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1. 发明申请

US20060223131A1 Protein arrays and methods of use thereof 审中-公开
标题翻译：蛋白质阵列及其使用方法
公开(公告)号：US20060223131A1
公开(公告)日：2006-10-05
申请号：US11229258
申请日：2005-09-15
申请人： Barry Schweitzer , James Ball , Paul Predki , Fang Zhou , Gregory Michaud
发明人： Barry Schweitzer , James Ball , Paul Predki , Fang Zhou , Gregory Michaud
IPC分类号： G01N33/53 , G06Q10/00 , C12M1/34
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00725 , G01N33/552 , G01N33/6842 , G01N33/6845 , G06Q50/22 , Y02A90/22
摘要： The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positionally addressable array comprising at least 100 proteins immobilized on functionalized glass surface, and identifying a protein on the positionally addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least 1000 human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state.
摘要翻译：本发明提供了包含至少1000种人蛋白质的人类蛋白质阵列。在另一个实施方案中，本发明提供了一种用于鉴定酶底物的方法，包括使酶与包含至少100个固定在官能化玻璃表面上的蛋白质的位置可寻址阵列接触，以及鉴定结合位置可寻址阵列上的蛋白质和/或由酶修饰，其中酶的蛋白质的结合或修饰表明蛋白质是酶的底物。在另外的实施方案中，本文提供了在非变性条件下制备至少1000种人类蛋白质的阵列的方法，包括在非变性状态下难以表达和/或难以分离的人类蛋白质。

2. 发明申请

US20060099704A1 Method for providing protein microarrays 审中-公开
标题翻译：提供蛋白质微阵列的方法
公开(公告)号：US20060099704A1
公开(公告)日：2006-05-11
申请号：US11183295
申请日：2005-07-14
申请人： Paul Predki , Barry Schweitzer
发明人： Paul Predki , Barry Schweitzer
IPC分类号： G06Q99/00 , C12M1/34
CPC分类号： G01N33/6842 , G01N33/6845 , G06Q10/103 , G06Q30/0601 , G16B25/00 , G16B50/00
摘要： The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein micorarray can include, in certain aspects, a computer function for performing some of the steps of the methods. Methods and kits for labeling a probe can include a control array that includes a molecule that binds to a label of a probe.
摘要翻译：本申请涉及用于向客户提供蛋白质微阵列产物和相关产品和服务的方法，用于标记蛋白质微阵列的探针的方法，试剂盒和系统，以及使用蛋白质微阵列测定蛋白质浓度的方法。用于提供蛋白质微阵列的方法可以在某些方面包括用于执行所述方法的一些步骤的计算机功能。用于标记探针的方法和试剂盒可包括包含结合探针标记的分子的对照阵列。

3. 发明申请

US20060141529A1 Compositions, kits and assays containing reagents directed to cortactin and an ARG/ABL protein kinase 审中-公开
标题翻译：含有针对cortactin和ARG / ABL蛋白激酶的试剂的组合物，试剂盒和测定
公开(公告)号：US20060141529A1
公开(公告)日：2006-06-29
申请号：US11191644
申请日：2005-07-27
申请人： Anthony Koleske , Scott Boyle , Greg Michaud , Barry Schweitzer , Paul Predki
发明人： Anthony Koleske , Scott Boyle , Greg Michaud , Barry Schweitzer , Paul Predki
IPC分类号： G01N33/53
CPC分类号： C12N9/1211 , A61K38/00 , G01N33/5041 , G01N2333/9121
摘要： It has been determined Cortactin interacts with an ARG/ABL protein kinase. Thus, provided herein are compositions, kits and assays containing reagents directed to Cortactin and an ARG/ABL protein kinase.
摘要翻译：已经确定Cortactin与ARG / ABL蛋白激酶相互作用。因此，本文提供了包含针对Cortactin和ARG / ABL蛋白激酶的试剂的组合物，试剂盒和测定法。

4. 发明申请

US20050118665A1 Methods for conducting assays for enzyme activity on protein microarrays 有权
标题翻译：蛋白质微阵列酶活性测定方法
公开(公告)号：US20050118665A1
公开(公告)日：2005-06-02
申请号：US10865431
申请日：2004-06-09
申请人： Fang Zhou , Barry Schweitzer
发明人： Fang Zhou , Barry Schweitzer
IPC分类号： C12Q1/00 , C12Q1/68 , C12Q1/37
CPC分类号： C12Q1/00
摘要： The present invention relates to methods of conducting assays for enzymatic activity on microarrays useful for the large-scale study of protein function, screening assays, and high-throughput analysis of enzymatic reactions. The invention relates to methods of using protein chips to assay the presence, amount, activity and/or function of enzymes present in a protein sample on a protein chip. In particular, the methods of the invention relate to conducting enzymatic assays using a microarray wherein a protein and a substance are immobilized on the surface of a solid support and wherein the protein and the substance are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the substance and the protein. The invention also relates to microarrays that have an enzyme and a substrate immobilized on their surface wherein the enzyme and the substrate are in proximity to each other sufficient for the occurrence of an enzymatic reaction between the enzyme and the substrate.
摘要翻译：本发明涉及对用于蛋白质功能的大规模研究，筛选测定和酶促反应的高通量分析的微阵列上的酶活性进行测定的方法。本发明涉及使用蛋白质芯片来测定存在于蛋白质芯片上的蛋白质样品中的酶的存在，量，活性和/或功能的方法。特别地，本发明的方法涉及使用微阵列进行酶测定，其中将蛋白质和物质固定在固体支持物的表面上，并且其中所述蛋白质和所述物质彼此接近，足以发生物质与蛋白质之间的酶反应。本发明还涉及具有固定在其表面上的酶和底物的微阵列，其中酶和底物相互接近，足以在酶和底物之间发生酶反应。

5. 发明申请

US20110034350A1 Protein Arrays and Methods of Use Thereof 审中-公开
标题翻译：蛋白质阵列及其使用方法
公开(公告)号：US20110034350A1
公开(公告)日：2011-02-10
申请号：US12768198
申请日：2010-04-27
申请人： Barry Schweitzer , James Ball , Paul F. Predki , Fang X. Zhou , Gregory A. Michaud
发明人： Barry Schweitzer , James Ball , Paul F. Predki , Fang X. Zhou , Gregory A. Michaud
IPC分类号： C40B50/06
CPC分类号： C12Q1/00 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00693 , B01J2219/00725 , G01N33/552 , G01N33/6842 , G01N33/6845 , G06Q50/22 , Y02A90/22
摘要： The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positionally addressable array comprising at least 100 proteins immobilized on functionalized glass surface, and identifying a protein on the positionally addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least 1000 human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state.
摘要翻译：本发明提供了包含至少1000种人蛋白质的人类蛋白质阵列。在另一个实施方案中，本发明提供了一种用于鉴定酶底物的方法，包括使酶与包含至少100个固定在官能化玻璃表面上的蛋白质的位置可寻址阵列接触，以及鉴定结合位置可寻址阵列上的蛋白质和/或由酶修饰，其中酶的蛋白质的结合或修饰表明蛋白质是酶的底物。在另外的实施方案中，本文提供了在非变性条件下制备至少1000种人类蛋白质的阵列的方法，包括在非变性状态下难以表达和/或难以分离的人类蛋白质。

6. 发明申请

US20060100788A1 Collections of matched biological reagents and methods for identifying matched reagents 审中-公开
标题翻译：匹配的生物试剂的集合和用于鉴定匹配试剂的方法
公开(公告)号：US20060100788A1
公开(公告)日：2006-05-11
申请号：US11112933
申请日：2005-04-22
申请人： John Carrino , Feng Liang , Siamak Baharloo , Barry Schweitzer
发明人： John Carrino , Feng Liang , Siamak Baharloo , Barry Schweitzer
IPC分类号： G06Q10/00 , G06F19/00
CPC分类号： G06Q30/0627 , G06Q30/06 , G06Q50/22 , Y02A90/22 , Y02A90/24
摘要： Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods for selecting an isolated biomolecule or biological research reagent from a collection of biological reagents.
摘要翻译：本文提供了选自更大量的生物试剂的匹配生物试剂的集合，其中匹配的生物试剂的收集涉及生物学元件。还提供了在匹配的生物试剂的集合中销售分离的生物分子或生物研究试剂的方法，以及从生物试剂的集合中选择分离的生物分子或生物研究试剂的方法。

7. 发明申请

US20100121738A1 METHOD FOR PROVIDING PROTEIN MICROARRAYS 审中-公开
标题翻译：提供蛋白微量元素的方法
公开(公告)号：US20100121738A1
公开(公告)日：2010-05-13
申请号：US12557163
申请日：2009-09-10
申请人： Paul F. PREDKI , Barry Schweitzer
发明人： Paul F. PREDKI , Barry Schweitzer
IPC分类号： G06Q50/00 , C40B40/10 , G06Q30/00 , G06F3/048 , G06K9/00
CPC分类号： G01N33/6842 , G01N33/6845 , G06Q10/103 , G06Q30/0601 , G16B25/00 , G16B50/00
摘要： The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein microarray can include, in certain aspects, a computer function for performing some of the steps of the methods. Methods and kits for labeling a probe can include a control array that includes a molecule that binds to a label of a probe.
摘要翻译：本申请涉及用于向客户提供蛋白质微阵列产物和相关产品和服务的方法，用于标记蛋白质微阵列的探针的方法，试剂盒和系统，以及使用蛋白质微阵列测定蛋白质浓度的方法。提供蛋白质微阵列的方法可以在某些方面包括用于执行所述方法的一些步骤的计算机功能。用于标记探针的方法和试剂盒可包括包含结合探针标记的分子的对照阵列。

8. 发明申请

US20060166227A1 Protein expression profiling 审中-公开
标题翻译：蛋白质表达谱
公开(公告)号：US20060166227A1
公开(公告)日：2006-07-27
申请号：US11187537
申请日：2005-07-22
申请人： Stephen Kingsmore , Girish Nallur , Barry Schweitzer
发明人： Stephen Kingsmore , Girish Nallur , Barry Schweitzer
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6816 , C12Q1/6837 , C12Q1/6844 , C12Q2565/501 , C12Q2531/125
摘要： Disclosed are compositions and methods for detecting small quantities of analytes such as proteins and peptides. The method involves associating a primer with an analyte and subsequently using the primer to mediate rolling circle replication of a circular DNA molecule. Amplification of the DNA circle is dependent on the presence of the primer. Thus, the disclosed method produces an amplified signal, via rolling circle amplification, from any analyte of interest. The amplified DNA remains associated with the analyte, via the primer, and so allows spatial detection of the analyte. The disclosed method can be used to detect and analyze proteins and peptides. Multiple proteins can be analyzed using microarrays to which the various proteins are immobilized. A rolling circle replication primer is then associated with the various proteins using a conjugate of the primer and a molecule that specifically binds the proteins to be detectable. Rolling circle replication from the primers results in production of a large amount of DNA at the sites in the array where the proteins are immobilized. The DNA produced by rolling circle replication can be further amplified in secondary and higher order amplification processes using second-stage or higher order primers in conjunction with second-stage or higher order amplification target circles. The amplified DNA serves as a readily detectable signal for the proteins. The disclosed method can also be used to compare the proteins expressed in two or more different samples. The information generated is analogous to the type of information gathered in nucleic acid expression profiles. The disclosed method allows sensitive and accurate detection and quantitation of proteins expressed in any cell or tissue.
摘要翻译：公开了用于检测少量分析物如蛋白质和肽的组合物和方法。该方法包括将底物与分析物缔合，随后使用引物介导环状DNA分子的滚环复制。 DNA环的扩增取决于引物的存在。因此，所公开的方法从感兴趣的任何分析物通过循环扩增产生扩增信号。扩增的DNA通过引物与分析物保持相关，因此允许分析物的空间检测。所公开的方法可用于检测和分析蛋白质和肽。可以使用固定有各种蛋白质的微阵列来分析多种蛋白质。然后使用引物和特异性结合蛋白质的可检测的分子的缀合物将滚环复制引物与各种蛋白质相关联。来自引物的滚环复制导致在固定有蛋白质的阵列中的位点产生大量的DNA。通过循环复制产生的DNA可以在次级和高级扩增过程中进一步扩增，使用第二级或更高级引物连同第二级或更高级扩增目标圆。扩增的DNA作为蛋白质的易检测信号。所公开的方法也可用于比较在两个或多个不同样品中表达的蛋白质。产生的信息类似于在核酸表达谱中收集的信息的类型。所公开的方法允许敏感且准确地检测和定量在任何细胞或组织中表达的蛋白质。

9. 发明申请

US20120094861A1 Compositions and Methods for Determining Immune Status 审中-公开
标题翻译：用于确定免疫状态的组合物和方法
公开(公告)号：US20120094861A1
公开(公告)日：2012-04-19
申请号：US13282290
申请日：2011-10-26
申请人： James Meegan , Alex Tikhonov , Barry Schweitzer , Gengxin Chen , Robert G. Ulrich
发明人： James Meegan , Alex Tikhonov , Barry Schweitzer , Gengxin Chen , Robert G. Ulrich
IPC分类号： C40B30/04 , C40B40/10
CPC分类号： G01N33/6845 , C07K14/35
摘要： The present invention provides compositions and methods for identifying molecules in samples that bind to molecules associated with pathogenic agents (e.g., infectious agents). In certain aspects, the invention may be used to identify individuals that have been exposed to one or more pathogenic agent or have generated antibodies in response to one or more pathogenic agent. In other aspects, the invention is directed to the identification of molecules of one or more pathogenic agent that may be used to generate immune responses in other individuals.
摘要翻译：本发明提供用于鉴定与病原体（例如感染因子）相关的分子结合的样品中的分子的组合物和方法。在某些方面，本发明可用于鉴定已经暴露于一种或多种病原体或已响应于一种或多种病原体产生抗体的个体。在其他方面，本发明涉及鉴定可用于在其他个体中产生免疫应答的一种或多种病原体的分子。

10. 发明申请

US20120004130A1 AUTOIMMUNE DISEASE BIOMARKERS 审中-公开
标题翻译：自杀性疾病生物标志物
公开(公告)号：US20120004130A1
公开(公告)日：2012-01-05
申请号：US13153262
申请日：2011-06-03
申请人： Dawn R. MATTOON , Barry Schweitzer , David Alcorta , Dhavalkumar Patel , Ronald Falk
发明人： Dawn R. MATTOON , Barry Schweitzer , David Alcorta , Dhavalkumar Patel , Ronald Falk
IPC分类号： C40B30/04 , C40B40/10 , G01N33/566
CPC分类号： G01N33/564 , G01N2800/102 , G01N2800/104
摘要： Provided herein are novel panels of biomarkers for the diagnosis of autoimmune diseases, and methods and kits for detecting these biomarkers in samples of individuals suspected of having an autoimmune disease. Also provided are methods of monitoring the progression of an autoimmune disease and methods of monitoring the efficacy and side effects of a treatment for an autoimmune disease.
摘要翻译：本文提供了用于诊断自身免疫疾病的生物标志物的新颖小组，以及用于在疑似患有自身免疫疾病的个体的样品中检测这些生物标志物的方法和试剂盒。还提供了监测自身免疫疾病进展的方法以及监测自身免疫疾病治疗的功效和副作用的方法。

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