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1. 发明申请

WO2009144522A1 A HEMODIALYSIS OR HEMO(DIA)FILTRATION APPARATUS AND A METHOD FOR CONTROLLING A HEMODIALYSIS OR HEMO(DIA)FILTRATION APPARATUS 审中-公开
标题翻译：血液透析或HEMO（DIA）过滤装置和控制HEMODIALYSIS或HEMO（DIA）过滤装置的方法
公开(公告)号：WO2009144522A1
公开(公告)日：2009-12-03
申请号：PCT/IB2008/001308
申请日：2008-05-26
申请人： GAMBRO LUNDIA AB , WALLENBORG, Anders , GEBHART, Thomas , SUFFRITTI, Mauro , MASALA, Pietro
发明人： WALLENBORG, Anders , GEBHART, Thomas , SUFFRITTI, Mauro , MASALA, Pietro
IPC分类号： A61M1/34 , A61M1/16
CPC分类号： A61M1/3639 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M2205/3331 , G06F19/00
摘要： In a hemodiafiltration apparatus, a control and command unit (11) halts a replacement fluid supply pump (8) and contemporaneously modifies the control mode of a blood pump (1) passing from a control based on the pump velocity to a control based on the blood pressure measured by a sensor (12) arranged downstream of a hemodiafilter (3). The aim is to prevent risks due to excessive hemoconcentration in the blood circuit between the ultrafiltration zone and the infusion zone.
摘要翻译：在血液透析过滤装置中，控制和指令单元（11）停止替换流体供应泵（8），同时将基于泵速度的控制通过的血液泵（1）的控制模式同时修改为基于通过布置在血液透析滤器（3）下游的传感器（12）测量的血压。目的是防止超滤区域和输注区域之间的血液循环过度血液浓缩引起的风险。

2. 发明申请

WO2019002067A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002067A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066522
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , WALLENBORG, Anders , FORS, Jonas , LINDGREN, Henrik , HÅKANSSON, Annmargret
IPC分类号： G16H40/40
摘要： A system (1) and a method for renal replacement therapy comprising a blood treatment unit (4) connected to a blood circuit (2) and a dialysis fluid circuit (3), the system (1) further comprises a control unit (31) configured to control the system (1) according to control instructions comprising to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and activate an automatic anti-fouling measure comprising a temporary change of the flow rate in the blood circuit (2) and a temporary decrease of the ultrafiltration rate wherein a timing of the temporary change and a timing of the temporary reduction are synchronized.

3. 发明申请

WO2016188951A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT II 审中-公开
标题翻译：用于提取血液治疗的装置II
公开(公告)号：WO2016188951A1
公开(公告)日：2016-12-01
申请号：PCT/EP2016/061569
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , LODI, Carlo Alberto , SURACE, Alessandro , WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , STERNBY, Jan , HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1605 , A61M1/1607 , A61M1/1609 , A61M1/1656 , A61M1/1666 , A61M1/3406 , A61M1/3609 , A61M2205/128 , A61M2230/005 , A61M2230/20 , A61M2230/65
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.
摘要翻译：提供一种体外血液处理装置，包括与血液回路（17）连接的过滤单元（2）和透析液回路（32），制备和调节透析液的组成的准备装置（9）控制单元（12）被配置为在透析供给管线（8）中将透析液的钠浓度值设定在设定点; 钠浓度的设定包括基于血浆电导率和基于透析中的至少一种物质的浓度的调整贡献项计算钠浓度值作为主要贡献项的代数和的子步骤在组中选择的液体包括碳酸氢盐，钾，乙酸盐，乳酸盐，柠檬酸盐，镁，钙，硫酸盐和磷酸盐。

4. 发明申请

WO2012035040A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：WO2012035040A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065894
申请日：2011-09-14
申请人： GAMBRO LUNDIA AB , HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
发明人： HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。还描述了相关的制造和验证方法。

5. 发明申请

WO2019002065A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002065A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066519
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , LINDGREN, Henrik , FORS, Jonas , HÅKANSSON, Annmargret , WALLENBORG, Anders
IPC分类号： G16H40/40
摘要： A system (1) and method for renal replacement therapy, where the system comprises a blood treatment unit (4) connected to a blood circuit (2) for extracorporeal circulation of blood, and a method for operating the system (1). The system (1) comprises inter alia a blood pump (19), a pre-dilution line (10), a post-dilution line (11), flow control means (12) and a control unit (31) configured to control the system (1) according to control instructions. The control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and to activate an automatic anti-fouling measure in order to create a flushing of the blood treatment unit (4) comprising an increase of a pre-dilution flow rate Qpre to more than 100% of a present value of the post-dilution flow rate Qpost.

6. 发明申请

WO2018095694A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
公开(公告)号：WO2018095694A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/077566
申请日：2017-10-27
申请人： GAMBRO LUNDIA AB
发明人： WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , HERTZ, Thomas , ROVATTI, Paolo , LODI, Carlo, Alberto , SURACE, Alessandro , STERNBY, Jan
IPC分类号： A61M1/16 , A61M1/34
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and/or the substitution fluid, measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.

7. 发明申请

WO2010043595A1 BLOOD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：血液处理装置和方法
公开(公告)号：WO2010043595A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063290
申请日：2009-10-12
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
发明人： HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus, comprising a blood treatment unit (D) configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps ( PF1, PF2; PF3, PF4) configured to pass blood treatment fluid through the blood treatment unit (D), a pair of blood pumps ( PB1, PB2) configured to extract untreated blood from a blood source (BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT), each blood pump comprising a pump chamber and a flexible member ( FM1; FM2) separating the pumping chamber into a first blood accumulating container (B1; B2) and a second working fluid accumulating container (F1; F2) where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. Further the apparatus comprises a control unit (P) and a measuring means configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers (F1; F2) whereby the pumped mass or volume of working fluid is determined by the control unit (P) at an arbitrary position of the flexible member (FM1, FM2).
摘要翻译：一种血液处理装置，包括：血液处理单元（D），被配置为接收未经处理的血液和新鲜血液处理液，并且发射处理过的血液和使用的血液处理液;一对流体泵（PF1，PF2; PF3，PF4）通过血液处理单元（D）通过血液处理液，构成为从血液源（BS）中提取未经处理的血液的一对血液泵（PB1，PB2），通过血液处理单元（D）将提取的血液通过，每个血液泵包括泵室和将泵送室分成第一血液积聚容器（B1; B2）和第二工作流体积聚容器（F1; B2）的柔性构件（FM1; FM2） F2），其中柔性构件构造成改变第一和第二蓄积容器之间的体积关系。此外，该装置包括控制单元（P）和测量装置，该测量装置被配置为发射指示接收到或从第二积聚容器（F1; F2）中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或者在柔性构件（FM1，FM2）的任意位置处由控制单元（P）确定工作流体的体积。

8. 发明申请

WO2018095690A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 审中-公开
公开(公告)号：WO2018095690A1
公开(公告)日：2018-05-31
申请号：PCT/EP2017/077528
申请日：2017-10-26
申请人： GAMBRO LUNDIA AB
发明人： WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , HERTZ, Thomas , ROVATTI, Paolo , LODI, Carlo, Alberto , SURACE, Alessandro , STERNBY, Jan
IPC分类号： A61M1/16 , A61M1/34
摘要： An extracorporeal blood treatment apparatus suitable for e.g. hemodiafiltration or hemofiltration pre-dilution treatment is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

9. 发明申请

WO2016188950A1 APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT I 审中-公开
标题翻译：用于提取血液治疗的装置
公开(公告)号：WO2016188950A1
公开(公告)日：2016-12-01
申请号：PCT/EP2016/061568
申请日：2016-05-23
申请人： GAMBRO LUNDIA AB
发明人： ROVATTI, Paolo , SURACE, Alessandro , LODI, Carlo Alberto , WALLENBORG, Anders , NILSSON, Anders , SOLEM, Kristian , STERNBY, Jan , HERTZ, Thomas
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/3609 , A61M2205/3317
摘要： An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid, and a sensor (11) for measuring conductivity of the dialysate (i.e. spent dialysis fluid); a control unit (12) configured for setting a sodium concentration in the dialysis fluid and after setting the dialysis fluid at the initial set point, circulating the dialysis fluid and blood trough the filtration unit (2), measuring an initial conductivity value of the dialysate at the beginning of the treatment, and calculating, based on the measured initial conductivity value of the spent dialysis fluid and on the corresponding conductivity value of the dialysis fluid, the value of the initial plasma conductivity, said circulating the dialysis fluid up to the calculating of the initial plasma conductivity being performed maintaining the dialysis fluid conductivity substantially constant.
摘要翻译：提供了一种体外血液处理装置，其包括连接到血液回路（17）和透析液回路（32）的过滤单元（2），用于制备和调节透析液的组成的制备装置（9）用于测量透析液（即用过的透析液）的电导率的传感器（11）; 控制单元（12），其被配置为设置透析液中的钠浓度，并且在初始设定点设定透析液之后，使透析液和血液循环通过过滤单元（2），测量透析液的初始电导率值在治疗开始时，基于所测量的用过的透析液的初始电导率值和透析液的相应电导率值，计算初始等离子体电导率的值，将透析液循环至计算执行初始血浆导电性，维持透析流体导电性基本上恒定。

10. 发明申请

WO2014095524A1 DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS 审中-公开
标题翻译：检测血液加压装置中的压力脉冲
公开(公告)号：WO2014095524A1
公开(公告)日：2014-06-26
申请号：PCT/EP2013/076233
申请日：2013-12-11
申请人： GAMBRO LUNDIA AB
发明人： STERNBY, Jan , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/36 , A61B5/00
CPC分类号： A61M1/14 , A61B5/7217 , A61M1/1605 , A61M1/1613 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/15 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/50 , A61M2230/04
摘要： A monitoring device (7) operates on a pressure signal from a blood processing apparatus, e.g. a dialysis machine, which has an extracorporeal blood circuit connected to a vascular system of a subject for pumping blood through a dialyzer, and a treatment fluid supply system for pumping a treatment fluid through the dialyzer. The monitoring device (7) has a first input block (50) for obtaining a first pressure signal (y) from a first pressure sensor (6a) in the extracorporeal blood circuit, and a second input block (51) for obtaining a second pressure signal (w) from a second pressure sensor (6b) in the treatment fluid supply system. An emulation block (56) generates, as a function of the second pressure signal (w), an emulated first pressure signal (y) which emulates a concurrent signal response of the first pressure sensor (6a), and a filtering block (53) generates a filtered signal (y) as a function of the first pressure signal (y) and the emulated first pressure signal (y), so as to suppress, in the filtered signal (}y) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system (lb). A pulse detection block (54) processes the filtered signal (y f ) for detection of subject pulses originating from the subject.
摘要翻译：监测装置（7）对来自血液处理装置的压力信号进行操作。透析机具有连接到受试者的血管系统的体外血液回路，用于通过透析器泵血，以及用于通过透析器泵送治疗流体的治疗液供给系统。监测装置（7）具有用于从体外血液回路中的第一压力传感器（6a）获得第一压力信号（y）的第一输入块（50）和用于获得第二压力来自处理液供给系统中的第二压力传感器（6b）的信号（w）。仿真块（56）根据第二压力信号（w）产生仿真第一压力传感器（6a）的并行信号响应的模拟第一压力信号（y）和滤波块（53），根据第一压力信号（y）和仿真的第一压力信号（y）产生滤波信号（y），以便抑制与第一压力信号（y）相比的滤波信号（y）来自治疗液供应系统（1b）的信号干扰。脉冲检测块（54）处理用于检测从被摄体发出的被摄体脉冲的滤波信号（yf）。

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