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1. 发明专利

UY36062A COMPOSICIONES DERIVADAS DE CICLODEXTRINA Y BUDESÓNIDO Y MÉTODOS 未知
公开(公告)号：UY36062A
公开(公告)日：2015-10-30
申请号：UY36062
申请日：2015-04-06
申请人： UNIV LIEGE , PAUL MAES
发明人： PAUL MAES , DIDIER CATALDO , BRIGITTE EVRARD , GILLES DUFOUR , TULLIO PASCAL DE
IPC分类号： A61P11/00 , A61K31/56 , A61K31/58 , A61K31/702 , A61K47/40 , A61P9/14 , A61P29/00 , C07J71/00
摘要： La presente invención se refiere a composiciones farmacéuticas novedosas y útiles formuladas con un compuesto de ciclodextrina y un derivado de budesónido para el tratamiento y/o prevención de la enfermedad pulmonar inflamatoria. La presente invención también se refiere a una técnica analítica útil y novedosa para la detección y la cuantificación de HP-ß -CD en solución. Más específicamente, la presente invención se refiere al uso de un análisis de 1H NMR validado para la detección y cuantificación de ciclodextrinas directamente en formulaciones farmacéuticas sin algunas etapas de extracción o separación para formulaciones químicas

2. 发明授权

US09993487B2 Cyclodextrin and budesonide derivative compositions and methods 有权
公开(公告)号：US09993487B2
公开(公告)日：2018-06-12
申请号：US14672831
申请日：2015-03-30
申请人： Universite de Liege , Paul Maes
发明人： Didier Cataldo , Brigitte Evrard , Gilles Dufour , Pascal de Tullio , Paul Maes
IPC分类号： A61K31/58 , A61K31/56 , A61K31/573 , C08B37/16 , C08L5/16 , A61K9/00 , A61K31/57 , A61K47/40 , A61K47/69
CPC分类号： A61K31/58 , A61K9/0073 , A61K31/56 , A61K31/57 , A61K31/573 , A61K47/40 , A61K47/6951 , C08B37/0015 , C08L5/16
摘要： The present invention relates to novel and useful pharmaceutical compositions formulated with a cyclodextrin compound and a budesonide derivative for the treatment and/or prevention of pulmonary inflammatory disease. The present invention also relates to a novel and useful analytical technique for the detection and the quantification of HP-β-CD in solution. More specifically, the present invention relates to the use of a validated 1H NMR analysis for the detection and quantification of cyclodextrins directly in pharmaceutical formulations without any extraction or separation steps for liquid formulations.

3. 发明授权

US07645901B2 Modified release formulations of a bupropion salt 有权
公开(公告)号：US07645901B2
公开(公告)日：2010-01-12
申请号：US11766213
申请日：2007-06-21
申请人： Werner Oberegger , Paul Maes , Stefano Turchetta , Pietro Massardo , Mohammad Ashty Saleh
发明人： Werner Oberegger , Paul Maes , Stefano Turchetta , Pietro Massardo , Mohammad Ashty Saleh
IPC分类号： C07C63/04
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

4. 发明授权

US07579380B2 Modified release formulations of a bupropion salt 有权
标题翻译：安非他酮盐的改良释放制剂
公开(公告)号：US07579380B2
公开(公告)日：2009-08-25
申请号：US11774109
申请日：2007-07-06
申请人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Ashty Saleh
发明人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Ashty Saleh
IPC分类号： A61K31/12
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
摘要翻译：本发明涉及包含安非他酮盐的药物组合物，制剂和药物，特别是包含有效量的安非他酮氢溴酸盐的改性释放片剂，以及使用安非他酮盐来制备治疗病症的药物。

5. 发明授权

US07572935B2 Modified release formulations of a bupropion salt 有权
公开(公告)号：US07572935B2
公开(公告)日：2009-08-11
申请号：US11762840
申请日：2007-06-14
申请人： Werner Oberegger , Paul Maes , Stefano Turchetta , Pietro Massardo , Mohammad Ashty Saleh
发明人： Werner Oberegger , Paul Maes , Stefano Turchetta , Pietro Massardo , Mohammad Ashty Saleh
IPC分类号： C07C63/08 , C07C49/80 , C07C225/10 , A61K31/136
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

6. 发明授权

US07569611B2 Modified release formulations of a bupropion salt 有权
公开(公告)号：US07569611B2
公开(公告)日：2009-08-04
申请号：US11762820
申请日：2007-06-14
申请人： Werner Oberegger , Paul Maes , Mohammad Ashty Saleh
发明人： Werner Oberegger , Paul Maes , Mohammad Ashty Saleh
IPC分类号： A61K31/135
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

7. 发明申请

US20080175873A1 MODIFIED RELEASE COMPOSITION OF AT LEAST ONE FORM OF VENLAFAXINE 审中-公开
标题翻译：至少一种芬替康的形式的改性释放组合物
公开(公告)号：US20080175873A1
公开(公告)日：2008-07-24
申请号：US11947883
申请日：2007-11-30
申请人： Fang Zhou , Paul Maes , Steven Frisbee
发明人： Fang Zhou , Paul Maes , Steven Frisbee
IPC分类号： A61K9/00 , A61K31/137 , A61P25/24
CPC分类号： A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/284 , A61K9/2866
摘要： The present invention relates to a modified release composition of at least one form of venlafaxine, which is an enhanced absorption delayed controlled release composition. The composition comprises a core comprising at least one form of venlafaxine, less than 10% of a gelling agent and a pharmaceutically acceptable excipient. The composition further comprises a modified release coating which substantially surrounds the core which provides a delayed controlled release of the at least one form of venlafaxine.
摘要翻译：本发明涉及至少一种形式的文拉法辛的改进释放组合物，其是增强的吸收延迟控释组合物。组合物包含包含至少一种形式的文拉法辛，小于10％的胶凝剂和药学上可接受的赋形剂的核心。所述组合物还包含基本上围绕所述芯的改性释放涂层，其提供所述至少一种形式的文拉法辛的延迟控制释放。

8. 发明申请

US20080033043A1 MODIFIED RELEASE FORMULATIONS OF A BUPROPION SALT 有权
公开(公告)号：US20080033043A1
公开(公告)日：2008-02-07
申请号：US11762840
申请日：2007-06-14
申请人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Saleh
发明人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Saleh
IPC分类号： A61K31/19 , A61K31/135 , A61P25/00 , C07C211/00 , C07C69/76
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

9. 发明申请

US20070276047A1 MODIFIED RELEASE FORMULATIONS OF A BUPROPION SALT 有权
公开(公告)号：US20070276047A1
公开(公告)日：2007-11-29
申请号：US11751768
申请日：2007-05-22
申请人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Saleh
发明人： Werner Oberegger , Fang Zhou , Paul Maes , Stefano Turchetta , Graham Jackson , Pietro Massardo , Mohammad Saleh
IPC分类号： A61K31/137
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K31/135 , A61K31/137 , C07B2200/13 , C07C225/16
摘要： The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.

10. 发明申请

US20050244498A1 Modified-release compositions of at least one form of venlafaxine 审中-公开
标题翻译：至少一种文拉法辛的改性释放组合物
公开(公告)号：US20050244498A1
公开(公告)日：2005-11-03
申请号：US11003028
申请日：2004-12-03
申请人： Pawan Seth , Paul Maes
发明人： Pawan Seth , Paul Maes
IPC分类号： A61K9/00 , A61K9/24 , A61K9/28 , A61K31/277
CPC分类号： A61K9/2866 , A61K9/282 , A61K9/284 , A61K31/277
摘要： The present invention relates to a modified release composition of at least one form of venlafaxine, which is an enhanced absorption delayed controlled release composition for oral administration suitable for once daily dosing. The composition comprises a core comprising at least one form of venlafaxine selected from the group consisting of venlafaxine, an active metabolite of venlafaxine, a pharmaceutically acceptable salt of venlafaxine, a pharmaceutically acceptable salt of an active metabolite of venlafaxine, and combinations thereof, and a pharmaceutically acceptable excipient. The composition further comprises a modified release coating which substantially surrounds the core. The compositions of the invention provide enhanced absorption delayed controlled release of the at least one form of venlafaxine such that the combined geometric mean ratio of the composition of the invention to the reference product for the AUC0-t or the Cmax for venlafaxine and its active metabolite O-desmethylvenlafaxine is greater than 2 after first administration of the composition under fed or fasting conditions.
摘要翻译：本发明涉及文拉法辛的至少一种形式的改性释放组合物，其是适用于每日一次给药的口服给药的增强的吸收延迟控释组合物。所述组合物包含核心，其包含选自文拉法辛，文拉法辛的活性代谢物，文拉法辛的药学上可接受的盐，文拉法辛的活性代谢物的药学上可接受的盐及其组合中的至少一种形式的文拉法辛和药学上可接受的赋形剂。组合物还包含基本上围绕芯的改性释放涂层。本发明的组合物提供增强的吸收延迟控制释放至少一种形式的文拉法辛，使得本发明的组合物与参考产品的组合几何平均比例用于AUC 0-t或对于文拉法辛及其活性代谢物O-去甲基文拉法辛的C max max大于2，在给予或禁食条件下首次施用组合物后。

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