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1. 发明申请

US20070252984A1 Autofocus Mechanism for Spectroscopic System 有权
标题翻译：光谱系统的自动聚焦机制
公开(公告)号：US20070252984A1
公开(公告)日：2007-11-01
申请号：US11570132
申请日：2005-06-07
申请人： Michael Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Rensen , Durk De Vries
发明人： Michael Van Beek , Gerald Lucassen , Marjolein Van Der Voort , Wouter Rensen , Durk De Vries
IPC分类号： G01B11/14 , G01J3/00
CPC分类号： G02B21/247 , G01J3/02 , G01J3/0237 , G01J3/44 , G01N21/645 , G01N21/65 , G01N2021/6463 , G01N2021/653 , G01N2021/655
摘要： The present invention provides an autofocus mechanism for a spectroscopic system that is adapted to determine a property of a volume of interest. The volume of interest has an optical property that varies with time. The invention provides measurement means that are adapted to measure the fluctuations of the optical property of the volume of interest for determining the position of the volume of interest. The spectroscopic system being further adapted to focus an excitation beam into the determined volume of interest and for collecting return radiation emanating from the volume of interest for spectroscopic analysis. Preferably, inelastically scattered radiation of an excitation beam is separated from elastically scattered radiation for spectroscopic analysis. The elastically scattered radiation of the excitation beam is in turn exploited in order to measure the fluctuations of the optical property of the volume of interest. Making use of a control loop allows for maximization of the amplitude and/or intensity of the fluctuation inherently specifying the position of a volume of interest e.g. the center of a capillary vessel.
摘要翻译：本发明提供一种用于分光系统的自动对焦机构，其适于确定感兴趣体积的性质。感兴趣的体积随着时间而变化。本发明提供了测量装置，其适于测量感兴趣体积的光学性质的波动以确定感兴趣体积的位置。光谱系统还适于将激发光束聚焦到所确定的感兴趣体积中，并用于收集从感兴趣体积发出的用于光谱分析的返回辐射。优选地，激发光束的非弹性散射辐射与用于光谱分析的弹性散射辐射分离。激发光束的弹性散射辐射又被利用来测量感兴趣体积的光学特性的波动。利用控制回路允许最大化固有地指定感兴趣体积的位置的波动的幅度和/或强度，毛细血管的中心。

2. 发明申请

US20080002199A1 Aberration Correction for Spectroscopic Analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US20080002199A1
公开(公告)日：2008-01-03
申请号：US11570133
申请日：2005-06-13
申请人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
发明人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
IPC分类号： G01J3/30 , G06F19/00
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).
摘要翻译：本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

3. 发明申请

US20070070328A1 Method of determining a property of a fluid and spectroscopic system 失效
标题翻译：确定流体和光谱系统性质的方法
公开(公告)号：US20070070328A1
公开(公告)日：2007-03-29
申请号：US10595358
申请日：2004-10-15
申请人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
发明人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
IPC分类号： G01N33/48 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/489
摘要： The present invention enables to determine the property of a fluid, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by means of an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective to the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.
摘要翻译：本发明能够确定流体的性质，例如用于体内血液分析的目的。首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。优选地，光学检测步骤是成像步骤。接下来，将目标转移到目标的焦点。在该位置，进行光学分光步骤。这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

4. 发明申请

US20070213609A1 PROBE HEAD FOR SPECTROSCOPIC ANALYSIS OF A FLUID 失效
标题翻译：用于流体光谱分析的探头
公开(公告)号：US20070213609A1
公开(公告)日：2007-09-13
申请号：US11568363
申请日：2005-02-14
申请人： Gerhardus Lucassen , Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker
发明人： Gerhardus Lucassen , Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker
IPC分类号： A61B5/1455 , G01J3/42
CPC分类号： A61B5/0059 , A61B5/489 , A61B2562/0242
摘要： The present invention provides a spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient. The spectroscopic system comprises a probe head that has at least an objective for directing an excitation beam into the volume of interest and for collecting return radiation. The spectroscopic system has further a base station having at least a spectroscopic analysis unit and a power supply. The system makes use of a beam combination unit, a filter unit and a focusing unit for combining and separating a variety of different optical signals and for precisely positioning the optical signals inside the volume of interest. The beam combination unit, the filter unit and the focusing unit can be variably implemented inside the probe head or inside the base station depending on a specific applications of the spectroscopic system, thereby allowing for a flexible and compact design of the probe head.
摘要翻译：本发明提供了一种用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。分光系统包括探头，该探头至少具有将激发光束引导到感兴趣体积中并用于收集返回辐射的目的。光谱系统还具有至少具有光谱分析单元和电源的基站。该系统利用光束组合单元，滤光器单元和聚焦单元，用于组合和分离各种不同的光信号，并将光信号精确地定位在感兴趣的体积内。根据分光系统的具体应用，光束组合单元，滤光器单元和聚焦单元可以可变地实现在探头内部或基站内部，从而允许探头的灵活且紧凑的设计。

5. 发明授权

US07511812B2 Aberration correction for spectroscopic analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US07511812B2
公开(公告)日：2009-03-31
申请号：US11570133
申请日：2005-06-13
申请人： Michael Cornelis Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
发明人： Michael Cornelis Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
IPC分类号： G01J3/30
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.
摘要翻译：确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

6. 发明申请

US20070293766A1 Transmission Based Imaging for Spectroscopic Analysis 审中-公开
标题翻译：基于透射的光谱分析成像
公开(公告)号：US20070293766A1
公开(公告)日：2007-12-20
申请号：US11574163
申请日：2005-08-24
申请人： Bernardus Bakker , Gerald Lucassen , Michael Van Beek , Marjolein Van Der Voort , Robert Hendriks , Frank Schuurmans
发明人： Bernardus Bakker , Gerald Lucassen , Michael Van Beek , Marjolein Van Der Voort , Robert Hendriks , Frank Schuurmans
IPC分类号： G01J3/28
CPC分类号： A61B5/489 , A61B5/0059 , A61B2562/0238 , G01J3/36 , G01J3/42 , G01N21/31 , G01N21/35 , G01N21/59
摘要： The present invention provides a spectroscopic system and a transmission based imaging system for a spectroscopic system as well as a probe head for a transmission based imaging system for a spectroscopic system and a corresponding transmission based imaging method. The spectroscopic system is preferably applicable to in vivo noninvasive blood analysis. Transmission based imaging makes use of a transmitted portion of an imaging or monitoring beam that has been transmitted through biological tissue. By means of transmission based imaging, a contrast decreasing impact of scattered radiation can be effectively reduced. Additionally, by arranging the imaging light source opposite to an objective lens of the spectroscopic system, unintended propagation of spectroscopic excitation radiation into free space can be effectively prevented.
摘要翻译：本发明提供了一种用于分光系统的光谱系统和基于透射的成像系统以及用于分光系统的基于透射的成像系统和相应的基于透射的成像方法的探针头。光谱系统优选适用于体内非侵入性血液分析。基于传输的成像利用已经通过生物组织传输的成像或监视光束的透射部分。通过基于传输的成像，可以有效降低散射辐射的对比度减小的影响。此外，通过将成像光源与分光系统的物镜相对设置，可以有效地防止光谱激发辐射的非预期传播进入自由空间。

7. 发明申请

US20070049830A1 Analysis of a composition with monitoring 审中-公开
标题翻译：分析一个组成与监测
公开(公告)号：US20070049830A1
公开(公告)日：2007-03-01
申请号：US10549056
申请日：2004-03-15
申请人： Robert Hendriks , Gerhardus Lucassen , Marjolein Van Der Voort , Gerwin Puppels , Michael Van Beek
发明人： Robert Hendriks , Gerhardus Lucassen , Marjolein Van Der Voort , Gerwin Puppels , Michael Van Beek
IPC分类号： A61B6/00
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/0075 , A61B5/14532 , G01N21/65
摘要： An analysis apparatus, in particular a spectroscopic analysis apparatus, comprises an excitation system for emitting an excitation beam to excite a target region. A a monitoring system images the target region. The monitoring system being arranged to produce a contrast image in a contrast wavelength range and produce a reference image in a reference wavelength range. the contrast image and the reference image are compared to accurately identify the target region, notably a capillary blood vessel in the patient's skin.
摘要翻译：分析装置，特别是光谱分析装置，包括用于发射激发光束以激发目标区域的激发系统。监控系统对目标区域进行成像。所述监视系统被布置成产生对比度波长范围内的对比度图像并产生参考波长范围内的参考图像。比较对比图像和参考图像以精确地识别目标区域，特别是患者皮肤中的毛细血管血管。

8. 发明申请

US20070252978A1 Method and Apparatus for Optical Spectroscopy 审中-公开
标题翻译：光谱学方法与装置
公开(公告)号：US20070252978A1
公开(公告)日：2007-11-01
申请号：US10596501
申请日：2004-12-13
申请人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
发明人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01N21/65 , G01J3/44 , G01J2003/4424
摘要： The present invention provides for a method of optical spectroscopy, in particular Raman spectroscopy for performing invasive or non-invasive blood analysis. The fluorescence component of return radiation which is received from a detection volume is eliminated which is enabled by the usage of a pulsed excitation light source. The pulse length is substantially shorter than the fluorescence life time Hence, the elimination of the fluorescence composent can be performed by time gating or by other electronics or optical means.
摘要翻译：本发明提供一种用于进行侵入性或非侵入性血液分析的光谱学方法，特别是拉曼光谱法。消除了从检测体积接收的返回辐射的荧光分量，其通过使用脉冲激发光源来实现。脉冲长度明显短于荧光寿命。因此，荧光成分的消除可以通过时间选通或其他电子学或光学方法进行。

9. 发明申请

US20060181791A1 Method and apparatus for determining a property of a fluid which flows through a biological tubular structure with variable numerical aperture 审中-公开
标题翻译：用于确定流过具有可变数值孔径的生物管状结构的流体的性质的方法和装置
公开(公告)号：US20060181791A1
公开(公告)日：2006-08-17
申请号：US10566346
申请日：2004-07-26
申请人： Michael Van Beek , Jan Baptist Horsten , Marjolein Van Der Voort , Gerhardus Lucassen , Peter Caspers
发明人： Michael Van Beek , Jan Baptist Horsten , Marjolein Van Der Voort , Gerhardus Lucassen , Peter Caspers
IPC分类号： G02B5/08 , G02B7/195
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/0068 , G01N21/4795 , G01N21/64 , G01N21/65 , G01N2021/653 , G01N2021/655
摘要： The present invention provides for an apparatus and a method for determining a property of a fluid which flows through a biological tubular structure, such as blood flowing through a capillary vessel (112) under the skin (114). This enables in vivo non-invasive blood analysis. An objective (108) having a variable numerical aperture (116) is used to enable automatic detection of a blood vessel (112) and to provide a high signal to noise ratio of the return radiation for the purposes of the spectroscopic analysis and to provide a small detection volume that fits completely within the target region.
摘要翻译：本发明提供一种用于确定流过生物管状结构（例如流过皮肤下面的毛细血管（112）的血液）的流体的性质的装置和方法。这使得能够进行体内非侵入性血液分析。具有可变数值孔径（116）的物镜（108）用于能够自动检测血管（112）并且为了进行光谱分析的目的提供返回辐射的高信噪比，并且提供小的检测体积完全适合目标区域。

10. 发明申请

US20080262324A1 Measurement Head For Non-Invasive Blood Analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US20080262324A1
公开(公告)日：2008-10-23
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： The present invention provides an efficient approach of attaching and fixing a measurement head for a spectroscopic system to a variety of different parts of the skin of a patient. The measurement head preferably features a compact design providing a flexible handling and offering a huge variety of application areas taking into account the plurality of properties of various portions of the skin. Furthermore, the measurement head features a robust and uncomplicated optical design not requiring a lateral shifting of the optical axis of the objective. Such transverse relative movements between the objective and a capillary vessel in the skin are preferably performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors measuring the contact pressure between the measurement head and the skin. This pressure information can further be exploited in order to calibrate the spectroscopic analysis means, to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：本发明提供了将用于分光系统的测量头附接和固定到患者皮肤的各种不同部分的有效方法。测量头优选地具有紧凑的设计，提供灵活的处理，并且考虑到皮肤的各个部分的多个性质，提供了各种各样的应用领域。此外，测量头具有坚固且不复杂的光学设计，不需要物镜的光轴的横向偏移。物体和皮肤中的毛细血管之间的这种横向相对移动优选通过相对于测量头的目标机械地移动皮肤来执行。此外，测量头适于承载测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以进一步利用该压力信息来校准光谱分析装置，以调节预定余量内的接触压力，从而规定用于毛细血管的光谱检查的最佳接触压力范围。

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