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1. 发明申请

WO2007022403A3 OCULAR GENE THERAPY USING AVALANCHE-MEDIATED TRANSFECTION 审中-公开
标题翻译：使用AVALANCHE-MEDIATED TRANSFECTION的OCULAR GENE THERAPY
公开(公告)号：WO2007022403A3
公开(公告)日：2010-04-22
申请号：PCT/US2006032249
申请日：2006-08-15
申请人： UNIV LELAND STANFORD JUNIOR , CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
发明人： CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , C07K14/811
摘要： The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma discharge between an electrode and the surrounding medium. The formation of a vapor bubble generates mechanical stress. Plasma discharge through the ionized vapor in the bubble enables connectivity between the electrode and the surrounding medium, so that mechanical stress and electric field are applied simultaneously, which results in permeabilization of the cells or tissue. This permeabilization in turn allows the nucleic acid to enter the cell or tissue. Cells or tissue containing the nucleic acid are then transplanted into an ocular region of the subject.
摘要翻译：本发明提供了治疗受试者眼部疾病的方法。在第一步骤中，将核酸引入细胞或组织。通过电子雪崩转染引入核酸。利用这种技术，高电场在电极和周围介质之间引起蒸汽气泡和等离子体放电。气泡的形成产生机械应力。通过气泡中的电离蒸汽的等离子体放电使得电极和周围介质之间能够连接，使得同时施加机械应力和电场，这导致细胞或组织的透化。这种渗透反过来又允许核酸进入细胞或组织。然后将含有核酸的细胞或组织移植到受试者的眼部区域。

2. 发明公开

EP1530449A4 ARTIFICIAL CORNEA 审中-公开
标题翻译：人工角膜
公开(公告)号：EP1530449A4
公开(公告)日：2006-05-03
申请号：EP03742068
申请日：2003-06-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： NOOLANDI JAAN , TA CHRISTOPHER , HUIE PHILIP JR , SMITH ALAN J , WAYMOUTH ROBERT , BLUMENKRANZ MARK
IPC分类号： A61F2/16 , A61L27/00 , A61F20060101 , A61F2/14 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： B82Y30/00 , A61F2/142 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/406 , A61L2300/414 , A61L2300/43 , A61L2300/432 , C08L89/06
摘要： The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.

3. 发明专利

CA2515830A1 SELF-SUFFICIENT RETINAL PROSTHESIS POWERED BY INTRAOCULAR PHOTOVOLTAIC CELLS 未知
公开(公告)号：CA2515830A1
公开(公告)日：2004-09-02
申请号：CA2515830
申请日：2004-01-23
申请人： UNIV LELAND STANFORD JUNIOR
发明人： BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER
IPC分类号： A61F20060101 , A61F2/14 , A61N1/08 , A61N1/36 , A61N1/372
摘要： A self-sufficient retinal prosthesis powered by intra-ocular photovoltaic cells illuminated only by ambient light is provided. Photovoltaic cells can be disposed at the periphery of the retina or in the anterior chamber of the eye. An adaptive retinal prosthesis is also provided, such that the number of pixels energized in the prosthesis is selected according to the variable available power from ambient light.

4. 发明申请

WO2004073547A3 SELF-SUFFICIENT RETINAL PROSTHESIS POWERED BY INTRAOCULAR PHOTOVOLTAIC CELLS 审中-公开
标题翻译：自发性紫外线照射引发的自发性后遗症
公开(公告)号：WO2004073547A3
公开(公告)日：2005-07-28
申请号：PCT/US2004001892
申请日：2004-01-23
申请人： UNIV LELAND STANFORD JUNIOR
发明人： PALANKER DANIEL V , VANKOV ALEXANDER , BLUMENKRANZ MARK
IPC分类号： A61F20060101 , A61F2/14 , A61N1/08 , A61N1/36 , A61N1/372
CPC分类号： A61N1/0543 , A61F2/02 , A61F2/14 , A61N1/36046 , A61N1/3787
摘要： A self-sufficient retinal prosthesis powered by intra-ocular photovoltaic cells illuminated only by ambient light is provided. Photovoltaic cells can be disposed at the periphery of the retina or in the anterior chamber of the eye. An adaptive retinal prosthesis is also provided, such that the number of pixels energized in the prosthesis is selected according to the variable available power from ambient light.
摘要翻译：提供由仅由环境光照亮的眼内光伏电池供电的自足视网膜假体。光伏电池可以设置在视网膜的周边或眼睛的前房中。还提供了自适应视网膜假体，使得根据来自环境光的可变功率来选择在假体中通电的像素的数量。

5. 发明申请

WO03105725A2 ARTIFICIAL CORNEA 审中-公开
标题翻译：人造角
公开(公告)号：WO03105725A2
公开(公告)日：2003-12-24
申请号：PCT/US0319312
申请日：2003-06-18
申请人： UNIV LELAND STANFORD JUNIOR
发明人： NOOLANDI JAAN , TA CHRISTOPHER , HUIE PHILIP JR , SMITH ALAN J , WAYMOUTH ROBERT , BLUMENKRANZ MARK
IPC分类号： A61L27/00 , A61F20060101 , A61F2/14 , A61F2/16 , A61L27/34 , A61L27/54 , A61L27/56 , A61F
CPC分类号： B82Y30/00 , A61F2/142 , A61L27/34 , A61L27/54 , A61L27/56 , A61L2300/406 , A61L2300/414 , A61L2300/43 , A61L2300/432 , C08L89/06
摘要： The invention provides implants suitable for use as an artificial cornea, and methods for making and using such implants. Artificial corneas having features of the invention may be two-phase artificial corneas, or may be three phase artificial corneas. These artificial corneas have a flexible, optically clear central core and a hydrophilic, porous skirt, both of which are biocompatible and allow for tissue integration. A three-phase artificial cornea will further have an interface region between the core and skirt. The artificial corneas have a high degree of ocular tolerance, and allow for tissue integration into the skirt and for epithelial cell growth over the surface of the prosthesis. The use of biocompatible material avoids the risk of disease transmission inherent with corneal transplants, and acts to minimize post-operative inflammation and so to reduce the chance or severity of tissue necrosis following implantation of the synthetic cornea onto a host eye.
摘要翻译：本发明提供适合用作人造角膜的植入物，以及制造和使用这种植入物的方法。具有本发明特征的人造角膜可以是两相人造角膜，也可以是三相人造角膜。这些人造角膜具有柔性的，光学透明的中心芯和亲水的多孔裙部，两者都是生物相容的并且允许组织整合。三相人造角膜还将具有在芯部和裙部之间的界面区域。人造角膜具有高度的眼部耐受性，并且允许组织整合到裙部中并且允许在假体表面上的上皮细胞生长。生物相容材料的使用避免了角膜移植固有的疾病传播的风险，并且起作用以使术后炎症最小化，从而降低植入人工角膜后的组织坏死的机会或严重程度。

6. 发明申请

WO02098357A3 MICROFABRICATED TISSUE AS A SUBSTRATE FOR PIGMENT EPITHELIUM TRANSPLANTATION 审中-公开
标题翻译：微晶组织作为上皮细胞移植的基质
公开(公告)号：WO02098357A3
公开(公告)日：2003-05-08
申请号：PCT/US0217363
申请日：2002-05-31
申请人： UNIV LELAND STANFORD JUNIOR , FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACY FRANCINE , LEE CHRISTINE , HUIE PHILIP JR , PALANKER DANIEL V , BILBAO KALAYAAN V
发明人： FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACY FRANCINE , LEE CHRISTINE , HUIE PHILIP JR , PALANKER DANIEL V , BILBAO KALAYAAN V
IPC分类号： C12M3/00 , A61F2/14 , A61L27/00 , A61L27/38 , C12N5/06 , A61F2/16
CPC分类号： A61F2/14 , A61L27/3604 , A61L27/3813 , A61L27/3839
摘要： Methods and apparatus for modifying membranous tissue 12 growing cells 14 on modified membranous tissue 12, and for transplantation of modified tissues 12 and modified tissues 12 with attached cells 14 are provided. In particular methods and apparatus for modifying membranous tissue 12 such as lens capsule tissue and inner limiting membrane tissue, for growing cells such as iris pigment epithelial IPE cells 14, retinal pigment epithelial RPE cells, stem cells, or other cells on modified membranous tissue 12, and for modifying membranous tissue 12 and growing cells 14 on biodegradable polymer substrates 16. A membranous surface 18 may be modified by contact with a stamp or by coating with a stencil having passages allowing access to portions of the membranous surface 18. A method of modifying membranous tissues 12 comprises depositing micropatterns of biomolecules onto membranous tissue 12 with a contacting surface such as a stamp.
摘要翻译：提供了用于修饰膜组织的方法和装置12，在修饰的膜组织12上生长细胞14，以及用于用附着细胞14移植修饰的组织12和修饰的组织12。特别是用于修饰膜组织12（例如晶状体囊组织和内限制膜组织）的方法和装置，用于在修饰的膜组织12上生长细胞如虹膜色素上皮细胞，视网膜色素上皮RPE细胞，视网膜色素上皮RPE细胞，干细胞或其他细胞，并且用于修饰可生物降解的聚合物基底16上的膜组织12和生长细胞14.膜表面18可以通过与印模接触或通过用具有允许进入膜表面18的部分的通道的模版涂布来改性。修饰膜组织12包括用诸如印模的接触表面将生物分子的微图案沉积到膜组织12上。

7. 发明公开

EP3003124A4 MODULAR LENS ADAPTERS FOR MOBILE ANTERIOR AND POSTERIOR SEGMENT OPHTHALMOSCOPY 无效转让
标题翻译： MODULARE LINSENADAPTERFÜRMOBILE OPHTHALMOSKOPIE DES VORDEREN UND DES HINTEREN AUGENSEGMENTS
公开(公告)号：EP3003124A4
公开(公告)日：2017-02-08
申请号：EP14804043
申请日：2014-05-30
申请人： UNIV LELAND STANFORD JUNIOR
发明人： MYUNG DAVID , CHANG ROBERT TIENHAN , HE LINGMIN , NUGENT ALEX , VAN HUYNH P , WONG IRA G , JAIS ALEXANDRE , BLUMENKRANZ MARK
IPC分类号： A61B3/10 , A61B3/117 , A61B3/12 , A61B3/14
CPC分类号： A61B3/1208 , A61B3/10 , A61B3/117 , A61B3/12 , A61B3/125 , A61B3/14 , A61B3/145 , A61B5/6898 , A61B2090/309 , A61B2560/0443
摘要： A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging device, a user is provided with tools for various mobile ophthalmoscopy imaging applications. Eye care practitioners can use their existing lenses to customize the modular lens adapter system in a cost-effective way, which allows for mobile and remote capture, viewing, and utilization of clinical images. The various modules are also adaptable to nearly any type of phone or tablet regardless of its dimensions or presence of a protective case. The invention also addresses the need for fewer, smaller, less expensive, and easier to use ophthalmic imaging equipment, which is further important in enabling a broad base of users.
摘要翻译：提供模块化镜头适配器系统或套件用于移动的前段和后段眼底镜检查。配备有各种镜头适配器模块，相应的镜片和移动成像装置，用户被提供用于各种移动眼底镜成像应用的工具。眼科护理人员可以使用其现有的镜头以经济高效的方式定制模块化镜头适配器系统，从而允许临床图像的移动和远程捕获，查看和利用。各种模块也适用于几乎任何类型的手机或平板电脑，无论其尺寸或保护壳的存在如何。本发明还涉及对更少，更小，更便宜和更易于使用的眼科成像设备的需求，这在使广泛的用户群体中更为重要。

8. 发明公开

EP1924698A4 OCULAR GENE THERAPY USING AVALANCHE-MEDIATED TRANSFECTION 审中-公开
标题翻译：基因治疗眼睛使用Avalanche可介导的转EYES
公开(公告)号：EP1924698A4
公开(公告)日：2010-12-15
申请号：EP06801803
申请日：2006-08-15
申请人： UNIV LELAND STANFORD JUNIOR
发明人： CHALBERG THOMAS W JR , BLUMENKRANZ MARK , PALANKER DANIEL V , VANKOV ALEXANDER , HUIE PHILIP JR , MARMOR MICHAEL F , CALOS MICHELE P
IPC分类号： C12N15/64 , C12M1/42 , C12N15/87
CPC分类号： C12N15/87 , C07K14/811

9. 发明专利

CA2913552A1 MODULAR LENS ADAPTERS FOR MOBILE ANTERIOR AND POSTERIOR SEGMENT OPHTHALMOSCOPY 未知
公开(公告)号：CA2913552A1
公开(公告)日：2014-12-04
申请号：CA2913552
申请日：2014-05-30
申请人： UNIV LELAND STANFORD JUNIOR
发明人： MYUNG DAVID , CHANG ROBERT TIENHAN , HE LINGMIN , NUGENT ALEX , VAN HUYNH P , WONG IRA G , JAIS ALEXANDRE , BLUMENKRANZ MARK
IPC分类号： A61B3/103
摘要： A modular lens adapter system or kit is provided for mobile anterior and posterior segment ophthalmoscopy. Equipped with various lens adapter modules, respective lenses and a mobile imaging device, a user is provided with tools for various mobile ophthalmoscopy imaging applications. Eye care practitioners can use their existing lenses to customize the modular lens adapter system in a cost-effective way, which allows for mobile and remote capture, viewing, and utilization of clinical images. The various modules are also adaptable to nearly any type of phone or tablet regardless of its dimensions or presence of a protective case. The invention also addresses the need for fewer, smaller, less expensive, and easier to use ophthalmic imaging equipment, which is further important in enabling a broad base of users.

10. 发明专利

AT340852T 未知
公开(公告)号：AT340852T
公开(公告)日：2006-10-15
申请号：AT02744712
申请日：2002-06-25
申请人： UNIV LELAND STANFORD JUNIOR
发明人： FISHMAN HARVEY A , BLUMENKRANZ MARK , BENT STACEY FRANCINE , BLOOM DAVID M , PETERMAN MARK C , ZIEBARTH JONATHAN M , LEE CHRISTINE , LENG THEODORE
IPC分类号： A61K9/22 , A61L27/00 , A61N1/05 , A61N1/36 , C12M1/42 , C12M3/00 , C12N5/0793 , G01N33/487
摘要： The invention provides microfabricated devices and methods for directing the growth of a cell process to form an artificial synapse. The devices are called artificial synapse chips. The artificial synapse comprises a nanofabricated aperture (about 50-100 nm in size) that connects the cell process to a chemical or electrical means of neuronal excitation. Such an aperture width mimics the length scales of a natural synapse and thus emphasizes the localized spatial relationship between a neuron and a stimulation source. The invention further provides devices and methods for regenerating a nerve fiber into an electrode. The invention thus provides a regeneration electrode that uses a novel neural interface for stimulation and that uses novel surface methods for directing neuronal growth making possible in vivo connection of the devices to neural circuitry in a retina and other anatomical locations.

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