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1. 发明授权

US07919749B2 Energy filter for cold field emission electron beam apparatus 有权
标题翻译：用于冷场发射电子束装置的能量滤波器
公开(公告)号：US07919749B2
公开(公告)日：2011-04-05
申请号：US12234453
申请日：2008-09-19
申请人： Fang Zhou , Juergen Frosien , Pavel Adamec
发明人： Fang Zhou , Juergen Frosien , Pavel Adamec
IPC分类号： H01J37/244
CPC分类号： H01J37/05 , H01J37/073 , H01J37/153 , H01J2237/057 , H01J2237/06341 , H01J2237/1207 , H01J2237/1534 , H01J2237/28
摘要： An electron beam apparatus and a method for providing an energy-filtered primary electron beam are described. Therein, a primary electron beam having an asymmetric first energy distribution is generated by means of an electron source. The primary electron beam is high-pass energy filtered using a retarding lens.
摘要翻译：描述了一种用于提供能量过滤的一次电子束的电子束装置和方法。其中，通过电子源产生具有不对称的第一能量分布的一次电子束。一次电子束是使用延迟透镜进行高通能量滤波。

2. 发明申请

US20070018562A1 Field emitter arrangement and method of cleansing an emitting surface of a field emitter 审中-公开
标题翻译：场发射器布置和清洁场发射器的发射表面的方法
公开(公告)号：US20070018562A1
公开(公告)日：2007-01-25
申请号：US11489979
申请日：2006-07-20
申请人： Pavel Adamec , Fang Zhou
发明人： Pavel Adamec , Fang Zhou
IPC分类号： H01J1/02
CPC分类号： H01J37/06 , H01J37/02 , H01J37/073 , H01J49/48 , H01J2237/06316
摘要： A field emitter arrangement and a method of cleaning an emitting surface of a field emitter are provided. The field emitter arrangement may include a field emitter tip having an emitting surface, wherein said field emitter tip is adapted to generate a primary beam of charged particles, and at least one electron source adapted to illuminate the emitting surface of the field emitter tip. The method of cleaning the emitting surface may include providing the field emitter having the emitting surface and at least one electron source adapted to illuminate the emitting surface and illuminating the emitting surface of the field emitter with a cleansing electron beam generated by the at least one electron source.
摘要翻译：提供场发射器布置和清洁场发射器的发射表面的方法。场发射器配置可以包括具有发射表面的场发射器尖端，其中所述场发射极尖端适于产生带电粒子的主光束，以及适于照射场发射器尖端的发射表面的至少一个电子源。清洁发射表面的方法可以包括提供具有发射表面的场致发射体和至少一个电子源，其适于照射发射表面并用由至少一个电子产生的清洁电子束照射场发射器的发射表面资源。

3. 发明授权

US07595490B2 Charged particle beam emitting device and method for operating a charged particle beam emitting device 有权
标题翻译：带电粒子束发射装置和用于操作带电粒子束发射装置的方法
公开(公告)号：US07595490B2
公开(公告)日：2009-09-29
申请号：US11469728
申请日：2006-09-01
申请人： Fang Zhou , Pavel Adamec , Jürgen Frosien , Jimmy Vishnipolsky
发明人： Fang Zhou , Pavel Adamec , Jürgen Frosien , Jimmy Vishnipolsky
IPC分类号： G01N23/00 , G21K7/00
CPC分类号： H01J37/073 , H01J2237/022 , H01J2237/06325
摘要： A method for operating a charged particle beam emitting device and, in particular, an electron beam emitting device including a cold field emitter is provided. The method includes the steps of placing the cold field emitter in a vacuum of a given pressure, the emitter exhibiting a high initial emission current I0 and a lower stable mean emission current IS under a given electric extraction field; applying the given electric extraction field to the emitter for emitting electrons from the emitter surface; performing a cleaning process by applying at least one heating pulse to the cold field emitter for heating the emitter surface, whereby the cleaning process is performed before the emission current of the cold field emitter has declined to the lower stable mean emission value IS; and repeating the cleaning process to keep the emission current of the emitter continuously above the substantially stable emission value IS.
摘要翻译：提供了一种用于操作带电粒子束发射器件的方法，特别是包括冷场发射器的电子束发射器件。该方法包括以下步骤：将冷场发射器置于给定压力的真空中，发射体在给定的电提取场下表现出高的初始发射电流I0和较低的稳定平均发射电流IS; 将给定的电提取场施加到发射器以从发射器表面发射电子; 通过向冷场发射器施加至少一个加热脉冲来加热发射体表面来执行清洁处理，由此在冷场发射器的发射电流已经下降到较低的稳定平均发射值IS之前进行清洁处理; 并重复清洁处理以将发射极的发射电流连续地保持在基本上稳定的发射值IS上。

4. 发明授权

US07982179B2 Beam current calibration system 有权
标题翻译：光束电流校准系统
公开(公告)号：US07982179B2
公开(公告)日：2011-07-19
申请号：US12366465
申请日：2009-02-05
申请人： Pavel Adamec , Fang Zhou
发明人： Pavel Adamec , Fang Zhou
IPC分类号： H01J23/00 , G12B13/00
CPC分类号： H01J37/244 , H01J37/261 , H01J2237/2443 , H01J2237/24507 , H01J2237/2826
摘要： A charged particle beam device is described. The charged particle beam device includes an emitter adapted for emitting a primary charged particle beam, a specimen location adapted for holding a specimen, from which secondary and/or backscattered charged particles are released on impingement of the primary charged particle beam, a detection unit adapted for detecting the secondary particles and/or secondary particles, and a beam guiding unit adapted for guiding the primary charged particle beam to the detection unit for impingement of a primary charged particle beam on the detection unit.
摘要翻译：描述带电粒子束装置。带电粒子束装置包括适于发射初级带电粒子束的发射器，适于保持试样的试样位置，从而从初级带电粒子束的冲击中释放辅助和/或反向散射的带电粒子，检测单元适于用于检测二次粒子和/或二次粒子的光束引导单元，以及用于将初级带电粒子束引导到检测单元的光束引导单元，用于将一次带电粒子束撞击在检测单元上。

5. 发明申请

US20070158588A1 CHARGED PARTICLE BEAM EMITTING DEVICE AND METHOD FOR OPERATING A CHARGED PARTICLE BEAM EMITTING DEVICE 有权
标题翻译：充电颗粒射束发射装置和用于操作充电颗粒光束发射装置的方法
公开(公告)号：US20070158588A1
公开(公告)日：2007-07-12
申请号：US11469728
申请日：2006-09-01
申请人： Fang Zhou , Pavel Adamec , Jurgen Frosien , Jimmy Vishnipolsky
发明人： Fang Zhou , Pavel Adamec , Jurgen Frosien , Jimmy Vishnipolsky
IPC分类号： A61N5/00
CPC分类号： H01J37/073 , H01J2237/022 , H01J2237/06325
摘要： A method for operating a charged particle beam emitting device and, in particular, an electron beam emitting device including a cold field emitter is provided. The method includes the steps of placing the cold field emitter in a vacuum of a given pressure, the emitter exhibiting a high initial emission current I0 and a lower stable mean emission current IS under a given electric extraction field; applying the given electric extraction field to the emitter for emitting electrons from the emitter surface; performing a cleaning process by applying at least one heating pulse to the cold field emitter for heating the emitter surface, whereby the cleaning process is performed before the emission current of the cold field emitter has declined to the lower stable mean emission value IS; and repeating the cleaning process to keep the emission current of the emitter continuously above the substantially stable emission value IS.
摘要翻译：提供了一种用于操作带电粒子束发射器件的方法，特别是包括冷场发射器的电子束发射器件。该方法包括以下步骤：将冷场发射器置于给定压力的真空中，发射体表现出高的初始发射电流I 0和较低的稳定平均发射电流I S，在给定的电提取场下; 将给定的电提取场施加到发射器以从发射器表面发射电子; 通过对冷场发射器施加至少一个加热脉冲来加热发射体表面来执行清洁处理，由此在冷场发射器的发射电流已经下降到较低的稳定平均发光值I < S

6. 发明授权

US08932628B2 Modified release formulations of a bupropion salt 有权
公开(公告)号：US08932628B2
公开(公告)日：2015-01-13
申请号：US11762343
申请日：2007-06-13
申请人： Werner Oberegger , Fang Zhou , Paul Maes , Graham Jackson , Mohammad Ashty Saleh
发明人： Werner Oberegger , Fang Zhou , Paul Maes , Graham Jackson , Mohammad Ashty Saleh
IPC分类号： A61K9/48 , A61K31/135 , A61K31/137 , A61K9/20 , C07C225/16 , A61K9/28
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

7. 发明申请

US20070293584A1 MODIFIED RELEASE FORMULATIONS OF A BUPROPION SALT 有权
标题翻译：改良释放盐的配方
公开(公告)号：US20070293584A1
公开(公告)日：2007-12-20
申请号：US11766251
申请日：2007-06-21
申请人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Saleh
发明人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Saleh
IPC分类号： A61K31/12 , A61P25/24
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
摘要翻译：本发明涉及包含安非他酮盐的药物组合物，制剂和药物，特别是包含有效量的安非他酮氢溴酸盐的改性释放片剂，以及使用安非他酮盐来制备治疗病症的药物。

8. 发明申请

US20060223131A1 Protein arrays and methods of use thereof 审中-公开
标题翻译：蛋白质阵列及其使用方法
公开(公告)号：US20060223131A1
公开(公告)日：2006-10-05
申请号：US11229258
申请日：2005-09-15
申请人： Barry Schweitzer , James Ball , Paul Predki , Fang Zhou , Gregory Michaud
发明人： Barry Schweitzer , James Ball , Paul Predki , Fang Zhou , Gregory Michaud
IPC分类号： G01N33/53 , G06Q10/00 , C12M1/34
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00725 , G01N33/552 , G01N33/6842 , G01N33/6845 , G06Q50/22 , Y02A90/22
摘要： The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positionally addressable array comprising at least 100 proteins immobilized on functionalized glass surface, and identifying a protein on the positionally addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least 1000 human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state.
摘要翻译：本发明提供了包含至少1000种人蛋白质的人类蛋白质阵列。在另一个实施方案中，本发明提供了一种用于鉴定酶底物的方法，包括使酶与包含至少100个固定在官能化玻璃表面上的蛋白质的位置可寻址阵列接触，以及鉴定结合位置可寻址阵列上的蛋白质和/或由酶修饰，其中酶的蛋白质的结合或修饰表明蛋白质是酶的底物。在另外的实施方案中，本文提供了在非变性条件下制备至少1000种人类蛋白质的阵列的方法，包括在非变性状态下难以表达和/或难以分离的人类蛋白质。

9. 发明申请

US20050118665A1 Methods for conducting assays for enzyme activity on protein microarrays 有权
标题翻译：蛋白质微阵列酶活性测定方法
公开(公告)号：US20050118665A1
公开(公告)日：2005-06-02
申请号：US10865431
申请日：2004-06-09
申请人： Fang Zhou , Barry Schweitzer
发明人： Fang Zhou , Barry Schweitzer
IPC分类号： C12Q1/00 , C12Q1/68 , C12Q1/37
CPC分类号： C12Q1/00
摘要： The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.
摘要翻译：本发明涉及对用于蛋白质功能的大规模研究，筛选测定和酶促反应的高通量分析的微阵列上的酶活性进行测定的方法。本发明涉及使用蛋白质芯片来测定存在于蛋白质芯片上的蛋白质样品中的酶的存在，量，活性和/或功能的方法。特别地，本发明的方法涉及使用微阵列进行酶测定，其中将蛋白质和物质固定在固体支持物的表面上，并且其中所述蛋白质和所述物质彼此接近，足以发生物质与蛋白质之间的酶反应。本发明还涉及具有固定在其表面上的酶和底物的微阵列，其中酶和底物相互接近，足以在酶和底物之间发生酶反应。

10. 发明授权

US10837423B2 Rotor reinforcing device for wind turbine 有权
公开(公告)号：US10837423B2
公开(公告)日：2020-11-17
申请号：US15772939
申请日：2016-08-11
申请人： Fang Zhou
发明人： Fang Zhou
IPC分类号： F03D1/06 , F03B17/06 , F03B13/26
CPC分类号： F03D1/0666 , F03B13/264 , F03B17/06 , F03B17/061 , F05B2240/21 , F05B2240/24 , F05B2240/50 , F05B2240/917 , F05B2280/6003 , Y02E10/72
摘要： A rotor reinforcing device to reinforce turbine rotor comprises a center connecting device which is fixed on a rotor hub, blade reinforcing members which are connected to the center connecting device and corresponding rotor blade, and guide structures which are configured to guide the blade reinforcing members to rotate around a longitudinal axis of the rotor blade. The rotor reinforcing device may be used to reinforce a rotor, a rotor-based wind turbine, a rotor-based ocean current turbine, a rotor-based tidal turbine and a rotor-based power generator.

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