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1. 发明申请

US20050288771A1 Novel stent for treatment of bifurcated lesions 有权
标题翻译：用于治疗分叉病变的新型支架
公开(公告)号：US20050288771A1
公开(公告)日：2005-12-29
申请号：US10863192
申请日：2004-06-08
申请人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
发明人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61M29/02 , A61F2/06
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91533 , A61F2002/91558 , A61F2210/0004 , A61F2250/0067
摘要： A stent includes a lattice defining a substantially cylindrical configuration having a proximal end portion and a distal end portion, and a middle portion between the proximal end and the distal end. The lattice being moveable from a crimped state to an expanded state, and a plurality of adjacent hoops. Each hoop has a plurality of adjacent loops. Additionally, the stent further includes a plurality of bridges connecting adjacent hoops and a plurality of extensions on the lattice. Each of the hoops and bridges define a cell. The proximal end portion and the distal end portion of the lattice have at least one cell respectively and the middle portion of the lattice has at least one cell. The plurality of extensions are on the middle portion of the lattice. The plurality of extensions are cantilevered projections from the bridges and/or hoops of the lattice. The plurality of extensions are movably deformable in a direction away from the lattice, for example, at least some of the extensions are movably deformable in a direction away from the bridges and at least some of the extensions are movably deformable in a direction away from the hoops.
摘要翻译：支架包括限定具有近端部分和远端部分的基本上圆柱形构造的格子，以及近端和远端之间的中间部分。格子可以从卷曲状态移动到展开状态，并且多个相邻的环。每个箍具有多个相邻的环。此外，支架还包括连接相邻环的多个桥和在晶格上的多个延伸部。每个环和桥定义一个单元格。晶格的近端部分和远端部分分别具有至少一个电池，并且晶格的中间部分具有至少一个电池。多个延伸部位于格子的中间部分。多个延伸部是从网格的桥和/或环的悬臂突起。所述多个延伸部在远离格子的方向上可移动地变形，例如，至少一些延伸部在远离桥梁的方向上可移动地变形，并且至少一些延伸部分沿着远离网格的方向可移动地变形箍

2. 发明申请

US20050131524A1 Method for treating a bifurcated vessel 审中-公开
标题翻译：治疗分叉血管的方法
公开(公告)号：US20050131524A1
公开(公告)日：2005-06-16
申请号：US10863142
申请日：2004-06-08
申请人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
发明人： David Majercak , Matthew Krever , Jin Park , Robert Burgermeister , Hikmat Hojeibane , Martin Leon
IPC分类号： A61M29/02 , A61F2/06 , A61F2/84 , A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054
摘要： A method for treating a bifurcated vessel, wherein the bifurcated vessel has a main vessel and a side branch vessel extending from the main vessel. The method includes the steps of: identifying a site in the main vessel and placing a stent at the site in the main vessel. The stent includes a lattice defining a substantially cylindrical configuration having a proximal end portion and a distal end portion, and a middle portion between the proximal end portion and the distal end portion. The lattice is movable from a crimped state to an expanded state. The lattice has a plurality of adjacent hoops. Each hoop has a plurality of adjacent loops, a plurality of bridges connecting adjacent hoops, and a plurality of extensions on at least some portions of the lattice. Each of the hoops and bridges define a cell. The proximal end portion and the distal end portion of the lattice have at least one cell respectively and the middle portion of the lattice has at least one cell. The at least one cell of the middle portion has spacing between adjacent hoops that is greater than spacing between adjacent hoops of the at least one cell of the proximal end portion and the distal end portion respectively. The at least one cell of the middle portion is dilated adjacent the side branch vessel and a surface of the side branch vessel is supported with at least one of the plurality of the extensions by deformably moving the at least one of the plurality of extensions away from the lattice and into contact with the surface of the side branch vessel.
摘要翻译：一种治疗分叉血管的方法，其中分叉血管具有主血管和从主血管延伸的侧支血管。该方法包括以下步骤：识别主容器中的位置并将支架放置在主容器中的位置处。支架包括限定具有近端部分和远端部分的基本上圆柱形构造的格子，以及近端部分和远端部分之间的中间部分。格子可以从卷曲状态移动到展开状态。格子具有多个相邻的箍。每个箍具有多个相邻的环，连接相邻环的多个桥，以及在该格的至少某些部分上的多个延伸部。每个环和桥定义一个单元格。晶格的近端部分和远端部分分别具有至少一个电池，并且晶格的中间部分具有至少一个电池。中间部分的至少一个单元在相邻的箍之间具有分别大于近端部分的至少一个单元和远端部分的相邻环之间的间隔的间隔。中间部分的至少一个单元在侧分支容器附近扩张，并且侧分支容器的表面由多个延伸部中的至少一个支撑，多个延伸部中的至少一个延伸部可变形地将多个延伸部中的至少一个远离格子并与侧支血管的表面接触。

3. 发明授权

US07918884B2 Stent for treatment of bifurcated lesions 有权
标题翻译：支架治疗分叉病变
公开(公告)号：US07918884B2
公开(公告)日：2011-04-05
申请号：US10863192
申请日：2004-06-08
申请人： David C. Majercak , Matthew Krever , Jin S. Park , Robert S. Burgermeister , Hikmat Hojeibane , Martin B. Leon
发明人： David C. Majercak , Matthew Krever , Jin S. Park , Robert S. Burgermeister , Hikmat Hojeibane , Martin B. Leon
IPC分类号： A61F2/01
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/821 , A61F2002/91533 , A61F2002/91558 , A61F2210/0004 , A61F2250/0067
摘要： A stent includes a lattice defining a substantially cylindrical configuration having a proximal end portion and a distal end portion, and a middle portion between the proximal end and the distal end. The lattice being moveable from a crimped state to an expanded state, and a plurality of adjacent hoops. Each hoop has a plurality of adjacent loops. Additionally, the stent further includes a plurality of bridges connecting adjacent hoops and a plurality of extensions on the lattice. Each of the hoops and bridges define a cell. The proximal end portion and the distal end portion of the lattice have at least one cell respectively and the middle portion of the lattice has at least one cell. The plurality of extensions are on the middle portion of the lattice. The plurality of extensions are cantilevered projections from the bridges and/or hoops of the lattice. The plurality of extensions are movably deformable in a direction away from the lattice, for example, at least some of the extensions are movably deformable in a direction away from the bridges and at least some of the extensions are movably deformable in a direction away from the hoops.
摘要翻译：支架包括限定具有近端部分和远端部分的基本上圆柱形构造的格子，以及近端和远端之间的中间部分。格子可以从卷曲状态移动到展开状态，并且多个相邻的环。每个箍具有多个相邻的环。此外，支架还包括连接相邻环的多个桥和在晶格上的多个延伸部。每个环和桥定义一个单元格。晶格的近端部分和远端部分分别具有至少一个电池，并且晶格的中间部分具有至少一个电池。多个延伸部位于格子的中间部分。多个延伸部是从网格的桥和/或环的悬臂突起。所述多个延伸部在远离格子的方向上可移动地变形，例如，至少一些延伸部在远离桥梁的方向上可移动地变形，并且至少一些延伸部分沿着远离网格的方向可移动地变形箍

4. 发明申请

US20070219611A1 Apparatus for treating a bifurcated region of a conduit 有权
标题翻译：用于处理导管的分叉区域的装置
公开(公告)号：US20070219611A1
公开(公告)日：2007-09-20
申请号：US11591656
申请日：2006-11-01
申请人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
发明人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
IPC分类号： A61F2/84 , A61F2/90
CPC分类号： A61F2/954 , A61F2/856 , A61F2/91 , A61F2/958 , A61F2250/0039 , A61F2250/006
摘要： A system for treating a diseased body conduit bifurcation that is readily deliverable into a region of a body conduit having typically asymmetric anatomy, such as a vessel bifurcation is provided. The system comprises a delivery device such as a catheter having a shaft with varying torsional properties along its length and a delivery apparatus mounted at its distal end. A distal end of the device can be inserted into the main branch and at least one side branch of a vessel bifurcation. The distal end includes at least two expansion members having expandable scaffolds or prostheses mounted thereon. One scaffold is configured such that one expansion member extends through the length of the scaffold while the other expansion member extends through the side-structure of the scaffold. A second scaffold is mounted on the expansion member extending through the side-structure of the first scaffold.
摘要翻译：提供了一种用于治疗容易输送到具有典型的不对称解剖结构（例如血管分叉）的体导管的区域中的患病体管道分叉的系统。该系统包括诸如导管的输送装置，其具有沿其长度具有变化的扭转特性的轴和安装在其远端的输送装置。装置的远端可插入主分支和血管分叉的至少一个侧支。远端包括至少两个膨胀构件，其具有安装在其上的可扩张支架或假体。一个支架构造成使得一个膨胀构件延伸穿过支架的长度，而另一个膨胀构件延伸穿过支架的侧面结构。第二支架安装在延伸穿过第一支架的侧面结构的膨胀构件上。

5. 发明授权

US08257419B2 Apparatus for treating a bifurcated region of a conduit 有权
标题翻译：用于处理导管的分叉区域的装置
公开(公告)号：US08257419B2
公开(公告)日：2012-09-04
申请号：US11591656
申请日：2006-11-01
申请人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
发明人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61F2/856 , A61F2/91 , A61F2/958 , A61F2250/0039 , A61F2250/006
摘要： A system for treating a diseased body conduit bifurcation that is readily deliverable into a region of a body conduit having typically asymmetric anatomy, such as a vessel bifurcation is provided. The system comprises a delivery device such as a catheter having a shaft with varying torsional properties along its length and a delivery apparatus mounted at its distal end. A distal end of the device can be inserted into the main branch and at least one side branch of a vessel bifurcation. The distal end includes at least two expansion members having expandable scaffolds or prostheses mounted thereon. One scaffold is configured such that one expansion member extends through the length of the scaffold while the other expansion member extends through the side-structure of the scaffold. A second scaffold is mounted on the expansion member extending through the side-structure of the first scaffold.
摘要翻译：提供了一种用于治疗容易输送到具有典型的不对称解剖结构（例如血管分叉）的体导管的区域中的患病体管道分叉的系统。该系统包括诸如导管的输送装置，其具有沿其长度具有变化的扭转特性的轴和安装在其远端的输送装置。装置的远端可插入主分支和血管分叉的至少一个侧支。远端包括至少两个膨胀构件，其具有安装在其上的可扩张支架或假体。一个支架构造成使得一个膨胀构件延伸穿过支架的长度，而另一个膨胀构件延伸穿过支架的侧面结构。第二支架安装在延伸穿过第一支架的侧面结构的膨胀构件上。

6. 发明授权

US08197536B2 Method for placing a medical device at a bifurcated conduit 有权
标题翻译：将医疗装置放置在分叉管道上的方法
公开(公告)号：US08197536B2
公开(公告)日：2012-06-12
申请号：US11591396
申请日：2006-11-01
申请人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
发明人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
IPC分类号： A61F2/28 , A61F11/00
CPC分类号： A61F2/954 , A61F2/856 , A61F2/91 , A61F2/958 , A61F2250/0039 , A61F2250/006
摘要： A method for treating a diseased body conduit at a bifurcation point is provided. A system having devices mounted thereon is advanced into the bifurcated region of the conduit. The system includes a delivery means, such as a catheter having a shaft with varying torsional properties along its length and a delivery apparatus mounted at its distal end. A distal end of the delivery means can be inserted into the main branch and at least one side branch of a vessel bifurcation. The distal end includes at least two expansion members having expandable devices or prostheses mounted thereon. One device is configured such that one expansion member extends through the length of the scaffold while the other expansion member extends through the side-structure of the scaffold. A second scaffold is mounted on the expansion member extending through the side-structure of the first scaffold. The devices are positioned within the main and side branches of the bifurcation and are expanded.
摘要翻译：提供了一种在分叉点处理患病体导管的方法。具有安装在其上的装置的系统进入导管的分叉区域。该系统包括输送装置，例如具有沿其长度具有变化的扭转特性的轴的导管和安装在其远端的输送装置。输送装置的远端可插入主分支和血管分叉的至少一个侧支。远端包括至少两个膨胀构件，其具有安装在其上的可扩张装置或假体。一个装置构造成使得一个膨胀构件延伸穿过支架的长度，而另一个膨胀构件延伸穿过支架的侧部结构。第二支架安装在延伸穿过第一支架的侧面结构的膨胀构件上。设备位于分叉的主分支和侧分支中，并被扩展。

7. 发明申请

US20100094334A1 PLICATION DEVICE WITH FORMABLE LINEAR FASTENER FOR USE IN THE DIRECT PLICATION ANNULOPLASTY TREATMENT OF MITRAL VALVE REGURGITATION 审中-公开
标题翻译：用于直接电镀的线性紧固件的电极装置用于治疗门静脉注射的ANNOLOPLASTY治疗
公开(公告)号：US20100094334A1
公开(公告)日：2010-04-15
申请号：US12349302
申请日：2009-01-06
申请人： Matthew Krever , Rudolph Cedro, JR. , Timothy Lash , David Majercak , Daniel H. Olsen
发明人： Matthew Krever , Rudolph Cedro, JR. , Timothy Lash , David Majercak , Daniel H. Olsen
IPC分类号： A61B17/00
CPC分类号： A61B17/0644 , A61B17/122 , A61B17/1285 , A61B2017/00243
摘要： A system for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular tissue each fixed by a retaining clip is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a prolapsable crossing catheter. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. The plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a formable linear retainer clip is deployed by the plication device in order to retain the plicated tissue in the plicated form. The formable linear retainer is formed into a reverse “C” clip by the jaws of the plication device acting in conjunction with a retainer pusher.
摘要翻译：描述了一种通过使用由固定夹固定的环形组织的一个或多个引导来重塑二尖瓣环的治疗二尖瓣反流的系统。该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。第一个是脱垂的交叉导管。第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。然后使用屈光装置在二尖瓣环的亚瓣膜区域进行肿瘤。第四，通过打浆装置展开一个可成形的线性保持夹，以便将复制的纸巾保持在复杂的形式中。可形成的线性保持器通过与保持器推动器结合起作用的打浆装置的夹爪形成为反向的“C”夹。

8. 发明申请

US20080125847A1 Method for placing a medical device at a bifurcated conduit 有权
标题翻译：将医疗装置放置在分叉管道上的方法
公开(公告)号：US20080125847A1
公开(公告)日：2008-05-29
申请号：US11591396
申请日：2006-11-01
申请人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
发明人： Matthew Krever , Robert Burgermeister , Edwin Schulting , Wilhelmus van Erp , Richard Dirks
IPC分类号： A61F2/06
CPC分类号： A61F2/954 , A61F2/856 , A61F2/91 , A61F2/958 , A61F2250/0039 , A61F2250/006
摘要： A method for treating a diseased body conduit at a bifurcation point is provided. A system having devices mounted thereon is advanced into the bifurcated region of the conduit. The system includes a delivery means, such as a catheter having a shaft with varying torsional properties along its length and a delivery apparatus mounted at its distal end. A distal end of the delivery means can be inserted into the main branch and at least one side branch of a vessel bifurcation. The distal end includes at least two expansion members having expandable devices or prostheses mounted thereon. One device is configured such that one expansion member extends through the length of the scaffold while the other expansion member extends through the side-structure of the scaffold. A second scaffold is mounted on the expansion member extending through the side-structure of the first scaffold. The devices are positioned within the main and side branches of the bifurcation and are expanded.
摘要翻译：提供了一种在分叉点处理患病体导管的方法。具有安装在其上的装置的系统进入导管的分叉区域。该系统包括输送装置，例如具有沿其长度具有变化的扭转特性的轴的导管和安装在其远端的输送装置。输送装置的远端可插入主分支和血管分叉的至少一个侧支。远端包括至少两个膨胀构件，其具有安装在其上的可扩张装置或假体。一个装置构造成使得一个膨胀构件延伸穿过支架的长度，而另一个膨胀构件延伸穿过支架的侧部结构。第二支架安装在延伸穿过第一支架的侧面结构的膨胀构件上。设备位于分叉的主分支和侧分支中，并被扩展。

9. 发明授权

US08226709B2 Method and system for plicating tissue in a minimally invasive medical procedure for the treatment of mitral valve regurgitation 有权
标题翻译：用于治疗二尖瓣反流的微创医疗程序中的组织的方法和系统
公开(公告)号：US08226709B2
公开(公告)日：2012-07-24
申请号：US12249388
申请日：2008-10-10
申请人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
发明人： Adam Groothuis , Matthew Krever , Timothy Lash , Rudolph Cedro , Ted Bachman , Paul D'Antonio , Erin Black , Daniel H. Olsen , Salvatore G. Caldarise , Natalie D. Macon , Paritosh Dhawale
IPC分类号： A61F2/24 , A61B17/10
CPC分类号： A61F2/2466 , A61B17/00234 , A61B17/29 , A61B2017/00243 , A61B2017/00292 , A61B2017/2905 , A61B2017/2923 , A61B2017/2925 , A61B2017/2927 , A61B2017/2939 , A61B2017/2946
摘要： A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a “C” shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.
摘要翻译：描述了通过使用由保持器固定的环形或相邻组织的一个或多个点进行重新形成二尖瓣环的治疗二尖瓣反流的系统和方法。该系统包括四个装置来实现这种经皮直接瓣膜瓣成形术。第一个是具有可脱垂或弯曲的尖端的交叉导管。第二，偏转引导导管用于提供用于将折叠装置引导到二尖瓣环的下瓣区域的适当位置的装置。第三，折叠装置然后用于在二尖瓣环的亚瓣膜区域进行。肿。第四，通过打浆装置展开具有可变形端部的“C”形保持器，以便将复制的组织保持在复制形式中。经口途径可用于将二尖瓣心房侧的组织挽留并保留，以减少二尖瓣反流。

10. 发明申请

US20130085562A1 APPARATUS FOR AND METHOD OF PULLING A TENSILE MEMBER FROM A MEDICAL DEVICE 审中-公开
标题翻译：用于从医疗装置拉伸拉伸成员的装置和方法
公开(公告)号：US20130085562A1
公开(公告)日：2013-04-04
申请号：US13260881
申请日：2011-06-22
申请人： Cesar Rincon , Matthew Krever , Daniel Olsen , Edward Johnson
发明人： Cesar Rincon , Matthew Krever , Daniel Olsen , Edward Johnson
IPC分类号： A61F2/95
摘要： Mechanisms for pulling a tensile member a predetermined distance from a medical device having an intracorporeal end and an extracorporeal end are disclosed. Such mechanisms may be safely operated using a robot, two hands, or in some embodiments, only one hand. Such mechanisms may include one or more cams, drums, or pulley-like members and a lever, and may be physically coupled to an extracorporeal portion of the medical device.
摘要翻译：公开了从具有体内末端和体外终端的医疗装置拉伸预定距离的拉伸构件的机构。这样的机构可以使用机器人，两只手，或在一些实施例中仅一只手来安全地操作。这种机构可以包括一个或多个凸轮，滚筒或滑轮状构件和杠杆，并且可以物理地联接到医疗装置的体外部分。

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