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1. 发明授权

US5283181A Conjugated enzyme electrode 失效
标题翻译：共轭酶电极
公开(公告)号：US5283181A
公开(公告)日：1994-02-01
申请号：US672238
申请日：1991-03-20
申请人： Isamu Uchida , Tomokazu Matsue , Hsien-Chang Chang , Akinori Ueno , Hiroshi Yamada
发明人： Isamu Uchida , Tomokazu Matsue , Hsien-Chang Chang , Akinori Ueno , Hiroshi Yamada
IPC分类号： G01N27/327 , C12Q1/00 , C12Q1/32 , C12N1/00
CPC分类号： C12Q1/005 , C12Q1/003 , Y10S435/817 , Y10S435/832
摘要： A conjugated enzyme electrode comprising diaphorase and an amino-acid dehydrogenase immobilized on a conductive support by a polyfunctional aldehyde is disclosed, by which amino acids can be rapidly determined with high sensitivity.
摘要翻译：公开了通过多官能醛固定在导电性支持体上的包含心肌黄酶和氨基酸脱氢酶的共轭酶电极，可以高灵敏度地迅速测定氨基酸。

2. 发明申请

US20060270071A1 METHOD OF REDUCING CHARGING DAMAGE TO INTEGRATED CIRCUITS DURING SEMICONDUCTOR MANUFACTURING 有权
标题翻译：在半导体制造过程中减少对集成电路充电损伤的方法
公开(公告)号：US20060270071A1
公开(公告)日：2006-11-30
申请号：US11379380
申请日：2006-04-20
申请人： Hsien-Chang Chang , Chia-Hsin Hou , Tsu-Yu Chu , Ko-Ting Chen
发明人： Hsien-Chang Chang , Chia-Hsin Hou , Tsu-Yu Chu , Ko-Ting Chen
IPC分类号： H01L21/66
CPC分类号： H01L21/266 , H01L21/823418 , H01L21/823481 , H01L27/0207
摘要： A semiconductor substrate having an integrated circuit die area surrounded by a scribe lane is provided. Within the integrated circuit die area, a first trench isolation region and a second trench isolation region are formed on the semiconductor substrate, wherein the first trench isolation region isolates a first active device region from a second active device region, and the second trench isolation region comprises a plurality of trench dummy features for reducing loading effect. A first gate electrode is formed on the first active device region and a second gate electrode on the second active device region. The first active device region is masked, while the second active device region and the trench dummy features are exposed. An ion implantation process is then performed to implant dopant species into the second active device region.
摘要翻译：提供具有被划线通道包围的集成电路管芯区域的半导体衬底。在集成电路管芯区域内，在半导体衬底上形成第一沟槽隔离区域和第二沟槽隔离区域，其中第一沟槽隔离区域将第一有源器件区域与第二有源器件区域隔离，第二沟槽隔离区域包括用于减小负载效应的多个沟槽虚拟特征。在第一有源器件区上形成第一栅电极，在第二有源器件区上形成第二栅电极。第一有源器件区域被掩蔽，而第二有源器件区域和沟槽虚拟特征被暴露。然后执行离子注入工艺以将掺杂剂物质注入到第二有源器件区域中。

3. 发明申请

US20050087444A1 Method for manufacturing microfluidic chip with electroosmotic flow controlled by inducing electric field through self-assembled monolayer 审中-公开
标题翻译：通过自组装单层诱导电场控制电渗流的微流控芯片的制造方法
公开(公告)号：US20050087444A1
公开(公告)日：2005-04-28
申请号：US10690509
申请日：2003-10-23
申请人： Hsien-Chang Chang , Ching-Chou Wu , Ren-Guen Wu
发明人： Hsien-Chang Chang , Ching-Chou Wu , Ren-Guen Wu
IPC分类号： B01L3/00 , C25B15/00 , F04B19/00 , G01N27/447
CPC分类号： B82Y30/00 , B01L3/502707 , B01L3/50273 , B01L2200/12 , B01L2400/0418 , B82Y40/00 , F04B19/006 , G01N27/44752
摘要： A method for manufacturing a microfluidic chip with electroosmotic flow (EOF) controlled by inducing a perpendicularly electric field through a self-assembled monolayer (SAM) is disclosed. The method is primarily to combine a top plate and a bottom plate; wherein the bottom plate has a gate electrode on an upper surface thereof and has the SAM formed on said gate electrode. The top plate has an elongate micro channel groove which is narrower than that of the gate electrode, recessed in a lower portion thereof and filled with a buffer solution. Accordingly, the flowing direction and the flowing velocity of said EOF are controlled by supplying high voltage to two ends of said micro channel groove to produce an electric field for driving EOF and supplying an inducing voltage to the gate electrode. The SAM of the present invention can be easily formed and thin enough to lower the inducing voltage required for controlling the zeta potential and have a smaller chip size. Furthermore, direction and velocity of the EOF can be controlled regardless of the acidic or neutral solution filled in the channel.
摘要翻译：公开了一种制造通过自组装单层（SAM）诱导垂直电场控制的电渗流（EOF）的微流控芯片的方法。该方法主要是结合顶板和底板; 其中所述底板在其上表面上具有栅电极，并且所述SAM形成在所述栅电极上。顶板具有细长的微沟槽，其窄于栅极电极的凹槽，并在其下部填充缓冲溶液。因此，所述EOF的流动方向和流动速度通过向所述微通道沟槽的两端供给高电压来产生驱动EOF的电场并向栅电极提供感应电压来控制。本发明的SAM可以容易地形成和足够薄以降低控制ζ电位所需的感应电压并具有更小的芯片尺寸。此外，无论在通道中填充的酸性或中性溶液如何，都可以控制EOF的方向和速度。

4. 发明申请

US20110244595A1 BIOMEDICAL CHIP FOR BLOOD COAGULATION TEST, METHOD OF PRODUCTION AND USE THEREOF 审中-公开
标题翻译：用于血液凝固测试的生物医药芯片，生产方法和使用方法
公开(公告)号：US20110244595A1
公开(公告)日：2011-10-06
申请号：US13073834
申请日：2011-03-28
申请人： Chen-Kuei Chung , Hsien-Chang Chang , Chia-Chern Chen , Yu-Sheng Chen , Cheng-Ting Li
发明人： Chen-Kuei Chung , Hsien-Chang Chang , Chia-Chern Chen , Yu-Sheng Chen , Cheng-Ting Li
IPC分类号： G01N33/48 , B23P11/00
CPC分类号： B01L3/5027 , B01L3/502707 , B01L2300/0816 , B01L2300/0867 , B01L2300/161 , B01L2400/0406 , G01N33/4905 , Y10T137/0402
摘要： In a biomedical chip for blood coagulation tests and its manufacturing method and use, the biomedical chip comprises a substrate layer, a middle layer, and a cap layer, engaged and stacked with each other to define a microfluidic channel which has a first inlet and an outlet of the microfluidic channel respectively. A mixing interval is expanded outward from the microfluidic channel and interconnected to a second inlet, and has an interconnect portion and a capillary portion disposed between the substrate layer and the cap layer, and more specifically disposed around the periphery of the interconnect portion. With the biomedical chip having the substrate layer and cap layer made of a hydrophilic material, the blood and the reagent can be driven automatically by the capillary force of the microfluidic channel to flow and mix with each other, and the hydrophilic capillary force can be permanently maintained.
摘要翻译：在用于血液凝固试验的生物医学芯片及其制造方法和用途中，生物医学芯片包括彼此接合和堆叠的基底层，中间层和盖层，以限定微流体通道，该微流体通道具有第一入口和微流体通道的出口。混合间隔从微流体通道向外扩展并互连到第二入口，并且具有设置在基底层和盖层之间的互连部分和毛细管部分，并且更具体地设置在互连部分周围。利用生物医学芯片具有由亲水材料制成的基底层和盖层，血液和试剂可以通过微流体通道的毛细力自动驱动以相互流动和混合，亲水毛细管力可以永久地保持。

5. 发明授权

US08614496B2 Method to scale down IC layout 有权
标题翻译：缩小IC布局的方法
公开(公告)号：US08614496B2
公开(公告)日：2013-12-24
申请号：US13347711
申请日：2012-01-11
申请人： Hsien-Chang Chang
发明人： Hsien-Chang Chang
IPC分类号： H01L21/70
CPC分类号： G06F17/5068
摘要： A method scales down an integrated circuit layout structure without substantially jeopardizing electronic characteristics of devices. First, a conductive line set includes a first conductive line and a second conductive line respectively passing through a first region and a second region. Second, a sizing-down operation is performed so that the first conductive line and the second conductive line respectively have a first region scaled-down line width, a first region scaled-down space and a first region scaled-down pitch in the first region as well as selectively have a second region original line width, a second region scaled-down space and a second region scaled-down pitch in the second region. The first region scaled-down line width and the second region original line width are substantially different from each other.
摘要翻译：一种方法可以缩小集成电路布局结构，而不会基本上危及设备的电子特性。首先，导线组包括分别通过第一区域和第二区域的第一导线和第二导线。其次，执行施胶操作，使得第一导电线和第二导线在第一区域中分别具有第一区域缩小线宽度，第一区域缩小空间和第一区域缩小间距以及在第二区域中选择性地具有第二区域原始线宽度，第二区域缩小空间和第二区域缩小间距。第一区域缩小线宽度和第二区域原始线宽度彼此大不相同。

6. 发明申请

US20120292184A1 MICROBIAL IDENTIFICATION AND MANIPULATION OF NANOSCALE BIOMOLECULES 有权
标题翻译：纳米生物分子的微生物鉴定和操作
公开(公告)号：US20120292184A1
公开(公告)日：2012-11-22
申请号：US13108216
申请日：2011-05-16
申请人： I-Fang CHENG , Hsien-Chang Chang , Cheng-Che Chung
发明人： I-Fang CHENG , Hsien-Chang Chang , Cheng-Che Chung
IPC分类号： G01N27/447 , C25B15/00 , B82Y40/00
CPC分类号： C12Q1/6816 , B03C5/005 , B03C5/026 , C12N13/00 , G01N33/536 , G01N33/558 , G01N33/569 , G01N33/582 , G01N33/583 , C12Q2565/629
摘要： A method of microbial identification is disclosed. The method includes the steps of assembling dielectrophoretic particles modified with specific DNA probes on a surface thereof in a continuous fluid at a predetermined location in a microchannel to form a particle assembly by a negative dielectrophoretic force and a hydrodynamic force provided by the continuous fluid, narrowing gaps between the dielectrophoretic particles of the particle assembly to enhance the electric field in the gaps between the dielectrophoretic particles, injecting a fluid containing target DNAs of a target microbe into the microchannel at a predetermined flow rate to move the target DNAs toward the particle assembly and generating a positive dielectrophoretic force by the enhanced electric field to attract the target DNAs toward the dielectrophoretic particles of the particle assembly for hybridization with the DNA probes. The present invention also discloses a method of manipulation of nanoscale biomolecules.
摘要翻译：公开了一种微生物识别方法。该方法包括以下步骤：在微通道中的预定位置处将表面上的特定DNA探针修饰的介电泳细粒组装在微通道中的预定位置处，以通过负介电电泳力和由连续流体提供的流体动力力形成粒子组件颗粒组件的介电电泳颗粒之间的间隙以增强介电电泳颗粒之间的间隙中的电场，以预定流速将含有目标微生物的目标DNA的流体注入微通道以将靶DNA移动到颗粒组件，并且通过增强的电场产生正的介电电泳力，以将靶DNA吸引到颗粒组件的介电电泳颗粒，以与DNA探针杂交。本发明还公开了一种操作纳米尺度生物分子的方法。

7. 发明授权

US07344963B2 Method of reducing charging damage to integrated circuits during semiconductor manufacturing 有权
标题翻译：在半导体制造过程中减少集成电路的充电损坏的方法
公开(公告)号：US07344963B2
公开(公告)日：2008-03-18
申请号：US11379380
申请日：2006-04-20
申请人： Hsien-Chang Chang , Chia-Hsin Hou , Tsu-Yu Chu , Ko-Ting Chen
发明人： Hsien-Chang Chang , Chia-Hsin Hou , Tsu-Yu Chu , Ko-Ting Chen
IPC分类号： H01L21/425 , H01L29/167
CPC分类号： H01L21/266 , H01L21/823418 , H01L21/823481 , H01L27/0207
摘要： A semiconductor substrate having an integrated circuit die area surrounded by a scribe lane is provided. Within the integrated circuit die area, a first trench isolation region and a second trench isolation region are formed on the semiconductor substrate, wherein the first trench isolation region isolates a first active device region from a second active device region, and the second trench isolation region comprises a plurality of trench dummy features for reducing loading effect. A first gate electrode is formed on the first active device region and a second gate electrode on the second active device region. The first active device region is masked, while the second active device region and the trench dummy features are exposed. An ion implantation process is then performed to implant dopant species into the second active device region.
摘要翻译：提供具有被划线通道包围的集成电路管芯区域的半导体衬底。在集成电路管芯区域内，在半导体衬底上形成第一沟槽隔离区域和第二沟槽隔离区域，其中第一沟槽隔离区域将第一有源器件区域与第二有源器件区域隔离，第二沟槽隔离区域包括用于减小负载效应的多个沟槽虚拟特征。在第一有源器件区上形成第一栅电极，在第二有源器件区上形成第二栅电极。第一有源器件区域被掩蔽，而第二有源器件区域和沟槽虚拟特征被暴露。然后执行离子注入工艺以将掺杂剂物质注入到第二有源器件区域中。

8. 发明授权

US08911605B2 Method for antibiotic susceptibility testing and determining minimum inhibitory concentration of the antibiotic 有权
标题翻译：抗生素敏感性检测方法，并确定抗生素的最小抑菌浓度
公开(公告)号：US08911605B2
公开(公告)日：2014-12-16
申请号：US13473717
申请日：2012-05-17
申请人： Cheng-Che Chung , I-Fang Cheng , Wen-Horng Yang , Hsien-Chang Chang
发明人： Cheng-Che Chung , I-Fang Cheng , Wen-Horng Yang , Hsien-Chang Chang
IPC分类号： G01N27/447 , G01N33/15 , C12Q1/18
CPC分类号： G01N33/15 , B03C5/005 , C12Q1/18
摘要： A method of antibiotic susceptibility testing is disclosed, and includes the following steps: (A) providing a sample to be tested wherein the sample contains a microbe; (B) adding an antibiotic into the sample, wherein the antibiotic serves to inhibit cell wall synthesis; (C) checking the sample by dielectrophoresis and observing a shape change of the microbe; and (D) determining whether the microbe is susceptible to the antibiotic according to the shape change thereof. The present invention also discloses a method for determining a minimum inhibitory concentration of the antibiotic.
摘要翻译：公开了一种抗生素敏感性试验方法，包括以下步骤：（A）提供样品，其中样品含有微生物; （B）将抗生素添加到样品中，其中抗生素用于抑制细胞壁合成; （C）通过介电电泳检查样品并观察微生物的形状变化; 和（D）根据其形状变化确定微生物是否易受抗生素的影响。本发明还公开了一种确定抗生素最小抑制浓度的方法。

9. 发明授权

US06689572B1 E. coli agglutination assay 失效
标题翻译：大肠杆菌凝集试验
公开(公告)号：US06689572B1
公开(公告)日：2004-02-10
申请号：US09687626
申请日：2000-10-13
申请人： Ya Hei Huang , Hsien-Chang Chang , Tsung Chain Chang
发明人： Ya Hei Huang , Hsien-Chang Chang , Tsung Chain Chang
IPC分类号： G01N33569
CPC分类号： G01N33/56916 , Y10S435/975
摘要： A method for detecting Escherichia coli in a sample by providing a sample suspected of containing Escherichia coli; contacting the sample with beads coated with a mixture of antibodies or anti-serum specific to one or more surface antigens of Escherichia coli, each of the one or more surface antigens having a molecular weight of 21±2 KDa, 26±2 KDa, 31±2 KDa, 36±2 KDa, 38±2 KDa, 67±2 KDa, or 77.8±2 KDa; and observing agglutination of the beads, where the presence of the agglutination indicates the presence of Escherichia coli in the sample.
摘要翻译：一种通过提供怀疑含有大肠杆菌的样品来检测样品中的大肠杆菌的方法; 使样品与涂覆有抗体混合物的珠粒或抗大肠杆菌一种或多种表面抗原特异性抗血清的珠粒接触，所述一种或多种表面抗原中的每一种具有21±2KDa的分子量，26±2KDa，31 ±2KDa，36±2KDa，38±2KDa，67±2KDa或77.8±2KDa; 并观察珠粒的凝集，其中凝集物的存在表明样品中存在大肠杆菌。

10. 发明授权

US08808518B2 Microbial identification and manipulation of nanoscale biomolecules 有权
标题翻译：微生物鉴定和纳米级生物分子的操作
公开(公告)号：US08808518B2
公开(公告)日：2014-08-19
申请号：US13108216
申请日：2011-05-16
申请人： I-Fang Cheng , Hsien-Chang Chang , Cheng-Che Chung
发明人： I-Fang Cheng , Hsien-Chang Chang , Cheng-Che Chung
IPC分类号： B01D57/02 , G01N33/536 , G01N33/58 , B03C5/02 , G01N33/569 , G01N33/558 , C12N13/00 , C12Q1/68 , B03C5/00
CPC分类号： C12Q1/6816 , B03C5/005 , B03C5/026 , C12N13/00 , G01N33/536 , G01N33/558 , G01N33/569 , G01N33/582 , G01N33/583 , C12Q2565/629
摘要： A method of microbial identification is disclosed. The method includes the steps of assembling dielectrophoretic particles modified with specific DNA probes on a surface thereof in a continuous fluid at a predetermined location in a microchannel to form a particle assembly by a negative dielectrophoretic force and a hydrodynamic force provided by the continuous fluid, narrowing gaps between the dielectrophoretic particles of the particle assembly to enhance the electric field in the gaps between the dielectrophoretic particles, injecting a fluid containing target DNAs of a target microbe into the microchannel at a predetermined flow rate to move the target DNAs toward the particle assembly and generating a positive dielectrophoretic force by the enhanced electric field to attract the target DNAs toward the dielectrophoretic particles of the particle assembly for hybridization with the DNA probes. The present invention also discloses a method of manipulation of nanoscale biomolecules.
摘要翻译：公开了一种微生物识别方法。该方法包括以下步骤：在微通道中的预定位置处将表面上的特定DNA探针修饰的介电泳细粒组装在微通道中的预定位置处，以通过负介电电泳力和由连续流体提供的流体动力力形成粒子组件颗粒组件的介电电泳颗粒之间的间隙以增强介电电泳颗粒之间的间隙中的电场，以预定流速将含有目标微生物的目标DNA的流体注入微通道以将靶DNA移动到颗粒组件，并且通过增强的电场产生正的介电电泳力，以将靶DNA吸引到颗粒组件的介电电泳颗粒，以与DNA探针杂交。本发明还公开了一种操作纳米尺度生物分子的方法。

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