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    • 4. 发明申请
    • ARTIFICIAL CORNEA
    • 人造石
    • WO2006116137A2
    • 2006-11-02
    • PCT/US2006015173
    • 2006-04-21
    • UNIV LELAND STANFORD JUNIORMYUNG DAVIDTA CHRISTOPHERFAROOQUI NABEELCURTIS FRANK WKOH WON-GUNKO JUNGMINNOOLANDI JAANCARRASCO MICHAEL R
    • MYUNG DAVIDTA CHRISTOPHERFAROOQUI NABEELCURTIS FRANK WKOH WON-GUNKO JUNGMINNOOLANDI JAANCARRASCO MICHAEL R
    • A61K35/30A61F2/14
    • A61F2/142A61F2/15A61K35/12
    • The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxy ethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
    • 本发明提供了一种人造角膜植入物,其具有光学透明的中心纤芯和围绕中心纤芯的多孔,亲水的,生物相容的裙部。 在一个实施方案中,中心芯由互穿双网络水凝胶制成,裙部由聚(2-羟乙基丙烯酸酯)(PHEA)制成。 在另一个实施例中,中心芯和裙部均由互穿双网络水凝胶制成。 人造角膜植入物还可以具有相互扩散区​​域,其中裙部组件与芯部件互穿,反之亦然。 在优选的实施方案中,生物分子连接到裙部,中心芯或两者。 这些生物分子可以是任何类型的生物分子,但优选支持上皮和/或成纤维细胞存活和生长的生物分子。 优选地,生物分子以空间选择性方式连接。 本发明还提供了一种使用光刻制造人造角膜植入物的方法。