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1. 发明申请

WO2011080186A1 CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT 审中-公开
标题翻译：控制流体转移到和/或从主体的流体装置
公开(公告)号：WO2011080186A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070547
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
发明人： OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61M1/36
CPC分类号： A61M1/3656 , A61B5/02125 , A61B5/0215 , A61B5/02405 , A61B5/4836 , A61M1/30 , A61M1/3643 , A61M1/3644 , A61M1/3653 , A61M1/3659 , A61M2205/3331 , A61M2205/6018
摘要： A control system (23) is arranged to control the operation of an apparatus (200) for for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.
摘要翻译：控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。控制系统可操作以在预处理模式和血液处理模式之间切换。血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或病人与血液回路（20）之间的能量传递，。控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别，采取专门的行动。该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。控制系统可以包括在用于血液处理的装置（200）中，例如透析机。

2. 发明申请

WO2009156174A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OR A FLUID CONNECTION 审中-公开
标题翻译：用于监测完整性或流体连接的方法和装置
公开(公告)号：WO2009156174A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/004640
申请日：2009-06-26
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.
摘要翻译：监视装置（25）基于来自压力传感器（4a-4c）的至少一个与时间有关的测量信号来监视第一和第二流体容纳系统（S1，S2）之间的流体连接（C）的完整性第一流体容纳系统（S1）。第一流体容纳系统（S1）包括第一脉冲发生器（3），第二流体容纳系统（S2）包括第二脉冲发生器（3'）。压力传感器（4a-4c）被布置成检测源自第一脉冲发生器（3）的第一脉冲和源自第二脉冲发生器（3'）的第二脉冲。流体连接（C）的完整性基于测量信号中第二个脉冲的存在来确定。可以通过在时域中分析测量信号和/或通过使用指示所述至少一个测量信号中的第二脉冲的定时的定时信息来检测第二脉冲。分析可以基于表示测量信号的时间窗内的信号值分布的参数值。例如，可以将参数值计算为信号值的统计色散测量值，或者可以由时间窗口内的信号值与第二脉冲的预测时间信号曲线的匹配产生。流体连接（C）可以建立在人体血液系统和体外血流回路之间，例如，用于体外血液治疗。

3. 发明申请

WO2012163737A1 BLOOD TREATMENT APPARATUS ADAPTED TO PRESERVE PARTS THEREOF 审中-公开
标题翻译：血液治疗装置适用于保留其部分
公开(公告)号：WO2012163737A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059520
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , WIESLANDER, Anders , JEPPSSON, Helena
发明人： HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , WIESLANDER, Anders , JEPPSSON, Helena
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/14 , A61M1/168 , A61M1/1682 , A61M1/1684 , A61M1/169 , A61M1/3643 , A61M1/3644 , A61M1/3649
摘要： A blood treatment apparatus adapted to preserve a blood treatment unit (20) between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit (20), ii) fill the blood treatment unit (20) with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, iii) maintain the preservation fluid in the blood treatment unit (20) until a next blood treatment session is prepared, iv) dispatch the preservation fluid from the blood treatment unit (20) in preparation of a next blood treatment session, and v) perform a next blood treatment session and thereby extend the use of the blood treatment unit (20). A related method is also described.
摘要翻译：一种血液处理装置，适于在血液处理会话之间保留血液处理单元（20）。血液处理装置构成为：i）进行血液处理对象，由此使用血液处理单元（20），ii）用包含至少一种处理液浓缩物的保存液填充血液处理单元（20）用于制备治疗液，iii）将血液处理单元（20）中的保存液保持直至制备下次血液处理时间为止，iv）从血液处理单元（20）调出保存液，准备下一个血液处理会话，以及v）执行下一个血液处理会话，从而延长血液处理单元（20）的使用。还描述了相关方法。

4. 发明申请

WO2003066135A1 METHOD AND APPARATUS FOR DETERMINING ACCESS FLOW 审中-公开
标题翻译：用于确定访问流的方法和装置
公开(公告)号：WO2003066135A1
公开(公告)日：2003-08-14
申请号：PCT/IB2002/004537
申请日：2002-10-31
申请人： GAMBRO LUNDIA AB , BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
发明人： BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
IPC分类号： A61M1/16
CPC分类号： A61M1/30 , A61M1/16 , A61M1/1605 , A61M1/1617 , A61M1/3656 , A61M2202/0498 , A61M2205/13 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/50 , A61M2230/65
摘要： A method and apparatus for determining a fluid flow rate in a blood access having an upstream position and a downstream position using a blood treatment apparatus including a blood treatment unit having a semi permeable membrane delimiting a first chamber through which blood removed from said blood access passes and a second chamber through which dialysis liquid passes, an arterial line and a venous line, connected to an inlet and an outlet of the first chamber respectively. The method for determining the fluid flow rate involves measurement of the post dialyzer concentration or conductivity before and after a flow reversal. The invention further involves a method for checking the operating configuration of the arterial and venous lines of the blood treatment apparatus.
摘要翻译：一种用于使用血液处理设备来确定具有上游位置和下游位置的血液通路中的流体流量的方法和装置，所述血液处理设备包括血液处理单元，所述血液处理单元具有限定从所述血液存取通过的血液通过所述血液通过的第一室的半透膜以及透析液通过的第二室，分别连接到第一室的入口和出口的动脉线和静脉管。用于确定流体流速的方法涉及在逆流之前和之后测量后透析器浓度或电导率。本发明还涉及一种用于检查血液处理装置的动脉和静脉线的操作构造的方法。

5. 发明申请

WO2012035040A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：WO2012035040A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065894
申请日：2011-09-14
申请人： GAMBRO LUNDIA AB , HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
发明人： HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。还描述了相关的制造和验证方法。

6. 发明申请

WO2005077262A1 PRESSURE SENSING 审中-公开
标题翻译：压力传感器
公开(公告)号：WO2005077262A1
公开(公告)日：2005-08-25
申请号：PCT/SE2005/000184
申请日：2005-02-11
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , DROTT, Johan , HERTZ, Thomas
发明人： JÖNSSON, Lennart , DROTT, Johan , HERTZ, Thomas
IPC分类号： A61B5/00
CPC分类号： A61M1/3639 , A61M2205/12 , A61M2205/3569 , Y10T29/49117
摘要： A biological fluid device (703) comprises a pressure sensor (702), which is arranged on the device. The pressure sensor comprises a compressible container, the compression of which is indicative of the pressure, and is capable of wireless communication.
摘要翻译：生物流体装置（703）包括布置在装置上的压力传感器（702）。压力传感器包括可压缩容器，其压缩表示压力，并且能够进行无线通信。

7. 发明申请

WO2010108955A1 DIALYSIS DEVICE 审中-公开
标题翻译： DIALYSIS设备
公开(公告)号：WO2010108955A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053837
申请日：2010-03-24
申请人： GAMBRO LUNDIA AB , DEBIOTECH S.A. , NEFTEL, Frédéric , BERNARD, Pascal , HERTZ, Thomas
发明人： NEFTEL, Frédéric , BERNARD, Pascal , HERTZ, Thomas
IPC分类号： A61M1/16 , G06F19/00
CPC分类号： A61M1/16 , A61M1/1613 , A61M1/28 , A61M1/3609 , A61M2205/3393 , A61M2205/502 , A61M2205/505 , A61M2205/52 , G06F19/00 , G06F19/3481 , G06Q50/22
摘要： A dialysis device comprising a prescriber interface and a programming means configured to allow, via the prescriber interface, input of a set of therapeutic objectives and a treatment plan and a re-evaluation means configured to, as a function of the therapeutic objectives and the treatment plan, suggest at least one treatment option comprising a set of settings of a treatment session to achieve said set of therapeutic objectives.
摘要翻译：一种透析装置，包括处方器接口和编程装置，其被配置为允许经由处方器界面输入一组治疗目标和治疗计划以及重新评估装置，其被配置为根据治疗目标和治疗计划，建议至少一个治疗选项包括治疗会话的一组设置以实现所述治疗目标集合。

8. 发明申请

WO2012038384A1 OBTAINING CONTROL SETTINGS FOR A DIALYSIS MACHINE 审中-公开
标题翻译：获取一台DIALYSIS机器的控制设置
公开(公告)号：WO2012038384A1
公开(公告)日：2012-03-29
申请号：PCT/EP2011/066253
申请日：2011-09-20
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas
发明人： HERTZ, Thomas
IPC分类号： A61M1/16
CPC分类号： A61M1/16 , A61M1/1611 , A61M1/1613 , A61M1/3609 , A61M2202/0498 , A61M2205/15 , A61M2205/52 , G06F19/00 , G06F19/3481 , G16H50/20
摘要： A dialysis machine is configured to perform treatment sessions of renal replacement therapy. Prior to each treatment session for an individual patient, a machine controller in the dialysis machine obtains from a logic device a set of current control settings of the machine-related parameters to be applied in the treatment session. In generating the control settings, the logic device obtains (21B) a set of therapeutic targets comprising a target value that represents part of a desired status of the patient after the treatment session, in terms of one or more physiological parameters for the patient. The logic device also obtains (21A) status data that represents the current status of the patient prior to the treatment session, and computes (22) the set of current control settings of the machine-related parameters, as a function of the set of therapeutic targets and the status data and at least partly based on a predictive model, which estimates the physiological response of the patient to the machine-related parameters during the treatment session. Thereby, the dialysis machine may be inherently controlled to achieve the desired status at the end of the treatment session, based on automatically computed control settings, which reduces the need for the patient to strictly adhere to a predetermined treatment plan, and for the caregiver to manually estimate control settings.
摘要翻译：透析机被配置为执行肾脏替代疗法的治疗阶段。在个体患者的每个治疗阶段之前，透析机器中的机器控制器从逻辑设备获得要在治疗会话中应用的机器相关参数的一组当前控制设置。在生成控制设置时，逻辑设备根据患者的一个或多个生理参数获得（21B）一组治疗目标，其包括在治疗会话之后代表患者的期望状态的一部分的目标值。逻辑设备还获得（21A）表示治疗过程之前的患者的当前状态的状态数据，并且计算（22）机器相关参数的当前控制设置的集合，作为治疗组的一组函数目标和状态数据，并且至少部分地基于预测模型，该预测模型在治疗期间估计患者对机器相关参数的生理反应。因此，可以固有地控制透析机，以便在治疗阶段结束时，基于自动计算的控制设置来实现期望的状态，这减少了对患者严格遵守预定治疗计划的需要，并且使护理者手动估算控制设置。

9. 发明申请

WO2005025726A2 PREPARATION OF LIQUIDS FOR A MEDICAL PROCEDURE 审中-公开
标题翻译：为医疗程序准备液体
公开(公告)号：WO2005025726A2
公开(公告)日：2005-03-24
申请号：PCT/SE2004/001298
申请日：2004-09-10
申请人： GAMBRO LUNDIA AB , ANDERSSON, Göran , BRINK, Mats , HERTZ, Thomas , JÖNSSON, Lennart , LINDGREN, Henrik
发明人： ANDERSSON, Göran , BRINK, Mats , HERTZ, Thomas , JÖNSSON, Lennart , LINDGREN, Henrik
IPC分类号： B01F
CPC分类号： A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M2205/3379 , B01F13/1055 , B01F15/00155 , B01F15/00253 , B01F15/0441 , G01F23/24 , G01F23/292 , G01F23/2962
摘要： In a method for preparing a liquid for a medical procedure by mixing at least two liquid components, batches of liquid are successively prepared for continuous withdrawal for use in the medical procedure. The pro-portioning is done using a continuous measurement method A mixing chamber (7), a system (1) and a device (2) for preparing a liquid for a medical procedure are also disclosed, as well as use of such system (1) and device (2). Further a method and a mixing chamber for proportioning components of a liquid for a medical procedure are disclosed.
摘要翻译：在通过混合至少两种液体组分制备用于医疗程序的液体的方法中，连续制备多批液体用于连续取出以用于医疗程序中。使用连续测量方法完成分配。还公开了用于制备用于医疗程序的液体的混合室（7），系统（1）和装置（2）以及这种系统（1 ）和设备（2）。另外还公开了一种方法和混合室，用于为医疗过程配比液体成分。

10. 发明申请

WO2019002065A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002065A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066519
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , LINDGREN, Henrik , FORS, Jonas , HÅKANSSON, Annmargret , WALLENBORG, Anders
IPC分类号： G16H40/40
摘要： A system (1) and method for renal replacement therapy, where the system comprises a blood treatment unit (4) connected to a blood circuit (2) for extracorporeal circulation of blood, and a method for operating the system (1). The system (1) comprises inter alia a blood pump (19), a pre-dilution line (10), a post-dilution line (11), flow control means (12) and a control unit (31) configured to control the system (1) according to control instructions. The control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and to activate an automatic anti-fouling measure in order to create a flushing of the blood treatment unit (4) comprising an increase of a pre-dilution flow rate Qpre to more than 100% of a present value of the post-dilution flow rate Qpost.

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