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1. 发明申请

US20070172530A1 Beverage 有权
标题翻译：饮料
公开(公告)号：US20070172530A1
公开(公告)日：2007-07-26
申请号：US11338746
申请日：2006-01-25
申请人： Tomonori Unno , Ayumu Nozawa , Yuko Suzuki
发明人： Tomonori Unno , Ayumu Nozawa , Yuko Suzuki
IPC分类号： A61K36/82 , A23F3/00
CPC分类号： A23F3/163 , A23F3/18 , A61K36/82
摘要： A beverage is prepared, which is a beverage containing catechin in ester form (A), catechin in free form (B), and caffeine (C), the contents thereof being (A)+(B)=500 to 6000 mg/L (1) (A)/[(A)+(B)]=0.7 to 1.0 (2) (A)/(C)=6 to 27, (3) to maintain a high concentration of catechin with high biological functionality, with improved flavor and improved product quality in regard to occurrence of sediment and the like.
摘要翻译：制备饮料，其是含有酯形式（A）的儿茶素，游离形式的儿茶素类（B）和咖啡因（C）的饮料，其含量为<？in-line-formula description =“在线式 “end =”lead“？>（A）+（B）= 500〜6000 mg / L（1）<？in-line-formula description =”In-line Formulas“end =”tail“？> -line-formula description =“In-line Formulas”end =“lead”？>（A）/ [（A）+（B）] = 0.7〜1.0（2）<？in-line-formula description =“In （A）/（C）= 6〜27，（3）<？在线公式描述=“内联式”结束=“尾”？>以保持高浓度的具有高生物功能的儿茶素，具有改善的风味和改善的关于沉淀物等的发生的产品质量。

2. 发明申请

US20100068363A1 BEVERAGE COMPRISING CATECHINS AND CAFFEINE 审中-公开
标题翻译：包含CATECHINS和CAFFEINE的饮料
公开(公告)号：US20100068363A1
公开(公告)日：2010-03-18
申请号：US12626177
申请日：2009-11-25
申请人： Tomonori UNNO , Ayumu Nozawa , Yuko Suzuki
发明人： Tomonori UNNO , Ayumu Nozawa , Yuko Suzuki
IPC分类号： A23F3/16
CPC分类号： A23F3/163 , A23F3/18 , A61K36/82
摘要： A beverage is prepared, which is a beverage containing catechins in ester form (A, mg/L), catechins in free form (B, mg/L), and caffeine (C, mg/L), the contents thereof being (1) (A+B)=500 to 6000 mg/L (2) (A)/(A+B)=0.7 to 1.0 (3) (A)/(C)=6 to 27, such that a high concentration of catechins with high biological functionality, improved flavor and improved product quality with low occurrence of sediment is maintained.
摘要翻译：制备饮料，其为含有酯形式的儿茶素类（A，mg / L），游离形式的儿茶素类（B，mg / L）和咖啡因（C，mg / L）的饮料，其含量为（1 ）（A + B）= 500〜6000mg / L（2）（A）/（A + B）= 0.7〜1.0（3）（A）/（C）= 6〜27，具有高生物功能的儿茶素，改善风味和改善的产品质量，并保持低沉积物的发生。

3. 发明授权

US07666452B2 Beverage comprising cathechins and caffeine 有权
标题翻译：饮料包括导管和咖啡因
公开(公告)号：US07666452B2
公开(公告)日：2010-02-23
申请号：US11338746
申请日：2006-01-25
申请人： Tomonori Unno , Ayumu Nozawa , Yuko Suzuki
发明人： Tomonori Unno , Ayumu Nozawa , Yuko Suzuki
IPC分类号： A61K36/82
CPC分类号： A23F3/163 , A23F3/18 , A61K36/82
摘要： A beverage is prepared, which is a beverage containing catechins in ester form (A, mg/L), catechins in free form (B, mg/L), and caffeine (C, mg/L), the contents thereof being (A+B)=500 to 6000 mg/L (1) (A)/(A+B)=0.7 to 1.0 (2) (A)/(C)=6 to 27, (3) such that a high concentration of catechins with high biological functionality, improved flavor and improved product quality with low occurrence of sediment is maintained.
摘要翻译：制备饮料，其为含有酯形式的儿茶素（A，mg / L），游离形式的儿茶素类（B，mg / L）和咖啡因（C，mg / L）的饮料，其含量为（A + B）= 500〜6000mg / L（1）（A）/（A + B）= 0.7〜1.0（2）（A）/（C）= 6〜27，（3）具有高生物功能的儿茶素，改善风味和改善的产品质量，并保持低沉积物的发生。

4. 发明申请

US20090156662A1 Fat Absorption Inhibitor 审中-公开
标题翻译：脂肪吸收抑制剂
公开(公告)号：US20090156662A1
公开(公告)日：2009-06-18
申请号：US12226672
申请日：2007-04-09
申请人： Ayumu Nozawa , Makoto Kobayashi , Tomonori Unno
发明人： Ayumu Nozawa , Makoto Kobayashi , Tomonori Unno
IPC分类号： A61K31/353 , A61P3/04
CPC分类号： A23K50/48 , A23F3/163 , A23F5/243 , A23K20/10 , A23K20/121 , A23L2/52 , A23L33/10 , A23L33/105 , A23L33/20 , A61K31/353 , A61K36/82
摘要： Disclosed is a composition or beverage/food for inhibiting the fat absorption, which is derived from a natural material and therefore is safe, and which can be ingested continuously. The composition or beverage/food comprises the following components: (A) theaflavine monogallate; (B) theaflavine; (C) theaflavine digallate; and (D) polyphenol, wherein these components satisfy the following requirements: (1) a weight-based content ratio [(A)/(B)] is 0.4-100%; (2) the weight of the component (A) is larger that that of the component (C); and (3) a weight-based content ratio [A)/(D)] is 0.01-1.0%. The composition or beverage/food can be used for the prevention or treatment of a disease such as arteriosclerosis and an ischemic heart disease (e.g., angina pectoris, myocardial infarction).
摘要翻译：公开了一种用于抑制脂肪吸收的组合物或饮料/食品，其衍生自天然材料，因此是安全的，并且可以连续摄取。组合物或饮料/食品包含以下成分：（A）茶黄素单糖酸酯; （B）茶黄素; （C）茶黄素; 和（D）多酚，其中这些组分满足以下要求：（1）重量含量比[（A）/（B）]为0.4-100％; （2）组分（A）的重量大于组分（C）的重量; 和（3）重量含量比[A] /（D）]为0.01〜1.0％。组合物或饮料/食物可用于预防或治疗诸如动脉硬化和缺血性心脏病（例如心绞痛，心肌梗塞）的疾病。

5. 发明授权

US5736575A Excitement accelerating agent 失效
标题翻译：兴奋加速剂
公开(公告)号：US5736575A
公开(公告)日：1998-04-07
申请号：US720198
申请日：1996-09-25
申请人： Takami Kakuda , Takanobu Takihara , Iwao Sakane , Ayumu Nozawa
发明人： Takami Kakuda , Takanobu Takihara , Iwao Sakane , Ayumu Nozawa
IPC分类号： A61K31/195 , A61K31/198 , A61P3/00 , A61P25/26
CPC分类号： A61K31/198
摘要： An excitement accelerating agent was produced by incorporating a very small amount of theanine as an effective compoment in a range that shows the excitement accelerating action. The very small amount in a range that shows the excitement accelerating action means a range containing theanine in an amount of from about 0.17 mg/kg to 0.85 mg/kg, preferably from about 0.17 mg/kg to 0.34 mg/kg based on the weight as an injection agent, and in an amount of from about 0.20 mg/kg to 2.8 mg/kg, preferably from about 0.50 mg/kg to 2.5 mg/kg (0.17/0.338-0.85/0.338) as an oral agent. A safe and effective excitement accelerating agent can be provided by utilizing sufficiently the excitement accelerating action given by theanine, and if it is regularly taken for a long period of time, it is also effective as a nutritious tonic, an energy-increasing agent, and a stamina-sustaining agent.
摘要翻译：通过在显示兴奋加速作用的范围内并入非常少量的茶氨酸作为有效成分来制备兴奋促进剂。显示兴奋促进作用的范围中的极少量是指含有约0.17mg / kg至0.85mg / kg，优选约0.17mg / kg至0.34mg / kg的茶氨酸的范围，基于重量作为注射剂，其口服剂的量为约0.20mg / kg至2.8mg / kg，优选为约0.50mg / kg至2.5mg / kg（0.17 / 0.338-0.85 / 0.338）。通过充分利用由茶氨酸引起的兴奋加速作用可以提供安全有效的兴奋促进剂，如果长期定期服用，也可以作为营养补品，增能剂和耐力维持剂。

6. 发明授权

US06462051B1 Composition for reducing mental fatigue, composition for maintaining and enhancing concentration, and composition for maintaining and enhancing mental vigor 有权
标题翻译：用于减少精神疲劳的成分，维持和增强浓度的组成，以及维持和增强精神活力的组成
公开(公告)号：US06462051B1
公开(公告)日：2002-10-08
申请号：US09951673
申请日：2001-09-14
申请人： Ayumu Nozawa , Yuko Sagesaka , Akio Sugimoto , Takami Kakuda
发明人： Ayumu Nozawa , Yuko Sagesaka , Akio Sugimoto , Takami Kakuda
IPC分类号： A61R3152
CPC分类号： A61K31/197 , A61K31/522 , A61K2300/00
摘要： The present invention is intended to provide compositions which exert excellent effects allowing improvement in the mental function of humans and animals other than humans, such as reduction of mental fatigue, maintenance and enhancement of concentration maintenance and enhancement of mental vigor, and the like. These compositions are provided as mentally functional compositions containing, as the active component, a mixture component comprising caffeine, theanine, and arginine which are contained in tea. It is preferable that caffeine, theanine, and arginine are mixed such that the mixing ratio approaches a ratio of 1:2:2. Further, by combining the above-described mixture component with sugar and citric acid, mentally functional foods and beverages can be also provided which are taken with ease and effective.
摘要翻译：本发明旨在提供具有优异效果的组合物，其能够改善人类以外的人类和动物的精神功能，例如减少精神疲劳，维持和增强集中维持和增强精神活力等。提供这些组合物作为精神功能组合物，其包含茶中含有的包含咖啡因，茶氨酸和精氨酸的混合组分作为活性组分。优选将咖啡因，茶氨酸和精氨酸混合，使得混合比接近1：2：2的比例。此外，通过将上述混合物组分与糖和柠檬酸组合，还可以提供易于有效的精神功能食品和饮料。

7. 发明授权

US06271259B1 Method for improving the brain function, inhibiting glutamate excitotoxicity and rescuing from neuronal death 失效
标题翻译：改善脑功能，抑制谷氨酸兴奋毒性和拯救神经元死亡的方法
公开(公告)号：US06271259B1
公开(公告)日：2001-08-07
申请号：US08646066
申请日：1996-05-07
申请人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
发明人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
IPC分类号： A01H3712
CPC分类号： A61K31/198 , A23L33/10 , A23V2002/00 , A23V2250/641 , A23V2250/708 , A23V2250/704 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/7052 , A23V2250/0644
摘要： This invention is characterized by a brain function improving preparation containing theanine not less than 50 &mgr;M. It was confirmed that theanine could increase intracellular Ca2+ concentration by acting on NMDA receptors even at a low dose of about 50 &mgr;M. Thus, the brain function improving preparation of this invention was shown to be capable of causing plastic change in neurons or neural circuit. Since theanine has been approved as a food additive and being consumed daily, its safety has no problem. Moreover, theanine passes the blood-brain barrier relatively easily and, thus, it is effective as an oral preparation.
摘要翻译：本发明的特征在于包含茶氨酸的脑功能改善制剂不低于50μM。证实茶氨酸可以通过作用于NMDA受体而增加细胞内Ca2 +浓度，即使在约50μM的低剂量下。因此，改善本发明制剂的脑功能被证明能够引起神经元或神经回路中的塑性变化。由于茶氨酸已被批准为食品添加剂并被日常消费，因此其安全性没有问题。此外，茶氨酸相对容易地通过血脑屏障，因此作为口服制剂是有效的。

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