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1. 发明申请

WO2019002065A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002065A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066519
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , LINDGREN, Henrik , FORS, Jonas , HÅKANSSON, Annmargret , WALLENBORG, Anders
IPC分类号： G16H40/40
摘要： A system (1) and method for renal replacement therapy, where the system comprises a blood treatment unit (4) connected to a blood circuit (2) for extracorporeal circulation of blood, and a method for operating the system (1). The system (1) comprises inter alia a blood pump (19), a pre-dilution line (10), a post-dilution line (11), flow control means (12) and a control unit (31) configured to control the system (1) according to control instructions. The control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and to activate an automatic anti-fouling measure in order to create a flushing of the blood treatment unit (4) comprising an increase of a pre-dilution flow rate Qpre to more than 100% of a present value of the post-dilution flow rate Qpost.

2. 发明申请

WO2018095694A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
公开(公告)号：WO2018095694A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/077566
申请日：2017-10-27
申请人： GAMBRO LUNDIA AB
发明人： WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , HERTZ, Thomas , ROVATTI, Paolo , LODI, Carlo, Alberto , SURACE, Alessandro , STERNBY, Jan
IPC分类号： A61M1/16 , A61M1/34
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

3. 发明申请

WO2009156174A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OR A FLUID CONNECTION 审中-公开
标题翻译：用于监测完整性或流体连接的方法和装置
公开(公告)号：WO2009156174A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/004640
申请日：2009-06-26
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.
摘要翻译：监视装置（25）基于来自压力传感器（4a-4c）的至少一个与时间有关的测量信号来监视第一和第二流体容纳系统（S1，S2）之间的流体连接（C）的完整性第一流体容纳系统（S1）。第一流体容纳系统（S1）包括第一脉冲发生器（3），第二流体容纳系统（S2）包括第二脉冲发生器（3'）。压力传感器（4a-4c）被布置成检测源自第一脉冲发生器（3）的第一脉冲和源自第二脉冲发生器（3'）的第二脉冲。流体连接（C）的完整性基于测量信号中第二个脉冲的存在来确定。可以通过在时域中分析测量信号和/或通过使用指示所述至少一个测量信号中的第二脉冲的定时的定时信息来检测第二脉冲。分析可以基于表示测量信号的时间窗内的信号值分布的参数值。例如，可以将参数值计算为信号值的统计色散测量值，或者可以由时间窗口内的信号值与第二脉冲的预测时间信号曲线的匹配产生。流体连接（C）可以建立在人体血液系统和体外血流回路之间，例如，用于体外血液治疗。

4. 发明申请

WO2023057187A1 CONFIGURING AN ARRANGEMENT TO GENERATE TREATMENT FLUID FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2023057187A1
公开(公告)日：2023-04-13
申请号：PCT/EP2022/075676
申请日：2022-09-15
申请人： GAMBRO LUNDIA AB
发明人： FORS, Jonas , HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/28 , A61M1/1656 , A61M1/287 , A61M2205/18 , A61M2205/502 , G16H20/17 , G16H50/30
摘要： A system comprises a fluid generation arrangement (FGA), a user interface (UI), and a control unit. The FGA is operable to mix one or more concentrates with water to generate a treatment fluid for use in renal replacement therapy. The control unit is connected to the UI and arranged to configure the FGA by a computer-implemented method. In the method, the control unit receives (201), from the UI, a candidate set value of a selected component of the treatment fluid, calculates (202), for the candidate set value, a calculated composition of the treatment fluid, and displays (204), on the UI, a respective concentration value of one or more components other than the selected component in the calculated composition. By the system, a caretaker is made aware of consequential changes in the composition of the treatment fluid, in addition the selected component. The system thereby facilitates the use of the on-line fluid generation while maintaining patient safety.

5. 发明申请

WO2019002067A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002067A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066522
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , WALLENBORG, Anders , FORS, Jonas , LINDGREN, Henrik , HÅKANSSON, Annmargret
IPC分类号： G16H40/40
摘要： A system (1) and a method for renal replacement therapy comprising a blood treatment unit (4) connected to a blood circuit (2) and a dialysis fluid circuit (3), the system (1) further comprises a control unit (31) configured to control the system (1) according to control instructions comprising to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and activate an automatic anti-fouling measure comprising a temporary change of the flow rate in the blood circuit (2) and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

6. 发明申请

WO2016188951A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT II 审中-公开
标题翻译：用于提取血液治疗的装置II
公开(公告)号：WO2016188951A1
公开(公告)日：2016-12-01
申请号：PCT/EP2016/061569
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , LODI, Carlo Alberto , SURACE, Alessandro , WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , STERNBY, Jan , HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1605 , A61M1/1607 , A61M1/1609 , A61M1/1656 , A61M1/1666 , A61M1/3406 , A61M1/3609 , A61M2205/128 , A61M2230/005 , A61M2230/20 , A61M2230/65
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
摘要翻译：提供一种体外血液处理装置，包括与血液回路（17）连接的过滤单元（2）和透析液回路（32），制备和调节透析液的组成的准备装置（9）控制单元（12）被配置为在透析供给管线（8）中将透析液的钠浓度值设定在设定点; 钠浓度的设定包括基于血浆电导率和基于透析中的至少一种物质的浓度的调整贡献项计算钠浓度值作为主要贡献项的代数和的子步骤在组中选择的液体包括碳酸氢盐，钾，乙酸盐，乳酸盐，柠檬酸盐，镁，钙，硫酸盐和磷酸盐。

7. 发明申请

WO2012035040A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：WO2012035040A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065894
申请日：2011-09-14
申请人： GAMBRO LUNDIA AB , HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
发明人： HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。还描述了相关的制造和验证方法。

8. 发明申请

WO2005077262A1 PRESSURE SENSING 审中-公开
标题翻译：压力传感器
公开(公告)号：WO2005077262A1
公开(公告)日：2005-08-25
申请号：PCT/SE2005/000184
申请日：2005-02-11
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , DROTT, Johan , HERTZ, Thomas
发明人： JÖNSSON, Lennart , DROTT, Johan , HERTZ, Thomas
IPC分类号： A61B5/00
CPC分类号： A61M1/3639 , A61M2205/12 , A61M2205/3569 , Y10T29/49117
摘要： A biological fluid device (703) comprises a pressure sensor (702), which is arranged on the device. The pressure sensor comprises a compressible container, the compression of which is indicative of the pressure, and is capable of wireless communication.
摘要翻译：生物流体装置（703）包括布置在装置上的压力传感器（702）。压力传感器包括可压缩容器，其压缩表示压力，并且能够进行无线通信。

9. 发明申请

WO2017080970A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT - II 审中-公开
标题翻译：用于体外血液处理的设备 - II
公开(公告)号：WO2017080970A1
公开(公告)日：2017-05-18
申请号：PCT/EP2016/076912
申请日：2016-11-08
申请人： GAMBRO LUNDIA AB
发明人： HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317 , A61M2230/20 , A61M2230/65
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysis fluid circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for determining or receiving a proposed value (κ prop.value ; C prop.value ) of a sodium concentration for the dialysis fluid in the dialysis supply line (8) and to determine a set value (fsetvaiue; C se tvalue) for the sodium concentration in the dialysis fluid as a function of the proposed value (κ prop.value ; Cprop.value). For at least an interval of proposed values for the sodium concentration, the control unit (12) is configured to determine the set value so that the set value is different from the proposed value (κ prop.value ; c prop.value ) and so that distinct set values are determined from distinct proposed values. The set value is biased towards a predetermined pivot value that represents e.g. the average sodium concentration in the blood of a population and may not be outside a reference range.
摘要翻译：提供了一种体外血液处理设备，其包括连接到血液回路（17）和透析液回路（32）的过滤单元（2），用于准备和调节的准备设备（9）透析液的组成; 控制单元（12）被配置成用于确定或接收用于所述透析液中的钠浓度的建议值（κsub.prop。value; C prop .value）透析供应管线（8），并确定透析液中钠浓度的设定值（fsetvaiue; C se tvalue），作为所提出的值的函数（κprop。value < / sub>; Cprop.value）。对于钠浓度的建议值的至少一个区间，控制单元（12）被配置为确定设定值，使得设定值不同于所提出的值（κprop。value）。 c _{prop.value ），并使不同的设置值由不同的建议值确定。该设定值偏向代表例如人口血液中钠的平均浓度，可能不在参考范围之外。}

10. 发明申请

WO2016188950A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT I 审中-公开
标题翻译：用于提取血液治疗的装置
公开(公告)号：WO2016188950A1
公开(公告)日：2016-12-01
申请号：PCT/EP2016/061568
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , SURACE, Alessandro , LODI, Carlo Alberto , WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , STERNBY, Jan , HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood trough the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.
摘要翻译：提供了一种体外血液处理装置，其包括连接到血液回路（17）和透析液回路（32）的过滤单元（2），用于制备和调节透析液的组成的制备装置（9）用于测量透析液（即用过的透析液）的电导率的传感器（11）; 控制单元（12），其被配置为设置透析液中的钠浓度，并且在初始设定点设定透析液之后，使透析液和血液循环通过过滤单元（2），测量透析液的初始电导率值在治疗开始时，基于所测量的用过的透析液的初始电导率值和透析液的相应电导率值，计算初始等离子体电导率的值，将透析液循环至计算执行初始血浆导电性，维持透析流体导电性基本上恒定。

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