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1. 发明授权

US06462051B1 Composition for reducing mental fatigue, composition for maintaining and enhancing concentration, and composition for maintaining and enhancing mental vigor 有权
标题翻译：用于减少精神疲劳的成分，维持和增强浓度的组成，以及维持和增强精神活力的组成
公开(公告)号：US06462051B1
公开(公告)日：2002-10-08
申请号：US09951673
申请日：2001-09-14
申请人： Ayumu Nozawa , Yuko Sagesaka , Akio Sugimoto , Takami Kakuda
发明人： Ayumu Nozawa , Yuko Sagesaka , Akio Sugimoto , Takami Kakuda
IPC分类号： A61R3152
CPC分类号： A61K31/197 , A61K31/522 , A61K2300/00
摘要： The present invention is intended to provide compositions which exert excellent effects allowing improvement in the mental function of humans and animals other than humans, such as reduction of mental fatigue, maintenance and enhancement of concentration maintenance and enhancement of mental vigor, and the like. These compositions are provided as mentally functional compositions containing, as the active component, a mixture component comprising caffeine, theanine, and arginine which are contained in tea. It is preferable that caffeine, theanine, and arginine are mixed such that the mixing ratio approaches a ratio of 1:2:2. Further, by combining the above-described mixture component with sugar and citric acid, mentally functional foods and beverages can be also provided which are taken with ease and effective.
摘要翻译：本发明旨在提供具有优异效果的组合物，其能够改善人类以外的人类和动物的精神功能，例如减少精神疲劳，维持和增强集中维持和增强精神活力等。提供这些组合物作为精神功能组合物，其包含茶中含有的包含咖啡因，茶氨酸和精氨酸的混合组分作为活性组分。优选将咖啡因，茶氨酸和精氨酸混合，使得混合比接近1：2：2的比例。此外，通过将上述混合物组分与糖和柠檬酸组合，还可以提供易于有效的精神功能食品和饮料。

2. 发明授权

US5501866A Product and method for inhibiting caffeine stimulation with theanine 失效
标题翻译：用茶氨酸抑制咖啡因刺激的产物和方法
公开(公告)号：US5501866A
公开(公告)日：1996-03-26
申请号：US408170
申请日：1995-03-21
申请人： Takami Kakuda , Takanobu Matsuura , Yuko Sagesaka , Toshio Kawasaki
发明人： Takami Kakuda , Takanobu Matsuura , Yuko Sagesaka , Toshio Kawasaki
IPC分类号： A23F3/36 , A23F5/20 , A61K31/198 , A61K31/52 , A23F3/00 , A23F5/00
CPC分类号： A61K31/198 , A23F3/363 , A23F5/202 , A61K31/52
摘要： The caffeine stimulation inhibitor that inhibits stimulation by combining the use of theanine extracted from tea leaves and/or a substance having theanine for its major active ingredient which is produced by extracting tea leaves with a solvent such as water, hot water or ethanol, chemical synthesis, microbial fermentation or plant tissue culturing. These active ingredients are able to inhibit the stimulatory action of caffeine without degrading the quality, such as the flavor and aroma, of caffeine-containing beverages and foods, allowing persons hypersensitive to caffeine to consume caffeine-containing beverages and foods without worry over its effects.
摘要翻译：咖啡因刺激抑制剂通过将从茶叶提取的茶氨酸和/或具有茶氨酸的物质与其主要活性成分组合来抑制刺激，所述主要活性成分通过用溶剂如水，热水或乙醇萃取茶叶而产生，化学合成，微生物发酵或植物组织培养。这些活性成分能够抑制咖啡因的刺激作用，而不会降低含咖啡因的饮料和食物的质量，如风味和香气，允许对咖啡因过敏的人消费含咖啡因的饮料和食物，而不用担心其影响。

3. 发明授权

US5736575A Excitement accelerating agent 失效
标题翻译：兴奋加速剂
公开(公告)号：US5736575A
公开(公告)日：1998-04-07
申请号：US720198
申请日：1996-09-25
申请人： Takami Kakuda , Takanobu Takihara , Iwao Sakane , Ayumu Nozawa
发明人： Takami Kakuda , Takanobu Takihara , Iwao Sakane , Ayumu Nozawa
IPC分类号： A61K31/195 , A61K31/198 , A61P3/00 , A61P25/26
CPC分类号： A61K31/198
摘要： An excitement accelerating agent was produced by incorporating a very small amount of theanine as an effective compoment in a range that shows the excitement accelerating action. The very small amount in a range that shows the excitement accelerating action means a range containing theanine in an amount of from about 0.17 mg/kg to 0.85 mg/kg, preferably from about 0.17 mg/kg to 0.34 mg/kg based on the weight as an injection agent, and in an amount of from about 0.20 mg/kg to 2.8 mg/kg, preferably from about 0.50 mg/kg to 2.5 mg/kg (0.17/0.338-0.85/0.338) as an oral agent. A safe and effective excitement accelerating agent can be provided by utilizing sufficiently the excitement accelerating action given by theanine, and if it is regularly taken for a long period of time, it is also effective as a nutritious tonic, an energy-increasing agent, and a stamina-sustaining agent.
摘要翻译：通过在显示兴奋加速作用的范围内并入非常少量的茶氨酸作为有效成分来制备兴奋促进剂。显示兴奋促进作用的范围中的极少量是指含有约0.17mg / kg至0.85mg / kg，优选约0.17mg / kg至0.34mg / kg的茶氨酸的范围，基于重量作为注射剂，其口服剂的量为约0.20mg / kg至2.8mg / kg，优选为约0.50mg / kg至2.5mg / kg（0.17 / 0.338-0.85 / 0.338）。通过充分利用由茶氨酸引起的兴奋加速作用可以提供安全有效的兴奋促进剂，如果长期定期服用，也可以作为营养补品，增能剂和耐力维持剂。

4. 发明授权

US06271259B1 Method for improving the brain function, inhibiting glutamate excitotoxicity and rescuing from neuronal death 失效
标题翻译：改善脑功能，抑制谷氨酸兴奋毒性和拯救神经元死亡的方法
公开(公告)号：US06271259B1
公开(公告)日：2001-08-07
申请号：US08646066
申请日：1996-05-07
申请人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
发明人： Takami Kakuda , Ayumu Nozawa , Takanobu Takihara , Iwao Sakane , Yoichiro Kuroda , Kazuo Kobayashi , Masahiro Kawahara , Akihiro Mizutani , Kazuyo Muramoto , Kunihiko Umezawa
IPC分类号： A01H3712
CPC分类号： A61K31/198 , A23L33/10 , A23V2002/00 , A23V2250/641 , A23V2250/708 , A23V2250/704 , A23V2250/2108 , A23V2250/7042 , A23V2250/7044 , A23V2250/7046 , A23V2250/7052 , A23V2250/0644
摘要： This invention is characterized by a brain function improving preparation containing theanine not less than 50 &mgr;M. It was confirmed that theanine could increase intracellular Ca2+ concentration by acting on NMDA receptors even at a low dose of about 50 &mgr;M. Thus, the brain function improving preparation of this invention was shown to be capable of causing plastic change in neurons or neural circuit. Since theanine has been approved as a food additive and being consumed daily, its safety has no problem. Moreover, theanine passes the blood-brain barrier relatively easily and, thus, it is effective as an oral preparation.
摘要翻译：本发明的特征在于包含茶氨酸的脑功能改善制剂不低于50μM。证实茶氨酸可以通过作用于NMDA受体而增加细胞内Ca2 +浓度，即使在约50μM的低剂量下。因此，改善本发明制剂的脑功能被证明能够引起神经元或神经回路中的塑性变化。由于茶氨酸已被批准为食品添加剂并被日常消费，因此其安全性没有问题。此外，茶氨酸相对容易地通过血脑屏障，因此作为口服制剂是有效的。

5. 发明授权

US06340489B1 Manufacturing process of carrot juice 有权
标题翻译：胡萝卜汁的制造工艺
公开(公告)号：US06340489B1
公开(公告)日：2002-01-22
申请号：US09449530
申请日：1999-11-29
申请人： Yuko Suzuki , Akio Sugimoto , Takami Kakuda , Yasuhiko Ikegawa
发明人： Yuko Suzuki , Akio Sugimoto , Takami Kakuda , Yasuhiko Ikegawa
IPC分类号： A23L202
CPC分类号： A23L2/46 , A23L2/02 , A23L2/70 , A23V2002/00 , A23V2250/032 , A23V2250/11
摘要： It is an object of the present invention to provide a manufacturing process of carrot juice capable of obtaining, with high yield, carrot juice having a high-quality and stable characteristic free from occurrence of cohesion with less fishiness. To this end, the present invention comprises, first, peeling washed raw carrot, carrying out enzyme deactivation processing within one day, preferably, within 12 hours after peeling, and second, completely deactivating pectin esterase activity of carrot and carrying out enzyme deactivation processing so that a residual rate of pectinase activity is less than 60%. Such an enzyme deactivation processing may be done by blanching carrot till an internal temperature reaches 70 to 80° C. in water at 70 to 80° C., or blanching carrot till an internal temperature reaches 60 to 70° C. in 0.02M to 0.05M citric acid solution at 60 to 70° C., or processing carrot with supercritical carbonic acid gas by a microbubble SC—CO2 method. The carrot subjected to the enzyme deactivation processing was crushed similarly to normal vegetable juice or fruit juice and squeezed, and the obtained squeezed juice is adjusted to an acid region or to about pH 4.2, for example, such as citric acid solution, after which it is sterilized and filled into a container to serve as the carrot juice.
摘要翻译：本发明的目的是提供一种胡萝卜汁的制造方法，其能够以高产率获得具有高质量且稳定的特征的胡萝卜汁，而不会发生内聚性较差的腥味。为此，本发明首先包括洗涤的生胡萝卜，在一天内，优选在剥离后12小时内进行酶失活处理，其次，完全失活胡萝卜素的果胶酯酶活性并进行酶失活处理果胶酶活性的残留率小于60％。这样的酶失活处理可以通过将胡萝卜漂洗直到内部温度在70〜80℃的水中达到70〜80℃，或者将胡萝卜漂白至内部温度达到60〜70℃，在0.02M〜在60〜70℃下加入0.05M柠檬酸溶液，或用微泡SC-CO2法加工具有超临界碳酸气体的胡萝卜。将进行酶失活处理的胡萝卜与普通蔬菜汁或果汁类似地粉碎并挤压，将得到的榨汁调节至酸性区域或约pH 4.2，例如柠檬酸溶液，之后将其将其灭菌并装入容器中作为胡萝卜汁。

6. 发明授权

US5071653A Camellia sinensis extracts that promote the growth of bifidobacterium 失效
标题翻译：山茶提取物促进双歧杆菌的生长
公开(公告)号：US5071653A
公开(公告)日：1991-12-10
申请号：US308736
申请日：1989-02-09
申请人： Takami Kakuda , Robert M. Parkhurst
发明人： Takami Kakuda , Robert M. Parkhurst
IPC分类号： A01N65/00 , A61K36/00 , A61K36/18 , A61K36/82 , A61P1/00 , A61P1/12 , C12N1/20 , C12N1/38
CPC分类号： C12N1/38 , A61K36/82
摘要： Substantially flavorless extracts from the leaves of C. sinensis are provided which promote the growth of Bifidobacterium. Compositions are provided by extracting water or ethanol-soluble solids from C. sinensis leaves with a polar organic solvent that is immiscible with water.
摘要翻译：提供了来自中华the the叶的大量无味的提取物，促进双歧杆菌的生长。通过用与水不混溶的极性有机溶剂从中华叶提取水或乙醇可溶性固体提供组合物。

7. 发明授权

US06589573B2 Xanthine oxidase inhibitor and method for producing the same 有权
公开(公告)号：US06589573B2
公开(公告)日：2003-07-08
申请号：US10013351
申请日：2001-12-13
申请人： Tomonori Unno , Iwao Sakane , Takami Kakuda
发明人： Tomonori Unno , Iwao Sakane , Takami Kakuda
IPC分类号： A61K3578
CPC分类号： A61K36/185
摘要： In order to provide a xanthine oxidase inhibitor having as an effective component an extract from highly safe plants, ten kinds of plant materials were compared for the xanthine oxidase inhibition activity, and in consequence Lagerstroemia speciosa (banaba) was found to have the strongest activity. In addition, it was found that the xanthine oxidase inhibition activity was present in an “crude extract” obtained by extracting banaba with hot water or the like, “resin adsorbed components” obtained by adsorbing the crude extract on a styrene-divinyl benzene synthetic resin or the like, and “organic solvent soluble components” obtained by the partition of the resin adsorbed component between water and an organic solvent. Among them, the “organic solvent soluble components” described above were purified with high performance liquid chromatography to obtain “ellagic acid,” an “ellagic acid derivative,” an “ellagic acid analog compound” and a “lignan,” which were found to have a more superior xanthine oxidase inhibitor activity. The present invention provides a xanthine oxidase inhibitor having each of these extracted materials as an effective component.

8. 发明申请

US20090047408A1 Method for Improving Absorbability of Epigallocatechin Gallate, Foods, Drinks and Food/Drink Materials Using the Same and Method for Producing the Same 审中-公开
标题翻译：提高表儿基儿茶素镓酸盐，食品，饮料和食品/饮料的吸收性能的方法及其制备方法
公开(公告)号：US20090047408A1
公开(公告)日：2009-02-19
申请号：US12085959
申请日：2006-12-01
申请人： Tomonori Unno , Takami Kakuda , Teruo Miyazawa , Kiyotaka Nakagawa
发明人： Tomonori Unno , Takami Kakuda , Teruo Miyazawa , Kiyotaka Nakagawa
IPC分类号： A23F3/14
CPC分类号： A23F3/20 , A23F3/163 , A23L2/52 , A23L33/10 , A23L33/105 , A61K9/0095 , A61K9/08 , A61K31/7048 , A61K36/82 , A61K47/22
摘要： Provided are a food, a drink and a food/drink material having improved EGCg absorbability, and a method of producing the same, by improving the absorbability of EGCg to be taken in. The contents of caffeine and/or epigallocatechin gallate are regulated so that the ratio by mass of caffeine to epigallocatechin gallate contained in a food, drink, food/drink material or oral ingesta comes close to 0.4.
摘要翻译：提供具有改善的EGCg吸收性的食品，饮料和食品/饮料材料及其制备方法，通过改善吸收的EGCg的吸收性。调节咖啡因和/或表没食子儿茶素没食子酸酯的含量，使得食物，饮料，食物/饮料或口服摄入中所含的咖啡因与表没食子儿茶素没食子酸酯的质量比例接近0.4。

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