10T428/31536Y10T428/31678
    • A hydrogel-metal assembly is provided. An intervening polymer network is used to bond together a water-swollen hydrogel layer and a biocompatible surface-modified metallic layer. The hydrogel layer is a water-swollen hydrogel layer of at least two interpenetrating polymers. The surface of the biocompatible surface-modified metallic layer is surface-modified with an inorganic material. The intervening polymer network has been chemically grafted to the inorganic material of the biocompatible surface-modified metallic layer through bi-functional linker molecules. The intervening polymer network is further physically or chemically cross-linked with the polymers of the water-swollen hydrogel. The hydrogel-metal assembly can be adapted to form a medical device, medical implant, an artificial implant, an orthopedic implant, or at least as part of a joint. The hydrogel-metal assembly is attractive for use as such implants or devices due to its characteristics such as, for example, low coefficient of friction, impact-absorption capacity or strength, and/or biocompatibility.
    • 提供了一种水凝胶 - 金属组件。 中间聚合物网络用于将水溶胀的水凝胶层和生物相容的表面改性金属层结合在一起。 水凝胶层是至少两个互穿聚合物的水溶胀水凝胶层。 生物相容性表面改性金属层的表面用无机材料进行表面改性。 中间聚合物网络已经通过双功能连接分子化学接枝到生物相容性表面改性金属层的无机材料上。 中间聚合物网络进一步与水溶胀的水凝胶的聚合物物理或化学交联。 水凝胶 - 金属组件可以适于形成医疗装置,医疗植入物,人造植入物,矫形植入物,或者至少作为关节的一部分。 水凝胶 - 金属组件由于其特征例如低摩擦系数,冲击吸收能力或强度和/或生物相容性而具有吸引力用于这种植入物或装置。
    • 5. 发明申请
    • ARTIFICIAL CORNEA
    • 人造石
    • WO2006116137A2
    • 2006-11-02
    • PCT/US2006015173
    • 2006-04-21
    • UNIV LELAND STANFORD JUNIORMYUNG DAVIDTA CHRISTOPHERFAROOQUI NABEELCURTIS FRANK WKOH WON-GUNKO JUNGMINNOOLANDI JAANCARRASCO MICHAEL R
    • MYUNG DAVIDTA CHRISTOPHERFAROOQUI NABEELCURTIS FRANK WKOH WON-GUNKO JUNGMINNOOLANDI JAANCARRASCO MICHAEL R
    • A61K35/30A61F2/14
    • A61F2/142A61F2/15A61K35/12
    • The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxy ethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
    • 本发明提供了一种人造角膜植入物,其具有光学透明的中心纤芯和围绕中心纤芯的多孔,亲水的,生物相容的裙部。 在一个实施方案中,中心芯由互穿双网络水凝胶制成,裙部由聚(2-羟乙基丙烯酸酯)(PHEA)制成。 在另一个实施例中,中心芯和裙部均由互穿双网络水凝胶制成。 人造角膜植入物还可以具有相互扩散区​​域,其中裙部组件与芯部件互穿,反之亦然。 在优选的实施方案中,生物分子连接到裙部,中心芯或两者。 这些生物分子可以是任何类型的生物分子,但优选支持上皮和/或成纤维细胞存活和生长的生物分子。 优选地,生物分子以空间选择性方式连接。 本发明还提供了一种使用光刻制造人造角膜植入物的方法。