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1. 发明申请

WO2007133266A2 INTERPENETRATING POLYMER NETWORK HYDROGEL CORNEAL PROSTHESIS 审中-公开
标题翻译：互聚聚合物网络水力发电机
公开(公告)号：WO2007133266A2
公开(公告)日：2007-11-22
申请号：PCT/US2006/047878
申请日：2006-12-14
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , TA, Christopher , FRANK, Curtis, W. , KOH, Won-gun , NOOLANDI, Jaan
发明人： MYUNG, David , TA, Christopher , FRANK, Curtis, W. , KOH, Won-gun , NOOLANDI, Jaan
IPC分类号： H01Q1/38
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和耐蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

2. 发明申请

WO2007133266A3 INTERPENETRATING POLYMER NETWORK HYDROGEL CORNEAL PROSTHESIS 审中-公开
标题翻译：互聚聚合物网络水力发电机
公开(公告)号：WO2007133266A3
公开(公告)日：2008-12-11
申请号：PCT/US2006047878
申请日：2006-12-14
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , TA CHRISTOPHER , FRANK CURTIS W , KOH WON-GUN , NOOLANDI JAAN
发明人： MYUNG DAVID , TA CHRISTOPHER , FRANK CURTIS W , KOH WON-GUN , NOOLANDI JAAN
IPC分类号： C08G18/34 , C08J3/24 , C08L33/24 , C12N5/071
CPC分类号： C12N5/0621 , A61F2/142 , A61F2/15 , A61L27/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/214 , A61L2300/23 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2430/16 , C12N2533/30 , C12N2533/54 , C08L71/02 , C08L33/08
摘要： The present invention provides materials that have high glucose and oxygen permeability, strength, water content, and resistance to protein adsorption. The materials include an interpenetrating polymer network (IPN) hydrogel that is coated with biomolecules. The IPN hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. Any biomolecules may be linked to the IPN hydrogels, but are preferably biomolecules that support the growth of cornea-derived cells. The material is designed to serve as a corneal prosthesis.
摘要翻译：本发明提供具有高葡萄糖和透氧性，强度，含水量和耐蛋白质吸附性的材料。这些材料包括涂覆有生物分子的互穿聚合物网络（IPN）水凝胶。 IPN水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。任何生物分子可以连接到IPN水凝胶，但优选是支持角膜衍生细胞生长的生物分子。该材料设计用作角膜假体。

3. 发明申请

WO2007108842A3 INTERPENETRATING POLYMER NETWORK HYDROGEL CONTACT LENSES 审中-公开
标题翻译： INTERPENETRATING聚合物网络HYDROGEL接触镜
公开(公告)号：WO2007108842A3
公开(公告)日：2008-02-28
申请号：PCT/US2006047170
申请日：2006-12-08
申请人： BOARD TRUSTEES OF THE LELAND S , MYUNG DAVID , NOOLANDI JAAN , TA CHRISTOPHER , FRANK CURTIS W
发明人： MYUNG DAVID , NOOLANDI JAAN , TA CHRISTOPHER , FRANK CURTIS W
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , C08L51/08
摘要： The present invention, provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网络水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

4. 发明申请

WO2008100617A1 STRAIN-HARDENED INTERPENETRATING POLYMER NETWORK HYDROGEL 审中-公开
标题翻译：应变硬化介质聚合物网络水凝胶
公开(公告)号：WO2008100617A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/002107
申请日：2008-02-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , HARTMANN, Laura , NOOLANDI, Jaan , TA, Christopher, N. , FRANK, Curtis, W.
发明人： MYUNG, David , HARTMANN, Laura , NOOLANDI, Jaan , TA, Christopher, N. , FRANK, Curtis, W.
IPC分类号： A61L27/52 , A61L31/04
CPC分类号： A61L27/52 , A61L27/48 , C08F265/04 , C08F283/00 , C08F283/06 , C08F290/00 , C08F290/06 , C08L51/003 , C08L2666/02
摘要： A strain-hardened interpenetrating polymer network (IPN) hydrogel is provided The IPN hydrogel is based on two different networks The first network is a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups The second network is a non-silicone network of ionizable monomers The second network has been polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network An aqueous salt solution having a neutral pH is used to ionize and swell the second network in the interpenetrating polymer network The swelling of the second network is constrained by the first network, and this constraining results in an increase in effective physical cross-links within the IPN, and increases its elastic modulus The strain-hardened IPN hydrogel is useful for medical, industrial, and personal hygiene purposes
摘要翻译：提供了应变硬化的互穿聚合物网络（IPN）水凝胶IPN水凝胶基于两个不同的网络。第一个网络是通过其端基聚合化学交联的预先形成的亲水非离子遥爪大分子单体的非硅氧烷网络第二网络是可离子化单体的非硅氧烷网络第二网络已经在第一网络存在下被聚合和化学交联并与第一网络形成了物理交联。具有中性pH的盐水溶液是用于电离和膨胀互穿聚合物网络中的第二网络第二网络的溶胀受第一网络约束，这种约束导致IPN内有效物理交联的增加，并增加其弹性模量应变硬化IPN水凝胶可用于医疗，工业和个人卫生目的

5. 发明申请

WO2007109134A3 INTRAOCULAR LENS IMPLANT 审中-公开
标题翻译：内窥镜植入物
公开(公告)号：WO2007109134A3
公开(公告)日：2008-07-03
申请号：PCT/US2007006634
申请日：2007-03-16
申请人： UNIV LELAND STANFORD JUNIOR , FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
发明人： FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
IPC分类号： A61F2/16
CPC分类号： A61L27/52 , A61F2/16 , A61F2/1635 , A61F2002/16905 , A61F2210/0061 , A61F2220/0008 , A61L2430/16
摘要： The present invention provides a hydrogel-based intraocular lens (110) capable of covalently binding to a lens capsule (130) upon implantation. The intraocular lens (1 10) is implanted through incision (120) in cornea (122) and into the lens capsule (130). The dehydrated intraocular lens (110) becomes fully swollen (114) within the capsule (130) which can then be controlled by zonules (140) to accommodate the curvature of the lens (140) to different distances.
摘要翻译：本发明提供一种在植入后能够共价结合透镜胶囊（130）的水凝胶型眼内透镜（110）。眼内透镜（110）通过切口（120）在角膜（122）中植入到晶状体囊（130）中。脱水的眼内透镜（110）在胶囊（130）内变得完全溶胀（114），然后可以通过小区（140）来控制，以将镜片（140）的曲率适应不同的距离。

6. 发明申请

WO2007109134A2 INTRAOCULAR LENS IMPLANT 审中-公开
标题翻译：内窥镜植入物
公开(公告)号：WO2007109134A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006634
申请日：2007-03-16
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , FRANK, Curtis, W. , TA, Christopher , MYUNG, David , NOOLANDI, Jaan , CARRASCO, Michael, R. , KOH, Won-gun
发明人： FRANK, Curtis, W. , TA, Christopher , MYUNG, David , NOOLANDI, Jaan , CARRASCO, Michael, R. , KOH, Won-gun
IPC分类号： A61F2/16
CPC分类号： A61L27/52 , A61F2/16 , A61F2/1635 , A61F2002/16905 , A61F2210/0061 , A61F2220/0008 , A61L2430/16
摘要： The present invention provides a hydrogel-based intraocular lens (IOL) implant that can covalently attach to a lens capsule on implantation into an eye. The inventive IOL has a high refractive index, high elasticity, and is of a similar size to a naturally occurring lens. In addition, the IOL can be implanted in a smaller, dehydrated state, allowing the IOL to be 1 placed in the lens capsule with a small incision (up to about 1/10 the. volume of the IOL). Exposure to fluid can then initiate rapid swelling of the dried polymer to the shape and dimensions of a natural lens, with full occupation of the lens capsule. Upon equilibrium swelling, the IOL can then make contact with the inner aspect of the lens capsule and covalently bind to it. By this attachment process, the IOL may accommodate in a manner identical to that of the natural lens.
摘要翻译：本发明提供一种水凝胶型眼内透镜（IOL）植入物，其可以植入眼睛中共价连接到晶状体囊。本发明的IOL具有高折射率，高弹性，并且具有与天然存在的透镜相似的尺寸。此外，IOL可以植入更小的脱水状态，允许IOL以小切口（高达IOL的约1/10体积）放置在镜片胶囊中。然后暴露于流体可以引发干燥的聚合物快速膨胀到天然晶状体的形状和尺寸，完全占据晶状体囊。在平衡肿胀时，IOL然后可以与镜片胶囊的内部部分接触并共价结合。通过该附接过程，IOL可以以与天然镜片相同的方式容纳。

7. 发明申请

WO2007108842A2 INTERPENETRATING POLYMER NETWORK HYDROGEL CONTACT LENSES 审中-公开
标题翻译： INTERPENETRATING聚合物网络HYDROGEL接触镜
公开(公告)号：WO2007108842A2
公开(公告)日：2007-09-27
申请号：PCT/US2006/047170
申请日：2006-12-08
申请人： THE BOARD TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , NOOLANDI, Jaan , TA, Christopher , FRANK, Curtis, W.
发明人： MYUNG, David , NOOLANDI, Jaan , TA, Christopher , FRANK, Curtis, W.
IPC分类号： A61F2/14
CPC分类号： G02B1/043 , C08L51/08
摘要： The present invention, provides interpenetrating polymer network hydrogels that have high oxygen permeability, strength, water content, and resistance to protein adsorption. The hydrogels include two interpenetrating polymer networks. The first polymer network is based on a hydrophilic telechelic macromonomer. The second polymer network is based on a hydrophilic monomer. The hydrophilic monomer is polymerized and cross-linked to form the second polymer network in the presence of the first polymer network. The telechelic macromonomer preferably has a molecular weight of between about 575 Da and about 20,000 Da. Mixtures of molecular weights may also be used. In a preferred embodiment, the hydrophilic telechelic macromonomer is PEG-diacrylate or PEG-dimethacrylate and the hydrophilic monomer is an acrylic-based monomer. The material is designed to serve as a contact lens.
摘要翻译：本发明提供了具有高透氧性，强度，含水量和耐蛋白质吸附性的互穿聚合物网络水凝胶。水凝胶包括两个互穿聚合物网络。第一个聚合物网络是基于亲水的遥爪大分子单体。第二聚合物网络基于亲水性单体。在第一聚合物网络的存在下，亲水单体聚合并交联以形成第二聚合物网络。遥爪大分子单体的分子量优选为约575Da至约20,000Da。也可以使用分子量的混合物。在优选的实施方案中，亲水遥爪大分子单体是PEG-二丙烯酸酯或PEG-二甲基丙烯酸酯，亲水性单体是丙烯酸类单体。该材料被设计成用作隐形眼镜。

8. 发明申请

WO2006042272A3 ARTIFICIAL CORNEAL IMPLANT 审中-公开
标题翻译：人造牙科植入物
公开(公告)号：WO2006042272A3
公开(公告)日：2007-02-08
申请号：PCT/US2005036648
申请日：2005-10-05
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
发明人： MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附在生物分子上。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

9. 发明申请

WO2003068403A1 DEVICE TO PRINT BIOFLUIDS 审中-公开
标题翻译：打印生物流的设备
公开(公告)号：WO2003068403A1
公开(公告)日：2003-08-21
申请号：PCT/US2003/004192
申请日：2003-02-12
申请人： FEMTODROP CORPORATION , NOOLANDI, Jaan
发明人： NOOLANDI, Jaan
IPC分类号： B01L3/02
CPC分类号： B01L3/0268 , B01J2219/00315 , B01J2219/0036 , B01L3/50853 , B01L2300/04 , B01L2400/027 , C40B60/14 , Y10T436/2575
摘要： An apparatus and method of printing microarrays by ejecting droplets of electrically conducting liquids from wells (12) onto a substrate (21) on top of a charged plate (20) using electrodes (18) inserted into the wells (12).
摘要翻译：一种通过使用插入孔（12）中的电极（18）将来自阱（12）的液滴喷射到带电板（20）顶部上的衬底（21）上的打印微阵列的装置和方法。

10. 发明申请

WO2009023276A1 SEQUENTIAL COUPLING OF BIOMOLECULE LAYERS TO POLYMERS 审中-公开
标题翻译：生物分子层向聚合物的顺序耦合
公开(公告)号：WO2009023276A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/009806
申请日：2008-08-15
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , BECK, Stayce , NOOLANDI, Jaan , TA, Christopher, N. , COCHRAN, Jennifer, R. , FRANK, Curtis, W.
发明人： MYUNG, David , BECK, Stayce , NOOLANDI, Jaan , TA, Christopher, N. , COCHRAN, Jennifer, R. , FRANK, Curtis, W.
IPC分类号： A61L27/14 , A61L27/52 , A61L27/54 , A61F2/14
CPC分类号： A61L27/34 , A61L15/32 , A61L27/14 , A61L27/48 , C08L89/00
摘要： A bio-mimetic or bio-implantable material based on a sequential process of coupling biomolecule layers to a polymer layer is provided. In general, the material could be based on two or more biomolecule layers starting with one of the layers covalently linked to the polymer layer via cross-linkers and the other layers sequentially and covalently linked using cross-linkers to the previously added layer. The polymer layer could be a hydrogel or an interpenetrating polymer network hydrogel. The first layer of biomolecules could be a collagen type, fibronectin, laminin, extracellular matrix protein, or any combinations thereof. The second layer of biomolecules typically is a growth factor, protein or stimulant. The cross-linkers are either water soluble or insoluble bifunctional cross-linkers or azide-active-ester crosslinkers. The material and process as taught in this invention are useful in the field of tissue engineering and wound healing.
摘要翻译：提供了基于将生物分子层耦合到聚合物层的顺序方法的生物模拟或生物可植入材料。通常，该材料可以基于两个或更多个生物分子层，其起始于通过交联剂共价连接到聚合物层的层之一，并且其它层使用交联剂顺序并共价连接到先前添加的层。聚合物层可以是水凝胶或互穿聚合物网络水凝胶。第一层生物分子可以是胶原型，纤连蛋白，层粘连蛋白，细胞外基质蛋白或其任何组合。第二层生物分子通常是生长因子，蛋白质或兴奋剂。交联剂是水溶性或不溶性双功能交联剂或叠氮化物 - 活性酯交联剂。本发明教导的材料和方法可用于组织工程和伤口愈合领域。

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