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1. 发明申请

US20060181791A1 Method and apparatus for determining a property of a fluid which flows through a biological tubular structure with variable numerical aperture 审中-公开
标题翻译：用于确定流过具有可变数值孔径的生物管状结构的流体的性质的方法和装置
公开(公告)号：US20060181791A1
公开(公告)日：2006-08-17
申请号：US10566346
申请日：2004-07-26
申请人： Michael Van Beek , Jan Baptist Horsten , Marjolein Van Der Voort , Gerhardus Lucassen , Peter Caspers
发明人： Michael Van Beek , Jan Baptist Horsten , Marjolein Van Der Voort , Gerhardus Lucassen , Peter Caspers
IPC分类号： G02B5/08 , G02B7/195
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/0068 , G01N21/4795 , G01N21/64 , G01N21/65 , G01N2021/653 , G01N2021/655
摘要： The present invention provides for an apparatus and a method for determining a property of a fluid which flows through a biological tubular structure, such as blood flowing through a capillary vessel (112) under the skin (114). This enables in vivo non-invasive blood analysis. An objective (108) having a variable numerical aperture (116) is used to enable automatic detection of a blood vessel (112) and to provide a high signal to noise ratio of the return radiation for the purposes of the spectroscopic analysis and to provide a small detection volume that fits completely within the target region.
摘要翻译：本发明提供一种用于确定流过生物管状结构（例如流过皮肤下面的毛细血管（112）的血液）的流体的性质的装置和方法。这使得能够进行体内非侵入性血液分析。具有可变数值孔径（116）的物镜（108）用于能够自动检测血管（112）并且为了进行光谱分析的目的提供返回辐射的高信噪比，并且提供小的检测体积完全适合目标区域。

2. 发明申请

US20070049830A1 Analysis of a composition with monitoring 审中-公开
标题翻译：分析一个组成与监测
公开(公告)号：US20070049830A1
公开(公告)日：2007-03-01
申请号：US10549056
申请日：2004-03-15
申请人： Robert Hendriks , Gerhardus Lucassen , Marjolein Van Der Voort , Gerwin Puppels , Michael Van Beek
发明人： Robert Hendriks , Gerhardus Lucassen , Marjolein Van Der Voort , Gerwin Puppels , Michael Van Beek
IPC分类号： A61B6/00
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/0075 , A61B5/14532 , G01N21/65
摘要： An analysis apparatus, in particular a spectroscopic analysis apparatus, comprises an excitation system for emitting an excitation beam to excite a target region. A a monitoring system images the target region. The monitoring system being arranged to produce a contrast image in a contrast wavelength range and produce a reference image in a reference wavelength range. the contrast image and the reference image are compared to accurately identify the target region, notably a capillary blood vessel in the patient's skin.
摘要翻译：分析装置，特别是光谱分析装置，包括用于发射激发光束以激发目标区域的激发系统。监控系统对目标区域进行成像。所述监视系统被布置成产生对比度波长范围内的对比度图像并产生参考波长范围内的参考图像。比较对比图像和参考图像以精确地识别目标区域，特别是患者皮肤中的毛细血管血管。

3. 发明申请

US20070213609A1 PROBE HEAD FOR SPECTROSCOPIC ANALYSIS OF A FLUID 失效
标题翻译：用于流体光谱分析的探头
公开(公告)号：US20070213609A1
公开(公告)日：2007-09-13
申请号：US11568363
申请日：2005-02-14
申请人： Gerhardus Lucassen , Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker
发明人： Gerhardus Lucassen , Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker
IPC分类号： A61B5/1455 , G01J3/42
CPC分类号： A61B5/0059 , A61B5/489 , A61B2562/0242
摘要： The present invention provides a spectroscopic system for determining a property of a fluid flowing through a volume of interest underneath the surface of the skin of a patient. The spectroscopic system comprises a probe head that has at least an objective for directing an excitation beam into the volume of interest and for collecting return radiation. The spectroscopic system has further a base station having at least a spectroscopic analysis unit and a power supply. The system makes use of a beam combination unit, a filter unit and a focusing unit for combining and separating a variety of different optical signals and for precisely positioning the optical signals inside the volume of interest. The beam combination unit, the filter unit and the focusing unit can be variably implemented inside the probe head or inside the base station depending on a specific applications of the spectroscopic system, thereby allowing for a flexible and compact design of the probe head.
摘要翻译：本发明提供了一种用于确定流过患者皮肤表面下方的感兴趣体积的流体的性质的光谱系统。分光系统包括探头，该探头至少具有将激发光束引导到感兴趣体积中并用于收集返回辐射的目的。光谱系统还具有至少具有光谱分析单元和电源的基站。该系统利用光束组合单元，滤光器单元和聚焦单元，用于组合和分离各种不同的光信号，并将光信号精确地定位在感兴趣的体积内。根据分光系统的具体应用，光束组合单元，滤光器单元和聚焦单元可以可变地实现在探头内部或基站内部，从而允许探头的灵活且紧凑的设计。

4. 发明申请

US20070252978A1 Method and Apparatus for Optical Spectroscopy 审中-公开
标题翻译：光谱学方法与装置
公开(公告)号：US20070252978A1
公开(公告)日：2007-11-01
申请号：US10596501
申请日：2004-12-13
申请人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
发明人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01N21/65 , G01J3/44 , G01J2003/4424
摘要： The present invention provides for a method of optical spectroscopy, in particular Raman spectroscopy for performing invasive or non-invasive blood analysis. The fluorescence component of return radiation which is received from a detection volume is eliminated which is enabled by the usage of a pulsed excitation light source. The pulse length is substantially shorter than the fluorescence life time Hence, the elimination of the fluorescence composent can be performed by time gating or by other electronics or optical means.
摘要翻译：本发明提供一种用于进行侵入性或非侵入性血液分析的光谱学方法，特别是拉曼光谱法。消除了从检测体积接收的返回辐射的荧光分量，其通过使用脉冲激发光源来实现。脉冲长度明显短于荧光寿命。因此，荧光成分的消除可以通过时间选通或其他电子学或光学方法进行。

5. 发明申请

US20070070328A1 Method of determining a property of a fluid and spectroscopic system 失效
标题翻译：确定流体和光谱系统性质的方法
公开(公告)号：US20070070328A1
公开(公告)日：2007-03-29
申请号：US10595358
申请日：2004-10-15
申请人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
发明人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
IPC分类号： G01N33/48 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/489
摘要： The present invention enables to determine the property of a fluid, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by means of an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective to the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.
摘要翻译：本发明能够确定流体的性质，例如用于体内血液分析的目的。首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。优选地，光学检测步骤是成像步骤。接下来，将目标转移到目标的焦点。在该位置，进行光学分光步骤。这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

6. 发明申请

US20060135861A1 Apparatus and method for blood analysis 审中-公开
标题翻译：血液分析仪器及方法
公开(公告)号：US20060135861A1
公开(公告)日：2006-06-22
申请号：US10544293
申请日：2004-01-19
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for blood analysis on vessels. An excitation system (exs) emits an excitation beam to excite a target region. A detection system (dsy) is provided for detecting and analyzing scattered radiation from the target region. Those areas are selected or predetermined so that only scattered radiation from blood in capillaries having a diameter below a predetermined diameter value and/or including an amount of red blood cells below a predetermined cell amount is analyzed. Thus, in contrast to analysis on whole blood or large amounts of blood cells less reabsorption and scattering of Raman light due to red blood cells is obtained. Further, the possibility to directly measure in the blood plasma without interference of the red blood cells, thereby yielding a higher signal-to-noise ratio, is given.
摘要翻译：本发明涉及用于血管分析的分析装置，特别是光谱分析装置。激发系统（exs）发射激发光束以激发目标区域。提供了一种用于检测和分析来自目标区域的散射辐射的检测系统（dsy）。选择或预定那些区域，以便仅分析具有低于预定直径值的直径的毛细血管和/或包括低于预定细胞量的红细胞量的来自血液的散射辐射。因此，与全血或大量血细胞的分析相反，获得了由于红细胞引起的拉曼光的再吸收和散射较少。此外，给出了在血浆中直接测量而不干扰红细胞，从而产生更高的信噪比的可能性。

7. 发明申请

US20060100524A1 Analysis apparatus and method 审中-公开
标题翻译：分析装置和方法
公开(公告)号：US20060100524A1
公开(公告)日：2006-05-11
申请号：US10541176
申请日：2003-12-04
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort
IPC分类号： A61B6/00
CPC分类号： G01J3/44 , A61B5/0059 , A61B5/0068 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analysing an object, such as the blood of a patient, and a corresponding analysis method. An excitation system (exs) emits an excitation beam (exb) to excite a target region and a beam separation unit (hm) separates at least part of elastically scattered radiation from inelastically scattered radiation, said scattered radiation being generated by the excitation beam (exb) at the target region. A monitoring system (lso) generates an image of the target region using the elastically scattered or the inelastically scattered radiation and defines a region of interest in said image. To increase efficiency of the recording of Raman spectra, a control unit (ctrl) is provided for controlling the excitation system (exs) such that the defined region of interest of the target region is excited and/or for controlling the detection system (dsy) such that only signals from the defined region of interest are detected, and a detection system (dsy) is provided for detecting scattered radiation from the defined region of interest generated by the excitation beam. Preferably the signal from the defined region of interest is averaged by distributing the laser excitation power over the defined region of interest area.
摘要翻译：本发明涉及一种用于分析诸如患者血液的物体的分析装置，特别是光谱分析装置和相应的分析方法。激发系统（exs）发射激发光束（exb）以激发目标区域，光束分离单元（hm）将弹性散射辐射的至少一部分与非弹性散射辐射分离，所述散射辐射由激发光束（exb ）在目标区域。监测系统（lso）使用弹性散射或非弹性散射的辐射产生目标区域的图像，并且定义所述图像中的感兴趣区域。为了提高拉曼光谱记录的效率，提供控制单元（ctrl）以控制激励系统（exs），使得目标区域的限定的目标区域被激发和/或用于控制检测系统（dsy）使得仅检测到来自限定的感兴趣区域的信号，并且提供检测系统（dsy），用于检测来自由激发光束产生的所定义的感兴趣区域的散射辐射。优选地，通过在所定义的感兴趣区域区域上分布激光激发功率来平均来自限定的感兴趣区域的信号。

8. 发明申请

US20100309466A1 SPECTROSCOPIC DETERMINATION OF ANALYTE CONCENTRATION 失效
标题翻译：分析浓度的光谱测定
公开(公告)号：US20100309466A1
公开(公告)日：2010-12-09
申请号：US11911557
申请日：2006-04-19
申请人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
发明人： Gerhardus Lucassen , Rufus Driessen , Kristiane Schmidt , Gerwin Puppels , Peter Caspers
IPC分类号： G01J3/40
CPC分类号： A61B5/14532 , A61B5/489
摘要： A spectroscopic apparatus, a method of determining a concentration and/or spatial gradient of an analyte of a bodily fluid and a corresponding computer program product are provided. The spectroscopic apparatus provides determination of a position of a capillary vessel (104) within a biological sample in order to focus spectroscopic excitation radiation to a volume (122). that is in close proximity to the capillary vessel but does not overlap with the capillary vessel. The provided apparatus, method, and computer program product advantageously exploit the permeability of the vessel wall with respect to an analyte that is subject to analyte concentration determination. By means of biological transport processes, the concentration of an analyte of a bodily fluid located in the capillary vessel influences the concentration in the surrounding of the capillary vessel. Spectroscopic analysis of a volume outside the capillary vessel can therefore serve for a precise and reliable analyte concentration determination inside the capillary vessel.
摘要翻译：提供了一种分光装置，确定体液分析物和相应的计算机程序产品的浓度和/或空间梯度的方法。分光装置提供对生物样品内的毛细血管（104）的位置的确定，以便将分光激发辐射聚焦到体积（122）。其紧邻毛细血管，但不与毛细血管重叠。所提供的装置，方法和计算机程序产品有利地利用容器壁相对于经受分析物浓度测定的分析物的渗透性。通过生物传输过程，位于毛细管中的体液分析物的浓度影响毛细血管周围的浓度。因此，毛细血管外部的体积的光谱分析可用于在毛细血管内进行精确和可靠的分析物浓度测定。

9. 发明申请

US20050117150A1 Depth selective ph measurement and uv exposure measurement 有权
标题翻译：深度选择性ph测量和紫外曝光测量
公开(公告)号：US20050117150A1
公开(公告)日：2005-06-02
申请号：US10506056
申请日：2002-02-28
申请人： Gerwin Puppels , Peter Caspers , Gerhardus Lucassen
发明人： Gerwin Puppels , Peter Caspers , Gerhardus Lucassen
IPC分类号： A61B5/00 , A61B5/103 , G01N21/65 , G01J3/44
CPC分类号： A61B5/14539 , A61B5/0059 , A61B5/0064 , A61B5/441 , A61B2562/0242 , G01N21/65
摘要： A Raman spectrum is measured inside animal tissue, such us human skin tissue, at a selected depth from a surface the tissue. A pH value is computed using a function that assigns a pH value as a function of the measured Raman spectrum. The computation may involve computing a number representing a ratio of concentrations of a protonated and a deprotonated version of a chemical substance from the Raman spectrum and generating pH information on the basis of said number. The chemical substance is for example a form of Urocanic acid (UCA). UV exposure is measured from the weight of the spectrum of cis-UCA.
摘要翻译：在动物组织内测量拉曼光谱，例如人类皮肤组织，从表面的选定深度组织。使用赋予pH值作为测量的拉曼光谱的函数的函数来计算pH值。该计算可以涉及计算表示来自拉曼光谱的化学物质的质子化和去质子化版本的浓度比的数量，并且基于所述数量产生pH信息。化学物质例如是一种形式的尿布酸（UCA）。紫外线照射是从顺式UCA光谱的重量测定的。

10. 发明申请

US20060129036A1 Apparatus for the ph determination of blood and method therefor 失效
标题翻译：血液测定装置及其方法
公开(公告)号：US20060129036A1
公开(公告)日：2006-06-15
申请号：US10559306
申请日：2004-05-27
申请人： Gerhardus Lucassen , Gerwin Puppels
发明人： Gerhardus Lucassen , Gerwin Puppels
IPC分类号： A61B5/00 , C12Q1/00
CPC分类号： A61B5/14539 , A61B5/1455 , G01J3/44 , G01N21/65
摘要： The present invention relates to a spectroscopic apparatus for non-invasive in vivo analysis of blood and to a corresponding analysis method, in particular for direct determination of the pH value of the blood. From a Raman signal detected from an excited target region containing blood at least one predetermined pH sensitive signal portion is determined, from which the pH value of the blood in the target region by use of a relationship between pH value and one or more band parameters of pH sensitive vibrations of at least one molecule or part of a molecule present in blood, in particular heme vibrations of hemoglobin, is determined.
摘要翻译：本发明涉及一种用于非侵入性体内血液分析的分光装置和相应的分析方法，特别是用于直接测定血液的pH值。根据从含有血液的激发目标区域检测到的至少一个预定的pH敏感信号部分的拉曼信号，通过使用pH值与一个或多个频带参数之间的关系来确定目标区域中的血液的pH值确定血液中至少一种分子或部分分子的pH敏感振动，特别是血红蛋白的血红素振动。

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