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1. 发明授权

US06271259B1 Method for improving the brain function, inhibiting glutamate excitotoxicity and rescuing from neuronal death 失效
标题翻译：改善脑功能，抑制谷氨酸兴奋毒性和拯救神经元死亡的方法
公开(公告)号：US06271259B1
公开(公告)日：2001-08-07
申请号：US08646066
申请日：1996-05-07
申请人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
发明人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
IPC分类号： A01H3712
CPC分类号： A61K31/198 , A23L33/10 , A23V2002/00 , A23V2250/641 , A23V2250/708 , A23V2250/704 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/7052 , A23V2250/0644
摘要： This invention is characterized by a brain function improving preparation containing theanine not less than 50 &mgr;M. It was confirmed that theanine could increase intracellular Ca2+ concentration by acting on NMDA receptors even at a low dose of about 50 &mgr;M. Thus, the brain function improving preparation of this invention was shown to be capable of causing plastic change in neurons or neural circuit. Since theanine has been approved as a food additive and being consumed daily, its safety has no problem. Moreover, theanine passes the blood-brain barrier relatively easily and, thus, it is effective as an oral preparation.
摘要翻译：本发明的特征在于包含茶氨酸的脑功能改善制剂不低于50μM。证实茶氨酸可以通过作用于NMDA受体而增加细胞内Ca2 +浓度，即使在约50μM的低剂量下。因此，改善本发明制剂的脑功能被证明能够引起神经元或神经回路中的塑性变化。由于茶氨酸已被批准为食品添加剂并被日常消费，因此其安全性没有问题。此外，茶氨酸相对容易地通过血脑屏障，因此作为口服制剂是有效的。

2. 发明授权

US5736575A Excitement accelerating agent 失效
标题翻译：兴奋加速剂
公开(公告)号：US5736575A
公开(公告)日：1998-04-07
申请号：US720198
申请日：1996-09-25
申请人： Takami Kakuda , Takanobu Takihara , Iwao Sakane , Ayumu Nozawa
发明人： Takami Kakuda , Takanobu Takihara , Iwao Sakane , Ayumu Nozawa
IPC分类号： A61K31/195 , A61K31/198 , A61P3/00 , A61P25/26
CPC分类号： A61K31/198
摘要： An excitement accelerating agent was produced by incorporating a very small amount of theanine as an effective compoment in a range that shows the excitement accelerating action. The very small amount in a range that shows the excitement accelerating action means a range containing theanine in an amount of from about 0.17 mg/kg to 0.85 mg/kg, preferably from about 0.17 mg/kg to 0.34 mg/kg based on the weight as an injection agent, and in an amount of from about 0.20 mg/kg to 2.8 mg/kg, preferably from about 0.50 mg/kg to 2.5 mg/kg (0.17/0.338-0.85/0.338) as an oral agent. A safe and effective excitement accelerating agent can be provided by utilizing sufficiently the excitement accelerating action given by theanine, and if it is regularly taken for a long period of time, it is also effective as a nutritious tonic, an energy-increasing agent, and a stamina-sustaining agent.
摘要翻译：通过在显示兴奋加速作用的范围内并入非常少量的茶氨酸作为有效成分来制备兴奋促进剂。显示兴奋促进作用的范围中的极少量是指含有约0.17mg / kg至0.85mg / kg，优选约0.17mg / kg至0.34mg / kg的茶氨酸的范围，基于重量作为注射剂，其口服剂的量为约0.20mg / kg至2.8mg / kg，优选为约0.50mg / kg至2.5mg / kg（0.17 / 0.338-0.85 / 0.338）。通过充分利用由茶氨酸引起的兴奋加速作用可以提供安全有效的兴奋促进剂，如果长期定期服用，也可以作为营养补品，增能剂和耐力维持剂。

3. 发明授权

US06589573B2 Xanthine oxidase inhibitor and method for producing the same 有权
公开(公告)号：US06589573B2
公开(公告)日：2003-07-08
申请号：US10013351
申请日：2001-12-13
申请人： Tomonori Unno , Iwao Sakane , Takami Kakuda
发明人： Tomonori Unno , Iwao Sakane , Takami Kakuda
IPC分类号： A61K3578
CPC分类号： A61K36/185
摘要： In order to provide a xanthine oxidase inhibitor having as an effective component an extract from highly safe plants, ten kinds of plant materials were compared for the xanthine oxidase inhibition activity, and in consequence Lagerstroemia speciosa (banaba) was found to have the strongest activity. In addition, it was found that the xanthine oxidase inhibition activity was present in an “crude extract” obtained by extracting banaba with hot water or the like, “resin adsorbed components” obtained by adsorbing the crude extract on a styrene-divinyl benzene synthetic resin or the like, and “organic solvent soluble components” obtained by the partition of the resin adsorbed component between water and an organic solvent. Among them, the “organic solvent soluble components” described above were purified with high performance liquid chromatography to obtain “ellagic acid,” an “ellagic acid derivative,” an “ellagic acid analog compound” and a “lignan,” which were found to have a more superior xanthine oxidase inhibitor activity. The present invention provides a xanthine oxidase inhibitor having each of these extracted materials as an effective component.

4. 发明授权

US06987126B2 Neutralizing agent for clostridium bacterial neurotoxins and preparation method thereof 有权
标题翻译：梭菌细菌神经毒素中和剂及其制备方法
公开(公告)号：US06987126B2
公开(公告)日：2006-01-17
申请号：US10702638
申请日：2003-11-07
申请人： Shin-ichi Sawamura , Masakazu Nishimura , Iwao Sakane
发明人： Shin-ichi Sawamura , Masakazu Nishimura , Iwao Sakane
IPC分类号： A61K31/353 , C07D311/30
CPC分类号： C07H17/07 , A23L3/3472 , A23L3/3544 , A23V2002/00 , A61K31/7048 , Y02A50/469 , A61K2300/00 , A23V2200/10 , A23V2250/214
摘要： Disclosed is a neutralizing agent for a clostridium bacterial neurotoxin and a preparation method thereof. The neutralizing agent contains a flavonol glycoside (A) or a flavonol glycoside (B). The flavonol glycoside (A) has a flavone skelton which has two hydroxyl groups at the 5 and 7 positions, at least one hydroxyl group bonding at either one of the 3′, 4′ and 5′ positions, and an ether linkage forming glycoside at the 3 position with a carbohydrate chain containing a rutinose skelton. The flavonol glycoside (B) has also another ether linkage at the 4′ position with a carbohydrate chain containing rhamnose. The neutralizing agent is prepared by separating the thearubigin fraction of black tea extract by elution with methanol/water solvent using a reverse phase liquid chromatography. A fraction eluted with methanol/water solvent containing 40% methanol and a fraction eluted with methanol/water solvent containing 60% methanol have high neutralizing activity, and at least one of them is collected.
摘要翻译：公开了一种细菌性神经毒素中和剂及其制备方法。中和剂含有黄酮醇苷（A）或黄酮醇苷（B）。黄酮醇苷（A）具有黄酮骨架，其在5和7位具有两个羟基，在3'，4'和5'位中的任一个上键合至少一个羟基，以及形成糖键的醚键 3位含有含有芦丁糖的碳水化合物链。黄酮醇苷（B）在4'位置还具有含有鼠李糖的糖链的另一个醚键。中和剂通过使用反相液相色谱法，用甲醇/水溶剂洗脱分离红茶提取物的红豆素部分来制备。用含有40％甲醇的甲醇/水溶剂洗脱的级分和用含有60％甲醇的甲醇/水溶剂洗脱的级分具有高中和活性，并收集至少一种。

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