专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070049830A1 Analysis of a composition with monitoring 审中-公开
标题翻译：分析一个组成与监测
公开(公告)号：US20070049830A1
公开(公告)日：2007-03-01
申请号：US10549056
申请日：2004-03-15
申请人： Robert Hendriks , Gerhardus Lucassen , Marjolein Van Der Voort , Gerwin Puppels , Michael Van Beek
发明人： Robert Hendriks , Gerhardus Lucassen , Marjolein Van Der Voort , Gerwin Puppels , Michael Van Beek
IPC分类号： A61B6/00
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/0075 , A61B5/14532 , G01N21/65
摘要： An analysis apparatus, in particular a spectroscopic analysis apparatus, comprises an excitation system for emitting an excitation beam to excite a target region. A a monitoring system images the target region. The monitoring system being arranged to produce a contrast image in a contrast wavelength range and produce a reference image in a reference wavelength range. the contrast image and the reference image are compared to accurately identify the target region, notably a capillary blood vessel in the patient's skin.
摘要翻译：分析装置，特别是光谱分析装置，包括用于发射激发光束以激发目标区域的激发系统。监控系统对目标区域进行成像。所述监视系统被布置成产生对比度波长范围内的对比度图像并产生参考波长范围内的参考图像。比较对比图像和参考图像以精确地识别目标区域，特别是患者皮肤中的毛细血管血管。

2. 发明申请

US20070252978A1 Method and Apparatus for Optical Spectroscopy 审中-公开
标题翻译：光谱学方法与装置
公开(公告)号：US20070252978A1
公开(公告)日：2007-11-01
申请号：US10596501
申请日：2004-12-13
申请人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
发明人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01N21/65 , G01J3/44 , G01J2003/4424
摘要： The present invention provides for a method of optical spectroscopy, in particular Raman spectroscopy for performing invasive or non-invasive blood analysis. The fluorescence component of return radiation which is received from a detection volume is eliminated which is enabled by the usage of a pulsed excitation light source. The pulse length is substantially shorter than the fluorescence life time Hence, the elimination of the fluorescence composent can be performed by time gating or by other electronics or optical means.
摘要翻译：本发明提供一种用于进行侵入性或非侵入性血液分析的光谱学方法，特别是拉曼光谱法。消除了从检测体积接收的返回辐射的荧光分量，其通过使用脉冲激发光源来实现。脉冲长度明显短于荧光寿命。因此，荧光成分的消除可以通过时间选通或其他电子学或光学方法进行。

3. 发明申请

US20060135861A1 Apparatus and method for blood analysis 审中-公开
标题翻译：血液分析仪器及方法
公开(公告)号：US20060135861A1
公开(公告)日：2006-06-22
申请号：US10544293
申请日：2004-01-19
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for blood analysis on vessels. An excitation system (exs) emits an excitation beam to excite a target region. A detection system (dsy) is provided for detecting and analyzing scattered radiation from the target region. Those areas are selected or predetermined so that only scattered radiation from blood in capillaries having a diameter below a predetermined diameter value and/or including an amount of red blood cells below a predetermined cell amount is analyzed. Thus, in contrast to analysis on whole blood or large amounts of blood cells less reabsorption and scattering of Raman light due to red blood cells is obtained. Further, the possibility to directly measure in the blood plasma without interference of the red blood cells, thereby yielding a higher signal-to-noise ratio, is given.
摘要翻译：本发明涉及用于血管分析的分析装置，特别是光谱分析装置。激发系统（exs）发射激发光束以激发目标区域。提供了一种用于检测和分析来自目标区域的散射辐射的检测系统（dsy）。选择或预定那些区域，以便仅分析具有低于预定直径值的直径的毛细血管和/或包括低于预定细胞量的红细胞量的来自血液的散射辐射。因此，与全血或大量血细胞的分析相反，获得了由于红细胞引起的拉曼光的再吸收和散射较少。此外，给出了在血浆中直接测量而不干扰红细胞，从而产生更高的信噪比的可能性。

4. 发明申请

US20060100524A1 Analysis apparatus and method 审中-公开
标题翻译：分析装置和方法
公开(公告)号：US20060100524A1
公开(公告)日：2006-05-11
申请号：US10541176
申请日：2003-12-04
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort
IPC分类号： A61B6/00
CPC分类号： G01J3/44 , A61B5/0059 , A61B5/0068 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analysing an object, such as the blood of a patient, and a corresponding analysis method. An excitation system (exs) emits an excitation beam (exb) to excite a target region and a beam separation unit (hm) separates at least part of elastically scattered radiation from inelastically scattered radiation, said scattered radiation being generated by the excitation beam (exb) at the target region. A monitoring system (lso) generates an image of the target region using the elastically scattered or the inelastically scattered radiation and defines a region of interest in said image. To increase efficiency of the recording of Raman spectra, a control unit (ctrl) is provided for controlling the excitation system (exs) such that the defined region of interest of the target region is excited and/or for controlling the detection system (dsy) such that only signals from the defined region of interest are detected, and a detection system (dsy) is provided for detecting scattered radiation from the defined region of interest generated by the excitation beam. Preferably the signal from the defined region of interest is averaged by distributing the laser excitation power over the defined region of interest area.
摘要翻译：本发明涉及一种用于分析诸如患者血液的物体的分析装置，特别是光谱分析装置和相应的分析方法。激发系统（exs）发射激发光束（exb）以激发目标区域，光束分离单元（hm）将弹性散射辐射的至少一部分与非弹性散射辐射分离，所述散射辐射由激发光束（exb ）在目标区域。监测系统（lso）使用弹性散射或非弹性散射的辐射产生目标区域的图像，并且定义所述图像中的感兴趣区域。为了提高拉曼光谱记录的效率，提供控制单元（ctrl）以控制激励系统（exs），使得目标区域的限定的目标区域被激发和/或用于控制检测系统（dsy）使得仅检测到来自限定的感兴趣区域的信号，并且提供检测系统（dsy），用于检测来自由激发光束产生的所定义的感兴趣区域的散射辐射。优选地，通过在所定义的感兴趣区域区域上分布激光激发功率来平均来自限定的感兴趣区域的信号。

5. 发明申请

US20060129036A1 Apparatus for the ph determination of blood and method therefor 失效
标题翻译：血液测定装置及其方法
公开(公告)号：US20060129036A1
公开(公告)日：2006-06-15
申请号：US10559306
申请日：2004-05-27
申请人： Gerhardus Lucassen , Gerwin Puppels
发明人： Gerhardus Lucassen , Gerwin Puppels
IPC分类号： A61B5/00 , C12Q1/00
CPC分类号： A61B5/14539 , A61B5/1455 , G01J3/44 , G01N21/65
摘要： The present invention relates to a spectroscopic apparatus for non-invasive in vivo analysis of blood and to a corresponding analysis method, in particular for direct determination of the pH value of the blood. From a Raman signal detected from an excited target region containing blood at least one predetermined pH sensitive signal portion is determined, from which the pH value of the blood in the target region by use of a relationship between pH value and one or more band parameters of pH sensitive vibrations of at least one molecule or part of a molecule present in blood, in particular heme vibrations of hemoglobin, is determined.
摘要翻译：本发明涉及一种用于非侵入性体内血液分析的分光装置和相应的分析方法，特别是用于直接测定血液的pH值。根据从含有血液的激发目标区域检测到的至少一个预定的pH敏感信号部分的拉曼信号，通过使用pH值与一个或多个频带参数之间的关系来确定目标区域中的血液的pH值确定血液中至少一种分子或部分分子的pH敏感振动，特别是血红蛋白的血红素振动。

6. 发明申请

US20050117150A1 Depth selective ph measurement and uv exposure measurement 有权
标题翻译：深度选择性ph测量和紫外曝光测量
公开(公告)号：US20050117150A1
公开(公告)日：2005-06-02
申请号：US10506056
申请日：2002-02-28
申请人： Gerwin Puppels , Peter Caspers , Gerhardus Lucassen
发明人： Gerwin Puppels , Peter Caspers , Gerhardus Lucassen
IPC分类号： A61B5/00 , A61B5/103 , G01N21/65 , G01J3/44
CPC分类号： A61B5/14539 , A61B5/0059 , A61B5/0064 , A61B5/441 , A61B2562/0242 , G01N21/65
摘要： A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.
摘要翻译：在动物组织内测量拉曼光谱，例如人类皮肤组织，从表面的选定深度组织。使用赋予pH值作为测量的拉曼光谱的函数的函数来计算pH值。该计算可以涉及计算表示来自拉曼光谱的化学物质的质子化和去质子化版本的浓度比的数量，并且基于所述数量产生pH信息。化学物质例如是一种形式的尿布酸（UCA）。紫外线照射是从顺式UCA光谱的重量测定的。

7. 发明申请

US20100309466A1 SPECTROSCOPIC DETERMINATION OF ANALYTE CONCENTRATION 失效
标题翻译：分析浓度的光谱测定
公开(公告)号：US20100309466A1
公开(公告)日：2010-12-09
申请号：US11911557
申请日：2006-04-19
申请人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
发明人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
IPC分类号： G01J3/40
CPC分类号： A61B5/14532 , A61B5/489
摘要： A spectroscopic apparatus, a method of determining a concentration and/or spatial gradient of an analyte of a bodily fluid and a corresponding computer program product are provided. The spectroscopic apparatus provides determination of a position of a capillary vessel (104) within a biological sample in order to focus spectroscopic excitation radiation to a volume (122). that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus, method, and computer program product advantageously exploit the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel.
摘要翻译：提供了一种分光装置，确定体液分析物和相应的计算机程序产品的浓度和/或空间梯度的方法。分光装置提供对生物样品内的毛细血管（104）的位置的确定，以便将分光激发辐射聚焦到体积（122）。其紧邻毛细血管，但不与毛细血管重叠。所提供的装置，方法和计算机程序产品有利地利用容器壁相对于经受分析物浓度测定的分析物的渗透性。通过生物传输过程，位于毛细管中的体液分析物的浓度影响毛细血管周围的浓度。因此，毛细血管外部的体积的光谱分析可用于在毛细血管内进行精确和可靠的分析物浓度测定。

8. 发明申请

US20070175278A1 Automated characterization and classification of microorganisms 失效
标题翻译：微生物的自动表征和分类
公开(公告)号：US20070175278A1
公开(公告)日：2007-08-02
申请号：US10556365
申请日：2004-05-11
申请人： Gerwin Puppels , Tom Bakker Schut , Kornelis Maquelin
发明人： Gerwin Puppels , Tom Bakker Schut , Kornelis Maquelin
IPC分类号： G01H17/00 , C12Q1/10
CPC分类号： G01N33/569 , G01N21/65
摘要： An instrument, method, use and software program to obtain information rapidly about microorganisms that may spread uncontrolled in hospitals, water supply, food or when used in bio terrorism are described. Vibrational spectroscopy provides data to a computer linked to one or more databases. Comparison of the spectral data and information retrieved from the databases is used to identify and classify the microorganisms, applying suitable algorithms, which algorithms are self-generating and self-adapting to new spectroscopic data. The system may alert for the detection of an outbreak or to take disinfection measures. Changes in the traditional taxonomic division of microorganisms have no influence on the instrument. It does not rely on an a priori knowledge about the taxonomic classification of the microbial strain, is straightforward and easily integrated in routine microbial procedures.
摘要翻译：描述了在医疗，供水，食品中或在生物恐怖主义中使用时可能传播不受控制的微生物的快速获取信息的工具，方法，使用和软件程序。振动光谱仪为连接到一个或多个数据库的计算机提供数据。使用从数据库检索的光谱数据和信息的比较来识别和分类微生物，应用合适的算法，哪些算法是自发生的并且适应于新的光谱数据。系统可能会警告爆发的检测或采取消毒措施。微生物传统分类学分类的变化对仪器没有影响。它不依赖于关于微生物菌株的分类学分类的先验知识，是直接和容易地集成在常规微生物程序中。

9. 发明申请

US20050179895A1 Optical spectrometer 有权
标题翻译：光谱仪
公开(公告)号：US20050179895A1
公开(公告)日：2005-08-18
申请号：US11034229
申请日：2005-01-12
申请人： Gerwin Puppels
发明人： Gerwin Puppels
IPC分类号： G01J3/18 , G01J3/447 , G01J3/28 , G01J3/44
CPC分类号： G01J3/18 , G01J3/447
摘要： Incoming light is spectrally analyzed by diffracting the incoming light with a grating. At least a part of the incoming light is split off so that this part contains mainly one polarization component of the incoming light. It is ensured that this split-off part and a remaining part of the incoming light reach the grating with their polarized component mainly parallel to a main direction of polarization which is diffracted with maximal efficiency by the grating. For this purpose, at least the split-off part is diffracted after being passed through a polarization rotating element.
摘要翻译：通过用光栅衍射入射光进行光谱分析。入射光的至少一部分被分离，使得该部分主要包含入射光的一个偏振分量。确保该分离部分和入射光的剩余部分以它们的偏振分量主要平行于通过光栅以最大效率衍射的主要偏振方向到达光栅。为此，至少分离部分在通过偏振旋转元件之后被衍射。

10. 发明申请

US20060139633A1 Use of high wavenumber raman spectroscopy for measuring tissue 有权
标题翻译：使用高波数拉曼光谱仪测量组织
公开(公告)号：US20060139633A1
公开(公告)日：2006-06-29
申请号：US10537074
申请日：2003-12-02
申请人： Gerwin Puppels , Rolf Wolthus , Senada Koljenovic
发明人： Gerwin Puppels , Rolf Wolthus , Senada Koljenovic
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B5/0071 , A61B5/0075 , A61B5/0086 , A61B5/441 , A61B5/4848 , G01J3/44 , G01N2021/656
摘要： The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm−1 spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.
摘要翻译：本发明涉及用于测量组织的拉曼信号的仪器，仪器包括激光器，用于测量拉曼信号的信号检测单元和光纤探针，其中光纤探针包括一根或多根光纤，用于引导将激光照射到组织上并用于收集由组织散射的光并将收集的光引导离开组织朝向信号检测单元，其中用于收集光的光纤或纤维在一个或多个部分中基本上不具有拉曼信号 2500-3700cm -1光谱区域，其中检测单元记录由所述光谱区域中的组织散射的拉曼信号。本发明使得动脉粥样硬化斑块的离体，体外和体内分析和诊断和肿瘤组织的检测具有优于现有技术的优点。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式