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1. 发明申请

WO2007109134A3 INTRAOCULAR LENS IMPLANT 审中-公开
标题翻译：内窥镜植入物
公开(公告)号：WO2007109134A3
公开(公告)日：2008-07-03
申请号：PCT/US2007006634
申请日：2007-03-16
申请人： UNIV LELAND STANFORD JUNIOR , FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
发明人： FRANK CURTIS W , TA CHRISTOPHER , MYUNG DAVID , NOOLANDI JAAN , CARRASCO MICHAEL R , KOH WON-GUN
IPC分类号： A61F2/16
CPC分类号： A61L27/52 , A61F2/16 , A61F2/1635 , A61F2002/16905 , A61F2210/0061 , A61F2220/0008 , A61L2430/16
摘要： The present invention provides a hydrogel-based intraocular lens (110) capable of covalently binding to a lens capsule (130) upon implantation. The intraocular lens (1 10) is implanted through incision (120) in cornea (122) and into the lens capsule (130). The dehydrated intraocular lens (110) becomes fully swollen (114) within the capsule (130) which can then be controlled by zonules (140) to accommodate the curvature of the lens (140) to different distances.
摘要翻译：本发明提供一种在植入后能够共价结合透镜胶囊（130）的水凝胶型眼内透镜（110）。眼内透镜（110）通过切口（120）在角膜（122）中植入到晶状体囊（130）中。脱水的眼内透镜（110）在胶囊（130）内变得完全溶胀（114），然后可以通过小区（140）来控制，以将镜片（140）的曲率适应不同的距离。

2. 发明申请

WO2007109134A2 INTRAOCULAR LENS IMPLANT 审中-公开
标题翻译：内窥镜植入物
公开(公告)号：WO2007109134A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006634
申请日：2007-03-16
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , FRANK, Curtis, W. , TA, Christopher , MYUNG, David , NOOLANDI, Jaan , CARRASCO, Michael, R. , KOH, Won-gun
发明人： FRANK, Curtis, W. , TA, Christopher , MYUNG, David , NOOLANDI, Jaan , CARRASCO, Michael, R. , KOH, Won-gun
IPC分类号： A61F2/16
CPC分类号： A61L27/52 , A61F2/16 , A61F2/1635 , A61F2002/16905 , A61F2210/0061 , A61F2220/0008 , A61L2430/16
摘要： The present invention provides a hydrogel-based intraocular lens (IOL) implant that can covalently attach to a lens capsule on implantation into an eye. The inventive IOL has a high refractive index, high elasticity, and is of a similar size to a naturally occurring lens. In addition, the IOL can be implanted in a smaller, dehydrated state, allowing the IOL to be 1 placed in the lens capsule with a small incision (up to about 1/10 the. volume of the IOL). Exposure to fluid can then initiate rapid swelling of the dried polymer to the shape and dimensions of a natural lens, with full occupation of the lens capsule. Upon equilibrium swelling, the IOL can then make contact with the inner aspect of the lens capsule and covalently bind to it. By this attachment process, the IOL may accommodate in a manner identical to that of the natural lens.
摘要翻译：本发明提供一种水凝胶型眼内透镜（IOL）植入物，其可以植入眼睛中共价连接到晶状体囊。本发明的IOL具有高折射率，高弹性，并且具有与天然存在的透镜相似的尺寸。此外，IOL可以植入更小的脱水状态，允许IOL以小切口（高达IOL的约1/10体积）放置在镜片胶囊中。然后暴露于流体可以引发干燥的聚合物快速膨胀到天然晶状体的形状和尺寸，完全占据晶状体囊。在平衡肿胀时，IOL然后可以与镜片胶囊的内部部分接触并共价结合。通过该附接过程，IOL可以以与天然镜片相同的方式容纳。

3. 发明申请

WO2006116137A3 ARTIFICIAL CORNEA 审中-公开
公开(公告)号：WO2006116137A3
公开(公告)日：2006-11-02
申请号：PCT/US2006/015173
申请日：2006-04-21
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , TA, Christopher , FAROOQUI, Nabeel , CURTIS, Frank, W. , KOH, Won-gun , KO, Jungmin , NOOLANDI, Jaan , CARRASCO, Michael, R.
发明人： MYUNG, David , TA, Christopher , FAROOQUI, Nabeel , CURTIS, Frank, W. , KOH, Won-gun , KO, Jungmin , NOOLANDI, Jaan , CARRASCO, Michael, R.
IPC分类号： A61F2/16
摘要： The present invention provides an artificial corneal implant (100) having an optically clear central core (110) and a porous, hydrophihc, biocompatible skirt ( 120) perpheral to the central core (110) In one embodiment, the central core (110) is made of an interpenetrating double network hydrogel and the skirt (120) is made of poly(2-hydroxyethyl acrylate In another embodiment, both the central core (110) and the skirt (120) are made of interpenetrating double network hydrogels The implant (100) may also have interdiffusion zone (130) in which the skirt (120) component is interpenetrated with the core (110) component, or vice versa In a preferred embodiment, biomolecules are linked to the skirt (120), core (110), or both These biomolecules are preferably molecules that support epithelial and/or fibroblast cell survival and growth The present invention also provides a method of making an artificial corneal implant (100) using photolithography

4. 发明申请

WO2006116137A2 ARTIFICIAL CORNEA 审中-公开
标题翻译：人造石
公开(公告)号：WO2006116137A2
公开(公告)日：2006-11-02
申请号：PCT/US2006015173
申请日：2006-04-21
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , TA CHRISTOPHER , FAROOQUI NABEEL , CURTIS FRANK W , KOH WON-GUN , KO JUNGMIN , NOOLANDI JAAN , CARRASCO MICHAEL R
发明人： MYUNG DAVID , TA CHRISTOPHER , FAROOQUI NABEEL , CURTIS FRANK W , KOH WON-GUN , KO JUNGMIN , NOOLANDI JAAN , CARRASCO MICHAEL R
IPC分类号： A61K35/30 , A61F2/14
CPC分类号： A61F2/142 , A61F2/15 , A61K35/12
摘要： The present invention provides an artificial corneal implant having an optically clear central core and a porous, hydrophilic, biocompatible skirt peripheral to the central core. In one embodiment, the central core is made of an interpenetrating double network hydrogel and the skirt is made of poly(2-hydroxy ethyl acrylate) (PHEA). In another embodiment, both the central core and the skirt are made of interpenetrating double network hydrogels. The artificial corneal implant may also have an interdiffusion zone in which the skirt component is interpenetrated with the core component, or vice versa. In a preferred embodiment, biomolecules are linked to the skirt, central core or both. These biomolecules may be any type of biomolecule, but are preferably biomolecules that support epithelial and/or fibroblast cell survival and growth. Preferably, the biomolecules are linked in a spatially selective manner. The present invention also provides a method of making an artificial corneal implant using photolithography.
摘要翻译：本发明提供了一种人造角膜植入物，其具有光学透明的中心纤芯和围绕中心纤芯的多孔，亲水的，生物相容的裙部。在一个实施方案中，中心芯由互穿双网络水凝胶制成，裙部由聚（2-羟乙基丙烯酸酯）（PHEA）制成。在另一个实施例中，中心芯和裙部均由互穿双网络水凝胶制成。人造角膜植入物还可以具有相互扩散区域，其中裙部组件与芯部件互穿，反之亦然。在优选的实施方案中，生物分子连接到裙部，中心芯或两者。这些生物分子可以是任何类型的生物分子，但优选支持上皮和/或成纤维细胞存活和生长的生物分子。优选地，生物分子以空间选择性方式连接。本发明还提供了一种使用光刻制造人造角膜植入物的方法。

5. 发明申请

WO2006042272A2 ARTIFICIAL CORNEAL IMPLANT 审中-公开
标题翻译：人造牙科植入物
公开(公告)号：WO2006042272A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/036648
申请日：2005-10-05
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , MYUNG, David , NOOLANDI, Jaan , SMITH, Alan, J. , FRANK, Curtis, W. , TA, Christopher , HU, Yin , KOH, Won-Gun , CARRASCO, Michael, R.
发明人： MYUNG, David , NOOLANDI, Jaan , SMITH, Alan, J. , FRANK, Curtis, W. , TA, Christopher , HU, Yin , KOH, Won-Gun , CARRASCO, Michael, R.
IPC分类号： A61K35/30 , A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，其中第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附于生物分子。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

6. 发明申请

WO2006042272A3 ARTIFICIAL CORNEAL IMPLANT 审中-公开
标题翻译：人造牙科植入物
公开(公告)号：WO2006042272A3
公开(公告)日：2007-02-08
申请号：PCT/US2005036648
申请日：2005-10-05
申请人： UNIV LELAND STANFORD JUNIOR , MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
发明人： MYUNG DAVID , NOOLANDI JAAN , SMITH ALAN J , FRANK CURTIS W , TA CHRISTOPHER , HU YIN , KOH WON-GUN , CARRASCO MICHAEL R
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61K35/44 , A61F2/142 , A61F2/145 , A61L27/26 , A61L27/3804 , A61L27/3813 , A61L27/3839 , A61L27/52 , A61L27/54 , A61L2300/25 , A61L2300/252 , A61L2300/602 , A61L2430/16 , C12N5/0621 , C12N2533/30 , C08L33/08 , C08L71/02
摘要： A material that can be applied as implants designed to artificially replace or augment the cornea, such as an artificial cornea, corneal onlay, or corneal inlay (intrastromal lens) is provided. The artificial corneal implant has a double network hydrogel with a first network interpenetrated with a second network. The first network and the second network are based on biocompatible polymers. At least one of the network polymers is based on a hydrophilic polymer. The artificial cornea or implant has epithelialization promoting biomolecules that are covalently linked to the surface of the double network hydrogel using an azide-active-ester chemical linker. Corneal epithelial cells or cornea-derived cells are adhered to the biomolecules. The double network has a physiologic diffusion coefficient to allow passage of nutrients to the adhered cells.
摘要翻译：提供了可以作为植入物被应用于人造地替代或增加角膜的材料，例如人造角膜，角膜镶嵌物或角膜嵌体（体内镜片）。人造角膜植入物具有双网络水凝胶，第一网络与第二网络互穿。第一个网络和第二个网络是基于生物相容的聚合物。至少一种网状聚合物是基于亲水性聚合物。人造角膜或植入物具有上皮促进生物分子，其使用叠氮化物 - 活性酯化学接头共价连接到双网络水凝胶的表面。角膜上皮细胞或角膜衍生细胞粘附在生物分子上。双网络具有生理扩散系数，以允许营养物质通过粘附细胞。

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