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1. 发明申请

US20060181791A1 Method and apparatus for determining a property of a fluid which flows through a biological tubular structure with variable numerical aperture 审中-公开
标题翻译：用于确定流过具有可变数值孔径的生物管状结构的流体的性质的方法和装置
公开(公告)号：US20060181791A1
公开(公告)日：2006-08-17
申请号：US10566346
申请日：2004-07-26
申请人： Michael Van Beek , Jan Baptist Horsten , Marjolein Van Der Voort , Gerhardus Lucassen , Peter Caspers
发明人： Michael Van Beek , Jan Baptist Horsten , Marjolein Van Der Voort , Gerhardus Lucassen , Peter Caspers
IPC分类号： G02B5/08 , G02B7/195
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/0068 , G01N21/4795 , G01N21/64 , G01N21/65 , G01N2021/653 , G01N2021/655
摘要： The present invention provides for an apparatus and a method for determining a property of a fluid which flows through a biological tubular structure, such as blood flowing through a capillary vessel (112) under the skin (114). This enables in vivo non-invasive blood analysis. An objective (108) having a variable numerical aperture (116) is used to enable automatic detection of a blood vessel (112) and to provide a high signal to noise ratio of the return radiation for the purposes of the spectroscopic analysis and to provide a small detection volume that fits completely within the target region.
摘要翻译：本发明提供一种用于确定流过生物管状结构（例如流过皮肤下面的毛细血管（112）的血液）的流体的性质的装置和方法。这使得能够进行体内非侵入性血液分析。具有可变数值孔径（116）的物镜（108）用于能够自动检测血管（112）并且为了进行光谱分析的目的提供返回辐射的高信噪比，并且提供小的检测体积完全适合目标区域。

2. 发明申请

US20100309466A1 SPECTROSCOPIC DETERMINATION OF ANALYTE CONCENTRATION 失效
标题翻译：分析浓度的光谱测定
公开(公告)号：US20100309466A1
公开(公告)日：2010-12-09
申请号：US11911557
申请日：2006-04-19
申请人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
发明人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
IPC分类号： G01J3/40
CPC分类号： A61B5/14532 , A61B5/489
摘要： A spectroscopic apparatus, a method of determining a concentration and/or spatial gradient of an analyte of a bodily fluid and a corresponding computer program product are provided. The spectroscopic apparatus provides determination of a position of a capillary vessel (104) within a biological sample in order to focus spectroscopic excitation radiation to a volume (122). that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus, method, and computer program product advantageously exploit the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel.
摘要翻译：提供了一种分光装置，确定体液分析物和相应的计算机程序产品的浓度和/或空间梯度的方法。分光装置提供对生物样品内的毛细血管（104）的位置的确定，以便将分光激发辐射聚焦到体积（122）。其紧邻毛细血管，但不与毛细血管重叠。所提供的装置，方法和计算机程序产品有利地利用容器壁相对于经受分析物浓度测定的分析物的渗透性。通过生物传输过程，位于毛细管中的体液分析物的浓度影响毛细血管周围的浓度。因此，毛细血管外部的体积的光谱分析可用于在毛细血管内进行精确和可靠的分析物浓度测定。

3. 发明申请

US20050117150A1 Depth selective ph measurement and uv exposure measurement 有权
标题翻译：深度选择性ph测量和紫外曝光测量
公开(公告)号：US20050117150A1
公开(公告)日：2005-06-02
申请号：US10506056
申请日：2002-02-28
申请人： Gerwin Puppels , Peter Caspers , Gerhardus Lucassen
发明人： Gerwin Puppels , Peter Caspers , Gerhardus Lucassen
IPC分类号： A61B5/00 , A61B5/103 , G01N21/65 , G01J3/44
CPC分类号： A61B5/14539 , A61B5/0059 , A61B5/0064 , A61B5/441 , A61B2562/0242 , G01N21/65
摘要： A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.
摘要翻译：在动物组织内测量拉曼光谱，例如人类皮肤组织，从表面的选定深度组织。使用赋予pH值作为测量的拉曼光谱的函数的函数来计算pH值。该计算可以涉及计算表示来自拉曼光谱的化学物质的质子化和去质子化版本的浓度比的数量，并且基于所述数量产生pH信息。化学物质例如是一种形式的尿布酸（UCA）。紫外线照射是从顺式UCA光谱的重量测定的。

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