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1. 发明申请

WO2012035040A1 BLOOD TREATMENT APPARATUS WITH FLOW DIVIDER FOR LIMITING AN ELECTRICAL CURRENT 审中-公开
标题翻译：用于限制电流的流量分配器的血液处理装置
公开(公告)号：WO2012035040A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065894
申请日：2011-09-14
申请人： GAMBRO LUNDIA AB , HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
发明人： HANSSON, Per , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , NILSSON, Anders , WALLENBORG, Anders , ANDERSSON, Johan
IPC分类号： A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/14 , A61M1/1601 , A61M1/3621 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , Y10T29/49002
摘要： A blood treatment apparatus (2) comprising: a blood treatment unit (10); a blood line (20) configured to extract blood from a blood source (21), pass the blood through the blood treatment unit (10) and deliver treated blood to a target vessel (22); and a fluid line (30) configured pass treatment fluid through the blood treatment unit (10) and deliver used treatment fluid to a fluid sink (32). A flow divider (40) is arranged in the fluid line (30) separates treatment fluid into to a first fluid section (51) and a second fluid section (53), thereby electrically isolating the fluid sections (51, 53) such that electrical current flowing in the fluid line (30) between the fluid sections (51, 53) is limited. Related manufacturing and verification methods are also described.
摘要翻译：一种血液处理装置（2），包括：血液处理单元（10）; 构成为从血液源（21）取出血液的血液线（20），使血液通过血液处理单元（10），将处理后的血液输送到目标血管（22）。并且流体管线（30）构造成通过处理液通过血液处理单元（10）并将使用的处理流体输送到流体槽（32）。在流体管线（30）中布置有分流器（40），其将处理流体分离成第一流体部分（51）和第二流体部分（53），从而将流体部分（51,53）电隔离，使得电气在流体管线（30）内流动的流体部分（51,53）之间的电流受到限制。还描述了相关的制造和验证方法。

2. 发明申请

WO2010043595A1 BLOOD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：血液处理装置和方法
公开(公告)号：WO2010043595A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063290
申请日：2009-10-12
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
发明人： HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A blood treatment apparatus, comprising a blood treatment unit (D) configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid, a pair of fluid pumps ( PF1, PF2; PF3, PF4) configured to pass blood treatment fluid through the blood treatment unit (D), a pair of blood pumps ( PB1, PB2) configured to extract untreated blood from a blood source (BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT), each blood pump comprising a pump chamber and a flexible member ( FM1; FM2) separating the pumping chamber into a first blood accumulating container (B1; B2) and a second working fluid accumulating container (F1; F2) where the flexible member is configured to vary a volume relationship between the first and the second accumulation containers. Further the apparatus comprises a control unit (P) and a measuring means configured to emit a feedback signal indicative of the amount of working fluid received into, or discharged from at least one of the second accumulation containers (F1; F2) whereby the pumped mass or volume of working fluid is determined by the control unit (P) at an arbitrary position of the flexible member (FM1, FM2).
摘要翻译：一种血液处理装置，包括：血液处理单元（D），被配置为接收未经处理的血液和新鲜血液处理液，并且发射处理过的血液和使用的血液处理液;一对流体泵（PF1，PF2; PF3，PF4）通过血液处理单元（D）通过血液处理液，构成为从血液源（BS）中提取未经处理的血液的一对血液泵（PB1，PB2），通过血液处理单元（D）将提取的血液通过，每个血液泵包括泵室和将泵送室分成第一血液积聚容器（B1; B2）和第二工作流体积聚容器（F1; B2）的柔性构件（FM1; FM2） F2），其中柔性构件构造成改变第一和第二蓄积容器之间的体积关系。此外，该装置包括控制单元（P）和测量装置，该测量装置被配置为发射指示接收到或从第二积聚容器（F1; F2）中的至少一个排出的工作流体的量的反馈信号，由此泵送的质量或者在柔性构件（FM1，FM2）的任意位置处由控制单元（P）确定工作流体的体积。

3. 发明申请

WO2010043593A1 BLOOD TREATMENT APPARATUS AND METHOD 审中-公开
标题翻译：血液处理装置和方法
公开(公告)号：WO2010043593A1
公开(公告)日：2010-04-22
申请号：PCT/EP2009/063285
申请日：2009-10-12
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
发明人： HOLMER, Mattias , JÖNSSON, Lennart , WALLENBORG, Anders , HANSSON, Per
IPC分类号： A61M1/16 , A61M1/30
CPC分类号： A61M1/16 , A61M1/1601 , A61M2205/50
摘要： A proposed blood treatment apparatus includes: a blood treatment unit (D), a pair of fluid pumps (PF1, PF2) and a pair of blood pumps (PB1, PB2). The blood treatment unit (D) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (PF1, PF2) are configured to pass blood treatment fluid through the blood treatment unit (D). The blood pumps (PB1, PB2) are configured to extract untreated blood from a blood source ( BS), pass extracted blood through the blood treatment unit (D) and deliver treated blood to a target vessel (BT). Flow measurement means (Q1, Q2, P) determines at least one blood f low parameter ( BQFI) reflecting an average flow in relation to the blood treatment unit (D) during a well-defined period of operation (T) of the apparatus, for example while completing one operation cycle. The at least one blood flow parameter (BQFI) is determined based on a difference between (i) a first amount (DMI) of fresh blood treatment fluid received into the blood treatment unit (D), and (ii) a second amount (DMO) of used blood treatment fluid emitted from the blood treatment unit (D) during another well-defined period (T a ).
摘要翻译：提出的血液处理装置包括：血液处理单元（D），一对流体泵（PF1，PF2）和一对血液泵（PB1，PB2）。血液处理单元（D）构成为能够接受未经处理的血液和新鲜的血液处理液，并且排出处理过的血液和使用的血液处理液。流体泵（PF1，PF2）被配置为使血液处理液通过血液处理单元（D）。血液泵（PB1，PB2）被构造成从血液源（BS）中提取未经处理的血液，通过血液处理单元（D）提取血液并将处理的血液输送到目标血管（BT）。流量测量装置（Q1，Q2，P）在装置的良好定义的操作时段（T）期间确定反映相对于血液处理单元（D）的平均流量的至少一个血液参数（BQFI）例如在完成一个操作周期。基于（i）接收到血液处理单元（D）中的新鲜血液处理液的第一量（DMI）和（ii）第二量（DMO）之间的差异来确定至少一个血流参数（BQFI））在另一个明确定义的时期（Ta）期间从血液处理单元（D）发射的使用的血液处理液。

4. 发明申请

WO2009127624A3 BLOOD TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2009127624A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054406
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

5. 发明申请

WO2012163737A1 BLOOD TREATMENT APPARATUS ADAPTED TO PRESERVE PARTS THEREOF 审中-公开
标题翻译：血液治疗装置适用于保留其部分
公开(公告)号：WO2012163737A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059520
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , WIESLANDER, Anders , JEPPSSON, Helena
发明人： HERTZ, Thomas , HOLMER, Mattias , JÖNSSON, Lennart , WIESLANDER, Anders , JEPPSSON, Helena
IPC分类号： A61M1/16 , A61M1/36
CPC分类号： A61M1/14 , A61M1/168 , A61M1/1682 , A61M1/1684 , A61M1/169 , A61M1/3643 , A61M1/3644 , A61M1/3649
摘要： A blood treatment apparatus adapted to preserve a blood treatment unit (20) between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit (20), ii) fill the blood treatment unit (20) with a preservation fluid comprising at least one treatment fluid concentrate of a type that is used to prepare the treatment fluid, iii) maintain the preservation fluid in the blood treatment unit (20) until a next blood treatment session is prepared, iv) dispatch the preservation fluid from the blood treatment unit (20) in preparation of a next blood treatment session, and v) perform a next blood treatment session and thereby extend the use of the blood treatment unit (20). A related method is also described.
摘要翻译：一种血液处理装置，适于在血液处理会话之间保留血液处理单元（20）。血液处理装置构成为：i）进行血液处理对象，由此使用血液处理单元（20），ii）用包含至少一种处理液浓缩物的保存液填充血液处理单元（20）用于制备治疗液，iii）将血液处理单元（20）中的保存液保持直至制备下次血液处理时间为止，iv）从血液处理单元（20）调出保存液，准备下一个血液处理会话，以及v）执行下一个血液处理会话，从而延长血液处理单元（20）的使用。还描述了相关方法。

6. 发明申请

WO2012175435A1 DISPOSABLES FOR BLOOD TREATMENT, AND METHODS OF OPERATING THE SAME 审中-公开
标题翻译：用于血液治疗的药物及其操作方法
公开(公告)号：WO2012175435A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061551
申请日：2012-06-18
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie , JÖNSSON, Lennart
发明人： JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie , JÖNSSON, Lennart
IPC分类号： A61M1/30 , A61M1/36
CPC分类号： A61M1/367 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/3621 , A61M2205/125 , A61M2205/128 , Y10T137/0318 , Y10T137/85986 , Y10T137/86035
摘要： A disposable for use in blood treatment comprises a blood treatment unit (8) and a pump arrangement (11) operable to pump blood through the blood treatment unit (8). The pump arrangement (11) comprises two membrane pumps (6, 7) connected in parallel on one side of the blood treatment unit (8). The disposable is operable in a single-needle mode, in which the pump arrangement (11) is operable to generate a pulsatile flow of blood through the blood treatment unit (8), and in a double-needle mode, in which the pump arrangement (11) is operable to generate an essentially continuous flow of blood through the blood treatment unit (8). The pump arrangement (11) is configured for connection to a supply system (1) of treatment fluid for the blood treatment unit (8) such that alternating flows of treatment fluid generated by the supply system (1) and supplied to the first and second membrane pumps (6, 7) causes the pump arrangement (11) to generate the desired flows of blood in the single-needle and double- needle modes. The treatment fluid may be used as motive fluid for displacing the blood in the membrane pumps (6, 7) and/or as control fluid for controlling opening and/or closing of upstream and downstream commutation valves (34, 35) in the membrane pumps (6, 7).
摘要翻译：用于血液处理的一次性用品包括血液处理单元（8）和可操作以将血液泵送通过血液处理单元（8）的泵装置（11）。泵装置（11）包括在血液处理单元（8）的一侧上并联连接的两个膜泵（6,7）。一次性可以单针模式操作，其中泵装置（11）可操作以通过血液处理单元（8）产生脉动血液流，并且在双针模式中，泵装置（11）可操作以通过血液处理单元（8）产生基本上连续的血液流。泵装置（11）构造成用于连接到用于血液处理单元（8）的处理流体的供应系统（1），使得由供应系统（1）产生并供应到第一和第二膜泵（6,7）使泵装置（11）以单针和双针模式产生所需的血液流。处理流体可以用作移动膜泵（6,7）中的血液的运动流体和/或用作控制膜泵中上游和下游换向阀（34,35）的打开和/或关闭的控制流体（6,7）。

7. 发明申请

WO2009127626A1 BLOOD TREATMENT APPARATUS 审中-公开
标题翻译：血液治疗装置
公开(公告)号：WO2009127626A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054408
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie
IPC分类号： A61M1/10 , A61M1/30
CPC分类号： A61M1/30 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/1086 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/3626 , A61M2205/331
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), at least one fluid pump (14, 15) and at least one blood pump (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pump(s) (14, 15) is(are) configured to pass blood treatment fluid through the blood treatment unit (8). The blood pump(s) ( 1a, 1b) is(are) configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, at least one of the fluid pumps (14, 15) is configured to control the operation of at least one blood pump (1a, 1b) via the blood treatment fluid. Moreover, at least one of the blood pumps (1a, 1b) is integrated into a joint apparatus element (D), which includes the blood treatment unit (8). Thus, this blood pump and the unit (8) may be mounted as well as be discarded jointly.
摘要翻译：提出的血液处理装置包括：血液处理单元（8），至少一个流体泵（14,15）和至少一个血液泵（1a，1b）。血液处理单元（8）构成为能够接收未经处理的血液和新鲜的血液处理液，并且排出经处理的血液和使用的血液处理液。流体泵（14,15）被配置为使血液处理流体通过血液处理单元（8）。血液泵（1a，1b）被构造成从血液源（S）中提取未经处理的血液，通过血液处理单元（8）提取血液并将处理的血液输送到目标血管（T）。此外，流体泵（14,15）中的至少一个构造成经由血液处理流体来控制至少一个血液泵（1a，1b）的操作。此外，血液泵（1a，1b）中的至少一个被集成到包括血液处理单元（8）的接合装置元件（D）中。因此，该血液泵和单元（8）可以被安装并被联合丢弃。

8. 发明申请

WO2011045167A1 MEMBRANE PUMP SYSTEM 审中-公开
标题翻译：膜泵系统
公开(公告)号：WO2011045167A1
公开(公告)日：2011-04-21
申请号：PCT/EP2010/064118
申请日：2010-09-24
申请人： GAMBRO LUNDIA AB , NILSSON, Eddie , JÖNSSON, Lennart , HOLMER, Mattias
发明人： NILSSON, Eddie , JÖNSSON, Lennart , HOLMER, Mattias
IPC分类号： A61M1/10 , A61M1/16 , F04B43/06
CPC分类号： A61M1/1639 , A61M1/1006 , A61M1/1037 , A61M1/106 , A61M1/16 , A61M2205/12 , F04B43/026 , F04B43/06
摘要： The present invention relates to a membrane pump and an apparatus comprising such a membrane pump. The membrane pump comprises a pumping chamber and a flexible member separating the pumping chamber into a first accumulation container and a second accumulation container. The flexible member is configured to be movable within the pumping chamber so as to vary a volume relationship between the first and second accumulation container. The second accumulation container is configured to receive an amount of working fluid to act on the flexible member and thus, in use, pump a first fluid from the first accumulation container. The first and the second accumulation container, each has an inlet opening for inlet of the respective fluid and an outlet opening for outlet of the respective fluid, the inlet opening being arranged on one side of the accumulation container and the outlet opening being arranged on the opposite side of the accumulation container. The flexible member is configured to show, when arranged in the pumping chamber and seen in a cross section along a plane extending through a pair of the inlet and outlet openings of the accumulation container, a thickness that is increased in a downstream direction.
摘要翻译：膜泵技术领域本发明涉及膜泵和包括这种膜泵的装置。膜泵包括泵送室和将泵送室分离成第一积聚容器和第二积聚容器的柔性构件。柔性构件被构造成在泵送室内可移动，以便改变第一和第二积聚容器之间的体积关系。第二积聚容器构造成接收一定量的工作流体以作用在柔性构件上，因此在使用中从第一积聚容器泵送第一流体。第一和第二蓄积容器各自具有用于各流体的入口的入口和用于各流体的出口的出口，入口开口布置在聚集容器的一侧上，出口开口布置在积聚容器的相对侧。柔性构件被构造成当布置在泵送室中并且沿着延伸穿过堆积容器的一对入口和出口开口的平面的横截面中看到时，其在下游方向上增加的厚度。

9. 发明申请

WO2005042059A2 A CIRCUIT FOR EXTRACORPOREAL BLOOD TREATMENT AND FLOW-INVERTING DEVICE UTILIZED THEREIN 审中-公开
标题翻译：用于体外血液处理的回路和用于其中的流动翻转装置
公开(公告)号：WO2005042059A2
公开(公告)日：2005-05-12
申请号：PCT/IB2004/003394
申请日：2004-10-18
申请人： GAMBRO LUNDIA AB , JONSSON, Lennart , HOLMER, Mattias , HANSSON, Per
发明人： JONSSON, Lennart , HOLMER, Mattias , HANSSON, Per
IPC分类号： A61M1/00
CPC分类号： A61M1/367 , A61M1/3658 , A61M39/223 , Y10T137/87249
摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.
摘要翻译：公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血泵之间。即使在由血泵控制的患者侧动脉和静脉分支中的反向循环之后，流动反转装置也允许过滤单元内的血流保持不变。

10. 发明申请

WO2012163870A1 METHOD AND DEVICE FOR DETECTING CONFIGURATIONS OF EXTRACORPOREAL BLOOD CIRCUIT, APPARATUS COMPRISING DETECTING DEVICE, AND COMPUTER PROGRAM FOR PERFORMING THE METHOD 审中-公开
标题翻译：用于检测超声波血液回路配置的方法和装置，包含检测装置的装置和用于执行方法的计算机程序
公开(公告)号：WO2012163870A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059929
申请日：2012-05-28
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , HOLMER, Mattias , NILSSON, Anders
发明人： JANSSON, Olof , HOLMER, Mattias , NILSSON, Anders
IPC分类号： A61M1/30 , A61M1/36
CPC分类号： A61M1/301 , A61M1/14 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/34 , A61M1/3403 , A61M1/3607 , A61M1/367 , A61M2205/18 , A61M2205/276 , A61M2205/3331 , A61M2205/3334 , A61M2205/50 , A61M2205/70 , A61M2205/702
摘要： A method for detecting a property of an extracorporeal line set (2, 9) in an apparatus (1) for extracorporeal blood treatment is disclosed. The extracorporeal line set (2, 9) is arranged to be connected to a patient. The method comprises the steps of: measuring a first pressure in a flow path (2) in said apparatus, measuring a second pressure in said flow path (2), comparing said first and second pressures, determining a detected extracorporeal line set property based on said pressure comparison. The detected property is at least one of a configuration of a blood access device and a blood tubing set property. A detecting device (20) for detecting a property of an extracorporeal line set (2, 9) in an apparatus (1) for extracorporeal blood treatment is also disclosed, as well as an apparatus (1) for extracorporeal blood treatment, a computer program for performing the method, and a computer-readable medium on which such computer program is stored.
摘要翻译：公开了一种用于检测用于体外血液处理的装置（1）中的体外线组（2,9）的性质的方法。体外线组（2,9）被布置成与患者连接。该方法包括以下步骤：测量所述装置中的流路（2）中的第一压力，测量所述流动路径（2）中的第二压力，比较所述第一和第二压力，确定检测到的体外线组属性，基于说压力比较。所检测的属性是血液导入装置和血管组合属性的构造中的至少一个。还公开了一种用于检测用于体外血液处理的装置（1）中的体外线组（2）的性质的检测装置（20），以及用于体外血液处理的装置（1），计算机程序用于执行该方法的计算机可读介质，以及存储该计算机程序的计算机可读介质。

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