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1. 发明申请

WO2009156174A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OR A FLUID CONNECTION 审中-公开
标题翻译：用于监测完整性或流体连接的方法和装置
公开(公告)号：WO2009156174A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/004640
申请日：2009-06-26
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.
摘要翻译：监视装置（25）基于来自压力传感器（4a-4c）的至少一个与时间有关的测量信号来监视第一和第二流体容纳系统（S1，S2）之间的流体连接（C）的完整性第一流体容纳系统（S1）。第一流体容纳系统（S1）包括第一脉冲发生器（3），第二流体容纳系统（S2）包括第二脉冲发生器（3'）。压力传感器（4a-4c）被布置成检测源自第一脉冲发生器（3）的第一脉冲和源自第二脉冲发生器（3'）的第二脉冲。流体连接（C）的完整性基于测量信号中第二个脉冲的存在来确定。可以通过在时域中分析测量信号和/或通过使用指示所述至少一个测量信号中的第二脉冲的定时的定时信息来检测第二脉冲。分析可以基于表示测量信号的时间窗内的信号值分布的参数值。例如，可以将参数值计算为信号值的统计色散测量值，或者可以由时间窗口内的信号值与第二脉冲的预测时间信号曲线的匹配产生。流体连接（C）可以建立在人体血液系统和体外血流回路之间，例如，用于体外血液治疗。

2. 发明申请

WO2011080186A1 CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT 审中-公开
标题翻译：控制流体转移到和/或从主体的流体装置
公开(公告)号：WO2011080186A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070547
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
发明人： OLDE, Bo , SOLEM, Kristian , HERTZ, Thomas , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61M1/36
CPC分类号： A61M1/3656 , A61B5/02125 , A61B5/0215 , A61B5/02405 , A61B5/4836 , A61M1/30 , A61M1/3643 , A61M1/3644 , A61M1/3653 , A61M1/3659 , A61M2205/3331 , A61M2205/6018
摘要： A control system (23) is arranged to control the operation of an apparatus (200) for for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20). The control system (23) is configured to, in the pre-treatment mode, process the measurement data for identification of a characteristic change indicating a connection of the blood circuit (20) to the vascular system of the patient, and, upon such identification, take dedicated action. The action may involve activating at least part of a patient protection system and/or enabling entry into the blood treatment mode. The control system may be included in an apparatus (200) for blood treatment, such as a dialysis machine.
摘要翻译：控制系统（23）被布置成控制用于体外血液处理的装置（200）的操作。装置（200）包括用于将血液回路（20）连接到患者血管系统的体外血液回路（20）和连接系统（C）。血液回路（20）包括血液处理装置（6）和至少一个泵送装置（3）。控制系统可操作以在预处理模式和血液处理模式之间切换。血液处理模式包括操作血液回路（20），以经由连接系统（C）从血管系统通过血液处理装置（6）泵送血液，并通过连接系统（C）返回血管系统。控制系统（23）可操作以从至少一个能量传递传感器（40）获得测量数据，所述能量传递传感器（40）布置成感测患者和连接系统（C）之间或病人与血液回路（20）之间的能量传递，。控制系统（23）被配置为在预处理模式下处理用于识别指示血液回路（20）与患者的血管系统的连接的特征变化的测量数据，并且在这种识别，采取专门的行动。该动作可以涉及激活患者保护系统的至少一部分和/或使得能够进入血液处理模式。控制系统可以包括在用于血液处理的装置（200）中，例如透析机。

3. 发明申请

WO2013000777A1 FILTERING OF A TIME-DEPENDENT PRESSURE SIGNAL 审中-公开
标题翻译：时间依赖压力信号的滤波
公开(公告)号：WO2013000777A1
公开(公告)日：2013-01-03
申请号：PCT/EP2012/061765
申请日：2012-06-20
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , HOLMER, Mattias , STERNBY, Jan
发明人： OLDE, Bo , SOLEM, Kristian , HOLMER, Mattias , STERNBY, Jan
IPC分类号： A61B5/021 , A61M1/36
CPC分类号： A61M1/3607 , A61B5/02108 , A61B5/6866 , A61B5/7217 , A61M1/34 , A61M1/3403 , A61M1/3621 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M2205/3331 , A61M2205/3368 , A61M2205/50 , B01D61/30 , B01D61/32 , G01L19/00
摘要： A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator is known to operate in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates corresponding a reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. These data sample(s) may be either cycle-synchronized so as to have a corresponding location in one or more other pulse cycles (e.g. in a preceding pulse cycle) as the current data sample, or be located in proximity to the current data sample. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient.
摘要翻译：装置去除压力传感器的压力信号中的第一脉冲，该压力传感器布置在流体容纳系统中，以检测源自第一脉冲发生器的第一脉冲和来自第二脉冲发生器的第二脉冲。已知第一脉冲发生器以脉冲周期的顺序操作，每个脉冲周期产生至少一个第一脉冲。设备重复获取当前数据样本，计算相应的参考值，并从当前数据样本中减去参考值。参考值根据相同压力信号中其他数据采样的函数计算。这些数据样本可以是周期同步的，以便在一个或多个其它脉冲周期（例如，在先前的脉冲周期中）具有相应位置作为当前数据样本，或者位于当前数据样本附近。流体容纳系统可以包括体外血流回路，例如，作为透析机的一部分，以及人类患者的心血管系统。

4. 发明申请

WO2003066135A1 METHOD AND APPARATUS FOR DETERMINING ACCESS FLOW 审中-公开
标题翻译：用于确定访问流的方法和装置
公开(公告)号：WO2003066135A1
公开(公告)日：2003-08-14
申请号：PCT/IB2002/004537
申请日：2002-10-31
申请人： GAMBRO LUNDIA AB , BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
发明人： BENE, Bernard , GOUX, Nicolas , HANSSON, Per , HERTZ, Thomas , JANSSON, Olof , PERSSON, Roland , STERNBY, Jan , ASBRINK, Perry
IPC分类号： A61M1/16
CPC分类号： A61M1/30 , A61M1/16 , A61M1/1605 , A61M1/1617 , A61M1/3656 , A61M2202/0498 , A61M2205/13 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/50 , A61M2230/65
摘要： A method and apparatus for determining a fluid flow rate in a blood access having an upstream position and a downstream position using a blood treatment apparatus including a blood treatment unit having a semi permeable membrane delimiting a first chamber through which blood removed from said blood access passes and a second chamber through which dialysis liquid passes, an arterial line and a venous line, connected to an inlet and an outlet of the first chamber respectively. The method for determining the fluid flow rate involves measurement of the post dialyzer concentration or conductivity before and after a flow reversal. The invention further involves a method for checking the operating configuration of the arterial and venous lines of the blood treatment apparatus.
摘要翻译：一种用于使用血液处理设备来确定具有上游位置和下游位置的血液通路中的流体流量的方法和装置，所述血液处理设备包括血液处理单元，所述血液处理单元具有限定从所述血液存取通过的血液通过所述血液通过的第一室的半透膜以及透析液通过的第二室，分别连接到第一室的入口和出口的动脉线和静脉管。用于确定流体流速的方法涉及在逆流之前和之后测量后透析器浓度或电导率。本发明还涉及一种用于检查血液处理装置的动脉和静脉线的操作构造的方法。

5. 发明申请

WO2010040827A1 HEAT EXCHANGER AND METHOD FOR HEAT EXCHANGING 审中-公开
标题翻译：热交换器和换热器的方法
公开(公告)号：WO2010040827A1
公开(公告)日：2010-04-15
申请号：PCT/EP2009/063169
申请日：2009-10-09
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , STERNBY, Jan , NILSSON, Eddie
发明人： JÖNSSON, Lennart , STERNBY, Jan , NILSSON, Eddie
IPC分类号： A61M1/34
CPC分类号： A61M1/3462 , A61M1/3621 , A61M5/44 , A61M2205/366 , F28D9/0075 , F28D9/0087 , F28D9/0093
摘要： The present invention relates to a method for exchanging heat between a effluent fluid (4) and a blood fluid and a heat exchanger (11) for heat exchange. The heat exchanger comprises a first and a second fluid circuit (19, 20) extending through the heat exchanger. The heat exchanger further comprises a stack of fluid plates (12, 13, 40) and a membrane (16) arranged between each of the fluid plates (12, 13, 40) where one interspace is formed between each fluid plate and membrane. The first and the second fluid circuit (19, 20) is each constituted by a passage extending through the fluid plates and membranes and along the fluid plates and membranes in at least two interspaces (17, 18). According to the method for heat exchanging an effluent fluid (4) is passed through the first fluid circuit (19) and a blood fluid is passed through the second fluid circuit (20) such that the effluent fluid (4) is passed along one side of a membrane (16) and simultaneously the blood fluid is passed along the other side of the membrane (16). Heat is thus exchanged between the effluent fluid (4) and the blood fluid over the membrane (16).
摘要翻译：本发明涉及一种用于在流出液（4）和血液流体之间进行热交换的方法和用于热交换的热交换器（11）。热交换器包括延伸穿过热交换器的第一和第二流体回路（19,20）。热交换器还包括一组流体板（12,13,40）和布置在每个流体板（12,13,40）之间的膜（16），其中在每个流体板和膜之间形成一个间隙。第一和第二流体回路（19,20）各自由在至少两个间隙（17,18）中延伸穿过流体板和膜并沿着流体板和膜延伸的通道构成。根据用于热交换的方法，流出物流体（4）通过第一流体回路（19），血液流过第二流体回路（20），使得流出物流体（4）沿着一侧的膜（16），并且同时使血液流体沿膜（16）的另一侧通过。因此，在流出液（4）和膜（16）之间的血液流体之间交换热量。

6. 发明申请

WO2011161064A1 PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL 审中-公开
标题翻译：从粉末材料制备医疗解决方案
公开(公告)号：WO2011161064A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060255
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
发明人： JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
IPC分类号： A61J1/20 , A61M1/16
CPC分类号： A61J1/20 , A61J1/2093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/167 , A61M1/287 , B65D31/14 , B65D81/18 , B65D81/20 , B65D81/2007 , B65D81/2023 , B65D81/2046
摘要： A package has a transport/storage state for storing powdery material which is to be mixed with a solvent to form a medical solution, e.g. for use in dialysis treatment. The package comprises a compartment (6) which is at least partially defined by two opposing wall portions, and a connector (10). In the transport/storage state, the compartment contains the powdery material in the form of at least two distinct sets (2A-2D) of powdery material of different compositions, where the opposing wall portions are brought into engagement with the powdery material so as to immobilize the sets of powdery material (2A-2D). When used for preparation of the medical solution, a fluid is selectively admitted into the package via the connector (10) so as to expand the compartment (6) and enable mixing of the sets (2A-2D) of powdery material with the solvent in the compartment (6).
摘要翻译：包装具有用于储存待与溶剂混合以形成医用溶液的粉末状材料的运输/储存状态，用于透析治疗。该包装件包括至少部分地由两个相对的壁部分限定的隔室（6）和连接器（10）。在运输/储存状态下，隔室含有至少两种不同组成的粉末材料组（2A-2D）形式的粉状材料，其中相对的壁部分与粉末材料接合，以便固定一组粉状材料（2A-2D）。当用于制备医用溶液时，通过连接器（10）将流体选择性地进入包装中，以便使隔室（6）膨胀，并使粉末材料组（2A-2D）与溶剂的组合隔室（6）。

7. 发明申请

WO2003080154A1 METHOD AND DEVICE FOR THE REMOVAL OF PARTIALLY PROTEIN BOUND SUBSTANCES 审中-公开
标题翻译：用于去除部分蛋白质结合物质的方法和装置
公开(公告)号：WO2003080154A1
公开(公告)日：2003-10-02
申请号：PCT/SE2003/000497
申请日：2003-03-25
申请人： GAMBRO LUNDIA AB , STERNBY, Jan , STERNBY, Berit
发明人： STERNBY, Jan , STERNBY, Berit
IPC分类号： A61M1/16
CPC分类号： B01D61/243 , A61M1/16 , A61M1/1607 , A61M1/1633 , A61M1/1647 , A61M1/165 , A61M1/1692 , A61M1/1696 , A61M1/341 , A61M1/3431 , A61M1/3465 , A61M2205/3317 , A61M2205/3324 , A61M2205/3334 , A61M2205/3368 , A61M2205/3393
摘要： A method and a device to increase the efficiency of dialysis for the removal from blood of substances that are more or less tightly bound to carriers such as albumin. According to the invention this is accomplished by a simultaneous significan increase of the flow rate of the dialysis fluid and of the area of the membrane that separates the blood from the dialysis fluid, compared to conventional dialysis.
摘要翻译：一种提高透析效率的方法和装置，用于从血液中去除或多或少紧密结合载体如白蛋白的物质。根据本发明，这是通过与常规透析相比，同时显着增加透析流体的流速和从透析液分离血液的膜的面积而实现的。

8. 发明申请

WO2010040819A1 HEAT EXCHANGER AND METHOD FOR HEAT EXCHANGING 审中-公开
标题翻译：热交换器和换热器的方法
公开(公告)号：WO2010040819A1
公开(公告)日：2010-04-15
申请号：PCT/EP2009/063148
申请日：2009-10-09
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , STERNBY, Jan , NILSSON, Eddie
发明人： JÖNSSON, Lennart , STERNBY, Jan , NILSSON, Eddie
IPC分类号： A61M1/36 , A61M5/44 , F28D9/00
CPC分类号： A61M1/3462 , A61M1/3621 , A61M5/44 , A61M2205/366 , F28D9/0075 , F28D9/0087 , F28D9/0093
摘要： The present invention relates to a method for exchanging heat between a primary fluid (W) and a secondary fluid 5 (X) and a heat exchanger (11) for heat exchange as well as an arrangement and a kit comprising a heat exchanger. The heat exchanger comprises a first and a second fluid circuit (19, 20) extending through the heat exchanger. The heat exchanger further comprises a stack of fluid plates (12, 13, 40) and a membrane (16) arranged between each of the fluid plates (12, 13, 40) where one interspace is formed between each fluid plate and membrane. The first and the second fluid circuit (19, 20) is each constituted by a passage extending through the fluid plates and membranes and along the fluid plates and membranes in at least two interspaces (17, 18). According to the method for heat exchanging a primary fluid (W) is passed through the first fluid circuit (19) and a secondary fluid (X) is passed through the second fluid circuit (20) such that the primary fluid (W) is passed along one side of a membrane (16) and simultaneously the secondary fluid (X) is passed along the other side of the membrane (16). Heat is thus exchanged between the primary fluid (W) and the secondary fluid (X) over the membrane (16).
摘要翻译：本发明涉及一种用于在一次流体（W）和二次流体5（X）和用于热交换的热交换器（11）之间进行热交换的方法以及包括热交换器的装置和套件。热交换器包括延伸穿过热交换器的第一和第二流体回路（19,20）。热交换器还包括一组流体板（12,13,40）和布置在每个流体板（12,13,40）之间的膜（16），其中在每个流体板和膜之间形成一个间隙。第一和第二流体回路（19,20）各自由在至少两个间隙（17,18）中延伸穿过流体板和膜并沿着流体板和膜延伸的通道构成。根据热交换方法，使第一流体（W）通过第一流体回路（19），并且次级流体（X）通过第二流体回路（20），使得主流体（W）通过沿着膜（16）的一侧，并且同时使第二流体（X）沿膜（16）的另一侧通过。因此，在膜（16）之间的主要流体（W）和次级流体（X）之间交换热量。

9. 发明申请

WO2012004103A1 AN AMBULATORY ULTRAFILTRATION DEVICE, RELATED METHODS AND A COMPUTER PROGRAM PRODUCT 审中-公开
标题翻译：一种超声波超声装置，相关方法和计算机程序产品
公开(公告)号：WO2012004103A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/060019
申请日：2011-06-16
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , STERNBY, Jan , WIESLANDER, Anders
发明人： JÖNSSON, Lennart , STERNBY, Jan , WIESLANDER, Anders
IPC分类号： A61M1/30
CPC分类号： A61M1/30 , A61M1/302 , A61M1/303 , A61M1/3427 , A61M1/3604 , A61M1/365 , A61M1/3672 , A61M2209/088
摘要： An ultrafiltration device is designed to be used for ambulatory SCUF or other types of continuous or intermittent ultrafiltration, typically while being worn or otherwise carried by the subject (S) that is being treated. The ambulatory ultrafiltration device comprises a blood filter (4) that has a blood side (6) for fluid communication with the vascular system of the subject (S), an ultrafiltrate side (7), and a semipermeable membrane (8) disposed between the blood side (6) and the ultrafiltrate side (7). The ambulatory ultrafiltration also comprises a buffer vessel (3) in fluid communication with the blood side (6) of the blood filter (4), and a blood pump (9). The blood pump (9) is controlled to alternate between a withdrawal phase and a return phase. In the withdrawal phase, blood is withdrawn on a blood path from the subject (S) via the blood filter (4) to the buffer vessel (3). In the return phase, blood is returned from the buffer vessel (3) to the subject (S) on the blood path. The blood filter (4) is arranged to remove ultrafiltrate from the blood during at least one of the withdrawal and return phases. The use of a single blood path for withdrawal of blood and return of treated blood makes the device suitable for ambulatory ultrafiltration.
摘要翻译：超滤装置设计用于移动SCUF或其他类型的连续或间歇超滤，通常在正在治疗的受试者（S）穿着或以其他方式携带时。动态超滤装置包括血液过滤器（4），其具有用于与受试者（S）的血管系统流体连通的血液侧（6），超滤液侧（7）和设置在所述受试者的血液系统之间的半透膜（8）血液侧（6）和超滤液侧（7）。动态超滤还包括与血液过滤器（4）的血液侧（6）流体连通的缓冲容器（3）和血液泵（9）。血泵（9）被控制为在抽出阶段和返回阶段之间交替。在取出阶段，血液在血液路径上从被检体（S）经由血液过滤器（4）抽出到缓冲容器（3）。在返回阶段，将血液从缓冲容器（3）返回到血液路径上的受试者（S）。血液过滤器（4）布置成在至少一个抽出和返回阶段期间从血液中除去超滤液。使用单个血液路径来取出血液并返回处理过的血液，使得该装置适合于动态超滤。

10. 发明申请

WO2009127624A3 BLOOD TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2009127624A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054406
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

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